Hairy cell leukemia risk factors: Difference between revisions
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{{Hairy cell leukemia}} | {{Hairy cell leukemia}} | ||
{{CMG}} {{AE}}{{HL}} | {{CMG}}; {{AE}} {{HL}}; {{GRR}} {{Nat}} | ||
==Overview== | ==Overview== | ||
The most potent [[risk factor]] in the development of [[hairy cell leukemia]] is chemical exposure. Other risk factors include [[radiation]] exposure, [[Ultraviolet|UV]] light and sawdust exposure. | |||
==Risk Factors== | ==Risk Factors== | ||
* | * Common risk factors in the development of [[hairy cell leukemia]] include the following:<ref name="pmid25174032">{{cite journal |vauthors=Monnereau A, Slager SL, Hughes AM, Smith A, Glimelius B, Habermann TM, Berndt SI, Staines A, Norman AD, Cerhan JR, Sampson JN, Morton LM, Clavel J |title=Medical history, lifestyle, and occupational risk factors for hairy cell leukemia: the InterLymph Non-Hodgkin Lymphoma Subtypes Project |journal=J. Natl. Cancer Inst. Monographs |volume=2014 |issue=48 |pages=115–24 |date=August 2014 |pmid=25174032 |pmc=4155459 |doi=10.1093/jncimonographs/lgu004 |url=}}</ref><ref name="pmid9466117">{{cite journal |vauthors=Nordström M, Hardell L, Magnusson A, Hagberg H, Rask-Andersen A |title=Occupation and occupational exposure to UV light as risk factors for hairy cell leukaemia evaluated in a case-control study |journal=Eur. J. Cancer Prev. |volume=6 |issue=5 |pages=467–72 |date=October 1997 |pmid=9466117 |doi= |url=}}</ref><ref name="pmid19017688">{{cite journal |vauthors=Orsi L, Delabre L, Monnereau A, Delval P, Berthou C, Fenaux P, Marit G, Soubeyran P, Huguet F, Milpied N, Leporrier M, Hemon D, Troussard X, Clavel J |title=Occupational exposure to pesticides and lymphoid neoplasms among men: results of a French case-control study |journal=Occup Environ Med |volume=66 |issue=5 |pages=291–8 |date=May 2009 |pmid=19017688 |pmc=2728754 |doi=10.1136/oem.2008.040972 |url=}}</ref><ref name="pmid7417955">{{cite journal |vauthors=Stewart DJ, Keating MJ |title=Radiation exposure as a possible etiologic factor in hairy cell leukemia (leukemic reticuloendotheliosis) |journal=Cancer |volume=46 |issue=7 |pages=1577–80 |date=October 1980 |pmid=7417955 |doi= |url=}}</ref><ref name="pmid7577624">{{cite journal |vauthors=Clavel J, Mandereau L, Cordier S, Le Goaster C, Hémon D, Conso F, Flandrin G |title=Hairy cell leukaemia, occupation, and smoking |journal=Br. J. Haematol. |volume=91 |issue=1 |pages=154–61 |date=September 1995 |pmid=7577624 |doi= |url=}}</ref> | ||
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! style="background: #4479BA; width: 150px; color: #FFFFFF;"|'''Risk Factor''' | ! style="background: #4479BA; width: 150px; color: #FFFFFF;" |'''Risk Factor''' | ||
! style="background: #4479BA; width: 600px; color: #FFFFFF;"|'''Description''' | ! style="background: #4479BA; width: 600px; color: #FFFFFF;" |'''Description''' | ||
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| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=left | ''' | | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align="left" | '''Chemical exposure'''|| style="padding: 5px 5px; background: #F5F5F5;" |Exposure to either [[herbicides]] or diesel may be correlated with an increased risk of [[hairy cell leukemia]]. | ||
|- | |- | ||
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=left | '''Radiation exposure'''|| style="padding: 5px 5px; background: #F5F5F5;" | | | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align="left" | '''Radiation exposure'''|| style="padding: 5px 5px; background: #F5F5F5;" | | ||
Excessive X ray imaging or prior radiotherapy may be associated with increased risk of hairy cell leukemia. | Excessive [[X-rays|X-ray]] imaging or prior [[radiotherapy]] may be associated with increased risk of [[hairy cell leukemia]]. | ||
|- | |- | ||
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=left | '''Sawdust exposure'''|| style="padding: 5px 5px; background: #F5F5F5;" |Occupations that involve exposure to sawdust and wood may be associated with increased risk of hairy cell leukemia development. | | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align="left" | '''Sawdust exposure'''|| style="padding: 5px 5px; background: #F5F5F5;" |Occupations that involve exposure to sawdust and wood may be associated with increased risk of [[hairy cell leukemia]] development. | ||
|- | |- | ||
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=left | '''Ethnicity'''|| style="padding: 5px 5px; background: #F5F5F5;" |Hairy cell leukemia usually more commonly affects individuals of the Ashkenazi Jewish ancestry | | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align="left" | '''Ethnicity'''|| style="padding: 5px 5px; background: #F5F5F5;" |[[Hairy cell leukemia]] usually more commonly affects individuals of the Ashkenazi Jewish ancestry. | ||
|- | |- | ||
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=left | '''Gender'''|| style="padding: 5px 5px; background: #F5F5F5;" | | | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align="left" | '''Gender'''|| style="padding: 5px 5px; background: #F5F5F5;" |Males are more commonly affected with [[hairy cell leukemia]] than females. | ||
|- | |- | ||
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=left | '''Age'''|| style="padding: 5px 5px; background: #F5F5F5;" |The chance to develop hairy cell leukemia increases as patients get older, | | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align="left" | '''Age'''|| style="padding: 5px 5px; background: #F5F5F5;" |The chance to develop [[hairy cell leukemia]] increases as patients get older, while it is rarely diagnosed in patients younger than 30 years of age. | ||
|- | |||
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align="left" | '''HLA haplotype'''|| style="padding: 5px 5px; background: #F5F5F5;" |Family members who are sharing the same [[Human leukocyte antigen|HLA]] [[haplotype]] are at increased risk for [[hairy cell leukemia]]. | |||
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Latest revision as of 17:20, 8 April 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]; Grammar Reviewer: Natalie Harpenau, B.S.[3]
Overview
The most potent risk factor in the development of hairy cell leukemia is chemical exposure. Other risk factors include radiation exposure, UV light and sawdust exposure.
Risk Factors
| Risk Factor | Description |
|---|---|
| Chemical exposure | Exposure to either herbicides or diesel may be correlated with an increased risk of hairy cell leukemia. |
| Radiation exposure |
Excessive X-ray imaging or prior radiotherapy may be associated with increased risk of hairy cell leukemia. |
| Sawdust exposure | Occupations that involve exposure to sawdust and wood may be associated with increased risk of hairy cell leukemia development. |
| Ethnicity | Hairy cell leukemia usually more commonly affects individuals of the Ashkenazi Jewish ancestry. |
| Gender | Males are more commonly affected with hairy cell leukemia than females. |
| Age | The chance to develop hairy cell leukemia increases as patients get older, while it is rarely diagnosed in patients younger than 30 years of age. |
| HLA haplotype | Family members who are sharing the same HLA haplotype are at increased risk for hairy cell leukemia. |
References
- ↑ Monnereau A, Slager SL, Hughes AM, Smith A, Glimelius B, Habermann TM, Berndt SI, Staines A, Norman AD, Cerhan JR, Sampson JN, Morton LM, Clavel J (August 2014). "Medical history, lifestyle, and occupational risk factors for hairy cell leukemia: the InterLymph Non-Hodgkin Lymphoma Subtypes Project". J. Natl. Cancer Inst. Monographs. 2014 (48): 115–24. doi:10.1093/jncimonographs/lgu004. PMC 4155459. PMID 25174032.
- ↑ Nordström M, Hardell L, Magnusson A, Hagberg H, Rask-Andersen A (October 1997). "Occupation and occupational exposure to UV light as risk factors for hairy cell leukaemia evaluated in a case-control study". Eur. J. Cancer Prev. 6 (5): 467–72. PMID 9466117.
- ↑ Orsi L, Delabre L, Monnereau A, Delval P, Berthou C, Fenaux P, Marit G, Soubeyran P, Huguet F, Milpied N, Leporrier M, Hemon D, Troussard X, Clavel J (May 2009). "Occupational exposure to pesticides and lymphoid neoplasms among men: results of a French case-control study". Occup Environ Med. 66 (5): 291–8. doi:10.1136/oem.2008.040972. PMC 2728754. PMID 19017688.
- ↑ Stewart DJ, Keating MJ (October 1980). "Radiation exposure as a possible etiologic factor in hairy cell leukemia (leukemic reticuloendotheliosis)". Cancer. 46 (7): 1577–80. PMID 7417955.
- ↑ Clavel J, Mandereau L, Cordier S, Le Goaster C, Hémon D, Conso F, Flandrin G (September 1995). "Hairy cell leukaemia, occupation, and smoking". Br. J. Haematol. 91 (1): 154–61. PMID 7577624.