Radiation proctitis causes: Difference between revisions
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{{Radiation proctitis}} | {{Radiation proctitis}} | ||
{{CMG}} {{AE}} | {{CMG}} {{AE}} [[User:Rekha|Rekha, M.D.]], {{MIR}} | ||
==Overview== | ==Overview== | ||
Common causes in the development of radiation proctitis include include high dose of [[radiation]], area of the [[radiation]] and mode of delivery of the [[radiation]]. | |||
==Causes== | ==Causes== | ||
===Common Causes=== | |||
Common causes in the development of radiation proctitis include:<ref name="pmid8996146">{{cite journal| author=Beard CJ, Propert KJ, Rieker PP, Clark JA, Kaplan I, Kantoff PW et al.| title=Complications after treatment with external-beam irradiation in early-stage prostate cancer patients: a prospective multiinstitutional outcomes study. | journal=J Clin Oncol | year= 1997 | volume= 15 | issue= 1 | pages= 223-9 | pmid=8996146 | doi=10.1200/JCO.1997.15.1.223 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8996146 }}</ref><ref name="pmid10705022">{{cite journal| author=Willett CG, Ooi CJ, Zietman AL, Menon V, Goldberg S, Sands BE et al.| title=Acute and late toxicity of patients with inflammatory bowel disease undergoing irradiation for abdominal and pelvic neoplasms. | journal=Int J Radiat Oncol Biol Phys | year= 2000 | volume= 46 | issue= 4 | pages= 995-8 | pmid=10705022 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10705022 }}</ref> | |||
* Dose of the radiation: <45 Gy are associated with few long-term radiation side effects. In contrast, doses between 45 and 70 Gy cause more complications, and doses above 70 Gy cause significant and longstanding injury to the surrounding area. | |||
* Area of the radiation.<ref name="pmid7713784">{{cite journal| author=Coia LR, Myerson RJ, Tepper JE| title=Late effects of radiation therapy on the gastrointestinal tract. | journal=Int J Radiat Oncol Biol Phys | year= 1995 | volume= 31 | issue= 5 | pages= 1213-36 | pmid=7713784 | doi=10.1016/0360-3016(94)00419-L | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7713784 }}</ref> | |||
* Mode of the delivery of the radiation: [[External beam radiotherapy|External beam radiation]], typically administered by a linear accelerator, results in significantly greater exposure to surrounding organs as compared with [[brachytherapy]], where [[radiation]] is administered via radioactive implants. Newer modalities of [[External beam radiotherapy|external beam radiation]] delivery, including three-dimensional conformal radiation therapy, intensity-modulated radiation therapy, and the use of heavy particles including [[protons]] and [[neutrons]], may be associated with a reduced risk of radiation toxicity. | |||
==References== | ==References== | ||
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[[Category:Oncology]] | [[Category:Oncology]] | ||
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[[Category:Oncology]] | |||
[[Category:Medicine]] | |||
[[Category:Gastroenterology]] | |||
[[Category:Surgery]] | |||
Latest revision as of 23:52, 6 November 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Rekha, M.D., Mahshid Mir, M.D. [2]
Overview
Common causes in the development of radiation proctitis include include high dose of radiation, area of the radiation and mode of delivery of the radiation.
Causes
Common Causes
Common causes in the development of radiation proctitis include:[1][2]
- Dose of the radiation: <45 Gy are associated with few long-term radiation side effects. In contrast, doses between 45 and 70 Gy cause more complications, and doses above 70 Gy cause significant and longstanding injury to the surrounding area.
- Area of the radiation.[3]
- Mode of the delivery of the radiation: External beam radiation, typically administered by a linear accelerator, results in significantly greater exposure to surrounding organs as compared with brachytherapy, where radiation is administered via radioactive implants. Newer modalities of external beam radiation delivery, including three-dimensional conformal radiation therapy, intensity-modulated radiation therapy, and the use of heavy particles including protons and neutrons, may be associated with a reduced risk of radiation toxicity.
References
- ↑ Beard CJ, Propert KJ, Rieker PP, Clark JA, Kaplan I, Kantoff PW; et al. (1997). "Complications after treatment with external-beam irradiation in early-stage prostate cancer patients: a prospective multiinstitutional outcomes study". J Clin Oncol. 15 (1): 223–9. doi:10.1200/JCO.1997.15.1.223. PMID 8996146.
- ↑ Willett CG, Ooi CJ, Zietman AL, Menon V, Goldberg S, Sands BE; et al. (2000). "Acute and late toxicity of patients with inflammatory bowel disease undergoing irradiation for abdominal and pelvic neoplasms". Int J Radiat Oncol Biol Phys. 46 (4): 995–8. PMID 10705022.
- ↑ Coia LR, Myerson RJ, Tepper JE (1995). "Late effects of radiation therapy on the gastrointestinal tract". Int J Radiat Oncol Biol Phys. 31 (5): 1213–36. doi:10.1016/0360-3016(94)00419-L. PMID 7713784.