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__NOTOC__
__NOTOC__
{{Neuroblastoma}}
{{Neuroblastoma}}
{{CMG}} {{AE}}{{HL}}
{{CMG}} {{AE}}{{ZAS}}{{HL}}


==Overview==
==Overview==
An elevated concentration of blood and urinary  [[vanillylmandelic acid]] (VMA) and [[homovanillic acid]] (HVA) is suggestive of neuroblastoma.<ref name="gov"> Neuroblastoma Treatment for health professionals. National Cancer Institute (2015) http://www.cancer.gov/types/neuroblastoma/hp/neuroblastoma-treatment-pdq#link/_534_toc Accessed on October, 7 2015</ref><ref name="wiki">Neuroblastoma. Wikipedia(2015) https://en.wikipedia.org/wiki/Neuroblastoma Accessed on October, 5 2015</ref>
laboratory findings of neuroblastoma include increased level [[ferritin]], [[catecholamine]], [[dopamine]], [[vanillylmandelic acid]] (VMA), [[homovanillic acid]] (HVA),  [[lactate dehydrogenase]] and  neuron-specific [[enolase]] levels. There are increased urinary [[catecholamine]], [[vanillylmandelic acid]] (VMA) and [[homovanillic acid]] (HVA) levels.


==Laboratory Findings==
==Laboratory Findings==
 
Laboratory findings consistent with the diagnosis of neuroblastoma include: <ref name="gov">Neuroblastoma Treatment for health professionals. National Cancer Institute (2015) http://www.cancer.gov/types/neuroblastoma/hp/neuroblastoma-treatment-pdq#link/_534_toc Accessed on October, 7 2015</ref><ref name="pmid21736987">{{cite journal| author=Colon NC, Chung DH| title=Neuroblastoma. | journal=Adv Pediatr | year= 2011 | volume= 58 | issue= 1 | pages= 297-311 | pmid=21736987 | doi=10.1016/j.yapd.2011.03.011 | pmc=PMC3668791 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21736987  }} </ref><ref>{{Cite journal
====Blood Tests====
| author = [[Nadja C. Colon]] & [[Dai H. Chung]]
* Reduced [[hemoglobin]] level
| title = Neuroblastoma
* Elevated [[ferritin]] level
| journal = [[Advances in pediatrics]]
* Elevated [[catecholamine]] levels
| volume = 58
* Elevated [[dopamine]] level
| issue = 1
* Elevated [[vanillylmandelic acid]] (VMA) level
| pages = 297–311
* Elevated [[homovanillic acid]] (HVA) level
| year = 2011
* Elevated [[lactate dehydrogenase]] level (>1500 U/ml)
| month =
* Elevated neuron-specific [[enolase]] level(>100 ng/ml)
| doi = 10.1016/j.yapd.2011.03.011
 
| pmid = 21736987
====Urinalysis====
}}</ref><ref>{{Cite journal
* Elevated concentration of [[catecholamine]] levels
| author = [[Sunghoon Kim]] & [[Dai H. Chung]]
* Elevated [[Vanillylmandelic acid]] (VMA) level
| title = Pediatric solid malignancies: neuroblastoma and Wilms' tumor
* Elevated [[Homovanillic acid]] (HVA) level
| journal = [[The Surgical clinics of North America]]
| volume = 86
| issue = 2
| pages = 469–487
| year = 2006
| month = April
| doi = 10.1016/j.suc.2005.12.008
| pmid = 16580935
}}</ref><ref name="gov">Neuroblastoma Treatment for health professionals. National Cancer Institute (2015) http://www.cancer.gov/types/neuroblastoma/hp/neuroblastoma-treatment-pdq#link/_534_toc Accessed on October, 7 2015</ref><ref name="pmid21736987">{{cite journal| author=Colon NC, Chung DH| title=Neuroblastoma. | journal=Adv Pediatr | year= 2011 | volume= 58 | issue= 1 | pages= 297-311 | pmid=21736987 | doi=10.1016/j.yapd.2011.03.011 | pmc=PMC3668791 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21736987  }} </ref><ref>{{Cite journal
| author = [[Andrew M. Davidoff]]
| title = Neuroblastoma
| journal = [[Seminars in pediatric surgery]]
| volume = 21
| issue = 1
| pages = 2–14
| year = 2012
| month = February
| doi = 10.1053/j.sempedsurg.2011.10.009
| pmid = 22248965
}}</ref><ref>{{Cite journal
| author = [[M. S. Blois]] & [[P. W. Banda]]
| title = Letter: Laboratory diagnosis of neuroblastoma
| journal = [[The New England journal of medicine]]
| volume = 295
| issue = 16
| pages = 899–900
| year = 1976
| month = October
| doi = 10.1056/NEJM197610142951617
| pmid = 958297
}}</ref>
*Blood tests
**Decreased [[hemoglobin]]
**Increased [[ferritin]]
**Increased [[catecholamine]]
**Increased [[dopamine]]
**Increased [[vanillylmandelic acid]] (VMA)
**Increased [[homovanillic acid]] (HVA)
**Increased [[lactate dehydrogenase]] (>1500 U/ml)
**Increased neuron-specific [[enolase]] (>100 ng/ml)
*Urine analysis
**Increased [[catecholamine]]
**Increased [[vanillylmandelic acid]] (VMA)
**Increased [[homovanillic acid]] (HVA)


==References==
==References==
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[[Category:Disease]]
[[Category:Disease]]
[[Category:Pediatrics]]
[[Category:Pediatrics]]
[[Category:Up-To-Date]]
[[Category:Oncology]]
[[Category:Medicine]]
[[Category:Neurology]]
[[Category:Neurosurgery]]

Latest revision as of 15:32, 6 March 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Zahir Ali Shaikh, MD[2]Haytham Allaham, M.D. [3]

Overview

laboratory findings of neuroblastoma include increased level ferritin, catecholamine, dopamine, vanillylmandelic acid (VMA), homovanillic acid (HVA), lactate dehydrogenase and neuron-specific enolase levels. There are increased urinary catecholamine, vanillylmandelic acid (VMA) and homovanillic acid (HVA) levels.

Laboratory Findings

Laboratory findings consistent with the diagnosis of neuroblastoma include: [1][2][3][4][1][2][5][6]

References

  1. ↑ 1.0 1.1 Neuroblastoma Treatment for health professionals. National Cancer Institute (2015) http://www.cancer.gov/types/neuroblastoma/hp/neuroblastoma-treatment-pdq#link/_534_toc Accessed on October, 7 2015
  2. ↑ 2.0 2.1 Colon NC, Chung DH (2011). "Neuroblastoma". Adv Pediatr. 58 (1): 297–311. doi:10.1016/j.yapd.2011.03.011. PMC 3668791. PMID 21736987.
  3. ↑ Nadja C. Colon & Dai H. Chung (2011). "Neuroblastoma". Advances in pediatrics. 58 (1): 297–311. doi:10.1016/j.yapd.2011.03.011. PMID 21736987.
  4. ↑ Sunghoon Kim & Dai H. Chung (2006). "Pediatric solid malignancies: neuroblastoma and Wilms' tumor". The Surgical clinics of North America. 86 (2): 469–487. doi:10.1016/j.suc.2005.12.008. PMID 16580935. Unknown parameter |month= ignored (help)
  5. ↑ Andrew M. Davidoff (2012). "Neuroblastoma". Seminars in pediatric surgery. 21 (1): 2–14. doi:10.1053/j.sempedsurg.2011.10.009. PMID 22248965. Unknown parameter |month= ignored (help)
  6. ↑ M. S. Blois & P. W. Banda (1976). "Letter: Laboratory diagnosis of neuroblastoma". The New England journal of medicine. 295 (16): 899–900. doi:10.1056/NEJM197610142951617. PMID 958297. Unknown parameter |month= ignored (help)

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