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{{Chancroid}}
{{Chancroid}}
{{CMG}}; {{AE}} {{YD}}; {{NRM}}; {{SSK}}
==Overview==
Patients may present with erythematous [[papules]], [[Boil|pustules]], or [[ulcers]] depending the stage of the chancroid. Ulcers are soft with irregular but sharp margins, and looks similar to a [[syphilitic]] [[chancre]]. Males typically have 1 ulcer while females typically have multiple. The most common location in males is the [[foreskin]] (prepuce). The most common location in females in the [[labia majora]]. Approximately 50% of patients may present with swollen [[inguinal]] [[lymph nodes]].
==Physical Examination==
===Vital Signs===
Typically normal
===Skin===
A patient may present with either of the following types of lesions on the genitals (or extremities in cases of cutaneous limb ulcers<ref name="pmid25271477">{{cite journal| author=Marks M, Chi KH, Vahi V, Pillay A, Sokana O, Pavluck A et al.| title=Haemophilus ducreyi associated with skin ulcers among children, Solomon Islands. | journal=Emerg Infect Dis | year= 2014 | volume= 20 | issue= 10 | pages= 1705-7 | pmid=25271477 | doi=10.3201/eid2010.140573 | pmc=PMC4193279 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25271477}}</ref><ref name="pmid25774793">{{cite journal| author=Gaston JR, Roberts SA, Humphreys TL| title=Molecular phylogenetic analysis of non-sexually transmitted strains of Haemophilus ducreyi. | journal=PLoS One | year= 2015 | volume= 10 | issue= 3 | pages= e0118613 | pmid=25774793 | doi=10.1371/journal.pone.0118613 | pmc=PMC4361675 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25774793  }} </ref>), depending on the stage of infection:<ref name="Spinola2002">{{cite journal|last1=Spinola|first1=S. M.|title=Immunopathogenesis of Haemophilus ducreyi Infection (Chancroid)|journal=Infection and Immunity|volume=70|issue=4|year=2002|pages=1667–1676|issn=00199567|doi=10.1128/IAI.70.4.1667-1676.2002}}</ref>
*Erythematous [[papules]]
*[[Boil|Pustules]]
*[[Ulcers]]
Ulcer characteristics:<ref name="ChancroidWikipedia">Chancroid. Wikipedia (July 16, 2015). https://en.wikipedia.org/wiki/Chancroid Accessed January 15, 2016.</ref>
*Ranges in size from 3 to 50 mm (1/8 to 2 inches) in diameter
*Tender
*Soft, nonindurated
*Irregular border
*Sharp margins
*Grey/yellow exudate
*Males typically have a single ulcer
*Females typically have multiplee ulcers
*May look similar to [[Syphilis|syphilitic]] [[chancre]]
===Common locations in males===
*[[Foreskin]] (prepuce) (most common)<ref name="ChancroidMedline">Chancroid. MedlinePlus (January 13, 2016). https://www.nlm.nih.gov/medlineplus/ency/article/000635.htm Accessed January 21, 2016.</ref>
*Groove behind the head of the penis ([[coronal sulcus]])
*Shaft of the penis
*Head of the penis ([[glans penis]])
*Opening of the penis ([[urethral meatus]])
*[[Scrotum]] (least common)
===Common locations in females===
*[[Labia majora]] (most common). "Kissing ulcers" may develop, defined as ulcers that occur on opposing surfaces of the labia.<ref name="ChancroidMedline"></ref>
*[[Labia minora]]
*[[Perineum|Perineal]] area
*Inner thighs (least common)
===Other Signs===
*Tender [[inguinal]] [[lymphadenitis]] in approximately 50% of patients, known as [[Bubo|buboes]] (typically unilateral and predominantly in males)<ref name="Lewis2003">{{cite journal|last1=Lewis|first1=D A|title=Chancroid: clinical manifestations, diagnosis, and management|journal=Sexually Transmitted Infections|volume=79|issue=1|year=2003|pages=68–71|issn=13684973|doi=10.1136/sti.79.1.68}}</ref>
*Approximately 25% of patients with lymphadenopathy may present with abscesses in lymph nodes or ruptured buboes


==Gallery==
==Gallery==
<gallery>
<gallery>
Image: Chancroid 11.jpeg| A chancroidal lesion. <SMALL><SMALL>''[http://phil.cdc.gov/phil/home.asp From Public Health Image Library (PHIL).] ''<ref name=PHIL> {{Cite web | title = Public Health Image Library (PHIL) | url = http://phil.cdc.gov/phil/home.asp}}</ref></SMALL></SMALL><gallery heights="175" widths="175">
Image:Chancroid01.jpg|Chancroid. <SMALL><SMALL>''[http://www.atlasdermatologico.com.br/  Adapted from Dermatology Atlas.]''<ref name="Dermatology Atlas">{{Cite web | title = Dermatology Atlas | url = http://www.atlasdermatologico.com.br/}}</ref></SMALL></SMALL>
Image:Chancroid02.jpg|Chancroid. <SMALL><SMALL>''[http://www.atlasdermatologico.com.br/  Adapted from Dermatology Atlas.]''<ref name="Dermatology Atlas">{{Cite web | title = Dermatology Atlas | url = http://www.atlasdermatologico.com.br/}}</ref></SMALL></SMALL>
Image:Chancroid03.jpg|Chancroid. <SMALL><SMALL>''[http://www.atlasdermatologico.com.br/  Adapted from Dermatology Atlas.]''<ref name="Dermatology Atlas">{{Cite web | title = Dermatology Atlas | url = http://www.atlasdermatologico.com.br/}}</ref></SMALL></SMALL>
Image:Chancroid04.jpg|Chancroid. <SMALL><SMALL>''[http://www.atlasdermatologico.com.br/  Adapted from Dermatology Atlas.]''<ref name="Dermatology Atlas">{{Cite web | title = Dermatology Atlas | url = http://www.atlasdermatologico.com.br/}}</ref></SMALL></SMALL>
Image:Chancroid05.jpg|Chancroid. <SMALL><SMALL>''[http://www.atlasdermatologico.com.br/  Adapted from Dermatology Atlas.]''<ref name="Dermatology Atlas">{{Cite web | title = Dermatology Atlas | url = http://www.atlasdermatologico.com.br/}}</ref></SMALL></SMALL>
Image:Chancroid06.jpg|Chancroid. <SMALL><SMALL>''[http://www.atlasdermatologico.com.br/  Adapted from Dermatology Atlas.]''<ref name="Dermatology Atlas">{{Cite web | title = Dermatology Atlas | url = http://www.atlasdermatologico.com.br/}}</ref></SMALL></SMALL>
Image:Chancroid07.jpg|Chancroid. <SMALL><SMALL>''[http://www.atlasdermatologico.com.br/  Adapted from Dermatology Atlas.]''<ref name="Dermatology Atlas">{{Cite web | title = Dermatology Atlas | url = http://www.atlasdermatologico.com.br/}}</ref></SMALL></SMALL>
Image:Chancroid08.jpg|Chancroid. <SMALL><SMALL>''[http://www.atlasdermatologico.com.br/  Adapted from Dermatology Atlas.]''<ref name="Dermatology Atlas">{{Cite web | title = Dermatology Atlas | url = http://www.atlasdermatologico.com.br/}}</ref></SMALL></SMALL>
Image:Chancroid09.jpg|Chancroid. <SMALL><SMALL>''[http://www.atlasdermatologico.com.br/  Adapted from Dermatology Atlas.]''<ref name="Dermatology Atlas">{{Cite web | title = Dermatology Atlas | url = http://www.atlasdermatologico.com.br/}}</ref></SMALL></SMALL>
Image:Haemophilus ducreyi 5811 lores.jpg| Chancroid infection has spread to the inguinal lymph nodes, which have enlarged forming buboes.
Image:Haemophilus ducreyi 5811 lores.jpg| Chancroid infection has spread to the inguinal lymph nodes, which have enlarged forming buboes.
Image:392px-Chancroid lesion haemophilus ducreyi PHIL 3728 lores.jpg|Penile chancroid lesion.
Image:392px-Chancroid lesion haemophilus ducreyi PHIL 3728 lores.jpg|Penile chancroid lesion.
</gallery>
</gallery>
</div>


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==References==
==References==
{{Reflist|2}}
{{Reflist|2}}


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Latest revision as of 17:21, 18 September 2017

Chancroid Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Yazan Daaboul, M.D.; Nate Michalak, B.A.; Serge Korjian M.D.

Overview

Patients may present with erythematous papules, pustules, or ulcers depending the stage of the chancroid. Ulcers are soft with irregular but sharp margins, and looks similar to a syphilitic chancre. Males typically have 1 ulcer while females typically have multiple. The most common location in males is the foreskin (prepuce). The most common location in females in the labia majora. Approximately 50% of patients may present with swollen inguinal lymph nodes.

Physical Examination

Vital Signs

Typically normal

Skin

A patient may present with either of the following types of lesions on the genitals (or extremities in cases of cutaneous limb ulcers[1][2]), depending on the stage of infection:[3]

Ulcer characteristics:[4]

  • Ranges in size from 3 to 50 mm (1/8 to 2 inches) in diameter
  • Tender
  • Soft, nonindurated
  • Irregular border
  • Sharp margins
  • Grey/yellow exudate
  • Males typically have a single ulcer
  • Females typically have multiplee ulcers
  • May look similar to syphilitic chancre

Common locations in males

Common locations in females

  • Labia majora (most common). "Kissing ulcers" may develop, defined as ulcers that occur on opposing surfaces of the labia.[5]
  • Labia minora
  • Perineal area
  • Inner thighs (least common)

Other Signs

  • Tender inguinal lymphadenitis in approximately 50% of patients, known as buboes (typically unilateral and predominantly in males)[6]
  • Approximately 25% of patients with lymphadenopathy may present with abscesses in lymph nodes or ruptured buboes

Gallery

References

  1. ↑ Marks M, Chi KH, Vahi V, Pillay A, Sokana O, Pavluck A; et al. (2014). "Haemophilus ducreyi associated with skin ulcers among children, Solomon Islands". Emerg Infect Dis. 20 (10): 1705–7. doi:10.3201/eid2010.140573. PMC 4193279. PMID 25271477.
  2. ↑ Gaston JR, Roberts SA, Humphreys TL (2015). "Molecular phylogenetic analysis of non-sexually transmitted strains of Haemophilus ducreyi". PLoS One. 10 (3): e0118613. doi:10.1371/journal.pone.0118613. PMC 4361675. PMID 25774793.
  3. ↑ Spinola, S. M. (2002). "Immunopathogenesis of Haemophilus ducreyi Infection (Chancroid)". Infection and Immunity. 70 (4): 1667–1676. doi:10.1128/IAI.70.4.1667-1676.2002. ISSN 0019-9567.
  4. ↑ Chancroid. Wikipedia (July 16, 2015). https://en.wikipedia.org/wiki/Chancroid Accessed January 15, 2016.
  5. ↑ 5.0 5.1 Chancroid. MedlinePlus (January 13, 2016). https://www.nlm.nih.gov/medlineplus/ency/article/000635.htm Accessed January 21, 2016.
  6. ↑ Lewis, D A (2003). "Chancroid: clinical manifestations, diagnosis, and management". Sexually Transmitted Infections. 79 (1): 68–71. doi:10.1136/sti.79.1.68. ISSN 1368-4973.
  7. ↑ 7.0 7.1 7.2 7.3 7.4 7.5 7.6 7.7 7.8 "Dermatology Atlas".
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