Neuroblastoma history and symptoms

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Zahir Ali Shaikh, MD[2]Haytham Allaham, M.D. [3]

Overview

A detailed history of presenting symptoms, family history and other associated symptoms should be undertaken when evaluating a patient of neuroblastoma. General neuroblastoma symptoms include; fever, irritability, fatigue, loss of appetite and weight loss. Other symptoms depending upon the anatomical location of neuroblastoma include abdominal pain, distension and constipation (abdomen), shortness of breath, chronic cough & difficulty swallowing (posterior mediastinum), weakness, numbness, paralysis (retroperitoneum), visual defects, facial bruising (head & neck) and pallor, bone pain (bone marrow metastases).

History

  • A detailed history of presenting symptoms (duration, onset, progression), a thorough family history and a review of other other associated symptoms should be undertaken when evaluating a patient of neuroblastoma. When obtaining the history focus on possible associated syndromes as well, such as:[1][2]

Symptoms

  • However, the specific clinical presentation of neuroblastoma is determined by the exact anatomical location of the tumor such as:[5][6][7]
  • Abdominal neuroblastoma symptoms:
  • Posterior mediastinum neuroblastoma symptoms:
  • Retroperitoneal neuroblastoma symptoms:
  • Head & neck neuroblastoma symptoms:
  • Metastatic neuroblastomas lesions located in the bone marrow symptoms:

References

  1. Sidharth Mahapatra & Kishore B.. Challagundla (2018). "Cancer, Neuroblastoma". PMID 28846355. Unknown parameter |month= ignored (help)
  2. John M. Maris (2010). "Recent advances in neuroblastoma". The New England journal of medicine. 362 (23): 2202–2211. doi:10.1056/NEJMra0804577. PMID 20558371. Unknown parameter |month= ignored (help)
  3. J. W. Duckett & C. E. Koop (1977). "Neuroblastoma". The Urologic clinics of North America. 4 (2): 285–295. PMID 331618. Unknown parameter |month= ignored (help)
  4. Nadja C. Colon & Dai H. Chung (2011). "Neuroblastoma". Advances in pediatrics. 58 (1): 297–311. doi:10.1016/j.yapd.2011.03.011. PMID 21736987.
  5. Neuroblastoma Childhood: Symptoms and Signs. Cancer.net http://www.cancer.net/cancer-types/neuroblastoma-childhood/symptoms-and-signs Accessed on October, 7 2015
  6. Colon NC, Chung DH (2011). "Neuroblastoma". Adv Pediatr. 58 (1): 297–311. doi:10.1016/j.yapd.2011.03.011. PMC 3668791. PMID 21736987.
  7. Titilope A. Ishola & Dai H. Chung (2007). "Neuroblastoma". Surgical oncology. 16 (3): 149–156. doi:10.1016/j.suronc.2007.09.005. PMID 17976976. Unknown parameter |month= ignored (help)

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