Primary biliary cirrhosis laboratory findings: Difference between revisions
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{{Primary biliary cirrhosis}} | {{Primary biliary cirrhosis}} | ||
{{CMG}}; {{AE}} | {{CMG}}; {{AE}} {{Anmol}} | ||
==Overview== | |||
Laboratory findings consistent with the diagnosis of primary biliary cirrhosis include elevated levels of [[bilirubin]], [[alkaline phosphatase]], [[gamma-glutamyl transpeptidase]], [[anti-mitochondrial antibodies]], [[lipids]], [[immunoglobulin M]], [[liver aminotransferases]]. | |||
==Laboratory Findings== | ==Laboratory Findings== | ||
*Laboratory findings consistent with the diagnosis of primary biliary cirrhosis include:<ref name="pmid18215315">{{cite journal| author=Kumagi T, Heathcote EJ| title=Primary biliary cirrhosis. | journal=Orphanet J Rare Dis | year= 2008 | volume= 3 | issue= | pages= 1 | pmid=18215315 | doi=10.1186/1750-1172-3-1 | pmc=2266722 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18215315 }} </ref><ref name="pmid12853201">{{cite journal| author=Talwalkar JA, Lindor KD| title=Primary biliary cirrhosis. | journal=Lancet | year= 2003 | volume= 362 | issue= 9377 | pages= 53-61 | pmid=12853201 | doi=10.1016/S0140-6736(03)13808-1 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12853201 }} </ref><ref name="pmid3793004">{{cite journal| author=Mitchison HC, Bassendine MF, Hendrick A, Bennett MK, Bird G, Watson AJ et al.| title=Positive antimitochondrial antibody but normal alkaline phosphatase: is this primary biliary cirrhosis? | journal=Hepatology | year= 1986 | volume= 6 | issue= 6 | pages= 1279-84 | pmid=3793004 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3793004 }} </ref><ref name="pmid1568727">{{cite journal| author=Crippin JS, Lindor KD, Jorgensen R, Kottke BA, Harrison JM, Murtaugh PA et al.| title=Hypercholesterolemia and atherosclerosis in primary biliary cirrhosis: what is the risk? | journal=Hepatology | year= 1992 | volume= 15 | issue= 5 | pages= 858-62 | pmid=1568727 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1568727 }} </ref> | |||
**[[Hyperbilirubinemia]] | |||
**Elevated [[alkaline phosphatase]] (2–10 times upper limit of normal) | |||
**Elevated [[gamma-glutamyl transpeptidase]] (GGT) | |||
**Elevated serum [[anti-mitochondrial antibodies]] (AMA) in more than 90% patients (titres of 1/40 or greater) | |||
**[[Hyperlipidemia]] | |||
**Elevated [[immunoglobulin M]] | |||
**Elevated [[liver aminotransferase]] | |||
*Some patients with primary biliary cirrhosis may have "nuclear-rim" and "multiple nuclear-dot" patterns, which is highly specific for primary biliary cirrhosis, particularly in AMA-negative patients. | |||
* | *Some patients with primary biliary cirrhosis may have elevated [[antinuclear antibody]] (35% patients) and [[anti-smooth muscle antibody]] (66% patients). | ||
* | |||
==References== | ==References== | ||
{{ | {{Reflist|2}} | ||
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[[Category:Gastroenterology]] | [[Category:Gastroenterology]] | ||
[[Category:Hepatology]] | [[Category:Hepatology]] | ||
[[Category:Disease]] | [[Category:Disease]] | ||
[[Category: | [[Category:Rheumatology]] | ||
[[Category:Medicine]] | |||
[[Category:Up-To-Date]] | |||
Latest revision as of 23:49, 29 July 2020
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Primary Biliary Cirrhosis Microchapters |
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Differentiating Primary Biliary Cirrhosis from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Primary biliary cirrhosis laboratory findings On the Web |
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American Roentgen Ray Society Images of Primary biliary cirrhosis laboratory findings |
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Risk calculators and risk factors for Primary biliary cirrhosis laboratory findings |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Anmol Pitliya, M.B.B.S. M.D.[2]
Overview
Laboratory findings consistent with the diagnosis of primary biliary cirrhosis include elevated levels of bilirubin, alkaline phosphatase, gamma-glutamyl transpeptidase, anti-mitochondrial antibodies, lipids, immunoglobulin M, liver aminotransferases.
Laboratory Findings
- Laboratory findings consistent with the diagnosis of primary biliary cirrhosis include:[1][2][3][4]
- Hyperbilirubinemia
- Elevated alkaline phosphatase (2–10 times upper limit of normal)
- Elevated gamma-glutamyl transpeptidase (GGT)
- Elevated serum anti-mitochondrial antibodies (AMA) in more than 90% patients (titres of 1/40 or greater)
- Hyperlipidemia
- Elevated immunoglobulin M
- Elevated liver aminotransferase
- Some patients with primary biliary cirrhosis may have "nuclear-rim" and "multiple nuclear-dot" patterns, which is highly specific for primary biliary cirrhosis, particularly in AMA-negative patients.
- Some patients with primary biliary cirrhosis may have elevated antinuclear antibody (35% patients) and anti-smooth muscle antibody (66% patients).
References
- ↑ Kumagi T, Heathcote EJ (2008). "Primary biliary cirrhosis". Orphanet J Rare Dis. 3: 1. doi:10.1186/1750-1172-3-1. PMC 2266722. PMID 18215315.
- ↑ Talwalkar JA, Lindor KD (2003). "Primary biliary cirrhosis". Lancet. 362 (9377): 53–61. doi:10.1016/S0140-6736(03)13808-1. PMID 12853201.
- ↑ Mitchison HC, Bassendine MF, Hendrick A, Bennett MK, Bird G, Watson AJ; et al. (1986). "Positive antimitochondrial antibody but normal alkaline phosphatase: is this primary biliary cirrhosis?". Hepatology. 6 (6): 1279–84. PMID 3793004.
- ↑ Crippin JS, Lindor KD, Jorgensen R, Kottke BA, Harrison JM, Murtaugh PA; et al. (1992). "Hypercholesterolemia and atherosclerosis in primary biliary cirrhosis: what is the risk?". Hepatology. 15 (5): 858–62. PMID 1568727.