Graft-versus-host disease laboratory findings: Difference between revisions
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==Overview== | ==Overview== | ||
The laboratory findings for GvHD focus on the organs involved. | The laboratory findings for GvHD focus on the organs involved. The most common laboratory findings include elevation of liver enzymes and total bilirubin. Other organ systems that are affected are not typically associated with abnormal laboratory findings. | ||
==Laboratory Findings== | ==Laboratory Findings== | ||
*Skin: There are no specific laboratory findings for skin GvHD. If there is a skin infection, the [[white blood cell]] count can be elevated. | *Skin: There are no specific laboratory findings for skin GvHD. If there is a skin infection, the [[white blood cell]] count can be elevated. | ||
*Liver: Laboratory findings include | *Liver: Laboratory findings indicative of liver involvements may include: | ||
**Elevated [[Bilirubin|total bilirubin]] (mostly [[conjugated bilirubin]]) - Note that high bilirubin is a diagnostic criteria for liver GvHD. | |||
**Elevated [[alkaline phosphatase]] | |||
**Elevated gamma-glutamyltransferase ([[GGT]]) | |||
**Elevated aspartate aminotransferase ([[AST]]) | |||
**Elevated alanine aminotransferase ([[ALT]]) | |||
**[[Hypoalbuminemia]] | |||
**Elevated prothrombin time ([[PT]]) | |||
**Elevated partial thromboplastin time ([[PTT]]) | |||
*GI tract: There are no specific laboratory findings for skin GvHD. However, if there is concurrent infection, the [[white blood cell]] can be elevated. In some cases, ESR and CRP can be elevated if there is inflammation. | *GI tract: There are no specific laboratory findings for skin GvHD. However, if there is concurrent infection, the [[white blood cell]] can be elevated. In some cases, [[Erythrocyte sedimentation rate|ESR]] and [[C-reactive protein|CRP]] can be elevated if there is inflammation. | ||
==References== | ==References== | ||
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{{WH}} | {{WH}} | ||
[[Category:Hematology]] | [[Category:Hematology]] | ||
[[Category:Immunology]] | [[Category:Immunology]] | ||
Latest revision as of 21:56, 29 July 2020
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Graft-versus-host disease |
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Differentiating Graft-versus-host disease from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Graft-versus-host disease laboratory findings On the Web |
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American Roentgen Ray Society Images of Graft-versus-host disease laboratory findings |
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Risk calculators and risk factors for Graft-versus-host disease laboratory findings |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Shyam Patel [2]
Overview
The laboratory findings for GvHD focus on the organs involved. The most common laboratory findings include elevation of liver enzymes and total bilirubin. Other organ systems that are affected are not typically associated with abnormal laboratory findings.
Laboratory Findings
- Skin: There are no specific laboratory findings for skin GvHD. If there is a skin infection, the white blood cell count can be elevated.
- Liver: Laboratory findings indicative of liver involvements may include:
- Elevated total bilirubin (mostly conjugated bilirubin) - Note that high bilirubin is a diagnostic criteria for liver GvHD.
- Elevated alkaline phosphatase
- Elevated gamma-glutamyltransferase (GGT)
- Elevated aspartate aminotransferase (AST)
- Elevated alanine aminotransferase (ALT)
- Hypoalbuminemia
- Elevated prothrombin time (PT)
- Elevated partial thromboplastin time (PTT)
- GI tract: There are no specific laboratory findings for skin GvHD. However, if there is concurrent infection, the white blood cell can be elevated. In some cases, ESR and CRP can be elevated if there is inflammation.