Hypopharyngeal cancer pathophysiology: Difference between revisions
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{{Hypopharyngeal cancer}} | {{Hypopharyngeal cancer}} | ||
{{CMG}} {{AE}}{{Faizan}} | {{CMG}} ; {{AE}}{{G.D.}}, {{Faizan}} | ||
==Overview== | ==Overview== | ||
Hypopharyngeal cancer arises from [[squamous cell]]s, which are [[cells]] that are normally involved in protection of [[Digestive|aerodigestive]] [[tract]]. Hypopharyngeal cancer is a rare type of [[malignant]] [[cancer]] which has a delayed onset of [[clinical]] manifestations. Hypopharyngeal cancer is usually diagnosed at an advanced stage and it spreads to other [[organs]] such as [[lungs]], [[mediastinum]], [[bones]], [[brain]], [[liver]], [[esophagus]], and [[thyroid gland]]. The [[Metastasis|metastatic]] invasion depends on the [[anatomic]] location of the hypopharyngeal cancer. Hypopharyngeal cancer is mostly differentiated as [[squamous]] [[cell]] [[carcinoma]], however, the [[undifferentiated]] type may be found in the [[Pyriform fossa|pyriform]] [[sinus]] region. The exact [[pathogenesis]] of the hypopharyngeal cancer is not exactly understood, but the ''[[P16 (gene)|p16]]'', ''[[cyclin D1]]'', ''[[NOTCH1]]'', and ''[[TP53]]'' [[gene]] [[mutations]] have been associated with the [[development]] of the hypopharyngeal cancer. Hypopharyngeal cancer is associated with [[sideropenic]] [[dysphagia]] and [[Paterson-Brown-Kelly syndrome|Paterson]] [[Brown]] [[Kelly-Paterson syndrome|Kelly]] [[syndrome]]. On gross [[pathology]], flattened [[plaques]], [[mucosal]] [[ulceration]], and raised margins of the [[lesion]] are the characteristic findings of hypopharyngeal cancer. On [[microscopic]] [[histopathological]] analysis, [[spindle cell]]s, basaloid cells, and [[nuclear]] [[atypia]] are the characteristic findings of hypopharyngeal cancer. | |||
==Pathophysiology== | ==Pathophysiology== | ||
*Hypopharyngeal cancer arises from [[squamous cell]]s, which are [[cells]] that are normally involved in protection of [[Digestive|aerodigestive]] [[tract]].<ref name="KohmuraHasegawa1999">{{cite journal|last1=Kohmura|first1=Takahide|last2=Hasegawa|first2=Yasuhisa|last3=Ogawa|first3=Tetsuya|last4=Matsuura|first4=Hidehiro|last5=Takahashi|first5=Masakatsu|last6=Yanagita|first6=Noriyuki|last7=Nakashima|first7=Tsutomu|title=Cyclin D1 and p53 Overexpression Predicts Multiple Primary Malignant Neoplasms of the Hypopharynx and Esophagus|journal=Archives of Otolaryngology–Head & Neck Surgery|volume=125|issue=12|year=1999|pages=1351|issn=0886-4470|doi=10.1001/archotol.125.12.1351}}</ref> | |||
*[[Development]] of hypopharyngeal cancer is the result of multiple [[genetic]] [[mutations]]. These [[mutations]] lead to activation of [[oncogenes]] and inactivation of [[tumor]] suppression [[genes]] which ultimately results in deregulated [[cellular]] [[proliferation]]. | |||
*[[Overexpression]] of ''[[TP53]]'' and [[Cyclin D1|c''yclin D1'']] may lead to multiple primary [[cancers]] of the [[hypopharynx]]. | |||
==Genetics== | ==Genetics== | ||
* Genes involved in the [[pathogenesis]] of hypopharyngeal cancer include:<ref name="KohmuraHasegawa1999" /><ref name="pmid12560383">{{cite journal |vauthors=Helliwell TR |title=acp Best Practice No 169. Evidence based pathology: squamous carcinoma of the hypopharynx |journal=J. Clin. Pathol. |volume=56 |issue=2 |pages=81–5 |date=February 2003 |pmid=12560383 |pmc=1769882 |doi= |url=}}</ref> | |||
**''[[P16 (gene)|p16]]'' | |||
**''[[Cyclin D1]]'' | |||
**''[[TP53]]'' | |||
**''[[NOTCH1]]'' | |||
==Associated Diseases== | |||
* Hypopharyngeal carcinoma is associated with:<ref name="pmid12560383">{{cite journal| author=Helliwell TR| title=acp Best Practice No 169. Evidence based pathology: squamous carcinoma of the hypopharynx. | journal=J Clin Pathol | year= 2003 | volume= 56 | issue= 2 | pages= 81-5 | pmid=12560383 | doi= | pmc=PMC1769882 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12560383 }} </ref> | |||
**[[Sideropenic dysphagia]] | |||
**[[Paterson-Brown-Kelly syndrome]] | |||
==Gross Pathology== | ==Gross Pathology== | ||
* On gross [[pathology]], hypopharyngeal cancer is characterized by:<ref name="pmid12560383">{{cite journal| author=Helliwell TR| title=acp Best Practice No 169. Evidence based pathology: squamous carcinoma of the hypopharynx. | journal=J Clin Pathol | year= 2003 | volume= 56 | issue= 2 | pages= 81-5 | pmid=12560383 | doi= | pmc=PMC1769882 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12560383 }} </ref> | |||
**Flattened [[plaques]] | |||
**Raised margins of the lesion | |||
**[[Mucosal]] [[ulceration]] | |||
**[[Tumor]] spread to [[piriform sinus]] | |||
**Exophytic | |||
[[File:Gross pathology of hypopharyngeal cancer.jpeg|thumb|none|300px|Gross pathology of hypopharyngeal cancer[https://commons.wikimedia.org/wiki/Category:Hypopharyngeal_cancer, from Wikimedia Commons]]] | |||
==Microscopic Pathology== | ==Microscopic Pathology== | ||
* On [[microscopic]] [[Histopathological|histopathologica]]<nowiki/>l analysis, hypopharyngeal carcinoma is characterized by:<ref name="pmid12560383">{{cite journal| author=Helliwell TR| title=acp Best Practice No 169. Evidence based pathology: squamous carcinoma of the hypopharynx. | journal=J Clin Pathol | year= 2003 | volume= 56 | issue= 2 | pages= 81-5 | pmid=12560383 | doi= | pmc=PMC1769882 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12560383 }} </ref> | |||
**[[Spindle cell]]s | |||
**Basaloid [[cells]] | |||
**[[Nuclear]] [[atypia]] | |||
**Abundant [[chromatin]] | |||
==Immunohistochemistry== | |||
* There are some [[immunohistochemistry]] markers involve in the hypopharyngeal cancer:<ref name="pmid12560383">{{cite journal| author=Helliwell TR| title=acp Best Practice No 169. Evidence based pathology: squamous carcinoma of the hypopharynx. | journal=J Clin Pathol | year= 2003 | volume= 56 | issue= 2 | pages= 81-5 | pmid=12560383 | doi= | pmc=PMC1769882 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12560383 }} </ref> | |||
**Beta [[catenin]] positive | |||
**C-erbB2 negative | |||
**[[Messenger RNA|mRNA]] translation initial factor positive | |||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
[[Category:Up-To-Date]] | |||
[[Category:Oncology]] | |||
[[Category:Medicine]] | |||
[[Category: | [[Category:Gastroenterology]] | ||
[[Category: | [[Category:Otolaryngology]] | ||
[[Category:Surgery]] | |||
Latest revision as of 16:33, 23 September 2019
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Hypopharyngeal cancer pathophysiology On the Web |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Gertrude Djouka, M.D.[2], Faizan Sheraz, M.D. [3]
Overview
Hypopharyngeal cancer arises from squamous cells, which are cells that are normally involved in protection of aerodigestive tract. Hypopharyngeal cancer is a rare type of malignant cancer which has a delayed onset of clinical manifestations. Hypopharyngeal cancer is usually diagnosed at an advanced stage and it spreads to other organs such as lungs, mediastinum, bones, brain, liver, esophagus, and thyroid gland. The metastatic invasion depends on the anatomic location of the hypopharyngeal cancer. Hypopharyngeal cancer is mostly differentiated as squamous cell carcinoma, however, the undifferentiated type may be found in the pyriform sinus region. The exact pathogenesis of the hypopharyngeal cancer is not exactly understood, but the p16, cyclin D1, NOTCH1, and TP53 gene mutations have been associated with the development of the hypopharyngeal cancer. Hypopharyngeal cancer is associated with sideropenic dysphagia and Paterson Brown Kelly syndrome. On gross pathology, flattened plaques, mucosal ulceration, and raised margins of the lesion are the characteristic findings of hypopharyngeal cancer. On microscopic histopathological analysis, spindle cells, basaloid cells, and nuclear atypia are the characteristic findings of hypopharyngeal cancer.
Pathophysiology
- Hypopharyngeal cancer arises from squamous cells, which are cells that are normally involved in protection of aerodigestive tract.[1]
- Development of hypopharyngeal cancer is the result of multiple genetic mutations. These mutations lead to activation of oncogenes and inactivation of tumor suppression genes which ultimately results in deregulated cellular proliferation.
- Overexpression of TP53 and cyclin D1 may lead to multiple primary cancers of the hypopharynx.
Genetics
- Genes involved in the pathogenesis of hypopharyngeal cancer include:[1][2]
Associated Diseases
- Hypopharyngeal carcinoma is associated with:[2]
Gross Pathology
- On gross pathology, hypopharyngeal cancer is characterized by:[2]
- Flattened plaques
- Raised margins of the lesion
- Mucosal ulceration
- Tumor spread to piriform sinus
- Exophytic
Microscopic Pathology
- On microscopic histopathological analysis, hypopharyngeal carcinoma is characterized by:[2]
- Spindle cells
- Basaloid cells
- Nuclear atypia
- Abundant chromatin
Immunohistochemistry
- There are some immunohistochemistry markers involve in the hypopharyngeal cancer:[2]
References
- ↑ 1.0 1.1 Kohmura, Takahide; Hasegawa, Yasuhisa; Ogawa, Tetsuya; Matsuura, Hidehiro; Takahashi, Masakatsu; Yanagita, Noriyuki; Nakashima, Tsutomu (1999). "Cyclin D1 and p53 Overexpression Predicts Multiple Primary Malignant Neoplasms of the Hypopharynx and Esophagus". Archives of Otolaryngology–Head & Neck Surgery. 125 (12): 1351. doi:10.1001/archotol.125.12.1351. ISSN 0886-4470.
- ↑ 2.0 2.1 2.2 2.3 2.4 Helliwell TR (February 2003). "acp Best Practice No 169. Evidence based pathology: squamous carcinoma of the hypopharynx". J. Clin. Pathol. 56 (2): 81–5. PMC 1769882. PMID 12560383.