Skin nodules: Difference between revisions
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==Overview== | ==Overview== | ||
A '''skin nodule''' that is > or equal to 1 cm is referred to as a nodule. There are many differential diagnoses for nodules as they can be subcutaneous, intraepidermal, dermal or exophytic. To obtain the correct diagnosis it is important to observe the growth rate, color, symptoms and any underlying conditions that may have caused the nodules. | A '''skin [[nodule]]''' that is > or equal to 1 cm is referred to as a [[nodule]]. There are many differential diagnoses for nodules as they can be [[subcutaneous]], [[intraepidermal]], [[dermal]] or exophytic. To obtain the correct diagnosis it is important to observe the growth rate, color, symptoms and any underlying conditions that may have caused the nodules. | ||
==Causes== | ==Causes== | ||
<div style="-webkit-user-select: none;"> | <div style="-webkit-user-select: none;"> | ||
===Life Threatening Causes=== | ===Life Threatening Causes=== | ||
*[[Granular cell tumor]] | *[[Granular cell tumor]] | ||
*[[Melanoma]] | *[[Melanoma]] | ||
*[[Squamous cell carcinoma of skin]] | *[[Squamous cell carcinoma of skin]] | ||
===Common Causes=== | ===Common Causes=== | ||
*[[Actinic keratosis]] | *[[Actinic keratosis]] | ||
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*[[Granuloma faciale]] | *[[Granuloma faciale]] | ||
*[[Juvenile xanthogranuloma]] | *[[Juvenile xanthogranuloma]] | ||
*[[Keloid]] | *[[Keloid]] | ||
*[[Keratoacanthoma]] | *[[Keratoacanthoma]] | ||
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*[[Lobomycosis]] | *[[Lobomycosis]] | ||
*[[Lymphocytosis|Lymphocytoma cutis]] | *[[Lymphocytosis|Lymphocytoma cutis]] | ||
*[[Merkel cell carcinoma]] | *[[Merkel cell carcinoma]] | ||
*Microcystic adnexal carcinoma | *Microcystic adnexal carcinoma | ||
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*[[Squamous cell carcinoma of skin]] | *[[Squamous cell carcinoma of skin]] | ||
*[[Nodules|Subcutaneous nodules]] | *[[Nodules|Subcutaneous nodules]] | ||
*[[Tophus]] | *[[Tophus]] | ||
*Trichofolliculoma | *Trichofolliculoma | ||
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|} | |} | ||
===Causes in Alphabetical Order=== | ===Causes in Alphabetical Order=== | ||
{{columns-list | {{columns-list| | ||
*[[Actinic keratosis]] | *[[Actinic keratosis]] | ||
*[[Lesion|Angiocentric immunoproliferative lesion]] | *[[Lesion|Angiocentric immunoproliferative lesion]] | ||
*[[Apolipoprotein c-ii deficiency]] | *[[Apolipoprotein c-ii deficiency]] | ||
*[[Apoprotein e deficiency]] | *[[Apoprotein e deficiency]] | ||
*[[Balamuthia mandrillaris]] | *[[Balamuthia mandrillaris]] | ||
*[[Basal cell papilloma]] | *[[Basal cell papilloma]] | ||
*[[Blau syndrome]] | *[[Blau syndrome]] | ||
*[[Blue nevus]] | *[[Blue nevus]] | ||
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*[[Cold panniculitis of haxthausen]] | *[[Cold panniculitis of haxthausen]] | ||
*[[Cole disease]] | *[[Cole disease]] | ||
*[[Cutaneous abscess]] | *[[Cutaneous abscess]] | ||
*[[Cutaneous metastasis]] | *[[Cutaneous metastasis]] | ||
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*[[Dermatofibrosarcoma protuberans]] | *[[Dermatofibrosarcoma protuberans]] | ||
*[[Desmoid]] | *[[Desmoid]] | ||
*[[Enchondromatosis]] | *[[Enchondromatosis]] | ||
*[[Eosinophilic cellulitis]] | *[[Eosinophilic cellulitis]] | ||
*[[Epidermal inclusion cyst]] | *[[Epidermal inclusion cyst]] | ||
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*[[Erythema nodosum]] | *[[Erythema nodosum]] | ||
*[[Familial cutaneous collagenoma]] | *[[Familial cutaneous collagenoma]] | ||
*[[Farber lipogranulomatosis]] | *[[Farber lipogranulomatosis]] | ||
*[[Focal dermal hypoplasia]] | *[[Focal dermal hypoplasia]] | ||
*[[Follicular infundibulum tumor]] | *[[Follicular infundibulum tumor]] | ||
*[[Garrod pads]] | *[[Garrod pads]] | ||
*[[Granular cell tumor]] | *[[Granular cell tumor]] | ||
*[[Granuloma annulare]] | *[[Granuloma annulare]] | ||
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*[[Infantile digital fibromatosis]] | *[[Infantile digital fibromatosis]] | ||
*[[Juvenile xanthogranuloma]] | *[[Juvenile xanthogranuloma]] | ||
*[[Keloid]] | *[[Keloid]] | ||
*[[Keratoacanthoma]] | *[[Keratoacanthoma]] | ||
*[[Leukemia cutis]] | *[[Leukemia cutis]] | ||
*[[Lipoid dermatoarthritis]] | *[[Lipoid dermatoarthritis]] | ||
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*[[Osler nodes]] | *[[Osler nodes]] | ||
*[[Osteopoikilosis]] | *[[Osteopoikilosis]] | ||
*[[Panniculitis]] | *[[Panniculitis]] | ||
*[[Pigmented naevus]] | *[[Pigmented naevus]] | ||
*[[Pilomatrixoma]] | *[[Pilomatrixoma]] | ||
*[[Pretibial myxoedema]] | *[[Pretibial myxoedema]] | ||
*[[Protothecosis]] | *[[Protothecosis]] | ||
*[[Pyogenic granuloma]] | *[[Pyogenic granuloma]] | ||
*[[Rheumatic fever]] | *[[Rheumatic fever]] | ||
*[[Sister mary joseph nodule]] | *[[Sister mary joseph nodule]] | ||
*[[Sitosterolemia]] | *[[Sitosterolemia]] | ||
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*[[Sporotrichosis]] | *[[Sporotrichosis]] | ||
*[[Squamous cell carcinoma of skin]] | *[[Squamous cell carcinoma of skin]] | ||
*[[Subcutaneous nodules]] | *[[Subcutaneous nodules]] | ||
*[[Systemic hyalinosis]] | *[[Systemic hyalinosis]] | ||
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*[[Trichofolliculoma]] | *[[Trichofolliculoma]] | ||
*[[Vitamin e deficiency]] | *[[Vitamin e deficiency]] | ||
*[[Xanthomata]] | *[[Xanthomata]] | ||
*[[Zygomycosis]] | *[[Zygomycosis]] |
Latest revision as of 22:53, 10 January 2020
WikiDoc Resources for Skin nodules |
Articles |
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Most recent articles on Skin nodules Most cited articles on Skin nodules |
Media |
Powerpoint slides on Skin nodules |
Evidence Based Medicine |
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Ongoing Trials on Skin nodules at Clinical Trials.gov Clinical Trials on Skin nodules at Google
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Guidelines / Policies / Govt |
US National Guidelines Clearinghouse on Skin nodules
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Books |
News |
Commentary |
Definitions |
Patient Resources / Community |
Patient resources on Skin nodules Discussion groups on Skin nodules Patient Handouts on Skin nodules Directions to Hospitals Treating Skin nodules Risk calculators and risk factors for Skin nodules
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Healthcare Provider Resources |
Causes & Risk Factors for Skin nodules |
Continuing Medical Education (CME) |
International |
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Business |
Experimental / Informatics |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Cafer Zorkun, M.D., Ph.D. [2] Luke Rusowicz-Orazem, B.S.
Overview
A skin nodule that is > or equal to 1 cm is referred to as a nodule. There are many differential diagnoses for nodules as they can be subcutaneous, intraepidermal, dermal or exophytic. To obtain the correct diagnosis it is important to observe the growth rate, color, symptoms and any underlying conditions that may have caused the nodules.
Causes
Life Threatening Causes
Common Causes
- Actinic keratosis
- Angiocentric immunoproliferative lesion
- Blue nevus
- Calcinosis cutis
- Cold panniculitis of haxthausen
- Cutaneous abscess
- Cutaneous metastasis
- Cutaneous nodules
- Dermatofibroma
- Dermatofibrosarcoma protuberans
- Desmoid
- Enchondromatosis
- Eosinophilic cellulitis
- Epidermal inclusion cyst
- Erythema elevatum diutinum
- Erythema induratum
- Erythema nodosum
- Familial cutaneous collagenoma
- Focal dermal hypoplasia
- Follicular infundibulum tumor
- Garrod pads
- Granular cell tumor
- Granuloma annulare
- Granuloma faciale
- Juvenile xanthogranuloma
- Keloid
- Keratoacanthoma
- Lipoid dermatoarthritis
- Lobomycosis
- Lymphocytoma cutis
- Merkel cell carcinoma
- Microcystic adnexal carcinoma
- Necrobiosis lipoidica
- Panniculitis
- Pigmented naevus
- Spitz nevus
- Squamous cell carcinoma of skin
- Subcutaneous nodules
- Tophus
- Trichofolliculoma
- Xanthomata
Causes by Organ System
Causes in Alphabetical Order
- Actinic keratosis
- Angiocentric immunoproliferative lesion
- Apolipoprotein c-ii deficiency
- Apoprotein e deficiency
- Balamuthia mandrillaris
- Basal cell papilloma
- Blau syndrome
- Blue nevus
- Botryomycosis
- Breast cancer
- Bronchogenic carcinoma
- Calcinosis cutis
- Calcinosis-raynaud-sclerodactyly-telangiectasia syndrome
- Cholestanol storage disease
- Cold panniculitis of haxthausen
- Cole disease
- Cutaneous abscess
- Cutaneous metastasis
- Cutaneous nodules
- Cysticercosis
- Dermatofibroma
- Dermatofibrosarcoma protuberans
- Desmoid
- Enchondromatosis
- Eosinophilic cellulitis
- Epidermal inclusion cyst
- Erythema elevatum diutinum
- Erythema induratum
- Erythema nodosum
- Familial cutaneous collagenoma
- Farber lipogranulomatosis
- Focal dermal hypoplasia
- Follicular infundibulum tumor
- Garrod pads
- Granular cell tumor
- Granuloma annulare
- Granuloma faciale
- Graves' disease
- Heberden nodes
- Hereditary leiomyomatosis
- Hidradenoma
- Infantile digital fibromatosis
- Juvenile xanthogranuloma
- Keloid
- Keratoacanthoma
- Leukemia cutis
- Lipoid dermatoarthritis
- Lipoid proteinosis
- Lipoma
- Lipoprotein lipase deficiency
- Lobomycosis
- Lymphocytoma cutis
- Malakoplakia
- Melanoma
- Merkel cell carcinoma
- Microcystic adnexal carcinoma
- Mycobacterium abscessus
- Mycobacterium marinum
- Mycobacterium ulcerans
- Myiasis
- Nakajo-nishimura syndrome
- Necrobiosis lipoidica
- Neurofibromatosis type 1
- Onchocerciasis
- Osler nodes
- Osteopoikilosis
- Panniculitis
- Pigmented naevus
- Pilomatrixoma
- Pretibial myxoedema
- Protothecosis
- Pyogenic granuloma
- Rheumatic fever
- Sister mary joseph nodule
- Sitosterolemia
- Spindle cell hemangioendothelioma
- Spitz nevus
- Sporotrichosis
- Squamous cell carcinoma of skin
- Subcutaneous nodules
- Systemic hyalinosis
- Systemic sclerosis
- Tendon nodules
- Tinea profunda
- Tophus
- Torg-winchester syndrome
- Trichofolliculoma
- Vitamin e deficiency
- Xanthomata
- Zygomycosis
Differential Diagnosis
In alphabetical order. [1] [2]
- Dermatofibroma
- Dermal/subcutaneous neoplasms
- Epidermoid
- Epidermal inclusion cyst
- Ganglion cyst
- Hypertrophic scars
- Kaposi's sarcoma
- Lipoma
- Nodular melanomas
- Pilar cyst
- Pyogenic granuloma
- Xanthoma
Diagnosis
History and Symptoms
- Note the morphology of the nodule
- size changes
- tenderness
- History
- malignancies/ rheumatoid arthritis
- immunosupression
- family history of melanoma
Laboratory Findings
- Appropriate cultures should taken of suppurative lesions
Other Diagnostic Studies
- Biopsy to determine characteristics of nodule
- Shave
- Punch
- Excisional
Treatment
- Treatment includes excision whether for cosmetic or symptomatic reasons
- Epidermoid cysts:
- Lesions must calm down before excision
- Intralesional steroids
- It must be completely removed to avoid a recurrent lesion