Vitamin B12 deficiency causes: Difference between revisions

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==Overview==
==Overview==
Common causes of vitamin B12 deficiency include insufficient dietary intake, as well as diseases and [[iatrogenic]] procedures causing problems in absorption. It is common in individuals adhering to [[vegetarian]] or [[vegan]] diets without external supplementation, due to primary sources including animal products such as meat, eggs, and dairy.


==Causes==
==Causes==
<div style="-webkit-user-select: none;">
<div style="-webkit-user-select: none;">
===Common Causes===
===Common Causes===
*[[Insufficient diet]]
*Insufficient diet
*[[Malabsorption syndrome]]
*[[Malabsorption syndrome]]
*[[Gastrectomy]]
*[[Gastrectomy]] <ref name="pmid28457771">{{cite journal |vauthors=Camarero-Shelly M, Pellitero S, Martínez E, Puig R, Leis A, Zavala R, Granada ML, Pastor C, Moreno P, Tarascó J, Balibrea J, Puig-Domingo M |title=[Vitamin B12 levels in the patient population attending an urban health centre in Madrid] |language=Spanish; Castilian |journal=Semergen |volume=44 |issue=3 |pages=161–167 |date=April 2018 |pmid=28457771 |doi=10.1016/j.semerg.2017.03.006 |url=}}</ref>
*[[Gastritis]]
*[[Gastritis]]
*[[Ileal resection]]
*[[Ileal resection]]
*[[Postgastrectomy syndrome]]
*[[Postgastrectomy syndrome]]
*[[Crohn's disease]]
*[[Crohn's disease]] <ref name="pmid28335526">{{cite journal |vauthors=Gomollón F, Gargallo CJ, Muñoz JF, Vicente R, Lue A, Mir A, García-Alvarado M, Gracia M, García-López S |title=Oral Cyanocobalamin is Effective in the Treatment of Vitamin B12 Deficiency in Crohn's Disease |journal=Nutrients |volume=9 |issue=3 |pages= |date=March 2017 |pmid=28335526 |pmc=5372971 |doi=10.3390/nu9030308 |url=}}</ref>
*[[Celiac disease]]
*[[Celiac disease]] <ref name="pmid5323299">{{cite journal |vauthors=Orskov I, Orskov F |title=Episome-carried surface antigen K88 of Escherichia coli. I. Transmission of the determinant of the K88 antigen and influence on the transfer of chromosomal markers |journal=J. Bacteriol. |volume=91 |issue=1 |pages=69–75 |date=January 1966 |pmid=5323299 |doi= |url=}}</ref>
*[[Bariatric surgery]]
*[[Bariatric surgery]]
*[[Idiopathic]]
*[[Idiopathic]]
 
*[[Bacterial]] infection
*long term Metformin use <ref name="pmid20488910">{{cite journal |vauthors=de Jager J, Kooy A, Lehert P, Wulffelé MG, van der Kolk J, Bets D, Verburg J, Donker AJ, Stehouwer CD |title=Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency: randomised placebo controlled trial |journal=BMJ |volume=340 |issue= |pages=c2181 |date=May 2010 |pmid=20488910 |pmc=2874129 |doi= |url=}}</ref>


===Causes by Organ System===
===Causes by Organ System===
{|style="width:80%; height:100px" border="1"
{| style="width:80%; height:100px" border="1"
|style="height:100px"; style="width:25%" border="1" bgcolor="LightSteelBlue" |'''Cardiovascular'''
| style="width:25%" bgcolor="LightSteelBlue" ; border="1" |'''Cardiovascular'''
|style="height:100px"; style="width:75%" border="1" bgcolor="Beige" | No underlying causes
| style="width:75%" bgcolor="Beige" ; border="1" | No underlying causes
|-
|-
|bgcolor="LightSteelBlue"| '''Chemical/Poisoning'''
| bgcolor="LightSteelBlue" | '''Chemical/Poisoning'''
|bgcolor="Beige"| [[Nitroux oxide abuse]]
| bgcolor="Beige" | [[Nitroux oxide abuse]]
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Dental'''
| '''Dental'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Dermatologic'''
| '''Dermatologic'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Drug Side Effect'''
| '''Drug Side Effect'''
|bgcolor="Beige"| [[Cimetidine]],  [[Glyburide ]],  [[Metformin hydrochloride]],  [[Neomycin]],  [[Omeprazole]],  [[Pantoprazole]],  [[Prolonged antiacid use]],  [[Rabeprazole]],  [[Ranitidine hydrochloride]],  [[Saxagliptin hydrochloride ]]
| bgcolor="Beige" | [[Cimetidine]],  [[Glyburide ]] ,  [[Metformin hydrochloride]],  [[Neomycin]],  [[Omeprazole]],  [[Pantoprazole]],  [[Prolonged antiacid use]],  [[Rabeprazole]],  [[Ranitidine hydrochloride]],  [[Saxagliptin hydrochloride ]]
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Ear Nose Throat'''
| '''Ear Nose Throat'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Endocrine'''
| '''Endocrine'''
|bgcolor="Beige"| [[Graves' disease]]
| bgcolor="Beige" | [[Graves' disease]]
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Environmental'''
| '''Environmental'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Gastroenterologic'''
| '''Gastroenterologic'''
|bgcolor="Beige"| [[Achlorhydria]],  [[Atrophic gastritis]],  [[Bariatric surgery]],  [[Blind loop syndrome]],  [[Bothriocephalosis]],  [[Celiac disease]],  [[Chronic pancreatitis]],  [[Cobalamin malabsorption]],  [[Crohn's disease]],  [[Gastrectomy]],  [[Gastritis]],  [[Grasbeck-imerslund disease]],  [[Ileal resection]],  [[Imerslund-najman-grasbeck anemia]],  [[Malabsorption syndrome]],  [[Pancreatic insufficiency]],  [[Pancreatitis]],  [[Postgastrectomy syndrome]],  [[Small bowel disease]]
| bgcolor="Beige" | [[Achlorhydria]],  [[Atrophic gastritis]],  [[Bariatric surgery]],  [[Blind loop syndrome]],  [[Bothriocephalosis]],  [[Celiac disease]],  [[Chronic pancreatitis]],  [[Cobalamin malabsorption]],  [[Crohn's disease]],  [[Gastrectomy]],  [[Gastritis]],  [[Grasbeck-imerslund disease]],  [[Ileal resection]],  [[Imerslund-najman-grasbeck anemia]],  [[Malabsorption syndrome]],  [[Pancreatic insufficiency]],  [[Pancreatitis]],  [[Postgastrectomy syndrome]],  [[Small bowel disease]]
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Genetic'''
| '''Genetic'''
|bgcolor="Beige"| [[Homocystinuria]],  [[Mthfr deficiency]]
| bgcolor="Beige" | [[Homocystinuria]],  [[Mthfr deficiency]]
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Hematologic'''
| '''Hematologic'''
|bgcolor="Beige"| [[Grasbeck-imerslund disease]],  [[Imerslund-najman-grasbeck anemia]],  [[Intrinsic factor deficiency ]],  [[Juvenile megaloblastic anemia]],  [[Macrocytic anemia]],  [[Megaloblastic anemia]],  [[Pernicious anemia]],  [[Transcobalamin deficiency]]
| bgcolor="Beige" | [[Grasbeck-imerslund disease]],  [[Imerslund-najman-grasbeck anemia]],  [[Intrinsic factor deficiency ]] ,  [[Juvenile megaloblastic anemia]],  [[Macrocytic anemia]],  [[Megaloblastic anemia]],  [[Pernicious anemia]],  [[Transcobalamin deficiency]]
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Iatrogenic'''
| '''Iatrogenic'''
|bgcolor="Beige"| [[Bariatric surgery]],  [[Gastrectomy]],  [[Ileal resection]],  [[N2o anesthesia ]],  [[Postgastrectomy syndrome]]
| bgcolor="Beige" | [[Bariatric surgery]],  [[Gastrectomy]],  [[Ileal resection]],  [[N2o anesthesia ]] ,  [[Postgastrectomy syndrome]]
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Infectious Disease'''
| '''Infectious Disease'''
|bgcolor="Beige"| [[Bothriocephalosis]],  [[Diphyllobothrium latum]]
| bgcolor="Beige" | [[Bothriocephalosis]],  [[Diphyllobothrium latum]]
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Musculoskeletal/Orthopedic'''
| '''Musculoskeletal/Orthopedic'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Neurologic'''
| '''Neurologic'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Nutritional/Metabolic'''
| '''Nutritional/Metabolic'''
|bgcolor="Beige"| [[Cobalamin malabsorption]],  [[Excessive alcohol consumption]],  [[Insufficient diet]],  [[Veganism]],  [[Vegetarianism]]
| bgcolor="Beige" | [[Cobalamin malabsorption]],  [[Excessive alcohol consumption]],  [[Insufficient diet]],  [[Veganism]],  [[Vegetarianism]]
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Obstetric/Gynecologic'''
| '''Obstetric/Gynecologic'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Oncologic'''
| '''Oncologic'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Ophthalmologic'''
| '''Ophthalmologic'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Overdose/Toxicity'''
| '''Overdose/Toxicity'''
|bgcolor="Beige"| [[Excessive alcohol consumption]],  [[Nitroux oxide abuse]]
| bgcolor="Beige" | [[Excessive alcohol consumption]],  [[Nitroux oxide abuse]]
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Psychiatric'''
| '''Psychiatric'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Pulmonary'''
| '''Pulmonary'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Renal/Electrolyte'''
| '''Renal/Electrolyte'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Rheumatology/Immunology/Allergy'''
| '''Rheumatology/Immunology/Allergy'''
|bgcolor="Beige"| [[Crohn's disease]],  [[Systemic lupus erythematosus]]
| bgcolor="Beige" | [[Crohn's disease]],  [[Systemic lupus erythematosus]]
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Sexual'''
| '''Sexual'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Trauma'''
| '''Trauma'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Urologic'''
| '''Urologic'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Miscellaneous'''
| '''Miscellaneous'''
|bgcolor="Beige"| [[Idiopathic]]
| bgcolor="Beige" | [[Idiopathic]]
|-
|-
|}
|}


===Cause in Alphabetical Order===
===Cause in Alphabetical Order===
{{columns-list|3|
{{columns-list|
*[[Achlorhydria]]
*[[Achlorhydria]]
*[[Atrophic gastritis]]
*[[Atrophic gastritis]]
Line 187: Line 189:
==References==
==References==
{{Reflist|2}}
{{Reflist|2}}
{{WH}}
{{WS}}


[[Category:Hematology]]
[[Category:Hematology]]
[[Category:Gastroenterology]]
[[Category:Gastroenterology]]
[[Category:Primary care]]
{{WH}}
{{WS}}

Latest revision as of 00:41, 30 July 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Luke Rusowicz-Orazem, B.S.

Overview

Common causes of vitamin B12 deficiency include insufficient dietary intake, as well as diseases and iatrogenic procedures causing problems in absorption. It is common in individuals adhering to vegetarian or vegan diets without external supplementation, due to primary sources including animal products such as meat, eggs, and dairy.

Causes

Common Causes

Causes by Organ System

Cardiovascular No underlying causes
Chemical/Poisoning Nitroux oxide abuse
Dental No underlying causes
Dermatologic No underlying causes
Drug Side Effect Cimetidine, Glyburide , Metformin hydrochloride, Neomycin, Omeprazole, Pantoprazole, Prolonged antiacid use, Rabeprazole, Ranitidine hydrochloride, Saxagliptin hydrochloride
Ear Nose Throat No underlying causes
Endocrine Graves' disease
Environmental No underlying causes
Gastroenterologic Achlorhydria, Atrophic gastritis, Bariatric surgery, Blind loop syndrome, Bothriocephalosis, Celiac disease, Chronic pancreatitis, Cobalamin malabsorption, Crohn's disease, Gastrectomy, Gastritis, Grasbeck-imerslund disease, Ileal resection, Imerslund-najman-grasbeck anemia, Malabsorption syndrome, Pancreatic insufficiency, Pancreatitis, Postgastrectomy syndrome, Small bowel disease
Genetic Homocystinuria, Mthfr deficiency
Hematologic Grasbeck-imerslund disease, Imerslund-najman-grasbeck anemia, Intrinsic factor deficiency , Juvenile megaloblastic anemia, Macrocytic anemia, Megaloblastic anemia, Pernicious anemia, Transcobalamin deficiency
Iatrogenic Bariatric surgery, Gastrectomy, Ileal resection, N2o anesthesia , Postgastrectomy syndrome
Infectious Disease Bothriocephalosis, Diphyllobothrium latum
Musculoskeletal/Orthopedic No underlying causes
Neurologic No underlying causes
Nutritional/Metabolic Cobalamin malabsorption, Excessive alcohol consumption, Insufficient diet, Veganism, Vegetarianism
Obstetric/Gynecologic No underlying causes
Oncologic No underlying causes
Ophthalmologic No underlying causes
Overdose/Toxicity Excessive alcohol consumption, Nitroux oxide abuse
Psychiatric No underlying causes
Pulmonary No underlying causes
Renal/Electrolyte No underlying causes
Rheumatology/Immunology/Allergy Crohn's disease, Systemic lupus erythematosus
Sexual No underlying causes
Trauma No underlying causes
Urologic No underlying causes
Miscellaneous Idiopathic

Cause in Alphabetical Order

References

  1. ↑ Camarero-Shelly M, Pellitero S, Martínez E, Puig R, Leis A, Zavala R, Granada ML, Pastor C, Moreno P, Tarascó J, Balibrea J, Puig-Domingo M (April 2018). "[Vitamin B12 levels in the patient population attending an urban health centre in Madrid]". Semergen (in Spanish; Castilian). 44 (3): 161–167. doi:10.1016/j.semerg.2017.03.006. PMID 28457771.
  2. ↑ Gomollón F, Gargallo CJ, Muñoz JF, Vicente R, Lue A, Mir A, García-Alvarado M, Gracia M, García-López S (March 2017). "Oral Cyanocobalamin is Effective in the Treatment of Vitamin B12 Deficiency in Crohn's Disease". Nutrients. 9 (3). doi:10.3390/nu9030308. PMC 5372971. PMID 28335526.
  3. ↑ Orskov I, Orskov F (January 1966). "Episome-carried surface antigen K88 of Escherichia coli. I. Transmission of the determinant of the K88 antigen and influence on the transfer of chromosomal markers". J. Bacteriol. 91 (1): 69–75. PMID 5323299.
  4. ↑ de Jager J, Kooy A, Lehert P, Wulffelé MG, van der Kolk J, Bets D, Verburg J, Donker AJ, Stehouwer CD (May 2010). "Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency: randomised placebo controlled trial". BMJ. 340: c2181. PMC 2874129. PMID 20488910.

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