Congenital rubella syndrome differential diagnosis: Difference between revisions

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__NOTOC__
__NOTOC__
{{Congenital rubella syndrome}}
[[Image:Home_logo1.png|right|250px|link=https://www.wikidoc.org/index.php/Congenital_rubella_syndrome]]
{{CMG}} ; {{AE}}  
{{CMG}}; {{AE}} {{DN}}  
 
==Overview==
==Overview==
The most important congenital infections, which can be transmitted vertically from mother to fetus are the [[TORCH infections]]. These infections have overlapping features and hence, must be differentiated from CRS.<ref name="pmid25677998">{{cite journal |vauthors=Neu N, Duchon J, Zachariah P |title=TORCH infections |journal=Clin Perinatol |volume=42 |issue=1 |pages=77–103, viii |year=2015 |pmid=25677998 |doi=10.1016/j.clp.2014.11.001 |url=}}</ref><ref name="pmid25654000">{{cite journal |vauthors=Ajij M, Nangia S, Dubey BS |title=Congenital rubella syndrome with blueberry muffin lesions and extensive metaphysitis |journal=J Clin Diagn Res |volume=8 |issue=12 |pages=PD03–4 |year=2014 |pmid=25654000 |pmc=4316306 |doi=10.7860/JCDR/2014/10271.5293 |url=}}</ref>


==Differentiating Congenital Rubella Syndrome from other Diseases==
==Differentiating Congenital Rubella Syndrome from other Diseases==


The most important congenital infections, which can be transmitted vertically from mother to fetus are the [[TORCH infections]]. These infections have overlapping features and hence, must be differentiated from CRS:<ref name="pmid25677998">{{cite journal |vauthors=Neu N, Duchon J, Zachariah P |title=TORCH infections |journal=Clin Perinatol |volume=42 |issue=1 |pages=77–103, viii |year=2015 |pmid=25677998 |doi=10.1016/j.clp.2014.11.001 |url=}}</ref><ref name="pmid25654000">{{cite journal |vauthors=Ajij M, Nangia S, Dubey BS |title=Congenital rubella syndrome with blueberry muffin lesions and extensive metaphysitis |journal=J Clin Diagn Res |volume=8 |issue=12 |pages=PD03–4 |year=2014 |pmid=25654000 |pmc=4316306 |doi=10.7860/JCDR/2014/10271.5293 |url=}}</ref>
<SMALL>
{| class="wikitable"
!Congenital Infection
!Cardiac Findings
!Skin Findings
!Ocular Findings
!Hepatosplenomegaly
!Hydrocephaly
!Microcephaly
!Intracranial Calcifications
!Hearing deficits
|-
!Toxoplasmosis
|—
|
* [[Petechiae]]
* [[Purpura]]
* [[Maculopapular rash]]
|
* [[Chorioretinitis]]
|✔
|✔
|✔
|Diffuse intracranial calcifications
|—
|-
!Treponema pallidum
|—
|
* [[Petechiae]]
* [[Purpura]]
* [[Maculopapular rash]]
|
* [[Chorioretinitis]]
* [[Glaucoma]]
|✔
|—
|—
|—
|—
|-
!Rubella
|
* [[Patent ductus arteriosus (PDA)]]
* [[Pulmonary artery stenosis]]
* [[Coarctation of the aorta]]
* [[Myocarditis]]
|
* [[Petechiae]]
* [[Purpura]]
|
* [[Chorioretinitis]]
* [[Cataracts]]
* [[Glaucoma]]
* [[Microphthalmia]]
|✔
|✔
|✔
|—
|✔
|-
!Cytomegalovirus (CMV)
|✔
|
* [[Petechiae]]
* [[Purpura]]
|
* [[Chorioretinitis]]
|✔
|—
|✔
|Periventricular calcifications
|✔
|-
!Herpes simplex virus (HSV)
|
* [[Myocarditis]]
|
* [[Petechiae]]
* [[Purpura]]
* [[Vesicles]]
|
* [[Chorioretinitis]]
|✔
|✔
|✔
|—
|✔
|-
!Parvovirus B19
|
* [[Myocarditis]]
|
* [[Petechiae]]
* [[Subcutaneous]] [[edema]]
|
* [[Chorioretinitis]]
* [[Cataracts]]
|✔
|—
|—
|—
|—
|}
</SMALL>


==References==
==References==
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{{WH}}
{{WH}}
{{WS}}
{{WS}}
[[Category:Emergency medicine]]
[[Category:Disease]]
[[Category:Up-To-Date]]
[[Category:Infectious disease]]
[[Category:Pediatrics]]
[[Category:Obstetrics]]

Latest revision as of 21:03, 29 July 2020

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Dima Nimri, M.D. [2]

Overview

The most important congenital infections, which can be transmitted vertically from mother to fetus are the TORCH infections. These infections have overlapping features and hence, must be differentiated from CRS.[1][2]

Differentiating Congenital Rubella Syndrome from other Diseases

The most important congenital infections, which can be transmitted vertically from mother to fetus are the TORCH infections. These infections have overlapping features and hence, must be differentiated from CRS:[1][2]

Congenital Infection Cardiac Findings Skin Findings Ocular Findings Hepatosplenomegaly Hydrocephaly Microcephaly Intracranial Calcifications Hearing deficits
Toxoplasmosis — ✔ ✔ ✔ Diffuse intracranial calcifications —
Treponema pallidum — ✔ — — — —
Rubella ✔ ✔ ✔ — ✔
Cytomegalovirus (CMV) ✔ ✔ — ✔ Periventricular calcifications ✔
Herpes simplex virus (HSV) ✔ ✔ ✔ — ✔
Parvovirus B19 ✔ — — — —

References

  1. ↑ 1.0 1.1 Neu N, Duchon J, Zachariah P (2015). "TORCH infections". Clin Perinatol. 42 (1): 77–103, viii. doi:10.1016/j.clp.2014.11.001. PMID 25677998.
  2. ↑ 2.0 2.1 Ajij M, Nangia S, Dubey BS (2014). "Congenital rubella syndrome with blueberry muffin lesions and extensive metaphysitis". J Clin Diagn Res. 8 (12): PD03–4. doi:10.7860/JCDR/2014/10271.5293. PMC 4316306. PMID 25654000.

Template:WH Template:WS

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