Growth hormone deficiency diagnostic criteria

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

The diagnosis of growth hormone deficiency is based on the direct hormonal criteria, indirect hormonal criteria and radiological evidence of response to GH treatment.

Diagnostic Criteria

• Diagnosis of growth hormone deficiency is a subject of debate due to high costs and complexity of investigations.
• Several types of evidence are used to diagnose GH deficiency:
  • Body measurements. GH deficiency accounts for only a minority of short stature among children.
  • Indirect hormonal criteria (IGF levels)
  • Direct hormonal criteria (secretory patterns of GH levels or responses to GH stimulation tests)
  • Response to GH treatment
  • Radiological evidence of pituitary dysfunction
• Many children and adults may not meet all the diagnostic criteria.
• An ideal diagnostic test cleanly separates people who would benefit from a treatment from those who would not.