Nasopharyngeal carcinoma other diagnostic studies: Difference between revisions

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{{Nasopharyngeal carcinoma}}
{{Nasopharyngeal carcinoma}}
{{CMG}} {{AE}}{{Faizan}}
{{CMG}} {{AE}}{{Homa}}{{Faizan}}
 
==Overview==
==Overview==
Biopsy may be helpful in the diagnosis of [[nasopharyngeal carcinoma]].
Nasopharyngoscopy may be helpful in the [[diagnosis]] of nasopharyngeal carcinoma. It is used for assessment of [[tumor]] extension, determination of [[mucosal]] surface involvement and [[biopsy]] of the primary [[tumor]]. [[Fine needle aspiration]] ([[FNA]]) for [[biopsy]] and [[histopathological]] [[analysis]] is used for [[diagnosis]] of nasopharyngeal carcinoma.
 
==Other Diagnostic Studies==
==Other Diagnostic Studies==
Biopsy may be helpful in the diagnosis of [[nasopharyngeal carcinoma]].
===Biopsy Findings===
Microscopic Features:<ref name= Librepathology>Nasopharyngeal carcinoma http://librepathology.org/wiki/index.php/Nasopharyngeal_carcinoma</ref>
*Prominent lymphoid component - '''key feature'''
*Features of [[squamous cell]] carcinoma:
**Cohesive cells with:
***Abundant dense [[eosinophilic]] cytoplasm
***Central nuclei +/- small/indistinct nucleoli
[[Image:Lymphoepithelioma_met_to_LN_6.jpg |thumb|none|250px| Nasopharyngeal carcinoma]]


==Immunohistochemistry==
'''<big>Nasopharyngoscopy</big>'''
*EBER +ve
 
*p16 -ve<ref name=pmid9546345>{{cite journal |author=Gulley ML, Nicholls JM, Schneider BG, Amin MB, Ro JY, Geradts J |title=Nasopharyngeal carcinomas frequently lack the p16/MTS1 tumor suppressor protein but consistently express the retinoblastoma gene product |journal=Am. J. Pathol. |volume=152 |issue=4 |pages=865–9 |year=1998 |month=April |pmid=9546345 |pmc=1858242 |doi= |url=}}</ref>
Nasopharyngoscopy may be helpful in the [[diagnosis]] of nasopharyngeal carcinoma. It is used for:<ref>{{Cite journal
| author = [[Muhyi Al-Sarraf]] & [[Maryada S. Reddy]]
| title = Nasopharyngeal carcinoma
| journal = [[Current treatment options in oncology]]
| volume = 3
| issue = 1
| pages = 21–32
| year = 2002
| month = February
| pmid = 12057084
}}</ref><ref name="KamranRiaz2015">{{cite journal|last1=Kamran|first1=Sophia C.|last2=Riaz|first2=Nadeem|last3=Lee|first3=Nancy|title=Nasopharyngeal Carcinoma|journal=Surgical Oncology Clinics of North America|volume=24|issue=3|year=2015|pages=547–561|issn=10553207|doi=10.1016/j.soc.2015.03.008}}</ref><ref name="WeiSham2005">{{cite journal|last1=Wei|first1=William I|last2=Sham|first2=Jonathan ST|title=Nasopharyngeal carcinoma|journal=The Lancet|volume=365|issue=9476|year=2005|pages=2041–2054|issn=01406736|doi=10.1016/S0140-6736(05)66698-6}}</ref>
 
*Assessment of [[tumor]] extension
*Determination of [[mucosal]] surface involvement
*[[Biopsy]] of the primary [[tumor]]
===Fine Needle Aspiration===
*[[Fine needle aspiration]] (FNA) for [[biopsy]] and [[histopathological]] [[analysis]] is used for [[diagnosis]] of nasopharyngeal carcinoma.<ref name="PastorLopez Pousa2017">{{cite journal|last1=Pastor|first1=M.|last2=Lopez Pousa|first2=A.|last3=del Barco|first3=E.|last4=Perez Segura|first4=P.|last5=Astorga|first5=B. Gonzalez|last6=Castelo|first6=B.|last7=Bonfill|first7=T.|last8=Martinez Trufero|first8=J.|last9=Grau|first9=J. Jose|last10=Mesia|first10=R.|title=SEOM clinical guideline in nasopharynx cancer (2017)|journal=Clinical and Translational Oncology|volume=20|issue=1|year=2017|pages=84–88|issn=1699-048X|doi=10.1007/s12094-017-1777-0}}</ref>
*To view [[microscopic]] features of nasopharyngeal carcinoma, click [[Nasopharyngeal carcinoma pathophysiology#Pathology|'''here''']].
 
*
 
==References==
==References==
{{Reflist|2}}
{{Reflist|2}}
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[[Category:Disease]]
 
[[Category:Types of cancer]]
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[[Category:Medicine]]
[[Category:Oncology]]
[[Category:Otolaryngology]]

Latest revision as of 22:54, 29 July 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Homa Najafi, M.D.[2]Faizan Sheraz, M.D. [3]

Overview

Nasopharyngoscopy may be helpful in the diagnosis of nasopharyngeal carcinoma. It is used for assessment of tumor extension, determination of mucosal surface involvement and biopsy of the primary tumor. Fine needle aspiration (FNA) for biopsy and histopathological analysis is used for diagnosis of nasopharyngeal carcinoma.

Other Diagnostic Studies

Nasopharyngoscopy

Nasopharyngoscopy may be helpful in the diagnosis of nasopharyngeal carcinoma. It is used for:[1][2][3]

Fine Needle Aspiration

References

  1. Muhyi Al-Sarraf & Maryada S. Reddy (2002). "Nasopharyngeal carcinoma". Current treatment options in oncology. 3 (1): 21–32. PMID 12057084. Unknown parameter |month= ignored (help)
  2. Kamran, Sophia C.; Riaz, Nadeem; Lee, Nancy (2015). "Nasopharyngeal Carcinoma". Surgical Oncology Clinics of North America. 24 (3): 547–561. doi:10.1016/j.soc.2015.03.008. ISSN 1055-3207.
  3. Wei, William I; Sham, Jonathan ST (2005). "Nasopharyngeal carcinoma". The Lancet. 365 (9476): 2041–2054. doi:10.1016/S0140-6736(05)66698-6. ISSN 0140-6736.
  4. Pastor, M.; Lopez Pousa, A.; del Barco, E.; Perez Segura, P.; Astorga, B. Gonzalez; Castelo, B.; Bonfill, T.; Martinez Trufero, J.; Grau, J. Jose; Mesia, R. (2017). "SEOM clinical guideline in nasopharynx cancer (2017)". Clinical and Translational Oncology. 20 (1): 84–88. doi:10.1007/s12094-017-1777-0. ISSN 1699-048X.

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