Cholinesterase: Difference between revisions

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{{SI}}
{{infobox protein
{{CMG}}
| Name = [[acetylcholinesterase|acetylcholinesterase (Yt blood group)]]
| caption = Diagram of [[Pacific electric ray]] acetylcholinesterase. From {{PDB|1EA5}}.
| image = Acethylcholinesterase_TC_1EA5.png
| width = 200
| HGNCid = 108
| Symbol = [https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=HGNC:108 ACHE]
| AltSymbols = YT
| EntrezGene = 43
| OMIM = 100740
| RefSeq = NM_015831
| UniProt = P22303
| PDB =
| ECnumber = 3.1.1.7
| Chromosome = 7
| Arm = q
| Band = 22
| LocusSupplementaryData =
}}
{{infobox protein
| Name = [[butyrylcholinesterase]]
| caption = Cartoon diagram of human butyrylcholinesterase. From {{PDB|1P0I}}.
| image = Butyrylcholinesterase 1P0I.png
| width =
| HGNCid = 983
| Symbol = [https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=HGNC:983 BCHE]
| AltSymbols = CHE1, CHE2, E1
| EntrezGene = 590
| OMIM = 177400
| RefSeq = NM_000055
| UniProt = P06276
| PDB =
| ECnumber = 3.1.1.8
| Chromosome = 3
| Arm = q
| Band = 26.1
| LocusSupplementaryData = -26.2
}}


== Overview == 
In [[biochemistry]], a '''cholinesterase''' or '''choline esterase''' is an [[esterase]] that [[lysis|lyses]] [[choline]]-based [[ester]]s, several of which serve as [[neurotransmitter]]s. Thus, it is either of two [[enzyme]]s that [[catalyst|catalyze]] the [[hydrolysis]] of these [[cholinergic]] neurotransmitters, such as breaking [[acetylcholine]] into choline and [[acetic acid]]. These reactions are necessary to allow a cholinergic [[neuron]] to return to its resting state after activation. For example, in [[muscle contraction]], acetylcholine at a [[neuromuscular junction]] triggers a contraction; but for the muscle to relax afterward, rather than remaining locked in a tense state, the acetylcholine must be broken down by a choline esterase. The main type for that purpose is [[acetylcholinesterase]] (also called choline esterase I<ref name="Dorlands">{{Citation |author=Elsevier |authorlink=Elsevier |title=Dorland's Illustrated Medical Dictionary |publisher=Elsevier |url=http://dorlands.com/ |postscript=.}}</ref> or erythrocyte cholinesterase); it is found mainly in [[chemical synapse]]s and [[red blood cell]] membranes. The other type is [[butyrylcholinesterase]] (also called choline esterase II<ref name="Dorlands"/> or plasma cholinesterase); it is found mainly in the [[blood plasma]].
* '''Cholinesterase''' catalyzes the hydolysis of acylcholines
* Reference range: '''3000-8000 U/l'''


== Differential Diagnosis ==  
== Types and nomenclature ==


In alphabetical order <ref>Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:77 ISBN 1591032016</ref>
The two types of cholinesterase are [[acetylcholinesterase]] (ACHE) and [[butyrylcholinesterase]] (BCHE). The difference between the two types has to do with their respective preferences for [[substrate (biochemistry)|substrate]]s: the former hydrolyses [[acetylcholine]] more quickly; the latter hydrolyses [[butyrylcholine]] more quickly.


=== Decreased ===
The term ''cholinesterase'' is sometimes used to refer specifically to butyrylcholinesterase,<ref name="Dorlands"/> but this [[usage]] produces the oddity that ''cholinesterase'' and ''false cholinesterase'' (''pseudocholinesterase'') under that scheme mean the same thing<ref name="Dorlands"/> (confusingly), and acetylcholinesterase is then called ''true cholinesterase'' in contrast,<ref name="Dorlands"/> producing the second oddity that ''cholinesterase'' and ''true cholinesterase'' then do not mean the same thing. But such usage is now outdated; the current, unambiguous [[HUGO Gene Nomenclature Committee|HGNC]] names and symbols are acetylcholinesterase (ACHE) and butyrylcholinesterase (BCHE).
* [[Acute]] [[infection]]
* [[Chronic]] [[malnutrition]]
* [[Cirrhosis]]
* [[Congenital]] [[deficiency]]
* [[Drug]]-[[toxicity]]
* [[Hepatitis]]
* [[Myocardial Infarction]]
* [[Nephrotic Syndrome]]
* [[Obstructive jaundice]]
* [[Tumor]]s, [[metastases]]
* [[Ulcerative colitis]]


=== Increased ===
Acetylcholinesterase ({{EC number|3.1.1.7}}) (ACHE), also known as AChE, choline esterase I, RBC cholinesterase, or erythrocyte cholinesterase, true cholinesterase, choline esterase I, or (most formally) acetylcholine acetylhydrolase, is found primarily in the [[blood]] on [[red blood cell]] membranes, in [[neuromuscular junction]]s, and in other neural [[synapse]]s. Acetylcholinesterase exists in multiple molecular forms.  In the mammalian brain the majority of AChE occurs as a tetrameric, G4 form (10) with much smaller amounts of a monomeric G1 (4S) form.<ref name="pmid15956816">{{cite journal | vauthors = Wang R, Tang XC | title = Neuroprotective effects of huperzine A. A natural cholinesterase inhibitor for the treatment of Alzheimer's disease | journal = Neuro-Signals | volume = 14 | issue = 1–2 | pages = 71–82 | year = 2005 | pmid = 15956816 | doi = 10.1159/000085387 }}</ref>
* Beginning stage of [[alcohol]]-[[toxic]] [[cirrhosis]]
 
* [[Coronary Heart Disease]]
Butyrylcholinesterase ({{EC number|3.1.1.8}}) (BCHE), also known as cholinesterase, choline esterase II, BChE, BuChE, pseudocholinesterase (PCE), plasma cholinesterase (PChE), serum cholinesterase (SChE), butylcholinesterase, or (most formally) acylcholine acylhydrolase, is produced in the [[liver]] and found primarily in [[blood plasma]]. The [[butyl]] and [[butyric acid|butyryl]] syllables both refer to [[butane]] with one of its terminal [[methyl group]]s substituted.
* [[Diabetes Mellitus]]
 
* [[Exudative enteropathy]] with [[albumin loss]]
The half-life of BCHE is approximately 10 to 14 days.<ref name="pmid6992635">{{cite journal | vauthors = Whittaker M | title = Plasma cholinesterase variants and the anaesthetist | journal = Anaesthesia | volume = 35 | issue = 2 | pages = 174–197 | year = 1980 | pmid = 6992635 | doi = 10.1111/j.1365-2044.1980.tb03800.x }}</ref> BCHE levels may be reduced in patients with advanced [[liver disease]].  The decrease must be greater than 75% before significant prolongation of neuromuscular blockade occurs with [[succinylcholine]].<ref>{{cite book | last1 = Barash | first1 = Paul G. | last2 = Cullen | first2 = Bruce F. | last3 = Stoelting | first3 = Robert K. | name-list-format = vanc  | title = Handbook of Clinical Anesthesia | date = 2006 | publisher = Lippincott Williams & Wilkins | location = Philadelphia | isbn = 978-0-7817-5745-4 | pages = 546–9 | edition = 5th }}</ref><ref>{{cite book | last1 = Miller | first1 = Ronald D. | name-list-format = vanc | title = Miller's Anesthesia | date = 2005 | publisher = Elsevier/Churchill Livingstone | location = Philadelphia, Penns. | isbn = 978-0-443-06618-4 | pages = 487–8 | edition = 6th }}</ref>
* [[Fatty liver]]
 
* [[Ddx:Hyperthyroidism|Hyperthyroidism]]
== Discovery ==
* [[Obesity]]
 
In 1968, Walo Leuzinger ''et al.'' successfully purified and crystallized acetylcholinesterase from [[electric eel]]s at Columbia University, NY.<ref name="pmid16591490">{{cite journal | vauthors = Leuzinger W, Baker AL | title = Acetylcholinesterase, I. Large-scale purification, homogeneity, and amino Acid analysis | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 57 | issue = 2 | pages = 446–51 | date = Feb 1967 | pmid = 16591490 | pmc = 335526 | doi = 10.1073/pnas.57.2.446 }}</ref><ref name="pmid5238989">{{cite journal | vauthors = Leuzinger W, Baker AL, Cauvin E | title = Acetylcholinesterase. II. Crystallization, absorption spectra, isoionic point | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 59 | issue = 2 | pages = 620–3 | date = Feb 1968 | pmid = 5238989 | pmc = 224717 | doi = 10.1073/pnas.59.2.620 }}</ref>
 
The 3D structure of acetylcholinesterase was first determined in 1991 by [[Joel Sussman]] ''et al.'' using protein from the [[Pacific electric ray]].<ref name="pmid1678899">{{cite journal | vauthors = Sussman JL, Harel M, Frolow F, Oefner C, Goldman A, Toker L, Silman I | title = Atomic structure of acetylcholinesterase from Torpedo californica: a prototypic acetylcholine-binding protein | journal = Science | volume = 253 | issue = 5022 | pages = 872–9 | date = Aug 1991 | pmid = 1678899 | doi = 10.1126/science.1678899 }}</ref>
 
Clinically useful quantities of butyrylcholinesterase were synthesized in 2007 by [[PharmAthene]], through the use of genetically modified goats.<ref name="pmid17660298">{{cite journal | vauthors = Huang YJ, Huang Y, Baldassarre H, Wang B, Lazaris A, Leduc M, Bilodeau AS, Bellemare A, Côté M, Herskovits P, Touati M, Turcotte C, Valeanu L, Lemée N, Wilgus H, Bégin I, Bhatia B, Rao K, Neveu N, Brochu E, Pierson J, Hockley DK, Cerasoli DM, Lenz DE, Karatzas CN, Langermann S | title = Recombinant human butyrylcholinesterase from milk of transgenic animals to protect against organophosphate poisoning | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 104 | issue = 34 | pages = 13603–8 | date = Aug 2007 | pmid = 17660298 | pmc = 1934339 | doi = 10.1073/pnas.0702756104 | laysummary = http://news.bbc.co.uk/1/hi/sci/tech/6912807.stm | laysource = BBC News }}</ref>
 
== Clinical significance ==
 
An absence or mutation of the BCHE enzyme leads to a medical condition known as [[pseudocholinesterase deficiency]]. This is a silent condition that manifests itself only when people that have the deficiency receive the muscle relaxants [[succinylcholine]] or [[mivacurium]] during a surgery.
 
Pseudocholinesterase deficiency may also affect local anaesthetic selection in dental procedures. The enzyme plays an important role in the metabolism of ester-based local anaesthetics, a deficiency lowers the margin of safety and increases the risk of systemic effects with this type of anaesthetic. The selection of an amide-based solution is recommended in such patients.
 
Elevation of plasma BCHE levels was observed in 90.5% cases of acute [[myocardial infarction]].<ref>{{cite book | last1 = Shinde | first1 = Rana | last2 = Chatterjea | first2 = MN | name-list-format = vanc | title = Textbook of Medical Biochemistry | date = 2005 | publisher = Jaypee Brothers Medical Publications (P) Ltd. | location = New Delhi | isbn = 978-9350254844 | page = 565 | edition = 6th }}</ref>
 
The presence of ACHE in the amniotic fluid may be tested in early pregnancy. A sample of amniotic fluid is removed by [[amniocentesis]], and presence of ACHE can confirm several common types of birth defect, including [[abdominal wall defects]] and [[neural tube defects]].<ref>[http://www.fbr.org/publications/resguide/rg-t_acheinh.html FBR Resource Guide: Acetylcholinesterase-Amniotic Fluid] {{webarchive|url=https://web.archive.org/web/20070625081717/http://www.fbr.org/publications/resguide/rg-t_acheinh.html |date=2007-06-25 }}. Foundation for Blood Research (September 7, 2007). Retrieved on 2007-11-21.</ref>
 
BCHE can be used as a [[prophylactic]] agent against [[nerve gas]] and other organophosphate poisoning.<ref name="pmid17660298"/>
 
== Inhibitors ==
 
A [[cholinesterase inhibitor]] (or "anticholinesterase") suppresses the action of the enzyme. Because of its essential function, chemicals that interfere with the action of cholinesterase are potent [[neurotoxin]]s, causing excessive salivation and eye-watering in low doses, followed by muscle spasms and ultimately death (examples are some [[snake venoms]], and the nerve gases [[sarin]] and [[VX (nerve agent)|VX]]). One counteracting medication is [[pralidoxime]]. The so-called nerve gases and many substances used in insecticides have been shown to act by combining with a residue of serine in the active site of acetylcholine esterase, inhibiting the enzyme completely. The enzyme acetylcholine esterase breaks down the neurotransmitter acetylcholine, which is released at nerve and muscle junctions, in order to allow the muscle or organ to relax. The result of acetylcholine esterase inhibition is that acetylcholine builds up and continues to act so that any nerve impulses are continually transmitted and muscle contractions do not stop.
 
Among the most common acetylcholinesterase inhibitors are phosphorus-based compounds, which are designed to bind to the active site of the [[enzyme]]. The structural requirements are a [[phosphorus]] atom bearing two [[lipophilic]] groups, a leaving group (such as a [[halide]] or [[thiocyanate]]), and a [[Polymer|terminal]] [[oxygen]]. The entry on [[Lawesson's reagent]] has some details on one sub-class of the phosphorus-based compounds.
 
Some [[benzodiazepines]], e.g. [[temazepam]] have an inhibitory effect on cholinesterase.<ref>{{cite journal | vauthors = Holmes JH, Kanfer I, Zwarenstein H | title = Effect of benzodiazepine derivatives on human blood cholinesterase in vitro | journal = Research Communications in Chemical Pathology and Pharmacology | volume = 21 | issue = 2 | pages = 367–70 | date = Aug 1978 | pmid = 29327 }}</ref>
 
Cholinesterase levels can be used as an indirect marker of arsenic exposure.<ref>{{cite journal | vauthors = Ali N, Hoque MA, Haque A, Salam KA, Karim MR, Rahman A, Islam K, Saud ZA, Khalek MA, Akhand AA, Hossain M, Mandal A, Karim MR, Miyataka H, Himeno S, Hossain K | title = Association between arsenic exposure and plasma cholinesterase activity: a population based study in Bangladesh | journal = Environmental Health | volume = 9 | pages = 36 | pmid = 20618979 | doi = 10.1186/1476-069X-9-36 | pmc=2911418}}</ref>
 
Outside of [[biochemical warfare]], anticholinesterases are also used for reversing medication induced paralysis during [[anesthesia]]; as well as in the treatment of [[myasthenia gravis]], [[glaucoma]], and [[Alzheimer's disease]].  Such compounds are used for killing [[insects]] in a range of products including [[sheep dip]], [[organophosphate]] pesticides, and [[carbamate]] pesticides.  In addition to acute poisoning as described above, a semi-acute poisoning characterized by strong mental disturbances can occur. Also, prolonged exposure can cause [[birth defects]].
 
==Pop culture==
* On [[Law & Order: Special Victims Unit (season 8)|season eight]] of ''[[Law and Order: SVU]]'', [[Olivia Benson]] is taken to the [[hospital]] after being exposed to [[organophosphates]], where she is told her cholinesterase level is low.
* In the film ''[[The I Inside]]'', Simon Cable is poisoned with cholinesterase inhibitors and he is given [[atropine]] and [[pralidoxime]] to help reverse the poison.  The doctor is also shown dispensing a [[diazepam]] at the beginning of the movie.
* In the film ''[[The Rock (film)|The Rock]]'', Dr. Goodspeed ([[Nicolas Cage]]) correctly describes the effects of the chemical weapon [[VX gas]] as a cholinesterase inhibitor to John Mason ([[Sean Connery]]) as they remove guidance chips from the rocket designed to deliver the gas into San Francisco from [[Alcatraz]].
* Indie band Ruet Caelum have a song entitled 'Showing Signs of Cholinesterase Inhibition"
*In the book "The Penultimate Truth" by [[Philip K. Dick]], members of underground tank divisions are banned from surfacing with the fear that they will be subject to a cholinesterase-destroying nerve gas attack.
 
==Additional images==
<gallery>
Image:Acetylcholine.svg|[[Acetylcholine]]
Image:Choline-skeletal.png|[[Choline]]
Image:Acetic-acid-2D-skeletal.svg|[[Acetic acid]]
Image:Butyrylcholine.png|[[Butyrylcholine]]
</gallery>


== References ==
== References ==
{{Reflist|2}}
{{reflist|33em}}
 


== External links ==
* [http://www.atsdr.cdc.gov/csem/cholinesterase/ ATSDR Case Studies in Environmental Medicine: Cholinesterase Inhibitors, Including Insecticides and Chemical Warfare Nerve Agents] U.S. [[Department of Health and Human Services]]
*[http://www.weizmann.ac.il/sb/faculty_pages/Sussman/movies.html Movies at weizmann.ac.il] showing the structure of acetylcholinesterase and interactions with various inhibitors.
* {{Proteopedia|Acetylcholinesterase}}
* {{PDB Molecule of the Month|54|Cholinesterase}}
* {{MeshName|Acetylcholinesterase}}
* {{MeshName|Pseudocholinesterase}}


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[[Category:Blood tests]]
[[Category:Acetylcholine]]
[[Category:Cardiology]]
[[Category:Peripheral membrane proteins]]
[[Category:Gastroenterology]]
[[Category:EC 3.1.1]]
[[Category:Endocrinology]]

Latest revision as of 21:57, 5 June 2018

acetylcholinesterase (Yt blood group)
File:Acethylcholinesterase TC 1EA5.png
Diagram of Pacific electric ray acetylcholinesterase. From PDB: 1EA5​.
Identifiers
SymbolACHE
Alt. symbolsYT
Entrez43
HUGO108
OMIM100740
RefSeqNM_015831
UniProtP22303
Other data
EC number3.1.1.7
LocusChr. 7 q22
butyrylcholinesterase
File:Butyrylcholinesterase 1P0I.png
Cartoon diagram of human butyrylcholinesterase. From PDB: 1P0I​.
Identifiers
SymbolBCHE
Alt. symbolsCHE1, CHE2, E1
Entrez590
HUGO983
OMIM177400
RefSeqNM_000055
UniProtP06276
Other data
EC number3.1.1.8
LocusChr. 3 q26.1-26.2

In biochemistry, a cholinesterase or choline esterase is an esterase that lyses choline-based esters, several of which serve as neurotransmitters. Thus, it is either of two enzymes that catalyze the hydrolysis of these cholinergic neurotransmitters, such as breaking acetylcholine into choline and acetic acid. These reactions are necessary to allow a cholinergic neuron to return to its resting state after activation. For example, in muscle contraction, acetylcholine at a neuromuscular junction triggers a contraction; but for the muscle to relax afterward, rather than remaining locked in a tense state, the acetylcholine must be broken down by a choline esterase. The main type for that purpose is acetylcholinesterase (also called choline esterase I[1] or erythrocyte cholinesterase); it is found mainly in chemical synapses and red blood cell membranes. The other type is butyrylcholinesterase (also called choline esterase II[1] or plasma cholinesterase); it is found mainly in the blood plasma.

Types and nomenclature

The two types of cholinesterase are acetylcholinesterase (ACHE) and butyrylcholinesterase (BCHE). The difference between the two types has to do with their respective preferences for substrates: the former hydrolyses acetylcholine more quickly; the latter hydrolyses butyrylcholine more quickly.

The term cholinesterase is sometimes used to refer specifically to butyrylcholinesterase,[1] but this usage produces the oddity that cholinesterase and false cholinesterase (pseudocholinesterase) under that scheme mean the same thing[1] (confusingly), and acetylcholinesterase is then called true cholinesterase in contrast,[1] producing the second oddity that cholinesterase and true cholinesterase then do not mean the same thing. But such usage is now outdated; the current, unambiguous HGNC names and symbols are acetylcholinesterase (ACHE) and butyrylcholinesterase (BCHE).

Acetylcholinesterase (EC 3.1.1.7) (ACHE), also known as AChE, choline esterase I, RBC cholinesterase, or erythrocyte cholinesterase, true cholinesterase, choline esterase I, or (most formally) acetylcholine acetylhydrolase, is found primarily in the blood on red blood cell membranes, in neuromuscular junctions, and in other neural synapses. Acetylcholinesterase exists in multiple molecular forms. In the mammalian brain the majority of AChE occurs as a tetrameric, G4 form (10) with much smaller amounts of a monomeric G1 (4S) form.[2]

Butyrylcholinesterase (EC 3.1.1.8) (BCHE), also known as cholinesterase, choline esterase II, BChE, BuChE, pseudocholinesterase (PCE), plasma cholinesterase (PChE), serum cholinesterase (SChE), butylcholinesterase, or (most formally) acylcholine acylhydrolase, is produced in the liver and found primarily in blood plasma. The butyl and butyryl syllables both refer to butane with one of its terminal methyl groups substituted.

The half-life of BCHE is approximately 10 to 14 days.[3] BCHE levels may be reduced in patients with advanced liver disease. The decrease must be greater than 75% before significant prolongation of neuromuscular blockade occurs with succinylcholine.[4][5]

Discovery

In 1968, Walo Leuzinger et al. successfully purified and crystallized acetylcholinesterase from electric eels at Columbia University, NY.[6][7]

The 3D structure of acetylcholinesterase was first determined in 1991 by Joel Sussman et al. using protein from the Pacific electric ray.[8]

Clinically useful quantities of butyrylcholinesterase were synthesized in 2007 by PharmAthene, through the use of genetically modified goats.[9]

Clinical significance

An absence or mutation of the BCHE enzyme leads to a medical condition known as pseudocholinesterase deficiency. This is a silent condition that manifests itself only when people that have the deficiency receive the muscle relaxants succinylcholine or mivacurium during a surgery.

Pseudocholinesterase deficiency may also affect local anaesthetic selection in dental procedures. The enzyme plays an important role in the metabolism of ester-based local anaesthetics, a deficiency lowers the margin of safety and increases the risk of systemic effects with this type of anaesthetic. The selection of an amide-based solution is recommended in such patients.

Elevation of plasma BCHE levels was observed in 90.5% cases of acute myocardial infarction.[10]

The presence of ACHE in the amniotic fluid may be tested in early pregnancy. A sample of amniotic fluid is removed by amniocentesis, and presence of ACHE can confirm several common types of birth defect, including abdominal wall defects and neural tube defects.[11]

BCHE can be used as a prophylactic agent against nerve gas and other organophosphate poisoning.[9]

Inhibitors

A cholinesterase inhibitor (or "anticholinesterase") suppresses the action of the enzyme. Because of its essential function, chemicals that interfere with the action of cholinesterase are potent neurotoxins, causing excessive salivation and eye-watering in low doses, followed by muscle spasms and ultimately death (examples are some snake venoms, and the nerve gases sarin and VX). One counteracting medication is pralidoxime. The so-called nerve gases and many substances used in insecticides have been shown to act by combining with a residue of serine in the active site of acetylcholine esterase, inhibiting the enzyme completely. The enzyme acetylcholine esterase breaks down the neurotransmitter acetylcholine, which is released at nerve and muscle junctions, in order to allow the muscle or organ to relax. The result of acetylcholine esterase inhibition is that acetylcholine builds up and continues to act so that any nerve impulses are continually transmitted and muscle contractions do not stop.

Among the most common acetylcholinesterase inhibitors are phosphorus-based compounds, which are designed to bind to the active site of the enzyme. The structural requirements are a phosphorus atom bearing two lipophilic groups, a leaving group (such as a halide or thiocyanate), and a terminal oxygen. The entry on Lawesson's reagent has some details on one sub-class of the phosphorus-based compounds.

Some benzodiazepines, e.g. temazepam have an inhibitory effect on cholinesterase.[12]

Cholinesterase levels can be used as an indirect marker of arsenic exposure.[13]

Outside of biochemical warfare, anticholinesterases are also used for reversing medication induced paralysis during anesthesia; as well as in the treatment of myasthenia gravis, glaucoma, and Alzheimer's disease. Such compounds are used for killing insects in a range of products including sheep dip, organophosphate pesticides, and carbamate pesticides. In addition to acute poisoning as described above, a semi-acute poisoning characterized by strong mental disturbances can occur. Also, prolonged exposure can cause birth defects.

Pop culture

  • On season eight of Law and Order: SVU, Olivia Benson is taken to the hospital after being exposed to organophosphates, where she is told her cholinesterase level is low.
  • In the film The I Inside, Simon Cable is poisoned with cholinesterase inhibitors and he is given atropine and pralidoxime to help reverse the poison. The doctor is also shown dispensing a diazepam at the beginning of the movie.
  • In the film The Rock, Dr. Goodspeed (Nicolas Cage) correctly describes the effects of the chemical weapon VX gas as a cholinesterase inhibitor to John Mason (Sean Connery) as they remove guidance chips from the rocket designed to deliver the gas into San Francisco from Alcatraz.
  • Indie band Ruet Caelum have a song entitled 'Showing Signs of Cholinesterase Inhibition"
  • In the book "The Penultimate Truth" by Philip K. Dick, members of underground tank divisions are banned from surfacing with the fear that they will be subject to a cholinesterase-destroying nerve gas attack.

Additional images

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Elsevier, Dorland's Illustrated Medical Dictionary, Elsevier.
  2. ↑ Wang R, Tang XC (2005). "Neuroprotective effects of huperzine A. A natural cholinesterase inhibitor for the treatment of Alzheimer's disease". Neuro-Signals. 14 (1–2): 71–82. doi:10.1159/000085387. PMID 15956816.
  3. ↑ Whittaker M (1980). "Plasma cholinesterase variants and the anaesthetist". Anaesthesia. 35 (2): 174–197. doi:10.1111/j.1365-2044.1980.tb03800.x. PMID 6992635.
  4. ↑ Barash PG, Cullen BF, Stoelting RK (2006). Handbook of Clinical Anesthesia (5th ed.). Philadelphia: Lippincott Williams & Wilkins. pp. 546–9. ISBN 978-0-7817-5745-4.
  5. ↑ Miller RD (2005). Miller's Anesthesia (6th ed.). Philadelphia, Penns.: Elsevier/Churchill Livingstone. pp. 487–8. ISBN 978-0-443-06618-4.
  6. ↑ Leuzinger W, Baker AL (Feb 1967). "Acetylcholinesterase, I. Large-scale purification, homogeneity, and amino Acid analysis". Proceedings of the National Academy of Sciences of the United States of America. 57 (2): 446–51. doi:10.1073/pnas.57.2.446. PMC 335526. PMID 16591490.
  7. ↑ Leuzinger W, Baker AL, Cauvin E (Feb 1968). "Acetylcholinesterase. II. Crystallization, absorption spectra, isoionic point". Proceedings of the National Academy of Sciences of the United States of America. 59 (2): 620–3. doi:10.1073/pnas.59.2.620. PMC 224717. PMID 5238989.
  8. ↑ Sussman JL, Harel M, Frolow F, Oefner C, Goldman A, Toker L, Silman I (Aug 1991). "Atomic structure of acetylcholinesterase from Torpedo californica: a prototypic acetylcholine-binding protein". Science. 253 (5022): 872–9. doi:10.1126/science.1678899. PMID 1678899.
  9. ↑ 9.0 9.1 Huang YJ, Huang Y, Baldassarre H, Wang B, Lazaris A, Leduc M, Bilodeau AS, Bellemare A, Côté M, Herskovits P, Touati M, Turcotte C, Valeanu L, Lemée N, Wilgus H, Bégin I, Bhatia B, Rao K, Neveu N, Brochu E, Pierson J, Hockley DK, Cerasoli DM, Lenz DE, Karatzas CN, Langermann S (Aug 2007). "Recombinant human butyrylcholinesterase from milk of transgenic animals to protect against organophosphate poisoning". Proceedings of the National Academy of Sciences of the United States of America. 104 (34): 13603–8. doi:10.1073/pnas.0702756104. PMC 1934339. PMID 17660298. Lay summary – BBC News.
  10. ↑ Shinde R, Chatterjea MN (2005). Textbook of Medical Biochemistry (6th ed.). New Delhi: Jaypee Brothers Medical Publications (P) Ltd. p. 565. ISBN 978-9350254844.
  11. ↑ FBR Resource Guide: Acetylcholinesterase-Amniotic Fluid Archived 2007-06-25 at the Wayback Machine.. Foundation for Blood Research (September 7, 2007). Retrieved on 2007-11-21.
  12. ↑ Holmes JH, Kanfer I, Zwarenstein H (Aug 1978). "Effect of benzodiazepine derivatives on human blood cholinesterase in vitro". Research Communications in Chemical Pathology and Pharmacology. 21 (2): 367–70. PMID 29327.
  13. ↑ Ali N, Hoque MA, Haque A, Salam KA, Karim MR, Rahman A, Islam K, Saud ZA, Khalek MA, Akhand AA, Hossain M, Mandal A, Karim MR, Miyataka H, Himeno S, Hossain K. "Association between arsenic exposure and plasma cholinesterase activity: a population based study in Bangladesh". Environmental Health. 9: 36. doi:10.1186/1476-069X-9-36. PMC 2911418. PMID 20618979.

External links

Retrieved from "https://www.wikidoc.org/index.php?title=Cholinesterase&oldid=1532193"