Endometrial cancer classification: Difference between revisions

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Latest revision as of 18:41, 26 November 2018

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Roukoz A. Karam, M.D.[2]

Overview

Endometrial cancer may be classified according to histology into either type I comprising 80% of endometrial cancers or type II accounting for around 20%.

Classification

Endometrial cancer may be classified according to histology into 2 types:^[1]

Type	Histology	Prognosis	Pathogenesis	Prevalence
Type I	Endometroid (adenocarcinoma)	Favorable (estrogen-responsive)	• May arise from atypical hyperplasia • Linked to unopposed estrogen stimulation	80%
Type II	• Endometroid • Serous • Clear cell • Mucinous • Squamous • Mesonephric • Undifferentiated	Typically bad prognosis	• Develops from atrophic endometrium • Not linked to hormonally driven pathogenesis	15-20%

References

↑ Bokhman JV (1983). "Two pathogenetic types of endometrial carcinoma". Gynecol Oncol. 15 (1): 10–7. PMID 6822361.

Template:WikiDoc Sources

[pmid6822361-1] Bokhman JV (1983). "Two pathogenetic types of endometrial carcinoma". Gynecol Oncol. 15 (1): 10–7. PMID 6822361.

[1]

@@ Line 1: / Line 1: @@
 __NOTOC__
 {{Endometrial cancer}}
-{{CMG}}
+{{CMG}}{{AE}}{{RAK}}
 ==Overview==
+Endometrial cancer may be classified according to histology into either type I comprising 80% of endometrial cancers or type II accounting for around 20%.
 ==Classification==
-Most endometrial cancers are [[carcinoma]]s (usually [[adenocarcinoma]]s), meaning that they originate from the single layer of [[epithelium|epithelial]] cells which line the endometrium and form the endometrial glands. There are many [[histopathology|microscopic]] subtypes of ''endometrial carcinoma'', including the common ''endometrioid'' type, in which the cancer cells grow in patterns reminiscent of normal endometrium, and the far more aggressive ''papillary serous'' and ''clear cell'' endometrial carcinomas. Some authorities have proposed that endometrial carcinomas be classified into two pathogenetic groups:<ref>{{cite journal |author=Bokhman JV |title=Two pathogenetic types of endometrial carcinoma |journal=Gynecol. Oncol. |volume=15 |issue=1 |pages=10-7 |year=1983 |pmid=6822361 |doi=}}</ref>
+Endometrial cancer may be classified according to histology into 2 types:<ref name="pmid6822361">{{cite journal| author=Bokhman JV| title=Two pathogenetic types of endometrial carcinoma. | journal=Gynecol Oncol | year= 1983 | volume= 15 | issue= 1 | pages= 10-7 | pmid=6822361 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6822361  }} </ref>
+{| class="wikitable"
-====Type I:====
+! style="background:#4479BA; color: #FFFFFF;" align="center" + |Type
-These cancers occur most commonly in pre- and peri-[[menopause|menopausal]] women, often with a history of unopposed [[estrogen]] exposure and/or [[endometrial hyperplasia]]. They are often minimally invasive into the underlying uterine wall, are of the ''[[Grading (tumors)|low-grade]] endometrioid'' type, and carry a good prognosis.
+! style="background:#4479BA; color: #FFFFFF;" align="center" + |Histology
+! style="background:#4479BA; color: #FFFFFF;" align="center" + |Prognosis
-====Type II:====
+! style="background:#4479BA; color: #FFFFFF;" align="center" + |Pathogenesis
-These cancers occur in older, post-menopausal women, are more common in African-Americans, and are not associated with increased exposure to estrogen. They are typically of the ''[[Grading (tumors)|high-grade]] endometrioid'', ''papillary serous'' or ''clear cell'' types, and carry a generally poor prognosis
+! style="background:#4479BA; color: #FFFFFF;" align="center" + |Prevalence
+|-
-In contrast to ''endometrial carcinomas'', the uncommon ''endometrial stromal [[sarcomas]]'' are cancers which originate in the non-glandular [[connective tissue]] of the endometrium. ''Malignant mixed müllerian tumor'' is a rare endometrial cancer which contains cancerous cells of both glandular and [[connective tissue]] appearance - in this case, the cell of origin is unknown.<ref name="Weidner's">{{cite book |author=Richard Cote, Saul Suster, Lawrence Weiss, Noel Weidner (Editor) |title=Modern Surgical Pathology (2 Volume Set) |publisher=W B Saunders |location=London |year= |pages= |isbn=0-7216-7253-1 |oclc= |doi=}}</ref>
+| style="background:#DCDCDC;" align="center" + |Type I
+| style="background:#F5F5F5;" align="center" + |Endometroid (adenocarcinoma)
-<gallery>
+| style="background:#F5F5F5;" align="center" + |Favorable (estrogen-responsive)
-Image:Endometrial stromal sarcoma gross.jpg|Endometrial stromal sarcoma
+| style="background:#F5F5F5;" align="left" + |• May arise from atypical hyperplasia <br> • Linked to unopposed estrogen stimulation
-Image:Uterine carcinosarcoma.jpg|Malignant mixed müllerian tumor
+| style="background:#F5F5F5;" align="center" + |80%
-</gallery>
+|-
+| style="background:#DCDCDC;" align="center" + |Type II
+| style="background:#F5F5F5;" align="left" + |• Endometroid <br>• Serous <br>• Clear cell <br>• Mucinous <br>• Squamous <br>• Mesonephric <br>• Undifferentiated
+| style="background:#F5F5F5;" align="center" + |Typically bad prognosis
+| style="background:#F5F5F5;" align="left" + |• Develops from atrophic endometrium <br>• Not linked to hormonally driven pathogenesis
+| style="background:#F5F5F5;" align="center" + |15-20%
+|}
 ==References==
@@ Line 29: / Line 37: @@
 {{WikiDoc Help Menu}}
 {{WikiDoc Sources}}
+ [[Category:Up-To-Date]]
+[[Category:Oncology]]
+[[Category:Medicine]]
+[[Category:Gynecology]]
+[[Category:Surgery]]

Endometrial cancer classification: Difference between revisions

Latest revision as of 18:41, 26 November 2018

Overview

Classification

References

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