Hepatoblastoma epidemiology and demographics: Difference between revisions
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==Overview== | ==Overview== | ||
Hepatoblastoma is a common tumor that tends to affect children aged less than five years. | Hepatoblastoma is a common tumor that tends to affect children aged less than five years. Males are more commonly affected with hepatoblastoma than females. The annual [[incidence]] of hepatoblastoma in the United States appears to have doubled from 8 (1975-1983) to 16 (2002-2009) per 100,000 children aged 19 years and younger. | ||
==Epidemiology and demographics== | ==Epidemiology and demographics== | ||
===Prevalence=== | |||
* Hepatoblastoma is the most common primary liver [[cancer]] in infants and children, [[tumor]] involves right lobe of [[liver]] more often.<ref name="pmid12939582">{{cite journal |vauthors=Darbari A, Sabin KM, Shapiro CN, Schwarz KB |title=Epidemiology of primary hepatic malignancies in U.S. children |journal=Hepatology |volume=38 |issue=3 |pages=560–6 |date=September 2003 |pmid=12939582 |doi=10.1053/jhep.2003.50375 |url=}}</ref> | |||
* Hepatic tumors represent approximately 0.5-2% of all the tumors in children and are responsible for 1-4% of all the solid tumors.<ref name="MadabhaviPatel2014">{{cite journal|last1=Madabhavi|first1=Irappa|last2=Patel|first2=Apurva|last3=Choudhary|first3=Mukesh|last4=Aagre|first4=Suhas|last5=Revannasiddaiah|first5=Swaroop|last6=Modi|first6=Gaurang|last7=Anand|first7=Asha|last8=Panchal|first8=Harsha|last9=Parikh|first9=Sonia|last10=Raut|first10=Shreeniwas|title=Paraneoplastic Recurrent Hypoglycaemic Seizures: An Initial Presentation of Hepatoblastoma in an Adolescent Male—A Rare Entity|journal=Case Reports in Pediatrics|volume=2014|year=2014|pages=1–5|issn=2090-6803|doi=10.1155/2014/104543}}</ref><ref name="AllanParikh2013">{{cite journal|last1=Allan|first1=Bassan J.|last2=Parikh|first2=Punam P.|last3=Diaz|first3=Sofia|last4=Perez|first4=Eduardo A.|last5=Neville|first5=Holly L.|last6=Sola|first6=Juan E.|title=Predictors of survival and incidence of hepatoblastoma in the paediatric population|journal=HPB|volume=15|issue=10|year=2013|pages=741–746|issn=1365182X|doi=10.1111/hpb.12112}}</ref><ref name="differential">Epidemiology of hepatoblastoma. Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/hepatoblastoma. Accessed on November 6, 2015</ref> | |||
* The incidence/[[prevalence]] of hepatoblastoma is approximately 0.05–0.15 patients per 100000 population in children younger than 15 years.<ref name="pmid23600968">{{cite journal |vauthors=Allan BJ, Parikh PP, Diaz S, Perez EA, Neville HL, Sola JE |title=Predictors of survival and incidence of hepatoblastoma in the paediatric population |journal=HPB (Oxford) |volume=15 |issue=10 |pages=741–6 |date=October 2013 |pmid=23600968 |pmc=3791112 |doi=10.1111/hpb.12112 |url=}}</ref> | |||
* Peak [[incidence]] means of 18 months, mostly in [[infants]] and children younger than 3 years old, with a male predilection. | |||
* Hepatoblastoma accounts for one percent of all primary [[malignancies]] in [[pediatrics]]. | |||
===Incidence=== | |||
* The annual incidence of hepatoblastoma in the United States appears to have doubled from 8 (1975-1983) to 16 (2002-2009) per 100,000 children aged 19 years and younger.<ref name="risk">Incidence. National Cancer Institute 2015. http://www.cancer.gov/types/liver/hp/child-liver-treatment-pdq#link/_570_toc. Accessed on October 28, 2015</ref> | |||
===Age=== | ===Age=== | ||
Hepatoblastoma | * Hepatoblastoma commonly affects children less than five years of age.<ref name="AllanParikh2013">{{cite journal|last1=Allan|first1=Bassan J.|last2=Parikh|first2=Punam P.|last3=Diaz|first3=Sofia|last4=Perez|first4=Eduardo A.|last5=Neville|first5=Holly L.|last6=Sola|first6=Juan E.|title=Predictors of survival and incidence of hepatoblastoma in the paediatric population|journal=HPB|volume=15|issue=10|year=2013|pages=741–746|issn=1365182X|doi=10.1111/hpb.12112}}</ref> | ||
* Approximately 90% of the cases occur among patients under 5 years of age and two-thirds of cases occur in the first 2 years of life. <ref name="risk" /> | |||
* Hepatoblastoma among adolescents and young adults is extremely rare.<ref name="MadabhaviPatel2014">{{cite journal|last1=Madabhavi|first1=Irappa|last2=Patel|first2=Apurva|last3=Choudhary|first3=Mukesh|last4=Aagre|first4=Suhas|last5=Revannasiddaiah|first5=Swaroop|last6=Modi|first6=Gaurang|last7=Anand|first7=Asha|last8=Panchal|first8=Harsha|last9=Parikh|first9=Sonia|last10=Raut|first10=Shreeniwas|title=Paraneoplastic Recurrent Hypoglycaemic Seizures: An Initial Presentation of Hepatoblastoma in an Adolescent Male—A Rare Entity|journal=Case Reports in Pediatrics|volume=2014|year=2014|pages=1–5|issn=2090-6803|doi=10.1155/2014/104543}}</ref> | |||
Males are more commonly affected with hepatoblastoma than females. <ref name=differential>Epidemiology of hepatoblastoma. Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/hepatoblastoma. Accessed on November 6, 2015 | ===Gender=== | ||
* Males are more commonly affected with hepatoblastoma than females.<ref name="differential">Epidemiology of hepatoblastoma. Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/hepatoblastoma. Accessed on November 6, 2015</ref> | |||
==References== | ==References== | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Nawal Muazam M.D.[2]
Overview
Hepatoblastoma is a common tumor that tends to affect children aged less than five years. Males are more commonly affected with hepatoblastoma than females. The annual incidence of hepatoblastoma in the United States appears to have doubled from 8 (1975-1983) to 16 (2002-2009) per 100,000 children aged 19 years and younger.
Epidemiology and demographics
Prevalence
- Hepatoblastoma is the most common primary liver cancer in infants and children, tumor involves right lobe of liver more often.[1]
- Hepatic tumors represent approximately 0.5-2% of all the tumors in children and are responsible for 1-4% of all the solid tumors.[2][3][4]
- The incidence/prevalence of hepatoblastoma is approximately 0.05–0.15 patients per 100000 population in children younger than 15 years.[5]
- Peak incidence means of 18 months, mostly in infants and children younger than 3 years old, with a male predilection.
- Hepatoblastoma accounts for one percent of all primary malignancies in pediatrics.
Incidence
- The annual incidence of hepatoblastoma in the United States appears to have doubled from 8 (1975-1983) to 16 (2002-2009) per 100,000 children aged 19 years and younger.[6]
Age
- Hepatoblastoma commonly affects children less than five years of age.[3]
- Approximately 90% of the cases occur among patients under 5 years of age and two-thirds of cases occur in the first 2 years of life. [6]
- Hepatoblastoma among adolescents and young adults is extremely rare.[2]
Gender
- Males are more commonly affected with hepatoblastoma than females.[4]
References
- ↑ Darbari A, Sabin KM, Shapiro CN, Schwarz KB (September 2003). "Epidemiology of primary hepatic malignancies in U.S. children". Hepatology. 38 (3): 560–6. doi:10.1053/jhep.2003.50375. PMID 12939582.
- ↑ 2.0 2.1 Madabhavi, Irappa; Patel, Apurva; Choudhary, Mukesh; Aagre, Suhas; Revannasiddaiah, Swaroop; Modi, Gaurang; Anand, Asha; Panchal, Harsha; Parikh, Sonia; Raut, Shreeniwas (2014). "Paraneoplastic Recurrent Hypoglycaemic Seizures: An Initial Presentation of Hepatoblastoma in an Adolescent Male—A Rare Entity". Case Reports in Pediatrics. 2014: 1–5. doi:10.1155/2014/104543. ISSN 2090-6803.
- ↑ 3.0 3.1 Allan, Bassan J.; Parikh, Punam P.; Diaz, Sofia; Perez, Eduardo A.; Neville, Holly L.; Sola, Juan E. (2013). "Predictors of survival and incidence of hepatoblastoma in the paediatric population". HPB. 15 (10): 741–746. doi:10.1111/hpb.12112. ISSN 1365-182X.
- ↑ 4.0 4.1 Epidemiology of hepatoblastoma. Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/hepatoblastoma. Accessed on November 6, 2015
- ↑ Allan BJ, Parikh PP, Diaz S, Perez EA, Neville HL, Sola JE (October 2013). "Predictors of survival and incidence of hepatoblastoma in the paediatric population". HPB (Oxford). 15 (10): 741–6. doi:10.1111/hpb.12112. PMC 3791112. PMID 23600968.
- ↑ 6.0 6.1 Incidence. National Cancer Institute 2015. http://www.cancer.gov/types/liver/hp/child-liver-treatment-pdq#link/_570_toc. Accessed on October 28, 2015