Graft-versus-host disease chest x ray: Difference between revisions
Shyam Patel (talk | contribs) |
Tarek Nafee (talk | contribs) No edit summary |
||
| (2 intermediate revisions by 2 users not shown) | |||
| Line 4: | Line 4: | ||
== Overview == | == Overview == | ||
A chest X-ray can be done to evaluate for pneumonitis, which can be a manifestation of pulmonary GvHD. A variety of radiographic features can be seen. | A chest X-ray can be done to evaluate for [[pneumonitis]], which can be a manifestation of pulmonary GvHD. A variety of radiographic features can be seen. | ||
==Chest X-Ray== | ==Chest X-Ray== | ||
A chest X-ray can be done to assess for immune attack in the lungs, such as [[pneumonitis]]. [[Pneumonitis]] is a less common GvHD manifestation compared to [[rash]], [[Liver disease|liver dysfunctio]]<nowiki/>n, and [[diarrhea]]. However, [[pneumonitis]] has been known to occur. [[Pneumonitis]] presents radiographically as a nodular or interstitial pattern. There can be inflammation in the [[Bronchiolar epithelium|peri-bronchiolar tissue]], resulting in variable areas of hyperdensity and hypodensity on the chest X-ray. [[Ground glass opacification on CT|Ground glass appearance]] and [[Consolidation (medicine)|consolidative opacities]] can also be seen.<ref name="pmid26205737">{{cite journal| author=Nishino M, Boswell EN, Hatabu H, Ghobrial IM, Ramaiya NH| title=Drug-Related Pneumonitis During Mammalian Target of Rapamycin Inhibitor Therapy: Radiographic Pattern-Based Approach in Waldenström Macroglobulinemia as a Paradigm. | journal=Oncologist | year= 2015 | volume= 20 | issue= 9 | pages= 1077-83 | pmid=26205737 | doi=10.1634/theoncologist.2015-0033 | pmc=4571812 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26205737 }} </ref> CT scan of the chest can better diagnose [[Pneumonitis|pneumonitis.]] | |||
A chest X-ray is also an important diagnostic tool in the evaluation of other stem cell transplant-related conditions, such as pneumonia, volume overload, [[transfusion-related acute lung injury]] ([[TRALI]]). Chest X-ray can help differentiate pulmonary GvHD from these conditions. Volume overload and transfusion-related acute lung injury (TRALI) will show blunting of the [[Costophrenic angle|costophrenic angles]] and [[Pulmonary vascular congestion|pulmonary vascular engorgement]], reflecting [[Fluid in the lungs|excess fluid in the lungs]]. | |||
==References== | ==References== | ||
| Line 16: | Line 16: | ||
{{WS}} | {{WS}} | ||
{{WH}} | {{WH}} | ||
Latest revision as of 14:17, 5 July 2017
|
Graft-versus-host disease |
|
Differentiating Graft-versus-host disease from other Diseases |
|---|
|
Diagnosis |
|
Treatment |
|
Case Studies |
|
Graft-versus-host disease chest x ray On the Web |
|
American Roentgen Ray Society Images of Graft-versus-host disease chest x ray |
|
Risk calculators and risk factors for Graft-versus-host disease chest x ray |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Shyam Patel [2]
Overview
A chest X-ray can be done to evaluate for pneumonitis, which can be a manifestation of pulmonary GvHD. A variety of radiographic features can be seen.
Chest X-Ray
A chest X-ray can be done to assess for immune attack in the lungs, such as pneumonitis. Pneumonitis is a less common GvHD manifestation compared to rash, liver dysfunction, and diarrhea. However, pneumonitis has been known to occur. Pneumonitis presents radiographically as a nodular or interstitial pattern. There can be inflammation in the peri-bronchiolar tissue, resulting in variable areas of hyperdensity and hypodensity on the chest X-ray. Ground glass appearance and consolidative opacities can also be seen.[1] CT scan of the chest can better diagnose pneumonitis.
A chest X-ray is also an important diagnostic tool in the evaluation of other stem cell transplant-related conditions, such as pneumonia, volume overload, transfusion-related acute lung injury (TRALI). Chest X-ray can help differentiate pulmonary GvHD from these conditions. Volume overload and transfusion-related acute lung injury (TRALI) will show blunting of the costophrenic angles and pulmonary vascular engorgement, reflecting excess fluid in the lungs.
References
- ↑ Nishino M, Boswell EN, Hatabu H, Ghobrial IM, Ramaiya NH (2015). "Drug-Related Pneumonitis During Mammalian Target of Rapamycin Inhibitor Therapy: Radiographic Pattern-Based Approach in Waldenström Macroglobulinemia as a Paradigm". Oncologist. 20 (9): 1077–83. doi:10.1634/theoncologist.2015-0033. PMC 4571812. PMID 26205737.