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{{Congenital rubella syndrome}}
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==Overview==
Originally, [[rubella]] was referred to as the ''third disease'', because it was thought to branch from [[measles]] or [[Scarlet fever]]. However, in 1814, it was recognized as a separate entity of disease and became known as ''[[German measles]]''.<ref name="pmid16580940">{{cite journal |vauthors=De Santis M, Cavaliere AF, Straface G, Caruso A |title=Rubella infection in pregnancy |journal=Reprod. Toxicol. |volume=21 |issue=4 |pages=390–8 |year=2006 |pmid=16580940 |doi=10.1016/j.reprotox.2005.01.014 |url=}}</ref><ref name="pmid4164540">{{cite journal |vauthors=Cooper LZ, Krugman S |title=Clinical manifestations of postnatal and congenital rubella |journal=Arch. Ophthalmol. |volume=77 |issue=4 |pages=434–9 |year=1967 |pmid=4164540 |doi= |url=}}</ref> In 1941, congenital rubella syndrome was recognized as a complication of [[rubella]] [[infection]] among [[pregnant]] women who became infected with the [[virus]] early in their [[pregnancy]].<ref name="pmid16580940">{{cite journal |vauthors=De Santis M, Cavaliere AF, Straface G, Caruso A |title=Rubella infection in pregnancy |journal=Reprod. Toxicol. |volume=21 |issue=4 |pages=390–8 |year=2006 |pmid=16580940 |doi=10.1016/j.reprotox.2005.01.014 |url=}}</ref><ref name="pmid4164540">{{cite journal |vauthors=Cooper LZ, Krugman S |title=Clinical manifestations of postnatal and congenital rubella |journal=Arch. Ophthalmol. |volume=77 |issue=4 |pages=434–9 |year=1967 |pmid=4164540 |doi= |url=}}</ref> An Australian ophthalmologist made the connection and reported 78 cases of congenital [[cataract]] among [[infants]] born to mothers who had a [[Rubella|rubella infection]] early in their [[pregnancy]].<ref name="pmid16580940">{{cite journal |vauthors=De Santis M, Cavaliere AF, Straface G, Caruso A |title=Rubella infection in pregnancy |journal=Reprod. Toxicol. |volume=21 |issue=4 |pages=390–8 |year=2006 |pmid=16580940 |doi=10.1016/j.reprotox.2005.01.014 |url=}}</ref><ref name="pmid4164540">{{cite journal |vauthors=Cooper LZ, Krugman S |title=Clinical manifestations of postnatal and congenital rubella |journal=Arch. Ophthalmol. |volume=77 |issue=4 |pages=434–9 |year=1967 |pmid=4164540 |doi= |url=}}</ref>
==Historical Perspective==
==Historical Perspective==
*Originally [[rubella]] was referred to as the ''third disease'', because it was thought to branch from [[measles]] or [[Scarlet fever]]. However, in 1814, it was recognized as a separate entity of disease and became known as ''[[German measles]]''.
*Originally, [[rubella]] was referred to as the ''third disease'', because it was thought to branch from [[measles]] or [[Scarlet fever]]. However, in 1814, it was recognized as a separate entity of disease and became known as ''[[German measles]]''.<ref name="pmid16580940">{{cite journal |vauthors=De Santis M, Cavaliere AF, Straface G, Caruso A |title=Rubella infection in pregnancy |journal=Reprod. Toxicol. |volume=21 |issue=4 |pages=390–8 |year=2006 |pmid=16580940 |doi=10.1016/j.reprotox.2005.01.014 |url=}}</ref><ref name="pmid4164540">{{cite journal |vauthors=Cooper LZ, Krugman S |title=Clinical manifestations of postnatal and congenital rubella |journal=Arch. Ophthalmol. |volume=77 |issue=4 |pages=434–9 |year=1967 |pmid=4164540 |doi= |url=}}</ref>
*It was not until 1941 that congenital rubella syndrome became recognized as a complication of [[rubella]] [[infection]] among [[pregnant]] women who became infected with the [[virus]] early in their [[pregnancy]].
*It was not until 1941 that congenital rubella syndrome became recognized as a complication of [[rubella]] [[infection]] among [[pregnant]] women who became infected with the [[virus]] early in their [[pregnancy]].<ref name="pmid16580940">{{cite journal |vauthors=De Santis M, Cavaliere AF, Straface G, Caruso A |title=Rubella infection in pregnancy |journal=Reprod. Toxicol. |volume=21 |issue=4 |pages=390–8 |year=2006 |pmid=16580940 |doi=10.1016/j.reprotox.2005.01.014 |url=}}</ref><ref name="pmid4164540">{{cite journal |vauthors=Cooper LZ, Krugman S |title=Clinical manifestations of postnatal and congenital rubella |journal=Arch. Ophthalmol. |volume=77 |issue=4 |pages=434–9 |year=1967 |pmid=4164540 |doi= |url=}}</ref>
*This connection was made by the Australian ophthalmologist, ''Norman Gregg'', who reported 78 cases of [[congenital cataract]] among [[pregnant]] women who were infected with [[rubella]] [[virus]] during the early phases of their [[pregnancy]].
*This connection was made by the Australian ophthalmologist, ''Norman Gregg'', who reported 78 cases of congenital [[cataract]] among [[pregnant]] women who were infected with [[rubella]] [[virus]] during the early phases of their [[pregnancy]].<ref name="pmid16580940">{{cite journal |vauthors=De Santis M, Cavaliere AF, Straface G, Caruso A |title=Rubella infection in pregnancy |journal=Reprod. Toxicol. |volume=21 |issue=4 |pages=390–8 |year=2006 |pmid=16580940 |doi=10.1016/j.reprotox.2005.01.014 |url=}}</ref><ref name="pmid4164540">{{cite journal |vauthors=Cooper LZ, Krugman S |title=Clinical manifestations of postnatal and congenital rubella |journal=Arch. Ophthalmol. |volume=77 |issue=4 |pages=434–9 |year=1967 |pmid=4164540 |doi= |url=}}</ref>
*[[Rubella]] [[virus]] was first isolated from tissue in 1962.<ref name="pmid4164540">{{cite journal |vauthors=Cooper LZ, Krugman S |title=Clinical manifestations of postnatal and congenital rubella |journal=Arch. Ophthalmol. |volume=77 |issue=4 |pages=434–9 |year=1967 |pmid=4164540 |doi= |url=}}</ref>


==References==
==References==
{{Reflist|2}}
{{Reflist|2}}
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Latest revision as of 21:03, 29 July 2020

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Dima Nimri, M.D. [2]

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Overview

Originally, rubella was referred to as the third disease, because it was thought to branch from measles or Scarlet fever. However, in 1814, it was recognized as a separate entity of disease and became known as German measles.[1][2] In 1941, congenital rubella syndrome was recognized as a complication of rubella infection among pregnant women who became infected with the virus early in their pregnancy.[1][2] An Australian ophthalmologist made the connection and reported 78 cases of congenital cataract among infants born to mothers who had a rubella infection early in their pregnancy.[1][2]

Historical Perspective

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 De Santis M, Cavaliere AF, Straface G, Caruso A (2006). "Rubella infection in pregnancy". Reprod. Toxicol. 21 (4): 390–8. doi:10.1016/j.reprotox.2005.01.014. PMID 16580940.
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Cooper LZ, Krugman S (1967). "Clinical manifestations of postnatal and congenital rubella". Arch. Ophthalmol. 77 (4): 434–9. PMID 4164540.


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