Membranoproliferative glomerulonephritis: Difference between revisions

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{{Membranoproliferative glomerulonephritis}}
{{Membranoproliferative glomerulonephritis}}
{{CMG}} {{APM}}; '''Associate Editor-In-Chief:''' {{OO}}{{CZ}}
{{CMG}} {{APM}}; '''Associate Editor-In-Chief:''' {{OO}}{{CZ}} {{N.F}}{{JSS}} [https://www.wikidoc.org/index.php?title=L.Farrukh&action=edit&redlink=1 <nowiki>L.Farrukh [6]</nowiki>]


== [[Membranoproliferative glomerulonephritis overview|Overview]] ==
==[[Membranoproliferative glomerulonephritis overview|Overview]]==


Membranoproliferative Glomerulonephritis (MPGN) is a relatively uncommon inflammatory glomerulopathy that can cause chronic nephritis. Based on the histological pattern of glomerular injury it has been described as a chronic kidney disease found mostly in children and young adults. Like many forms of glomerulopathies, membranoproliferative glomerulonephritis (glomerulopathy) has been a diagnosis of tissue pathology rather the diagnosis of a specific disease entity. Therefore, the term membranoploriferative glomerulonephritis (MPGN) relates to a pattern of glomerular injury characterized by mesangial proliferation and expansion, lobularization of the glomerular tufts and double contours which can be caused by many disease states <ref name="pmid27356907">{{cite journal| author=Lionaki S, Gakiopoulou H, Boletis JN| title=Understanding the complement-mediated glomerular diseases: focus on membranoproliferative glomerulonephritis and C3 glomerulopathies. | journal=APMIS | year= 2016 | volume= 124 | issue= 9 | pages= 725-35 | pmid=27356907 | doi=10.1111/apm.12566 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27356907  }} </ref>.
==[[Membranoproliferative glomerulonephritis historical perspective|Historical Perspective]]==
Glomerular injury occurs due to deposition of immune complexes on the glomerular mesangium or on the glomerular basement membrane.  MPGN has been categorized into 3 types based on the histological pattern of glomerular damage. Clinically, MPGN often present with hematuria, varying degrees of proteinuria, with or without Glomerular filtration rate impairment depending on the severity of glomerular injury, and the underlying etiology.
==[[Membranoproliferative glomerulonephritis classification|Classification]]==


== [[Membranoproliferative glomerulonephritis historical perspective|Historical Perspective]] ==
==[[Membranoproliferative glomerulonephritis pathophysiology|Pathophysiology]]==


== [[Membranoproliferative glomerulonephritis classification|Classification]] ==
==[[Membranoproliferative glomerulonephritis causes|Causes]]==


Classification of MPGN based on immunofluorescence microscopy is a result of all advances in the understanding of the pathogenesis of the disease. Based on this advanced techniques, there are three types of MPGN <ref name="pmid21839367">{{cite journal| author=Sethi S, Fervenza FC| title=Membranoproliferative glomerulonephritis: pathogenetic heterogeneity and proposal for a new classification. | journal=Semin Nephrol | year= 2011 | volume= 31 | issue= 4 | pages= 341-8 | pmid=21839367 | doi=10.1016/j.semnephrol.2011.06.005 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21839367  }} </ref>;
==[[Membranoproliferative glomerulonephritis differential diagnosis|Differentiating Membranoproliferative glomerulonephritis from other Diseases]]==
*Immune-complex-mediated MPGN (Type I)
*Complement-mediated MPGN  (Type II)
*Non-Ig/complement-mediated MPGN  (Type III)


== [[Membranoproliferative glomerulonephritis pathophysiology|Pathophysiology]] ==
==[[Membranoproliferative glomerulonephritis epidemiology and demographics|Epidemiology and Demographics]]==
==[[Membranoproliferative glomerulonephritis risk factors|Risk Factors]]==


== [[Membranoproliferative glomerulonephritis causes|Causes]] ==
==[[Membranoproliferative glomerulonephritis natural history, complications and prognosis|Natural History, Complications and Prognosis]]==


== [[Membranoproliferative glomerulonephritis differential diagnosis|Differentiating Membranoproliferative glomerulonephritis from other Diseases]] ==
| [[Membranoproliferative glomerulonephritis electrocardiogram|Electrocardiogram]] | [[Membranoproliferative glomerulonephritis chest x ray|Chest X Ray]] | [[Membranoproliferative glomerulonephritis CT|CT]] | [[Membranoproliferative glomerulonephritis MRI|MRI]] | [[Membranoproliferative glomerulonephritis echocardiography or ultrasound|Echocardiography or Ultrasound]] | [[Membranoproliferative glomerulonephritis other imaging findings|Other Imaging Findings]] | [[Membranoproliferative glomerulonephritis other diagnostic studies|Other Diagnostic Studies]]


== [[Membranoproliferative glomerulonephritis epidemiology and demographics|Epidemiology and Demographics]] ==
==Treatment==
 
== [[Membranoproliferative glomerulonephritis risk factors|Risk Factors]] ==
== [[Membranoproliferative glomerulonephritis natural history, complications and prognosis|Natural History, Complications and Prognosis]] ==
 
== Diagnosis ==
 
[[Membranoproliferative glomerulonephritis history and symptoms|History and Symptoms]] | [[Membranoproliferative glomerulonephritis physical examination|Physical Examination]] | [[Membranoproliferative glomerulonephritis laboratory findings|Laboratory Findings]] | [[Membranoproliferative glomerulonephritis electrocardiogram|Electrocardiogram]] | [[Membranoproliferative glomerulonephritis chest x ray|Chest X Ray]] | [[Membranoproliferative glomerulonephritis CT|CT]] | [[Membranoproliferative glomerulonephritis MRI|MRI]] | [[Membranoproliferative glomerulonephritis echocardiography or ultrasound|Echocardiography or Ultrasound]] | [[Membranoproliferative glomerulonephritis other imaging findings|Other Imaging Findings]] | [[Membranoproliferative glomerulonephritis other diagnostic studies|Other Diagnostic Studies]]
 
== Treatment ==


[[Membranoproliferative glomerulonephritis medical therapy|Medical Therapy]] | [[Membranoproliferative glomerulonephritis surgery|Surgery]] | [[Membranoproliferative glomerulonephritis primary prevention|Primary Prevention]] | [[Membranoproliferative glomerulonephritis secondary prevention|Secondary Prevention]] | [[Membranoproliferative glomerulonephritis cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Membranoproliferative glomerulonephritis future or investigational therapies|Future or Investigational Therapies]]
[[Membranoproliferative glomerulonephritis medical therapy|Medical Therapy]] | [[Membranoproliferative glomerulonephritis surgery|Surgery]] | [[Membranoproliferative glomerulonephritis primary prevention|Primary Prevention]] | [[Membranoproliferative glomerulonephritis secondary prevention|Secondary Prevention]] | [[Membranoproliferative glomerulonephritis cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Membranoproliferative glomerulonephritis future or investigational therapies|Future or Investigational Therapies]]


==Case Studies==
==Case Studies==
[[Membranoproliferative glomerulonephritis case study one|Case #1]]




{{Nephrology}}
{{Nephrology}}


[[Category:Nephrology]]
[[Category:Nephrology]]
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Latest revision as of 15:18, 6 September 2020

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Membranoproliferative glomerulonephritis
ICD-10 N00-N08 with .2 suffix
ICD-9 581.2, 582.2, 583.2
MeSH D015432

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Ali Poyan Mehr, M.D. [2]; Associate Editor-In-Chief: Olufunmilola Olubukola M.D.[3]Cafer Zorkun, M.D., Ph.D. [4] Nazia Fuad M.D. Jogeet Singh Sekhon, M.D. [5] L.Farrukh [6]

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