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__NOTOC__
__NOTOC__
{{Hemophilia}} {{CMG}}; {{AE}} {{Simrat}}
{{Hemophilia}}  
{{CMG}}; {{AE}} {{Sab}}{{Simrat}}{{FNY}}{{VE}}
==Overview==
==Overview==
Common risk factors in the development of hemophilia are family history of bleeding and male gender.
The most potent risk factor in the development of hemophilia is the family history of hemophilia. Other [[Risk factor|risk factors]] include [[Male|male sex]] and [[Cancer|malignancies]].


==Risk Factors of Hemophilia A and B==
==Risk Factors==
Risk factors for hemophilia A and B include
 
*Family history of bleeding  
==== Common Risk Factors<ref name="pmid11396445">{{cite journal |vauthors=Mannucci PM, Tuddenham EG |title=The hemophilias--from royal genes to gene therapy |journal=N. Engl. J. Med. |volume=344 |issue=23 |pages=1773–9 |date=June 2001 |pmid=11396445 |doi=10.1056/NEJM200106073442307 |url=}}</ref><ref name="Ingram1976">{{cite journal|last1=Ingram|first1=G I|title=The history of haemophilia.|journal=Journal of Clinical Pathology|volume=29|issue=6|year=1976|pages=469–479|issn=0021-9746|doi=10.1136/jcp.29.6.469}}</ref><ref>How Hemophilia is Inherited | Hemophilia | NCBDDD | CDC. Available at http://www.cdc.gov/ncbddd/hemophilia/inheritance-pattern.html. Accessed on Sept 20, 2016</ref><ref name="pmid24533955">{{cite journal |vauthors=Di Michele DM, Gibb C, Lefkowitz JM, Ni Q, Gerber LM, Ganguly A |title=Severe and moderate haemophilia A and B in US females |journal=Haemophilia |volume=20 |issue=2 |pages=e136–43 |date=March 2014 |pmid=24533955 |doi=10.1111/hae.12364 |url=}}</ref> ====
*Male gender<ref>{{Cite web | title = Hemophilia risk factors| url =https://www.nlm.nih.gov/medlineplus/ency/article/000538.htm }}</ref>
 
*[[Family history]] of hemophilia/bleeding.
*[[Male]] sex
 
==== Risk Factors for Acquired Hemophilia<ref name="pmid28960809">{{cite journal |vauthors=Napolitano M, Siragusa S, Mancuso S, Kessler CM |title=Acquired haemophilia in cancer: A systematic and critical literature review |journal=Haemophilia |volume=24 |issue=1 |pages=43–56 |date=January 2018 |pmid=28960809 |doi=10.1111/hae.13355 |url=}}</ref><ref name="pmid22321904">{{cite journal| author=Knoebl P, Marco P, Baudo F, Collins P, Huth-Kühne A, Nemes L et al.| title=Demographic and clinical data in acquired hemophilia A: results from the European Acquired Haemophilia Registry (EACH2). | journal=J Thromb Haemost | year= 2012 | volume= 10 | issue= 4 | pages= 622-31 | pmid=22321904 | doi=10.1111/j.1538-7836.2012.04654.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22321904  }}</ref><ref name="pmid28470674">{{cite journal| author=Kruse-Jarres R, Kempton CL, Baudo F, Collins PW, Knoebl P, Leissinger CA et al.| title=Acquired hemophilia A: Updated review of evidence and treatment guidance. | journal=Am J Hematol | year= 2017 | volume= 92 | issue= 7 | pages= 695-705 | pmid=28470674 | doi=10.1002/ajh.24777 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28470674  }}</ref><ref name="pmid20529258">Collins P, Baudo F, Huth-Kühne A, Ingerslev J, Kessler CM, Castellano ME et al. (2010) [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=20529258 Consensus recommendations for the diagnosis and treatment of acquired hemophilia A.] ''BMC Res Notes'' 3 ():161. [http://dx.doi.org/10.1186/1756-0500-3-161 DOI:10.1186/1756-0500-3-161] PMID: [https://pubmed.gov/20529258 20529258]</ref> ====
 
*[[Cancer|Malignancy]]
 
* [[Pregnancy]]
* [[Autoimmune disorders]] ([[Systemic lupus erythematosus|SLE]], [[rheumatoid arthritis]])
* [[Infection|Infections]] ([[Hepatitis C]], [[AIDS]])
* [[:Category:Drugs|Drugs]] ([[Interferon-alpha]])
* [[Dermatology|Dermatological]] conditions ([[Pemphigus]], [[psoriasis]])


==References==
==References==
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[[Category:Needs content]]
[[Category:Disease]]
[[Category:Disease]]
[[Category:Hematology]]
[[Category:Hematology]]
[[Category:Pediatrics]]
[[Category:Pediatrics]]
[[Category:Neonatology]]
[[Category:Neonatology]]

Latest revision as of 15:11, 2 August 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sabawoon Mirwais, M.B.B.S, M.D.[2]Simrat Sarai, M.D. [3]Fahd Yunus, M.D. [4]Vahid Eidkhani, M.D.

Overview

The most potent risk factor in the development of hemophilia is the family history of hemophilia. Other risk factors include male sex and malignancies.

Risk Factors

Common Risk Factors[1][2][3][4]

Risk Factors for Acquired Hemophilia[5][6][7][8]

References

  1. Mannucci PM, Tuddenham EG (June 2001). "The hemophilias--from royal genes to gene therapy". N. Engl. J. Med. 344 (23): 1773–9. doi:10.1056/NEJM200106073442307. PMID 11396445.
  2. Ingram, G I (1976). "The history of haemophilia". Journal of Clinical Pathology. 29 (6): 469–479. doi:10.1136/jcp.29.6.469. ISSN 0021-9746.
  3. How Hemophilia is Inherited | Hemophilia | NCBDDD | CDC. Available at http://www.cdc.gov/ncbddd/hemophilia/inheritance-pattern.html. Accessed on Sept 20, 2016
  4. Di Michele DM, Gibb C, Lefkowitz JM, Ni Q, Gerber LM, Ganguly A (March 2014). "Severe and moderate haemophilia A and B in US females". Haemophilia. 20 (2): e136–43. doi:10.1111/hae.12364. PMID 24533955.
  5. Napolitano M, Siragusa S, Mancuso S, Kessler CM (January 2018). "Acquired haemophilia in cancer: A systematic and critical literature review". Haemophilia. 24 (1): 43–56. doi:10.1111/hae.13355. PMID 28960809.
  6. Knoebl P, Marco P, Baudo F, Collins P, Huth-Kühne A, Nemes L; et al. (2012). "Demographic and clinical data in acquired hemophilia A: results from the European Acquired Haemophilia Registry (EACH2)". J Thromb Haemost. 10 (4): 622–31. doi:10.1111/j.1538-7836.2012.04654.x. PMID 22321904.
  7. Kruse-Jarres R, Kempton CL, Baudo F, Collins PW, Knoebl P, Leissinger CA; et al. (2017). "Acquired hemophilia A: Updated review of evidence and treatment guidance". Am J Hematol. 92 (7): 695–705. doi:10.1002/ajh.24777. PMID 28470674.
  8. Collins P, Baudo F, Huth-Kühne A, Ingerslev J, Kessler CM, Castellano ME et al. (2010) Consensus recommendations for the diagnosis and treatment of acquired hemophilia A. BMC Res Notes 3 ():161. DOI:10.1186/1756-0500-3-161 PMID: 20529258

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