Thiamylal: Difference between revisions

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Thiamylal
Clinical data
Synonyms	Thiamylal, Thioseconal, Surital
AHFS/Drugs.com	International Drug Names
ATCvet code	Template:Infobox drug/formatATCvet; Template:Infobox drug/formatATCvet;
Legal status
Legal status	CA: Schedule III ; US: Schedule III ;
Pharmacokinetic data
Metabolism	Hepatic
Elimination half-life	14.3 h (cats)
Identifiers
	IUPAC name 5-allyl-5-(1-methylbutyl)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione;
CAS Number	77-27-0 ;
PubChem CID	3032285;
DrugBank	DB01154 ;
ChemSpider	2297298 ;
UNII	01T23W89FR;
KEGG	D06106 ;
ChEBI	CHEBI:9536 ;
ChEMBL	ChEMBL440 ;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C12H18N2O2S
Molar mass	254.35 g/mol
3D model (JSmol)	Interactive image;
	SMILES O=C1NC(=S)NC(=O)C1(C(C)CCC)C\C=C;
	InChI InChI=1S/C12H18N2O2S/c1-4-6-8(3)12(7-5-2)9(15)13-11(17)14-10(12)16/h5,8H,2,4,6-7H2,1,3H3,(H2,13,14,15,16,17) ; Key:XLOMZPUITCYLMJ-UHFFFAOYSA-N ;
(verify)

VisualWikitext

Latest revision as of 20:32, 10 April 2015

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Thiamylal (Surital) is a barbiturate derivative invented in the 1950s. It has sedative, anticonvulsant, and hypnotic effects, and is used as a strong but short acting sedative. Thiamylal is still in current use, primarily for induction in surgical anaesthesia ^[1] or as an anticonvulsant to counteract side effects from other anaesthetics.^[2] It is the thiobarbiturate analogue of secobarbital.

References

↑ Hsieh MY, Hung GY, Hsieh YL, Chang CY, Hwang B. Deep sedation with methohexital or thiamylal with midazolam for invasive procedures in children with acute lymphoblastic leukemia. Acta Paediatrica Taiwan. 2005 Sep-Oct;46(5):294-300.
↑ Tsai CJ, Wang HM, Lu IC, Tai CF, Wang LF, Soo LY, Lu DV. Seizure after local anesthesia for nasopharyngeal angiofibroma. Kaohsiung Journal of Medical Sciences. 2007 Feb;23(2):97-100.

[1] Hsieh MY, Hung GY, Hsieh YL, Chang CY, Hwang B. Deep sedation with methohexital or thiamylal with midazolam for invasive procedures in children with acute lymphoblastic leukemia. Acta Paediatrica Taiwan. 2005 Sep-Oct;46(5):294-300.

[2] Tsai CJ, Wang HM, Lu IC, Tai CF, Wang LF, Soo LY, Lu DV. Seizure after local anesthesia for nasopharyngeal angiofibroma. Kaohsiung Journal of Medical Sciences. 2007 Feb;23(2):97-100.

[1]

[2]

@@ Line 2: / Line 2: @@
 | verifiedrevid = 470606310
 | IUPAC_name = 5-allyl-5-(1-methylbutyl)-2-thioxodihydropyrimidine-4,6(1''H'',5''H'')-dione
-| image = ThiamylalSVG.svg
+| image = ThiamylalSVG.png
 | width = 100
@@ Line 59: / Line 59: @@
 }}
+              __NOTOC__
+{{SI}}
+{{CMG}}
+==Overview==
 '''Thiamylal''' ('''Surital''') is a [[barbiturate]] derivative invented in the 1950s. It has [[sedative]], [[anticonvulsant]], and [[hypnotic]] effects, and is used as a strong but short acting sedative. Thiamylal is still in current use, primarily for induction in [[surgical]] [[anaesthesia]] <ref> Hsieh MY, Hung GY, Hsieh YL, Chang CY, Hwang B. Deep sedation with methohexital or thiamylal with midazolam for invasive procedures in children with acute lymphoblastic leukemia. Acta Paediatrica Taiwan. 2005 Sep-Oct;46(5):294-300. </ref> or as an anticonvulsant to counteract side effects from other anaesthetics.<ref> Tsai CJ, Wang HM, Lu IC, Tai CF, Wang LF, Soo LY, Lu DV. Seizure after local anesthesia for nasopharyngeal angiofibroma. Kaohsiung Journal of Medical Sciences. 2007 Feb;23(2):97-100. </ref> It is the thiobarbiturate analogue of [[secobarbital]].
 == References ==
-<references />
+{{Reflist|2}}
-{{Sedatives}}
-{{GABAAR PAMs}}
 [[Category:Thiobarbiturates]]
-[[Category:GABAA receptor positive allosteric modulators]]
+[[Category:Drug]]
-{{nervous-system-drug-stub}}

Thiamylal: Difference between revisions

Latest revision as of 20:32, 10 April 2015

Overview

References

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