Infectious Disease Project Organ-Based Infections Musculoskeletal System: Difference between revisions

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{{tab2-inactive|Infectious Disease Project Pathogen-Based Infections|Pathogen-Based Infections}}
{{tab2-inactive|Infectious Disease Project Pathogen-Based Infections|Pathogen-Based Infections}}
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==''WikiDoc Infectious Disease Project'' — Organ-Based Infections==
==''WikiDoc Infectious Disease Project'' — Organ-Based Infections — Musculoskeletal ==
===Osteomyelitis===
'''Osteomyelitis'''
:{{Regimen|Candidal_osteomyelitis|Preferred Regimen: [[Fluconazole]] 400 mg (6 mg/kg) IV/PO daily {{or}} [[Lipid-based Amphotericin B]] 3-5 mg/kg IV daily for two weeks, followed by [[Fluconazole]] <br> Alternative Regimen: [[Caspofungin]] 70 mg IV oading dose, then 50 mg/day IV {{or}} [[Micafungin]] 100 mg/day IV {{or}} [[Anidulafungin]] 200 mg IV loading dose, then 100 mg/day IV}}
:Chronic_osteomyelitis
:Contiguous_with_vascular_insufficiency
:Contiguous_without_vascular_insufficiency
:Diabetic_foot
:Foot_bone
:Foot_puncture_wound
:Hematogenous
:Hemoglobinopathy
:Prosthetic_joint_infection
:Spinal_implant
:Sternal


====Candidal osteomyelitis====
'''Bursitis'''
{{Rx|Preferred Regimen}}
* '''[[Fluconazole]]''' 400 mg (6 mg/kg) IV/po daily {{or}} '''[[Lipid-based Amphotericin B]]''' 3-5 mg/kg daily for two weeks, followed by '''[[Fluconazole]]'''
</li>
{{Rx|Alternative Regimen}}
* '''[[Caspofungin]]''' 70 mg loading dose, then 50 mg/day IV {{or}} '''[[Micafungin]]''' 100 mg/day IV or Anidulafungin 200 mg IV loading dose, then 100 mg/day IV
</li>


====Chronic osteomyelitis====
'''Lyme_arthritis'''
{{Rx|Preferred Regimen}}
* '''[[Systemic antibiotics]]''' per culture and susceptibility results {{and}}
* '''[[Surgical debridement]]'''
</li>


====Contiguous with vascular insufficiency====
'''Reactive_arthritis'''
{{Rx|Preferred Regimen}}
:Reiter's_syndrome
* '''[[Systemic antibiotics]]''' per culture and susceptibility results {{and}}
:Post-streptococcal_arthritis
* '''[[Surgical debridement]]''' {{and}}
* '''[[Revascularization]]''' if possible
</li>


====Contiguous without vascular insufficiency====
'''Septic_arthritis'''
{{Rx|Preferred Regimen}}
:Brucellosis
* '''[[Vancomycin]]''' 1 gm IV q12h {{and}}
:Candida
* '''[[Ceftazidime]]''' 2 gm IV q8h {{or}} '''[[Cefepime]]''' 2 gm IV q12h
:Disseminated_gonococcal_infection
</li>
:Gram-negative_bacilli
{{Rx|Alternative Regimen}}
:Histoplasmosis
* '''[[Linezolid]]''' 600 mg po/IV bid {{and}}
:Lyme_disease
* '''[[Ceftazidime]]''' 2 gm IV q8h {{or}} '''[[Cefepime]]''' 2 gm IV q12h
:Mycobacterium_tuberculosis
</li>
:Pneumococcal
{{Rx|Gram-negative bacilli}}
:Staphylococcal
* '''[[Ciprofloxacin]]''' 750 mg po bid {{or}} '''[[Linezolid]]''' 600 mg po/IV bid
:Streptococcal
</li>
:Post-intraarticular_injection
{{Rx|Staphylococcus aureus (MRSA/MSSA)}}
* '''[[Ciprofloxacin]]''' 750 mg po bid {{or}} '''[[Levofloxacin]]''' 750 mg po once daily if susceptible {{and}}
* '''[[Rifampin]]''' 300-450 mg po bid {{or}} '''[[Rifampin]]''' 600 mg po once daily if susceptible
</li>
{{Rx|MSSA}}
* '''[[Nafcillin]]''' 2 gm IV q4h {{or}} '''[[Oxacillin]]''' 2 gm IV q4h {{or}} '''[[Cefazolin]]''' 2 gm IV q8h
</li>
{{Rx|MRSA}}
* '''[[Vancomycin]]''' 15-20 mg/kg IV q8-12h targeting trough concentrations of 15-20 mg/L
</li>


====Diabetic foot====
'''Gangrene'''
{{Rx|Chronic infection}}
* '''[[Levofloxacin]]''' 750 mg IV/PO q24h {{or}} '''[[Cefoxitin]]''' 1 g IV q4h (or 2 g IV q6–8h) {{or}} '''[[Ceftriaxone]]''' 1–2 g/day IV/IM q12–24h {{or}} '''[[Ampicillin-Sulbactam]]''' 1.5–3 g IV/IM q6h {{or}} '''[[Moxifloxacin]]''' 400 mg IV/PO q24h {{or}} '''[[Ertapenem]]''' 1 g IV/IM q24h {{or}} '''[[Tigecycline]]''' 100 mg IV, then 50 mg IV q12h {{or}} '''[[Imipenem-Cilastatin]]''' 0.5–1 g IV q6–8h
</li>
{{Rx|Recent antibiotic use}}
* '''[[Levofloxacin]]''' 750 mg IV/PO q24h {{or}} '''[[Cefoxitin]]''' 1 g IV q4h (or 2 g IV q6–8h) {{or}} '''[[Ceftriaxone]]''' 1–2 g/day IV/IM q12–24h {{or}} '''[[Ampicillin-Sulbactam]]''' 1.5–3 g IV/IM q6h {{or}} '''[[Moxifloxacin]]''' 400 mg IV/PO q24h {{or}} '''[[Ertapenem]]''' 1 g IV/IM q24h {{or}} '''[[Tigecycline]]''' 100 mg IV, then 50 mg IV q12h {{or}} '''[[Imipenem-Cilastatin]]''' 0.5–1 g IV q6–8h
</li>
{{Rx|High Risk for MRSA}}
* '''[[Linezolid]]''' 600 mg IV/PO q12h {{or}} '''[[Daptomycin]]''' 4 mg/kg IV q24h {{or}} '''[[Vancomycin]]''' 15–20 mg/kg IV q8–12h (trough: 10–20 mg/L)
</li>
{{Rx|High Risk for Pseudomonas aeruginosa}}
* '''[[Piperacillin–Tazobactam]]''' 3.375 g IV q6–8h
</li>
{{Rx|Polymicrobial Infection}}
* ('''[[Vancomycin]]''' 15–20 mg/kg IV q8–12h {{or}} '''[[Linezolid]]''' 600 mg IV/PO q12h {{or}} '''[[Daptomycin]]''' 4 mg/kg IV q24h) {{and}}
* ('''[[Piperacillin–Tazobactam]]''' 3.375 g IV q6–8h {{or}} '''[[Imipenem-Cilastatin]]''' 0.5–1 g IV q6–8h {{or}} '''[[Ertapenem]]''' 1 g IV/IM q24h {{or}} '''[[Meropenem]]''' 1 g IV/IM q24h) {{or}} ('''[[Metronidazole]]''' 15 mg/kg IV, then 7.5 mg/kg IV q6h {{plus}} '''[[Ceftazidime]]''' 2 g IV q8h {{or}} '''[[Cefepime]]''' 2 g IV q8h {{or}} '''[[Aztreonam]]''' 2 g IV q6–8h)
</li>


====Foot bone====
'''Myonecrosis'''
{{Rx|Preferred Regimen}}
* '''[[Ciprofloxacin]]''' 750 mg po bid {{or}} '''[[Levofloxacin]]''' 750 mg po q24h
</li>
{{Rx|Alternative Regimen}}
* '''[[Ceftazidime]]''' 2 gm IV q8h {{or}} '''[[Cefepime]]''' 2 gm IV q8h {{or}} '''[[Meropenem]]''' 1 gm IV q8h
</li>


====Foot puncture wound====
'''Necrotizing_fascitis'''
{{Rx|Preferred Regimen}}
:Clostridial
* '''Cleanse wound''' {{and}}
:Staphylococcal
* '''Tetanus booster''' if due {{and}}
:Streptococcal
* '''X-ray''' to exclude presence of radio-opaque foreign body
:Synergistic
</li>


====Hematogenous====
'''Pyomyositis'''
{{Rx|Preferred Regimen}}
<div style="clear: both; width: 98%; border: 0px solid #999999; padding: 0em 0em 0em 0em; font-size: 100%; background: #F9F9F9; -webkit-user-select: none;"></div></div>
* MRSA likely – '''[[Vancomycin]]''' 15–20 mg/kg IV q8–12h {{and2}} ('''[[Ceftriaxone]]''' 1–2 g/day IV/IM q12–24h {{or}} '''[[Ceftazidime]]''' 2 gm IV q8h {{or}} '''[[Cefepime]]''' 2 gm IV q12h)
* MRSA unlikely – ('''[[Nafcillin]]''' {{or}} '''[[Oxacillin]]''') {{and2}} ('''[[Ceftriaxone]]''' 1–2 g/day IV/IM q12–24h {{or}} '''[[Ceftazidime]]''' 2 gm IV q8h {{or}} '''[[Cefepime]]''' 2 gm IV q12h)
</li>
{{Rx|Alternative Regimen}}
* '''[[Linezolid]]''' 600 mg po/IV bid {{or}} '''[[Daptomycin]]''' 4 mg/kg IV q24h to replace vancomycin
* '''[[Ciprofloxacin]]''' 750 mg po bid {{or}} '''[[Levofloxacin]]''' 750 mg IV/PO q24h {{or}} '''[[Aztreonam]]''' 2 g IV q6–8h to replace a third-generation cephalosporin
</li>
 
====Hemoglobinopathy====
{{Rx|Preferred Regimen}}
* '''[[Ciprofloxacin]]''' 400 mg IV q12h {{or}} '''[[Ceftriaxone]]''' 2 gm IV q24h
</li>
{{Rx|Alternative Regimen}}
* '''[[Ciprofloxacin]]''' 750 mg po bid for 6 weeks {{or}} '''[[Levofloxacin]]''' 750 mg po q24h for 6 weeks
</li>
 
====Prosthetic joint infection====
{{Rx|MSSA/MSSE}}
* ('''[[Nafcillin]]''' 2 gm IV q4h {{or}} '''[[Oxacillin]]''' 2 gm IV q4h IV) {{plus}} '''[[Rifampin]]''' 300 mg po bid {{or2}}
* '''[[Cefazolin]]''' 2 gm IV q8h {{plus}} '''[[Rifampin]]''' 300 mg po bid for 2-6 weeks followed by ('''[[Ciprofloxacin]]''' 750 mg po bid {{or}} '''[[Levofloxacin]]''' 750 mg po q24h) {{plus}} '''[[Rifampin]]''' 300 mg po bid for 3-6 months
</li>
{{Rx|MRSA/MRSE}}
* '''[[Vancomycin]]''' 15-20 mg/kg IV q8-12h {{plus}} '''[[Rifampin]]''' 300 mg po bid for 2-6 weeks followed by ('''[[Ciprofloxacin]]''' 750 mg po bid {{or}} '''[[Levofloxacin]]''' 750 mg po q24h) {{plus}} '''[[Rifampin]]''' 300 mg po bid for 3-6 months
</li>
{{Rx|Streptococcus}}
* '''[[Penicillin G]]''' 20 million units IV continuous infusion q24h or in 6 divided doses {{or}} '''[[Ceftriaxone]]''' 2 gm IV q24h x 4-6 weeks
</li>
{{Rx|Enterococcus}}
* Penicillin-susceptible – '''[[Ampicillin]]''' 12 gm IV {{or}} '''[[Penicillin G]]''' 20 million units IV continuous infusion q24h or in 6 divided doses x 4-6 weeks
* Penicillin-resistant – '''[[Vancomycin]]''' 15 mg/kg IV q12h x 4-6 week
</li>
{{Rx|Propionibacterium acnes}}
* '''[[Penicillin G]]''' 20 million units IV continuous infusion or in 6 divided doses {{or}} '''[[Ceftriaxone]]''' 2 gm IV q24h x 4-6 weeks
</li>
{{Rx|Gram-negative enteric bacilli}}
* '''[[Ertapenem]]''' 1 gm q24h IV {{or}} '''[[Ceftriaxone]]''' 2 gm IV q24h {{or}} '''[[Cefepime]]''' 2 gm IV q12h for 4-6 weeks
</li>
{{Rx|Pseudomonas aeruginosa}}
* '''[[Cefepime]]''' 2 gm IV q12h {{or}} '''[[Meropenem]]''' 1 gm IV q8h for 4-6 weeks {{and}}
* '''[[Tobramycin]]''' 5.1 mg/kg once daily IV for 4-6 weeks
</li>
 
====Spinal implant====
{{Rx|MSSA/MSSE}}
* ('''[[Nafcillin]]''' 2 gm IV q4h {{or}} '''[[Oxacillin]]''' 2 gm IV q4h IV) {{plus}} '''[[Rifampin]]''' 300 mg po bid {{or2}}
* '''[[Cefazolin]]''' 2 gm IV q8h {{plus}} '''[[Rifampin]]''' 300 mg po bid for 2-6 weeks followed by ('''[[Ciprofloxacin]]''' 750 mg po bid {{or}} '''[[Levofloxacin]]''' 750 mg po q24h) {{plus}} '''[[Rifampin]]''' 300 mg po bid for 3-6 months
</li>
{{Rx|MRSA/MRSE}}
* '''[[Vancomycin]]''' 15-20 mg/kg IV q8-12h {{plus}} '''[[Rifampin]]''' 300 mg po bid for 2-6 weeks followed by ('''[[Ciprofloxacin]]''' 750 mg po bid {{or}} '''[[Levofloxacin]]''' 750 mg po q24h) {{plus}} '''[[Rifampin]]''' 300 mg po bid for 3-6 months
</li>
{{Rx|Streptococcus}}
* '''[[Penicillin G]]''' 20 million units IV continuous infusion q24h or in 6 divided doses {{or}} '''[[Ceftriaxone]]''' 2 gm IV q24h x 4-6 weeks
</li>
{{Rx|Enterococcus}}
* Penicillin-susceptible – '''[[Ampicillin]]''' 12 gm IV {{or}} '''[[Penicillin G]]''' 20 million units IV continuous infusion q24h or in 6 divided doses x 4-6 weeks
* Penicillin-resistant – '''[[Vancomycin]]''' 15 mg/kg IV q12h x 4-6 week
</li>
{{Rx|Propionibacterium acnes}}
* '''[[Penicillin G]]''' 20 million units IV continuous infusion or in 6 divided doses {{or}} '''[[Ceftriaxone]]''' 2 gm IV q24h x 4-6 weeks
</li>
{{Rx|Gram-negative enteric bacilli}}
* '''[[Ertapenem]]''' 1 gm q24h IV {{or}} '''[[Ceftriaxone]]''' 2 gm IV q24h {{or}} '''[[Cefepime]]''' 2 gm IV q12h for 4-6 weeks
</li>
{{Rx|Pseudomonas aeruginosa}}
* '''[[Cefepime]]''' 2 gm IV q12h {{or}} '''[[Meropenem]]''' 1 gm IV q8h for 4-6 weeks {{and}}
* '''[[Tobramycin]]''' 5.1 mg/kg once daily IV for 4-6 weeks
</li>
 
====Sternal====
{{Rx|Preferred Regimen}}
* '''[[Vancomycin]]''' 15-30 mg/kg IV q 8-12h targeting trough of 15-20 μg/mL {{or}} '''[[Nafcillin]]''' 2 gm IV q4h
</li>
{{Rx|Alternative Regimen}}
* '''[[Linezolid]]''' 600 mg IV/po bid
</li>
 
===Bursitis===
{{Rx|Preferred Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
{{Rx|Alternative Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
 
===Lyme arthritis===
{{Rx|Preferred Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
{{Rx|Alternative Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
 
===Reactive arthritis===
{{Rx|Preferred Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
{{Rx|Alternative Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
====Reiter's syndrome====
{{Rx|Preferred Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
{{Rx|Alternative Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
====Post-streptococcal arthritis====
{{Rx|Preferred Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
{{Rx|Alternative Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
===Septic arthritis===
{{Rx|Preferred Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
{{Rx|Alternative Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
====Brucellosis====
{{Rx|Preferred Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
{{Rx|Alternative Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
====Candida====
{{Rx|Preferred Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
{{Rx|Alternative Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
====Gonococcal, disseminated infection====
{{Rx|Preferred Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
{{Rx|Alternative Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
====Gram-negative bacilli====
{{Rx|Preferred Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
{{Rx|Alternative Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
====Histoplasmosis====
{{Rx|Preferred Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
{{Rx|Alternative Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
====Lyme disease====
{{Rx|Preferred Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
{{Rx|Alternative Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
====Mycobacterium tuberculosis====
{{Rx|Preferred Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
{{Rx|Alternative Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
====Pneumococcal====
{{Rx|Preferred Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
{{Rx|Alternative Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
====Staphylococcal====
{{Rx|Preferred Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
{{Rx|Alternative Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
====Streptococcal====
{{Rx|Preferred Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
{{Rx|Alternative Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
====Post-intraarticular injection====
{{Rx|Preferred Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
{{Rx|Alternative Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
===Gangrene===
{{Rx|Preferred Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
{{Rx|Alternative Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
 
===Myonecrosis===
{{Rx|Preferred Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
{{Rx|Alternative Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
===Necrotizing fascitis===
{{Rx|Preferred Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
{{Rx|Alternative Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
====Clostridial====
{{Rx|Preferred Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
{{Rx|Alternative Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
====Staphylococcal====
{{Rx|Preferred Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
{{Rx|Alternative Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
====Streptococcal====
{{Rx|Preferred Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
{{Rx|Alternative Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
====Synergistic====
{{Rx|Preferred Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
{{Rx|Alternative Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
===Pyomyositis===
{{Rx|Preferred Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
{{Rx|Alternative Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
 
</div>

Latest revision as of 04:13, 13 May 2015

    Mission Statement    
    Antimicrobial Agents    
    Organ-Based Infections    
    Pathogen-Based Infections    

WikiDoc Infectious Disease Project — Organ-Based Infections — Musculoskeletal

Osteomyelitis

Candidal_osteomyelitis
Preferred Regimen: Fluconazole 400 mg (6 mg/kg) IV/PO daily OR Lipid-based Amphotericin B 3-5 mg/kg IV daily for two weeks, followed by Fluconazole
Alternative Regimen: Caspofungin 70 mg IV oading dose, then 50 mg/day IV OR Micafungin 100 mg/day IV OR Anidulafungin 200 mg IV loading dose, then 100 mg/day IV
Chronic_osteomyelitis
Contiguous_with_vascular_insufficiency
Contiguous_without_vascular_insufficiency
Diabetic_foot
Foot_bone
Foot_puncture_wound
Hematogenous
Hemoglobinopathy
Prosthetic_joint_infection
Spinal_implant
Sternal

Bursitis

Lyme_arthritis

Reactive_arthritis

Reiter's_syndrome
Post-streptococcal_arthritis

Septic_arthritis

Brucellosis
Candida
Disseminated_gonococcal_infection
Gram-negative_bacilli
Histoplasmosis
Lyme_disease
Mycobacterium_tuberculosis
Pneumococcal
Staphylococcal
Streptococcal
Post-intraarticular_injection

Gangrene

Myonecrosis

Necrotizing_fascitis

Clostridial
Staphylococcal
Streptococcal
Synergistic

Pyomyositis

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