Disseminated intravascular coagulation causes: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Template:DIC}} | {{Template:DIC}} | ||
{{CMG}}; {{AE}} {{Ochuko}} | {{CMG}}; {{AE}} {{Ochuko}} {{OK}} | ||
==Overview== | ==Overview== | ||
There are a variety of causes of DIC | There are a variety of causes of [[DIC]], all usually causing the release of [[chemicals]] into the [[blood]] that instigates the [[coagulation]]. Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated. [[Disseminated intravascular coagulation]] in itself is a life-threatening condition and must be treated as such irrespective of the cause. Common causes include [[abruptio placentae]], [[amniotic fluid embolism]], [[aortic aneurysm]], [[blood transfusion]] reaction, drugs (e.g. [[Amphetamines]]), beractant [[eclampsia]], giant [[hemangioma]], [[graft-versus-host disease]], [[HELLP syndrome]] and hemolytic transfusion reaction. | ||
==Causes== | ==Causes== | ||
===Life Threatening Causes=== | ===Life Threatening Causes=== | ||
Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated. | Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated.<ref name="pmid6773170">{{cite journal |vauthors=Spero JA, Lewis JH, Hasiba U |title=Disseminated intravascular coagulation. Findings in 346 patients |journal=Thromb. Haemost. |volume=43 |issue=1 |pages=28–33 |date=February 1980 |pmid=6773170 |doi= |url=}}</ref> | ||
Disseminated intravascular coagulation in itself is a life-threatening condition and must be treated as such irrespective of the cause. | Disseminated intravascular coagulation in itself is a life-threatening condition and must be treated as such irrespective of the cause.<ref name="pmid19222477">{{cite journal |vauthors=Levi M, Toh CH, Thachil J, Watson HG |title=Guidelines for the diagnosis and management of disseminated intravascular coagulation. British Committee for Standards in Haematology |journal=Br. J. Haematol. |volume=145 |issue=1 |pages=24–33 |date=April 2009 |pmid=19222477 |doi=10.1111/j.1365-2141.2009.07600.x |url=}}</ref><ref name="pmid18066597">{{cite journal |vauthors=Ghosh K, Shetty S |title=Blood coagulation in falciparum malaria--a review |journal=Parasitol. Res. |volume=102 |issue=4 |pages=571–6 |date=March 2008 |pmid=18066597 |doi=10.1007/s00436-007-0832-0 |url=}}</ref><ref name="pmid580488">{{cite journal |vauthors=Siegal T, Seligsohn U, Aghai E, Modan M |title=Clinical and laboratory aspects of disseminated intravascular coagulation (DIC): a study of 118 cases |journal=Thromb. Haemost. |volume=39 |issue=1 |pages=122–34 |date=February 1978 |pmid=580488 |doi= |url=}}</ref> | ||
===Common Causes=== | ===Common Causes=== | ||
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===Causes by Organ System=== | ===Causes by Organ System=== | ||
{|style="width:80%; height:100px" border="1" | {| style="width:80%; height:100px" border="1" | ||
| | | style="width:25%" bgcolor="LightSteelBlue" ; border="1" | '''Cardiovascular''' | ||
| | | style="width:75%" bgcolor="Beige" ; border="1" | [[Aortic aneurysm]], [[malignant hypertension]], [[myocardial infarction]], [[septic shock]], [[shock]], [[vasculitis]] | ||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
| '''Chemical / poisoning''' | | '''Chemical / poisoning''' | ||
|bgcolor="Beige"| [[snake bite|Snake bite (elapid)]] | | bgcolor="Beige" | [[snake bite|Snake bite (elapid)]] | ||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
| '''Dermatologic''' | | '''Dermatologic''' | ||
|bgcolor="Beige"| [[Purpura fulminans]], [[Raynaud's disease]], [[rheumatoid arthritis]], [[vasculitis]] | | bgcolor="Beige" | [[Purpura fulminans]], [[Raynaud's disease]], [[rheumatoid arthritis]], [[vasculitis]] | ||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
| '''Drug Side Effect''' | | '''Drug Side Effect''' | ||
|bgcolor="Beige"| [[Amphetamine]], [[cocaine]], [[indomethacin]], [[interleukin 2]], [[Mafenide]], [[serotonin syndrome]], [[Dinoprostone]] | | bgcolor="Beige" | [[Amphetamine]], [[cocaine]], [[indomethacin]], [[interleukin 2]], [[Mafenide]], [[serotonin syndrome]], [[Dinoprostone]] | ||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
| '''Ear Nose Throat''' | | '''Ear Nose Throat''' | ||
|bgcolor="Beige"| No underlying causes | | bgcolor="Beige" | No underlying causes | ||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
| '''Endocrine''' | | '''Endocrine''' | ||
|bgcolor="Beige"| No underlying causes | | bgcolor="Beige" | No underlying causes | ||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
| '''Environmental''' | | '''Environmental''' | ||
|bgcolor="Beige"| No underlying causes | | bgcolor="Beige" | No underlying causes | ||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
| '''Gastroenterologic''' | | '''Gastroenterologic''' | ||
|bgcolor="Beige"| [[Acute fatty liver of pregnancy]], [[hepatic failure|acute hepatic failure]], [[acute pancreatitis]], [[Crohn disease]], [[hepatic failure|fulminant hepatic failure]], [[liver disease]], [[ulcerative colitis]] | | bgcolor="Beige" | [[Acute fatty liver of pregnancy]], [[hepatic failure|acute hepatic failure]], [[acute pancreatitis]], [[Crohn disease]], [[hepatic failure|fulminant hepatic failure]], [[liver disease]], [[ulcerative colitis]] | ||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
| '''Genetic''' | | '''Genetic''' | ||
|bgcolor="Beige"| No underlying causes | | bgcolor="Beige" | No underlying causes | ||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
| '''Hematologic''' | | '''Hematologic''' | ||
|bgcolor="Beige"| [[transfusion reaction|Acute hemolytic transfusion reactions]], [[acute myeloid leukemia]], [[acute promyelocytic leukemia]], [[antiphospholipid syndrome]], [[Kasabach-Merritt syndrome]], [[myeloproliferative syndrome]], [[paroxysmal nocturnal hemoglobinuria]], [[purpura fulminans]], [[Trousseau's syndrome]] | | bgcolor="Beige" | [[transfusion reaction|Acute hemolytic transfusion reactions]], [[acute myeloid leukemia]], [[acute promyelocytic leukemia]], [[antiphospholipid syndrome]], [[Kasabach-Merritt syndrome]], [[myeloproliferative syndrome]], [[paroxysmal nocturnal hemoglobinuria]], [[purpura fulminans]], [[Trousseau's syndrome]] | ||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
| '''Iatrogenic''' | | '''Iatrogenic''' | ||
|bgcolor="Beige"| [[transplant rejection|Acute renal allograft rejection]], [[Denver shunt]], [[surgery|extensive surgery]], [[LeVeen shunt]], [[liver transplantation]], [[peritoneovenous shunt]], [[prosthetic devices]], [[serotonin syndrome]], [[surgery]], [[anesthesia|recent anesthesia]], [[ventricular assist devices]] | | bgcolor="Beige" | [[transplant rejection|Acute renal allograft rejection]], [[Denver shunt]], [[surgery|extensive surgery]], [[LeVeen shunt]], [[liver transplantation]], [[peritoneovenous shunt]], [[prosthetic devices]], [[serotonin syndrome]], [[surgery]], [[anesthesia|recent anesthesia]], [[ventricular assist devices]] | ||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
| '''Infectious Disease''' | | '''Infectious Disease''' | ||
|bgcolor="Beige"| [[arenavirus|Arenaviruses]], [[Argentine hemorrhagic fever]], [[aspergillosis]], [[hemorrhagic fever|Bolivian hemorrhagic fever]], [[capnocytophaga canimorsus]], [[CMV]], [[HELLP syndrome]], [[hepatitis|hepatitis viruses]], [[histoplasmosis]], [[malaria|malaria (malignant tertian)]], [[meningococcemia|meningococcal septicaemia]], [[mycoplasma pneumoniae]], [[neisseria meningiditis]], [[osteomyelitis]], [[rocky mountain spotted fever]], [[sarcoidosis]], [[sepsis]], [[septic shock]], [[African trypanosomiasis|sleeping sickness (East African)]], [[streptococcus pneumoniae]], [[tuberculosis]], [[typhoid fever]], [[hemorrhagic fever|viral hemorrhagic fevers]], [[VZV]] | | bgcolor="Beige" | [[arenavirus|Arenaviruses]], [[Argentine hemorrhagic fever]], [[aspergillosis]], [[hemorrhagic fever|Bolivian hemorrhagic fever]], [[capnocytophaga canimorsus]], [[CMV]], [[HELLP syndrome]], [[hepatitis|hepatitis viruses]], [[histoplasmosis]], [[malaria|malaria (malignant tertian)]], [[meningococcemia|meningococcal septicaemia]], [[mycoplasma pneumoniae]], [[neisseria meningiditis]], [[osteomyelitis]], [[rocky mountain spotted fever]], [[sarcoidosis]], [[sepsis]], [[septic shock]], [[African trypanosomiasis|sleeping sickness (East African)]], [[streptococcus pneumoniae]], [[tuberculosis]], [[typhoid fever]], [[hemorrhagic fever|viral hemorrhagic fevers]], [[VZV]] | ||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
| '''Musculoskeletal / Ortho''' | | '''Musculoskeletal / Ortho''' | ||
|bgcolor="Beige"| [[Osteomyelitis]] | | bgcolor="Beige" | [[Osteomyelitis]] | ||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
| '''Neurologic''' | | '''Neurologic''' | ||
|bgcolor="Beige"| [[Antiphospholipid syndrome]], [[meningococcemia|meningococcal septicaemia]], [[neisseria meningiditis]] | | bgcolor="Beige" | [[Antiphospholipid syndrome]], [[meningococcemia|meningococcal septicaemia]], [[neisseria meningiditis]] | ||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
| '''Nutritional / Metabolic''' | | '''Nutritional / Metabolic''' | ||
|bgcolor="Beige"| No underlying causes | | bgcolor="Beige" | No underlying causes | ||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
| '''Obstetric/Gynecologic''' | | '''Obstetric/Gynecologic''' | ||
|bgcolor="Beige"| [[Abruptio placentae]], [[amniotic fluid embolism]], [[dead fetus syndrome]], [[eclampsia]], [[HELLP syndrome]], [[intrauterine death]], [[pre-eclampsia]], [[retained intrauterine fetal demise]], [[septic abortion]] | | bgcolor="Beige" | [[Abruptio placentae]], [[amniotic fluid embolism]], [[dead fetus syndrome]], [[eclampsia]], [[HELLP syndrome]], [[intrauterine death]], [[pre-eclampsia]], [[retained intrauterine fetal demise]], [[septic abortion]] | ||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
| '''Oncologic''' | | '''Oncologic''' | ||
|bgcolor="Beige"| [[Acute myeloid leukemia]], [[acute promyelocytic leukemia]], [[carcinoma|Cancers of lung, pancreas, prostate and stomach]], [[hemangioma|giant hemangioma]], [[Kasabach-Merritt syndrome]], [[malignancy]], [[mucin|mucin-secreting adenocarcinoma]], [[paraneoplastic syndrome]], [[Trousseau's syndrome]] | | bgcolor="Beige" | [[Acute myeloid leukemia]], [[acute promyelocytic leukemia]], [[carcinoma|Cancers of lung, pancreas, prostate and stomach]], [[hemangioma|giant hemangioma]], [[Kasabach-Merritt syndrome]], [[malignancy]], [[mucin|mucin-secreting adenocarcinoma]], [[paraneoplastic syndrome]], [[Trousseau's syndrome]] | ||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
| '''Opthalmologic''' | | '''Opthalmologic''' | ||
|bgcolor="Beige"| No underlying causes | | bgcolor="Beige" | No underlying causes | ||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
| '''Overdose / Toxicity''' | | '''Overdose / Toxicity''' | ||
|bgcolor="Beige"| [[Amphetamine]], [[cocaine]] | | bgcolor="Beige" | [[Amphetamine]], [[cocaine]] | ||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
| '''Psychiatric''' | | '''Psychiatric''' | ||
|bgcolor="Beige"| No underlying causes | | bgcolor="Beige" | No underlying causes | ||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
| '''Pulmonary''' | | '''Pulmonary''' | ||
|bgcolor="Beige"| [[Acute respiratory distress syndrome]], [[empyema]], [[mycoplasma pneumoniae]], [[sarcoidosis]], [[streptococcus pneumoniae]], [[tuberculosis]] | | bgcolor="Beige" | [[Acute respiratory distress syndrome]], [[empyema]], [[mycoplasma pneumoniae]], [[sarcoidosis]], [[streptococcus pneumoniae]], [[tuberculosis]] | ||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
| '''Renal / Electrolyte''' | | '''Renal / Electrolyte''' | ||
|bgcolor="Beige"| [[Renal failure]] | | bgcolor="Beige" | [[Renal failure]] | ||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
| '''Rheum / Immune / Allergy''' | | '''Rheum / Immune / Allergy''' | ||
|bgcolor="Beige"| [[transplant rejection|Acute renal allograft rejection]], [[antiphospholipid syndrome]], [[interleukin 2]], [[macrophage-activation syndrome]], [[paraneoplastic syndrome]], [[Raynaud's disease]], [[rheumatoid arthritis]], [[sarcoidosis]], [[vasculitis]] | | bgcolor="Beige" | [[transplant rejection|Acute renal allograft rejection]], [[antiphospholipid syndrome]], [[interleukin 2]], [[macrophage-activation syndrome]], [[paraneoplastic syndrome]], [[Raynaud's disease]], [[rheumatoid arthritis]], [[sarcoidosis]], [[vasculitis]] | ||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
| '''Sexual''' | | '''Sexual''' | ||
|bgcolor="Beige"| No underlying causes | | bgcolor="Beige" | No underlying causes | ||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
| '''Trauma''' | | '''Trauma''' | ||
|bgcolor="Beige"| [[Burns]], [[crush syndrome]], [[head injury]], [[electrical injury|lightning strike]], [[motor vehicle accidents]], [[soft tissue injury|severe tissue injury]], [[trauma]] | | bgcolor="Beige" | [[Burns]], [[crush syndrome]], [[head injury]], [[electrical injury|lightning strike]], [[motor vehicle accidents]], [[soft tissue injury|severe tissue injury]], [[trauma]] | ||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
| '''Urologic''' | | '''Urologic''' | ||
|bgcolor="Beige"| No underlying causes | | bgcolor="Beige" | No underlying causes | ||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
| '''Dental''' | | '''Dental''' | ||
|bgcolor="Beige"| No underlying causes | | bgcolor="Beige" | No underlying causes | ||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
| '''Miscellaneous''' | | '''Miscellaneous''' | ||
|bgcolor="Beige"| [[Heat stroke]], [[hyperthermia]], [[prosthetic devices]], [[snake bite|Snake bite (elapid)]], [[venomous snake|venomous snakes]] | | bgcolor="Beige" | [[Heat stroke]], [[hyperthermia]], [[prosthetic devices]], [[snake bite|Snake bite (elapid)]], [[venomous snake|venomous snakes]] | ||
|- | |- | ||
|} | |} | ||
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[[Category:Hematology]] | [[Category:Hematology]] | ||
[[Category:Cardiology]] | [[Category:Cardiology]] | ||
{{WS}} | {{WS}} | ||
{{WH}} | {{WH}} |
Latest revision as of 14:25, 30 August 2018
Disseminated intravascular coagulation Microchapters |
Differentiating Disseminated intravascular coagulation from other Diseases |
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Diagnosis |
Treatment |
Case Studies |
Disseminated intravascular coagulation causes On the Web |
American Roentgen Ray Society Images of Disseminated intravascular coagulation causes |
Directions to Hospitals Treating Disseminated intravascular coagulation |
Risk calculators and risk factors for Disseminated intravascular coagulation causes |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ogheneochuko Ajari, MB.BS, MS [2] Omer Kamal, M.D.[3]
Overview
There are a variety of causes of DIC, all usually causing the release of chemicals into the blood that instigates the coagulation. Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated. Disseminated intravascular coagulation in itself is a life-threatening condition and must be treated as such irrespective of the cause. Common causes include abruptio placentae, amniotic fluid embolism, aortic aneurysm, blood transfusion reaction, drugs (e.g. Amphetamines), beractant eclampsia, giant hemangioma, graft-versus-host disease, HELLP syndrome and hemolytic transfusion reaction.
Causes
Life Threatening Causes
Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated.[1]
Disseminated intravascular coagulation in itself is a life-threatening condition and must be treated as such irrespective of the cause.[2][3][4]
Common Causes
- Abruptio placentae
- Amniotic fluid embolism
- Aortic aneurysm
- Blood transfusion reaction
- Drugs (e.g. Amphetamines), Beractant
- Eclampsia
- Giant hemangioma
- Graft-versus-host disease
- HELLP syndrome
- Hemolytic transfusion reaction
- Liver disease
- Malignancy (especially APL)
- Sepsis (esp. gram-negative bacteria)
- Severe allergic reaction
- Transplant rejection
- Trauma (e.g. Fat embolism, head injury)
- Venomous snake
- Viral hemorrhagic fever
Causes by Organ System
Causes in Alphabetical Order
References
- ↑ Spero JA, Lewis JH, Hasiba U (February 1980). "Disseminated intravascular coagulation. Findings in 346 patients". Thromb. Haemost. 43 (1): 28–33. PMID 6773170.
- ↑ Levi M, Toh CH, Thachil J, Watson HG (April 2009). "Guidelines for the diagnosis and management of disseminated intravascular coagulation. British Committee for Standards in Haematology". Br. J. Haematol. 145 (1): 24–33. doi:10.1111/j.1365-2141.2009.07600.x. PMID 19222477.
- ↑ Ghosh K, Shetty S (March 2008). "Blood coagulation in falciparum malaria--a review". Parasitol. Res. 102 (4): 571–6. doi:10.1007/s00436-007-0832-0. PMID 18066597.
- ↑ Siegal T, Seligsohn U, Aghai E, Modan M (February 1978). "Clinical and laboratory aspects of disseminated intravascular coagulation (DIC): a study of 118 cases". Thromb. Haemost. 39 (1): 122–34. PMID 580488.
- ↑ 5.0 5.1 5.2 5.3 5.4 Lurie S, Feinstein M, Mamet Y (2000). "Disseminated intravascular coagulopathy in pregnancy: thorough comprehension of etiology and management reduces obstetricians' stress". Arch Gynecol Obstet. 263 (3): 126–30. PMID 10763841.