C4 glomerulopathy: Difference between revisions
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{{C4 glomerulopathy}} | {{C4 glomerulopathy}} | ||
{{CMG}}; {{APM}} {{AE} | {{CMG}}; {{APM}} {{AE}} {{OO}} {{ Norina Usman}} | ||
{{SK}} glomerulonephritis; C4 glomerulonephritis; dense deposit disease | {{SK}} glomerulonephritis; C4 glomerulonephritis; dense deposit disease | ||
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==[[C4 glomerulopathy historical perspective|Historical Perspective]]== | ==[[C4 glomerulopathy historical perspective|Historical Perspective]]== | ||
There is limited information about the historical perspective of C4 glomerulopathy. | |||
==[[C4 glomerulopathy classification|Classification]]== | ==[[C4 glomerulopathy classification|Classification]]== | ||
C4 glomerulopathy may be classified based on complement deposition into Dense Deposit Disease (DDD) and C4 Glomerulonephritis (C4GN). | |||
==[[C4 glomerulopathy pathophysiology|Pathophysiology]]== | ==[[C4 glomerulopathy pathophysiology|Pathophysiology]]== | ||
It is thought that C4 glomerulopathy is the result of the activation of immune complex glomerulonephritis or lectin pathway of the complement. | |||
==[[C4 glomerulopathy causes|Causes]]== | ==[[C4 glomerulopathy causes|Causes]]== | ||
C4 glomerulopathy may be caused by mutation of complement factor,anti-factor H, anti-factor B, or C4 nephritic factor. | |||
==[[C4 glomerulopathy differential diagnosis|Differentiating C4 glomerulopathy from other Diseases]]== | ==[[C4 glomerulopathy differential diagnosis|Differentiating C4 glomerulopathy from other Diseases]]== | ||
C4 glomerulopathy must be differentiated from other diseases that cause proteinuria, hematuria, and peripheral edema, such as IgA nephropathy, membranous nephropathy, focal segmental glomerulus /minimal change disease, membranoproliferative glomerulonephritis, and lupus nephritis. | |||
==[[C4 glomerulopathy epidemiology and demographics|Epidemiology and Demographics]]== | ==[[C4 glomerulopathy epidemiology and demographics|Epidemiology and Demographics]]== | ||
There is not much information available about the incidence and prevalence. | |||
==[[C4 glomerulopathy risk factors|Risk factors]]== | ==[[C4 glomerulopathy risk factors|Risk factors]]== | ||
There are no established risk factors for C4 glomerulopathy. | |||
==[[C4 glomerulopathy screening|Screening]]== | ==[[C4 glomerulopathy screening|Screening]]== | ||
There is insufficient information to recommend routine screening for C4 glomerulopathy. | |||
==[[C4 glomerulopathy natural history|Natural History, Complications and Prognosis]]== | ==[[C4 glomerulopathy natural history|Natural History, Complications and Prognosis]]== | ||
If left untreated, C4 glomerulopathy may progress to develop renal failure. | |||
==Diagnosis== | ==Diagnosis== | ||
Latest revision as of 03:27, 25 August 2020
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C4 glomerulopathy Microchapters |
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C4 glomerulopathy On the Web |
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American Roentgen Ray Society Images of C4 glomerulopathy |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Ali Poyan Mehr, M.D. [2] Associate Editor(s)-in-Chief: Olufunmilola Olubukola M.D.[3] Norina Usman, M.B.B.S[4]
Synonyms and keywords: glomerulonephritis; C4 glomerulonephritis; dense deposit disease
Overview
Historical Perspective
There is limited information about the historical perspective of C4 glomerulopathy.
Classification
C4 glomerulopathy may be classified based on complement deposition into Dense Deposit Disease (DDD) and C4 Glomerulonephritis (C4GN).
Pathophysiology
It is thought that C4 glomerulopathy is the result of the activation of immune complex glomerulonephritis or lectin pathway of the complement.
Causes
C4 glomerulopathy may be caused by mutation of complement factor,anti-factor H, anti-factor B, or C4 nephritic factor.
Differentiating C4 glomerulopathy from other Diseases
C4 glomerulopathy must be differentiated from other diseases that cause proteinuria, hematuria, and peripheral edema, such as IgA nephropathy, membranous nephropathy, focal segmental glomerulus /minimal change disease, membranoproliferative glomerulonephritis, and lupus nephritis.
Epidemiology and Demographics
There is not much information available about the incidence and prevalence.
Risk factors
There are no established risk factors for C4 glomerulopathy.
Screening
There is insufficient information to recommend routine screening for C4 glomerulopathy.
Natural History, Complications and Prognosis
If left untreated, C4 glomerulopathy may progress to develop renal failure.
Diagnosis
History and Symptoms | Physical Examination | Laboratory Findings | X ray | CT | MRI | Echocardiography or Ultrasound | Other Imaging Studies | Other Diagnostic Studies
Treatment
Surgery | Medical therapy | Primary Prevention | Secondary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies