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==Overview==
==Overview==


Common risk factors in the development of insulinoma include female gender, age:40-60 years, [[Multiple endocrine neoplasia type 1|MEN1]] syndrome, [[Von Hippel-Lindau Disease|von Hippel-Lindau]] disease, and [[Neurofibromatosis type I|Neurofibromatosis 1]].  
Common risk factors in the development of insulinoma include female gender, age group 40-60 years, [[Multiple endocrine neoplasia type 1|MEN1]] syndrome, [[Von Hippel-Lindau Disease|Von Hippel-Lindau]] disease, and [[Neurofibromatosis type I|neurofibromatosis 1]].


==Risk Factors==
==Risk Factors==


===Common Risk Factors===
===Common Risk Factors===
*Common [[risk factors]] in the development of insulinoma include:
Common [[risk factors]] in the development of insulinoma include:
**Gender: [[Females]] are more at risk of developing insulinoma than [[males]].
*Gender
**[[Age]]: People who are in the age range of 40-60 years.
**[[Females]] are more at risk of developing insulinoma than [[males]].
**[[Genetics]]: persons with [[family history]] of [[pancreatic neuroendocrine tumor]]<nowiki/>s are at higher risk of developing insulinomas. <ref name="pmid23742779">{{cite journal| author=Zhan HX, Cong L, Zhao YP, Zhang TP, Chen G| title=Risk factors for the occurrence of insulinoma: a case-control study. | journal=Hepatobiliary Pancreat Dis Int | year= 2013 | volume= 12 | issue= 3 | pages= 324-8 | pmid=23742779 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23742779  }} </ref>
*[[Age]]
***People with associated [[Multiple endocrine neoplasia type 1]] syndrome ([[Multiple endocrine neoplasia type 1|MEN 1]]). <ref name="pmid1677058">{{cite journal| author=Service FJ, McMahon MM, O'Brien PC, Ballard DJ| title=Functioning insulinoma--incidence, recurrence, and long-term survival of patients: a 60-year study. | journal=Mayo Clin Proc | year= 1991 | volume= 66 | issue= 7 | pages= 711-9 | pmid=1677058 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1677058  }} </ref><ref name="pmid9735690">{{cite journal| author=Boukhman MP, Karam JH, Shaver J, Siperstein AE, Duh QY, Clark OH| title=Insulinoma--experience from 1950 to 1995. | journal=West J Med | year= 1998 | volume= 169 | issue= 2 | pages= 98-104 | pmid=9735690 | doi= | pmc=1305178 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9735690  }} </ref><ref name="pmid23742779">{{cite journal |vauthors=Zhan HX, Cong L, Zhao YP, Zhang TP, Chen G |title=Risk factors for the occurrence of insulinoma: a case-control study |journal=HBPD INT |volume=12 |issue=3 |pages=324–8 |year=2013 |pmid=23742779 |doi= |url=}}</ref><ref name="urlInsulinoma - Health Encyclopedia - University of Rochester Medical Center">{{cite web |url=https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=134&contentid=219 |title=Insulinoma - Health Encyclopedia - University of Rochester Medical Center |format= |work= |accessdate=}}</ref>
**People who are in the age range of 40-60 years.
*[[Genetics]]
**Persons with [[family history]] of [[pancreatic neuroendocrine tumor]]<nowiki/>s are at higher risk of developing insulinomas. <ref name="pmid23742779">{{cite journal| author=Zhan HX, Cong L, Zhao YP, Zhang TP, Chen G| title=Risk factors for the occurrence of insulinoma: a case-control study. | journal=Hepatobiliary Pancreat Dis Int | year= 2013 | volume= 12 | issue= 3 | pages= 324-8 | pmid=23742779 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23742779  }} </ref>
**People with associated [[Multiple endocrine neoplasia type 1]] syndrome ([[Multiple endocrine neoplasia type 1|MEN 1]]).<ref name="pmid23742779">{{cite journal |vauthors=Zhan HX, Cong L, Zhao YP, Zhang TP, Chen G |title=Risk factors for the occurrence of insulinoma: a case-control study |journal=HBPD INT |volume=12 |issue=3 |pages=324–8 |year=2013 |pmid=23742779 |doi= |url=}}</ref><ref name="pmid1677058">{{cite journal| author=Service FJ, McMahon MM, O'Brien PC, Ballard DJ| title=Functioning insulinoma--incidence, recurrence, and long-term survival of patients: a 60-year study. | journal=Mayo Clin Proc | year= 1991 | volume= 66 | issue= 7 | pages= 711-9 | pmid=1677058 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1677058  }} </ref><ref name="pmid9735690">{{cite journal| author=Boukhman MP, Karam JH, Shaver J, Siperstein AE, Duh QY, Clark OH| title=Insulinoma--experience from 1950 to 1995. | journal=West J Med | year= 1998 | volume= 169 | issue= 2 | pages= 98-104 | pmid=9735690 | doi= | pmc=1305178 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9735690  }} </ref><ref name="urlInsulinoma - Health Encyclopedia - University of Rochester Medical Center">{{cite web |url=https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=134&contentid=219 |title=Insulinoma - Health Encyclopedia - University of Rochester Medical Center |format= |work= |accessdate=}}</ref>


===Less Common Risk Factors===
===Less Common Risk Factors===
*Less common [[risk factors]] in the development of insulinoma include:
Less common [[risk factors]] in the development of insulinoma include:
**[[Von Hippel-Lindau Disease|Von Hippel-Lindau]] disease
*[[Von Hippel-Lindau Disease|Von Hippel-Lindau]] disease
**[[Neurofibromatosis type I|Neurofibromatosis]] type 1 <ref name="pmid23742779">{{cite journal |vauthors=Zhan HX, Cong L, Zhao YP, Zhang TP, Chen G |title=Risk factors for the occurrence of insulinoma: a case-control study |journal=HBPD INT |volume=12 |issue=3 |pages=324–8 |year=2013 |pmid=23742779 |doi= |url=}}</ref><ref name="urlInsulinoma - Health Encyclopedia - University of Rochester Medical Center">{{cite web |url=https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=134&contentid=219 |title=Insulinoma - Health Encyclopedia - University of Rochester Medical Center |format= |work= |accessdate=}}</ref>
*[[Neurofibromatosis type I|Neurofibromatosis]] type 1 <ref name="pmid23742779">{{cite journal |vauthors=Zhan HX, Cong L, Zhao YP, Zhang TP, Chen G |title=Risk factors for the occurrence of insulinoma: a case-control study |journal=HBPD INT |volume=12 |issue=3 |pages=324–8 |year=2013 |pmid=23742779 |doi= |url=}}</ref><ref name="urlInsulinoma - Health Encyclopedia - University of Rochester Medical Center">{{cite web |url=https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=134&contentid=219 |title=Insulinoma - Health Encyclopedia - University of Rochester Medical Center |format= |work= |accessdate=}}</ref>


==References==
==References==
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Latest revision as of 02:07, 27 November 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Amandeep Singh M.D.[2]

Overview

Common risk factors in the development of insulinoma include female gender, age group 40-60 years, MEN1 syndrome, Von Hippel-Lindau disease, and neurofibromatosis 1.

Risk Factors

Common Risk Factors

Common risk factors in the development of insulinoma include:

Less Common Risk Factors

Less common risk factors in the development of insulinoma include:

References

  1. 1.0 1.1 1.2 Zhan HX, Cong L, Zhao YP, Zhang TP, Chen G (2013). "Risk factors for the occurrence of insulinoma: a case-control study". Hepatobiliary Pancreat Dis Int. 12 (3): 324–8. PMID 23742779.
  2. Service FJ, McMahon MM, O'Brien PC, Ballard DJ (1991). "Functioning insulinoma--incidence, recurrence, and long-term survival of patients: a 60-year study". Mayo Clin Proc. 66 (7): 711–9. PMID 1677058.
  3. Boukhman MP, Karam JH, Shaver J, Siperstein AE, Duh QY, Clark OH (1998). "Insulinoma--experience from 1950 to 1995". West J Med. 169 (2): 98–104. PMC 1305178. PMID 9735690.
  4. 4.0 4.1 "Insulinoma - Health Encyclopedia - University of Rochester Medical Center".

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