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==Overview==
==Overview==
The incidence of delayed [[puberty]] ([[hypogonadotropic hypogonadism]]) is approximately 1-10 cases per 100,000 individuals worldwide.The precise prevalence of delayed [[puberty]] is not known. The whole [[puberty]] disorders prevalence is about 3000 cases per 100,000 individuals worldwide. Delayed [[puberty]] is a condition commonly seen in  children under 15 years of age. Delayed [[puberty]] usually occurs in individuals of all races. A definite diagnosis of the mean age of [[puberty]] onset in any specific societies can help to reduce the effects of [[ethnicity]] on delayed [[puberty]] [[epidemiology]]. Boys are more commonly affected by delayed [[puberty]] ([[constitutional delay of puberty]]) than girls.


==Epidemiology and Demographics==
==Epidemiology and Demographics==
===Incidence===
*The incidence of delayed [[puberty]] ([[hypogonadotropic hypogonadism]]) is approximately 1-10 cases per 100,000 individuals worldwide.
*Idiopathic [[hypogonadotropic hypogonadism]] is responsible for approximately 10% of delayed [[puberty]] in boys.
*[[Klinefelter's syndrome]] (hypergonadotropic hypogonadism) accounts for 5-10% of delayed puberty in boys.<ref name="PalmertDunkel2012">{{cite journal|last1=Palmert|first1=Mark R.|last2=Dunkel|first2=Leo|title=Delayed Puberty|journal=New England Journal of Medicine|volume=366|issue=5|year=2012|pages=443–453|issn=0028-4793|doi=10.1056/NEJMcp1109290}}</ref>
===Prevalence===
*The prevalence of delayed [[puberty]] is unknown.
*Prevalence of puberty disorders is about 3000 cases per 100,000 individuals worldwide.<ref name="pmid19547638">{{cite journal |vauthors=Brämswig J, Dübbers A |title=Disorders of pubertal development |journal=Dtsch Arztebl Int |volume=106 |issue=17 |pages=295–303; quiz 304 |year=2009 |pmid=19547638 |pmc=2689583 |doi=10.3238/arztebl.2009.0295 |url=}}</ref>
*The prevalence of primary [[amenorrhea]] in the US is < 0.1%.<ref name="pmid12836721">{{cite journal |vauthors=Timmreck LS, Reindollar RH |title=Contemporary issues in primary amenorrhea |journal=Obstet. Gynecol. Clin. North Am. |volume=30 |issue=2 |pages=287–302 |year=2003 |pmid=12836721 |doi= |url=}}</ref>
===Case-fatality rate===
*The case-fatality rate of delayed [[puberty]] is approximately zero. There is no reported case of [[mortality]] due to delayed [[puberty]].
===Age===
*Delayed puberty is commonly seen in children under 15 years of age.
===Race===
*Delayed [[puberty]] usually affects individuals of all races.
*Different races have different [[puberty]] onset ages; [[menarche]] occurs in African-American girls at age (12.2 yrs) earlier than White girls (12.9 yrs), which is because of [[Body mass index|body mass index (BMI)]] difference between races.<ref name="pmid15541646">{{cite journal |vauthors=Styne DM |title=Puberty, obesity and ethnicity |journal=Trends Endocrinol. Metab. |volume=15 |issue=10 |pages=472–8 |year=2004 |pmid=15541646 |doi=10.1016/j.tem.2004.10.008 |url=}}</ref>
*A definite diagnosis of the mean age of [[puberty]] onset in any specific societiy can help to reduce the effects of [[ethnicity]] on delayed [[puberty]] [[epidemiology]].
===Gender===
*Boys are more commonly affected by delayed [[puberty]] ([[constitutional delay of puberty]]) than girls.<ref name="urlwww.bsped.org.uk">{{cite web |url=http://www.bsped.org.uk/patients/docs/delayed_puberty_tr_version.pdf |title=www.bsped.org.uk |format= |work= |accessdate=}}</ref>
*The boy to girl ratio is approximately 2 to 1 in [[constitutional delay of puberty]].
===Developed and Developing Countries===
* Although there is a difference between the age of [[puberty]] onset in [[Developed country|developed]] and developing countries, [[epidemiology]] of delayed [[puberty]] is same.


==References==
==References==
{{Reflist|2}}
{{Reflist|2}}


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Latest revision as of 21:15, 29 July 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Eiman Ghaffarpasand, M.D. [2]

Overview

The incidence of delayed puberty (hypogonadotropic hypogonadism) is approximately 1-10 cases per 100,000 individuals worldwide.The precise prevalence of delayed puberty is not known. The whole puberty disorders prevalence is about 3000 cases per 100,000 individuals worldwide. Delayed puberty is a condition commonly seen in children under 15 years of age. Delayed puberty usually occurs in individuals of all races. A definite diagnosis of the mean age of puberty onset in any specific societies can help to reduce the effects of ethnicity on delayed puberty epidemiology. Boys are more commonly affected by delayed puberty (constitutional delay of puberty) than girls.

Epidemiology and Demographics

Incidence

Prevalence

  • The prevalence of delayed puberty is unknown.
  • Prevalence of puberty disorders is about 3000 cases per 100,000 individuals worldwide.[2]
  • The prevalence of primary amenorrhea in the US is < 0.1%.[3]

Case-fatality rate

  • The case-fatality rate of delayed puberty is approximately zero. There is no reported case of mortality due to delayed puberty.

Age

  • Delayed puberty is commonly seen in children under 15 years of age.

Race

  • Delayed puberty usually affects individuals of all races.
  • Different races have different puberty onset ages; menarche occurs in African-American girls at age (12.2 yrs) earlier than White girls (12.9 yrs), which is because of body mass index (BMI) difference between races.[4]
  • A definite diagnosis of the mean age of puberty onset in any specific societiy can help to reduce the effects of ethnicity on delayed puberty epidemiology.

Gender

Developed and Developing Countries

References

  1. ↑ Palmert, Mark R.; Dunkel, Leo (2012). "Delayed Puberty". New England Journal of Medicine. 366 (5): 443–453. doi:10.1056/NEJMcp1109290. ISSN 0028-4793.
  2. ↑ Brämswig J, Dübbers A (2009). "Disorders of pubertal development". Dtsch Arztebl Int. 106 (17): 295–303, quiz 304. doi:10.3238/arztebl.2009.0295. PMC 2689583. PMID 19547638.
  3. ↑ Timmreck LS, Reindollar RH (2003). "Contemporary issues in primary amenorrhea". Obstet. Gynecol. Clin. North Am. 30 (2): 287–302. PMID 12836721.
  4. ↑ Styne DM (2004). "Puberty, obesity and ethnicity". Trends Endocrinol. Metab. 15 (10): 472–8. doi:10.1016/j.tem.2004.10.008. PMID 15541646.
  5. ↑ "www.bsped.org.uk" (PDF).

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