Systemic lupus erythematosus causes: Difference between revisions
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{{CMG}}; {{AE}} {{MIR}} {{RT}} | {{CMG}}; {{AE}} {{MIR}} {{RT}} | ||
==Overview== | ==Overview== | ||
There are no established causes | There are no established direct causes of systemic lupus erythematosus. Common contributory factors in the development of systemic lupus erythematosus include [[genetic]] predisposition, [[Auto-immune disease|auto-immune diseases]], and use of drugs. Less common factors include environmental factors and exposure to [[Ultraviolet light|ultraviolet (UV) light.]] | ||
==Causes== | ==Causes== | ||
* [[Genetic]] predisposition:<ref name="pmid8749564">{{cite journal |vauthors=Schur PH |title=Genetics of systemic lupus erythematosus |journal=Lupus |volume=4 |issue=6 |pages=425–37 |year=1995 |pmid=8749564 |doi=10.1177/096120339500400603 |url=}}</ref> | * [[Genetic]] predisposition:<ref name="pmid8749564">{{cite journal |vauthors=Schur PH |title=Genetics of systemic lupus erythematosus |journal=Lupus |volume=4 |issue=6 |pages=425–37 |year=1995 |pmid=8749564 |doi=10.1177/096120339500400603 |url=}}</ref> | ||
** [[HLA]] class [[polymorphism]] | **[[HLA]] class [[polymorphism]] | ||
** [[Complement]] genes | ** [[Complement]] genes | ||
** Female sexual gene due to high levels of [[estrogen]] and [[prolactin]] | ** Female sexual gene due to high levels of [[estrogen]] and [[prolactin]] | ||
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* Infections | * Infections | ||
** [[Parvovirus B19]] | |||
** [[Epstein-Barr virus|Epstein-Barr virus (EBV)]] | ** [[Epstein-Barr virus|Epstein-Barr virus (EBV)]] | ||
** [[Trypanosomiasis]] | ** [[Trypanosomiasis]] | ||
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** Can exacerbate or induce systemic manifestations of SLE | ** Can exacerbate or induce systemic manifestations of SLE | ||
* Drug-induced lupus | * Drug-induced lupus | ||
==References== | ==References== | ||
Latest revision as of 12:58, 17 October 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mahshid Mir, M.D. [2] Raviteja Guddeti, M.B.B.S. [3]
Overview
There are no established direct causes of systemic lupus erythematosus. Common contributory factors in the development of systemic lupus erythematosus include genetic predisposition, auto-immune diseases, and use of drugs. Less common factors include environmental factors and exposure to ultraviolet (UV) light.
Causes
- Genetic predisposition:[1]
- HLA class polymorphism
- Complement genes
- Female sexual gene due to high levels of estrogen and prolactin
- Auto-immune disease[2]
- Exposure to ultraviolet (UV) light[3]
- Can exacerbate or induce systemic manifestations of SLE
- Drug-induced lupus
References
- ↑ Schur PH (1995). "Genetics of systemic lupus erythematosus". Lupus. 4 (6): 425–37. doi:10.1177/096120339500400603. PMID 8749564.
- ↑ Cutolo M, Sulli A, Seriolo B, Accardo S, Masi AT (1995). "Estrogens, the immune response and autoimmunity". Clin. Exp. Rheumatol. 13 (2): 217–26. PMID 7656468.
- ↑ Cooper GS, Dooley MA, Treadwell EL, St Clair EW, Gilkeson GS (2002). "Risk factors for development of systemic lupus erythematosus: allergies, infections, and family history". J Clin Epidemiol. 55 (10): 982–9. PMID 12464374.