Large cell carcinoma of the lung causes: Difference between revisions

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==Overview==
==Overview==


Causes of large cell carcinoma of the lung, are those of non-small cell lung cancers. Common causes include precursor lesions, such as metaplasia or dysplasia induced by smoking, asbestos exposure, ionizing radiation, atmospheric pollution, and chronic interstitial pneumonitis. Less common causes of large cell carcinoma of the lung include chromium and nickel exposure, vinyl chloride exposure, and inorganic arsenic exposure.<ref name="NSCL"> National Cancer Institute: PDQ® Non-Small Cell Lung Cancer Treatment. Bethesda, MD: National Cancer Institute. Date last modified January 22. http://www.cancer.gov/types/lung/hp/non-small-cell-lung-treatment-pdq. Accessed February 23, 2015</ref>
Common causes of large cell carcinoma of lung include [[smoking]], [[Asbestos|asbestos exposure]], [[ionizing radiation]], atmospheric pollution, and chronic [[interstitial pneumonitis]]. Less common causes of large cell carcinoma of the lung include chromium and nickel exposure, vinyl chloride exposure, and inorganic arsenic exposure.


==Common Causes==
==Common Causes==
*Common causes of large cell carcinoma of the lung include precursor lesions, such as metaplasia or dysplasia.  
* There are no precursor lesions associated with most of the types of large cell carcinoma except for basaloid carcinoma.<ref name="pmid9232332">{{cite journal |vauthors=Muscat JE, Stellman SD, Zhang ZF, Neugut AI, Wynder EL |title=Cigarette smoking and large cell carcinoma of the lung |journal=Cancer Epidemiol. Biomarkers Prev. |volume=6 |issue=7 |pages=477–80 |date=July 1997 |pmid=9232332 |doi= |url=}}</ref>
*Precursor lesions of large cell carcinoma of the lung, include:<ref name="NSCL"> National Cancer Institute: PDQ® Non-Small Cell Lung Cancer Treatment. Bethesda, MD: National Cancer Institute. Date last modified January 22. http://www.cancer.gov/types/lung/hp/non-small-cell-lung-treatment-pdq. Accessed February 23, 2015</ref>
 
:*Smoking (active/passive)  
*Common causes of large cell carcinoma of the lung include:<ref name="NSCL">National Cancer Institute: PDQ® Non-Small Cell Lung Cancer Treatment. Bethesda, MD: National Cancer Institute. Date last modified January 22. http://www.cancer.gov/types/lung/hp/non-small-cell-lung-treatment-pdq. Accessed February 23, 2015</ref><ref name="pmid26039012">{{cite journal |vauthors=Fasano M, Della Corte CM, Papaccio F, Ciardiello F, Morgillo F |title=Pulmonary Large-Cell Neuroendocrine Carcinoma: From Epidemiology to Therapy |journal=J Thorac Oncol |volume=10 |issue=8 |pages=1133–41 |date=August 2015 |pmid=26039012 |pmc=4503246 |doi=10.1097/JTO.0000000000000589 |url=}}</ref>
:*Asbestos exposure
:*[[Smoking]] (active/passive)  
:*Chronic interstitial pneumonitis
:*[[Asbestos|Asbestos exposure]]
:*Ionizing radiation
:*Chronic [[interstitial pneumonitis]]
:*[[Ionizing radiation]]
:*Atmospheric pollution
:*Atmospheric pollution


==Less Common Causes==
==Less Common Causes==
*Less common causes of large cell carcinoma of the lung, include:<ref name="NSCL"> National Cancer Institute: PDQ® Non-Small Cell Lung Cancer Treatment. Bethesda, MD: National Cancer Institute. Date last modified January 22. http://www.cancer.gov/types/lung/hp/non-small-cell-lung-treatment-pdq. Accessed February 23, 2015</ref>
*Less common causes of large cell carcinoma of the lung, include:<ref name="NSCL">National Cancer Institute: PDQ® Non-Small Cell Lung Cancer Treatment. Bethesda, MD: National Cancer Institute. Date last modified January 22. http://www.cancer.gov/types/lung/hp/non-small-cell-lung-treatment-pdq. Accessed February 23, 2015</ref><ref name="pmid9404741">{{cite journal |vauthors=Barbone F, Bovenzi M, Cavallieri F, Stanta G |title=Cigarette smoking and histologic type of lung cancer in men |journal=Chest |volume=112 |issue=6 |pages=1474–9 |date=December 1997 |pmid=9404741 |doi= |url=}}</ref>
:*Inorganic arsenic exposure
:*Inorganic arsenic exposure
:*Chromium, nickel exposure
:*Chromium, nickel exposure
:*Vinyl chloride exposure
:*Vinyl chloride exposure
:*Radon exposure
:*[[Radon|Radon exposure]]
:*Halogen ether exposure
:*Halogen ether exposure


==References==
==References==
{{reflist|2}}
{{reflist|2}}


[[Category:Types of cancer]]
[[Category:Types of cancer]]
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Latest revision as of 21:07, 28 February 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Maria Fernanda Villarreal, M.D. [2]

Overview

Common causes of large cell carcinoma of lung include smoking, asbestos exposure, ionizing radiation, atmospheric pollution, and chronic interstitial pneumonitis. Less common causes of large cell carcinoma of the lung include chromium and nickel exposure, vinyl chloride exposure, and inorganic arsenic exposure.

Common Causes

  • There are no precursor lesions associated with most of the types of large cell carcinoma except for basaloid carcinoma.[1]
  • Common causes of large cell carcinoma of the lung include:[2][3]

Less Common Causes

  • Less common causes of large cell carcinoma of the lung, include:[2][4]
  • Inorganic arsenic exposure
  • Chromium, nickel exposure
  • Vinyl chloride exposure
  • Radon exposure
  • Halogen ether exposure

References

  1. Muscat JE, Stellman SD, Zhang ZF, Neugut AI, Wynder EL (July 1997). "Cigarette smoking and large cell carcinoma of the lung". Cancer Epidemiol. Biomarkers Prev. 6 (7): 477–80. PMID 9232332.
  2. 2.0 2.1 National Cancer Institute: PDQ® Non-Small Cell Lung Cancer Treatment. Bethesda, MD: National Cancer Institute. Date last modified January 22. http://www.cancer.gov/types/lung/hp/non-small-cell-lung-treatment-pdq. Accessed February 23, 2015
  3. Fasano M, Della Corte CM, Papaccio F, Ciardiello F, Morgillo F (August 2015). "Pulmonary Large-Cell Neuroendocrine Carcinoma: From Epidemiology to Therapy". J Thorac Oncol. 10 (8): 1133–41. doi:10.1097/JTO.0000000000000589. PMC 4503246. PMID 26039012.
  4. Barbone F, Bovenzi M, Cavallieri F, Stanta G (December 1997). "Cigarette smoking and histologic type of lung cancer in men". Chest. 112 (6): 1474–9. PMID 9404741.


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