Enterobiasis pathophysiology: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Enterobiasis}} | {{Enterobiasis}} | ||
{{CMG}} | {{CMG}}; {{AE}} {{MMF}} | ||
==Overview== | |||
''[[Enterobius vermicularis]]'' is usually transmitted via the feco-oral route to the human host. It reproduces in the small intestine of humans only. The gravid female worm lays eggs in the perianal area usually at night and causes pruritus. In addition to the fingernail contamination, the infective eggs can be transmitted via the dust and fomites. | |||
==Pathophysiology== | ==Pathophysiology== | ||
===Pathogenesis=== | ===Pathogenesis=== | ||
*It is postulated that ''Enterobius vermicularis'' triggers an inflammatory response which is associated with the low-grade eosinophilia. Allergic response to the worm protein is considered | *It is postulated that ''[[Enterobius vermicularis]]'' triggers an inflammatory response which is associated with the low-grade [[eosinophilia]]. | ||
*The infective eggs of ''E. vermicularis'' are ingested via contaminated hands or fomites(clothing, toys, bed, furniture, animals' fur etc). The eggs mature into adult Enterobius in 15-40 days. Male adult larvae fertilize the female (in lower ileum) and are passed out in stools without producing symptoms. Adult females settle in the lower ileum, caecum, appendix and ascending colon. The gravid worm migrates from the colon to the rectal area. At night eggs laid on the perianal skin by the uterine contraction(s) of the gravid worm. | *Allergic response to the worm protein is considered the cause of [[pruritus]]; usually pruritus ani (perianal pruritus).<ref name="Parasitic diseases">{{cite book | last = Katz | first = Michael | title = Parasitic Diseases | publisher = Springer US | location = New York, NY | year = 1989 | isbn = 978-1-4684-0327-5 }}</ref> | ||
*At oviposition, the eggs are immature and non-infective. They become infective within 6 hours at body temperature. In cool, moist environment with little ventilation eggs remain viable for up to three weeks. However, the infectivity decreases with time. Eggs do not tolerate heat that well which might be the reason that enterobiasis is more common in temperate than tropical climates. | ====Lifecycle==== | ||
*In rare cases | The lifecycle of ''[[Enterobius vermicularis]]'' is completed in the human host and comprises of the following stages:<ref name="pmid7959218">{{cite journal |vauthors=Cook GC |title=Enterobius vermicularis infection |journal=Gut |volume=35 |issue=9 |pages=1159–62 |year=1994 |pmid=7959218 |pmc=1375686 |doi= |url=}}</ref><ref name="pmid21286054">{{cite journal |vauthors=Caldwell JP |title=Pinworms (enterobius vermicularis) |journal=Can Fam Physician |volume=28 |issue= |pages=306–9 |year=1982 |pmid=21286054 |pmc=2306321 |doi= |url=}}</ref> | ||
*The infective eggs of ''[[Enterobius vermicularis|E. vermicularis]]'' are ingested via contaminated hands or fomites (clothing, toys, bed, furniture, animals' fur etc). The eggs mature into adult Enterobius in 15-40 days. | |||
*Male adult larvae fertilize the female (in lower ileum) and are passed out in stools without producing symptoms. Adult females settle in the lower [[ileum]], [[caecum]], [[appendix]] and [[ascending colon]]. The gravid worm migrates from the colon to the rectal area. At night eggs laid on the perianal skin by the uterine contraction(s) of the gravid worm. | |||
*At oviposition, the eggs are immature and non-infective. They become infective within 6 hours at body temperature. | |||
*In cool, moist environment with little ventilation eggs remain viable for up to three weeks. However, the infectivity decreases with time. Eggs do not tolerate heat that well which might be the reason that enterobiasis is more common in temperate than tropical climates. | |||
*In rare cases, pinworms are found in the vagina and even more rarely in the [[uterus]], [[fallopian tubes]], liver, and [[peritoneum]], but the worms cannot survive long in these places. | |||
The image shown below depicts the life cycle of the pinworm.<ref name="urlCDC - Enterobiasis - Biology">{{cite web |url=https://www.cdc.gov/parasites/pinworm/biology.html |title=CDC - Enterobiasis - Biology |format= |work= |accessdate=}}</ref> | |||
[[Image:E.vermicularis LifeCycle.gif|center|''Enterobius'' Lifecycle]] | |||
===Mode of Transmission=== | ===Mode of Transmission=== | ||
''E. Vermicularis'' is transmitted via these four modes: | ''[[Enterobius vermicularis|E. Vermicularis]]'' is transmitted via these four modes:<ref name="pmid7959218">{{cite journal |vauthors=Cook GC |title=Enterobius vermicularis infection |journal=Gut |volume=35 |issue=9 |pages=1159–62 |year=1994 |pmid=7959218 |pmc=1375686 |doi= |url=}}</ref> | ||
#Direct infection from the anal and perianal regions by infected fingernails. | #Direct infection from the anal and perianal regions by infected fingernails. | ||
#Exposure to viable eggs on fomites (clothing, toys, bed, furniture, fur of pets etc). | #Exposure to viable eggs on fomites (clothing, toys, bed, furniture, fur of pets etc). | ||
#By dust contaminated with embryonated(infected) eggs. | #By dust contaminated with embryonated (infected) eggs. | ||
#Retroinfection; migration of the larvae into sigmoid colon & caecum after hatching on the anal mucosa. | #Retroinfection; migration of the larvae into sigmoid colon & caecum after hatching on the anal mucosa. | ||
== | ==Image== | ||
<gallery> | <gallery> | ||
Image: Pinworm05.jpeg| Life cycle of Enterobius vermicularis, otherwise known as the ''human pinworm''. <SMALL><SMALL>''[http://phil.cdc.gov/phil/home.asp From Public Health Image Library (PHIL).] ''<ref name=PHIL> {{Cite web | title = Public Health Image Library (PHIL) | url = http://phil.cdc.gov/phil/home.asp}}</ref></SMALL></SMALL> | Image: Pinworm05.jpeg| Life cycle of Enterobius vermicularis, otherwise known as the ''human pinworm''. <SMALL><SMALL>''[http://phil.cdc.gov/phil/home.asp From Public Health Image Library (PHIL).] ''<ref name=PHIL> {{Cite web | title = Public Health Image Library (PHIL) | url = http://phil.cdc.gov/phil/home.asp}}</ref></SMALL></SMALL> | ||
</gallery> | |||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
{{WH}} | |||
{{WS}} | |||
[[Category:Needs overview]] | [[Category:Needs overview]] | ||
[[Category:Disease]] | [[Category:Disease]] | ||
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[[Category:Nematodes]] | [[Category:Nematodes]] | ||
[[Category:Proctology]] | [[Category:Proctology]] | ||
[[Category:Pediatrics]] | |||
[[Category:Emergency medicine]] | |||
[[Category:Up-To-Date]] | |||
[[Category:Infectious disease]] | [[Category:Infectious disease]] | ||
[[Category: | [[Category:Gastroenterology]] | ||
Latest revision as of 21:35, 29 July 2020
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Enterobiasis pathophysiology On the Web |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Furqan M M. M.B.B.S[2]
Overview
Enterobius vermicularis is usually transmitted via the feco-oral route to the human host. It reproduces in the small intestine of humans only. The gravid female worm lays eggs in the perianal area usually at night and causes pruritus. In addition to the fingernail contamination, the infective eggs can be transmitted via the dust and fomites.
Pathophysiology
Pathogenesis
- It is postulated that Enterobius vermicularis triggers an inflammatory response which is associated with the low-grade eosinophilia.
- Allergic response to the worm protein is considered the cause of pruritus; usually pruritus ani (perianal pruritus).[1]
Lifecycle
The lifecycle of Enterobius vermicularis is completed in the human host and comprises of the following stages:[2][3]
- The infective eggs of E. vermicularis are ingested via contaminated hands or fomites (clothing, toys, bed, furniture, animals' fur etc). The eggs mature into adult Enterobius in 15-40 days.
- Male adult larvae fertilize the female (in lower ileum) and are passed out in stools without producing symptoms. Adult females settle in the lower ileum, caecum, appendix and ascending colon. The gravid worm migrates from the colon to the rectal area. At night eggs laid on the perianal skin by the uterine contraction(s) of the gravid worm.
- At oviposition, the eggs are immature and non-infective. They become infective within 6 hours at body temperature.
- In cool, moist environment with little ventilation eggs remain viable for up to three weeks. However, the infectivity decreases with time. Eggs do not tolerate heat that well which might be the reason that enterobiasis is more common in temperate than tropical climates.
- In rare cases, pinworms are found in the vagina and even more rarely in the uterus, fallopian tubes, liver, and peritoneum, but the worms cannot survive long in these places.
The image shown below depicts the life cycle of the pinworm.[4]
Mode of Transmission
E. Vermicularis is transmitted via these four modes:[2]
- Direct infection from the anal and perianal regions by infected fingernails.
- Exposure to viable eggs on fomites (clothing, toys, bed, furniture, fur of pets etc).
- By dust contaminated with embryonated (infected) eggs.
- Retroinfection; migration of the larvae into sigmoid colon & caecum after hatching on the anal mucosa.
Image
-
![Life cycle of Enterobius vermicularis, otherwise known as the human pinworm. From Public Health Image Library (PHIL). [5]](/images/5/53/Pinworm05.jpeg)
Life cycle of Enterobius vermicularis, otherwise known as the human pinworm. From Public Health Image Library (PHIL). [5]
![Life cycle of Enterobius vermicularis, otherwise known as the human pinworm. From Public Health Image Library (PHIL). [5]](/index.php/File:Pinworm05.jpeg)
References
- ↑ Katz, Michael (1989). Parasitic Diseases. New York, NY: Springer US. ISBN 978-1-4684-0327-5.
- ↑ 2.0 2.1 Cook GC (1994). "Enterobius vermicularis infection". Gut. 35 (9): 1159–62. PMC 1375686. PMID 7959218.
- ↑ Caldwell JP (1982). "Pinworms (enterobius vermicularis)". Can Fam Physician. 28: 306–9. PMC 2306321. PMID 21286054.
- ↑ "CDC - Enterobiasis - Biology".
- ↑ "Public Health Image Library (PHIL)".