Erythroleukemia: Difference between revisions

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{{Erythroleukemia}}
{{SI}}
{{CMG}}
{{CMG}};  {{AE}}{{MA}} [mailto:malihash@bidmc.harvard.edu] [mailto:malihash@bidmc.harvard.edu]
{{SK}}Pure erythroid leukemia,  FAB ( French-American-British)  M6, acute erythroid leukemia, Di Guglielmo’s disease


{{SK}} Acute erythroid leukemia; acute Di Guglielmo's syndrome; erythroleukemia; Erythroleukaemia; Erythraemic myelosis; Erythremic myelosis; Erythroleukaemia, FAB M6; M6 - Acute erythroleukaemia; M6 - Acute erythroleukemia
==Overview==
==[[Erythroleukemia overview|Overview]]==
Erythroleukemia was first discovered by M. Copelli, in 1912. In 1917, Di Guglielmo, Italian [[Hematology|hematologist]], described [[leukemic]] nature of the erythroleukemia. Erythroleukemia accounts for < 5 % of [[acute myeloid leukemia|acute myeloid leukemia (AML)]]. Erythroleukemia may be classified into 2 groups: [[De novo]] cases of erythroleukemia and secondary erythroleukemia. Erythroleukemia may be classified according to previous version [[World Health Organization|WHO]] into 2 sub-types : The [[erythroid]]/[[myeloid]] type and the pure type. Erythroleukemia is the [[neoplastic]] proliferation of [[myeloid]] and [[erythroid]] precursors of [[bone marrow]] [[Hematopoietic stem cell|hematopoietic stem cells]]. A pure [[erythroid]] proliferation may also occur. The [[erythroblasts]] do not [[Staining|stain]] with [[myeloperoxidase|myeloperoxidase (MPO)]]. [[Marker|Markers]] of [[myeloid]] lineage can not be expressed on the [[erythroblasts]]. [[Leukemia|Leukemic]] [[Cell (biology)|cells]] are positive for [[myeloid]] [[Marker|markers]] such as [[CD117]], [[CD13]], [[CD33]], and[[myeloperoxidase|myeloperoxidase (MPO)]]. [[Megakaryocyte|Megakaryocytes]] [[Antigen|antigens]] can be positive in some cases of erythroleukemia, such as CD41 and [[CD61]]. Erythroleukemia may be caused by [[translocation]] t(1;16) generating the [[fusion gene]] [[NFIA]]/[[CBFA2T3]]. Erythroleukemia must be differentiated from [[MDS]] with [[erythroid]] predominance, other types of [[AML]] with increased [[erythroid]] precursors, [[AML]] with [[myelodysplasia]]-related changes. Non-[[Cancer|neoplastic]] disorders that can cause [[erythroid]] predominance in the [[bone marrow]] such as [[megaloblastic anemia]] due to [[vitamin B12]] or [[folate]] deficiency, heavy metal [[intoxication]] such as [[arsenic]], drug effects (such as [[antineoplastic agents]] or [[chloramphenicol]]) are other [[Differential diagnosis|differential diagnoses]]. The [[incidence]] of erythroleukemia is approximately 0.077 per 100,000 individuals worldwide. Erythroleukemia commonly affects individuals older than 50 years of age with a [[median]] age of 65. There is no racial predilection to erythroleukemia. Men are more commonly affected by erythroleukemia than women. The [[male]] to [[female]] ratio is approximately 2 to 1. There are no established [[Risk factor|risk factors]] for [[de novo]] cases of erythroleukemia. The most potent [[risk factor]] in the development of [[secondary]] erythroleukemia is previous [[myelodysplastic syndrome|myelodysplastic syndrome (MDS)]]. There is insufficient evidence to recommend routine [[screening]] for erythroleukemia. If left untreated, [[Patient|patients]] with erythroleukemia may progress to develop [[bleeding]] due to [[disseminated intravascular coagulation|disseminated intravascular coagulation (DIC)]]. Common [[Complication (medicine)|complications]] of erythroleukemia include [[infection]] and [[bleeding]]. [[Therapy]] related [[Complication (medicine)|complications]] are [[rash]], [[Cardiomyopathy|cardiomyopathy]] and [[cerebellar]] [[toxicity]]''.'' [[Prognosis]] is generally poor. [[Median]] survival ranges from 3 - 9 months after the initial [[diagnosis]]. A high [[proerythroblast]]/[[myeloblast]] ratio correlates with worse outcome. The [[diagnosis]] of erythroleukemia is based on the 2016 version of [[World Health Organization|WHO]] [[classification]] for [[AML]]. History and [[Symptom|symptoms]] include [[fatigue]], [[Malaise]], [[bone pain]], [[abdominal pain]], [[weight loss]], [[Easy bruising]], [[Fever]], and [[Dyspnea]]. [[Patient|Patients]] with erythroleukemia usually appear [[anemic]].  [[Physical examination]] of [[Patient|patients]] with erythroleukemia may include [[Ecchymoses]] or [[petechiae]], [[Hepatomegaly]], [[Splenomegaly]], [[Lymphadenopathy]], and [[headache]]. [[Medical laboratory|Laboratory]] findings include [[Pancytopenia]], few [[peripheral blood]] [[blast|blasts]], [[Dysplasia]] in [[bone marrow]] and [[peripheral blood]], [[Dysplasia|dysplastic]] [[PAS stain|PAS]] positive [[erythroblasts]] with overexpression of the [[multidrug resistance|multidrug resistance (MDR)]] [[gene]] product [[P-glycoprotein]], and high frequency of [[mutations]], especially of [[TP53]]. [[Electrocardiogram]] is useful for the assessment of [[QT interval]] prior to starting [[chemotherapy]]. An [[x-ray]] may be helpful in the [[diagnosis]] of [[Complication (medicine)|complications]] of erythroleukemia management which include [[infection]], volume overload. [[Chest X-ray|Chest x-ray]] is also useful for [[venous]] [[catheter]] placement for [[chemotherapy]]. An [[echocardiogram]] is helpful for assessing [[cardiac]] function ([[ejection fraction]]) in [[Patient|patients]] with [[acute myeloid leukemia]] before and after receiving [[anthracycline]] [[chemotherapy]]. An [[ultrasound]] is useful for the [[diagnosis]] of [[lower extremity]] [[thrombosis]], which commonly occurs in [[Patient|patients]] with [[acute myeloid leukemia]]. [[Abdominal]] and [[chest]] [[Computed tomography|CT scan]] may be helpful in the [[diagnosis]] of [[acute myeloid leukemia]]. Findings on [[CT scan]] suggestive of [[acute myeloid leukemia]] include [[lymphadenopathy]], [[hepatomegaly]], [[splenomegaly]] and [[pulmonary embolism]] because of [[Deep vein thrombosis|deep venous thrombosis]]. [[Brain]] [[MRI]] is helpful in the [[diagnosis]] of [[CNS]] [[bleeding]] in [[acute myeloid leukemia|acute myeloid leukemia (AML)]]. There are no other [[imaging]] findings associated with erythroleukemia. Other [[Diagnosis|diagnostic]] studies include [[cytogenetics]] and [[flow cytometry]]. [[Pharmacology|Pharmacologic]] [[Medicine|medical]] [[therapy]] is recommended for [[Patient|patients]] with erythroleukemia who are not candidates for intensive [[chemotherapy]] or [[Allogeneic|allogenic]] [[hematopoietic stem cell]] [[Organ transplant|transplantation]]. [[Pharmacology|Pharmacologic]] [[Medicine|medical]] [[Therapy|therapies]] for erythroleukemia include hypomethylating agents (HMA) such as [[Azacytidine|azacitidine]] and [[Decitabine]]. [[Surgery|Surgical]] interventions include [[Allogeneic|allogenic]] [[hematopoietic stem cell]] [[Organ transplant|transplantation]] (Allo-SCT). There are no established measures for the [[Prevention (medical)|primary prevention]] of erythroleukemia. Effective measures for the [[Prevention (medical)|secondary prevention]] of erythroleukemia include maintenance of [[Remission (medicine)|remission]] treatment post-[[Organ transplant|transplant]].
==[[Erythroleukemia classification|Classification]]==
==Historical Perspective==
* Erythroleukemia was first discovered by M. Copelli, in 1912.<ref name="pmid21091147">{{cite journal |vauthors=Santos FP, Bueso-Ramos CE, Ravandi F |title=Acute erythroleukemia: diagnosis and management |journal=Expert Rev Hematol |volume=3 |issue=6 |pages=705–18 |date=December 2010 |pmid=21091147 |doi=10.1586/ehm.10.62 |url=}}</ref>


==[[Erythroleukemia pathophysiology|Pathophysiology]]==
* In 1917, Di Guglielmo, Italian [[Hematology|hematologist]], described [[leukemic]] nature of the erythroleukemia. [[Erythroblasts]] may have [[vacuolization]] in the [[cytoplasm]] surrounding the [[nucleus]] (pearl necklace).


==[[Erythroleukemia causes|Causes]]==
==Classification==
* Erythroleukemia accounts for < 5 % of [[acute myeloid leukemia|acute myeloid leukemia (AML)]].
* Erythroleukemia may be classified into 2 groups: [[De novo]] cases of erythroleukemia and secondary erythroleukemia.
* Erythroleukemia may be classified according to previous version [[World Health Organization|WHO]] into 2 sub-types : The [[erythroid]]/[[myeloid]] type and the pure type.<ref name="pmid12752097">{{cite journal |vauthors=Forestier E, Heim S, Blennow E, Borgström G, Holmgren G, Heinonen K, Johannsson J, Kerndrup G, Andersen MK, Lundin C, Nordgren A, Rosenquist R, Swolin B, Johansson B |title=Cytogenetic abnormalities in childhood acute myeloid leukaemia: a Nordic series comprising all children enrolled in the NOPHO-93-AML trial between 1993 and 2001 |journal=Br. J. Haematol. |volume=121 |issue=4 |pages=566–77 |date=May 2003 |pmid=12752097 |doi= |url=}}</ref>


==[[Erythroleukemia differential diagnosis|Differentiating Erythroleukemia from other Diseases]]==
* [[Diagnosis]] of [[erythroid]]/[[myeloid]] type, based on previous version [[WHO]]:


==[[Erythroleukemia epidemiology and demographics|Epidemiology and Demographics]]==
** [[Erythroid]] precursors more than 50% of the cells in [[bone marrow]]
** The [[blast]]<nowiki/>[[blast|s]] comprise of 20% or more of the non-[[erythroid]] [[Cell (biology)|cells]]
'''2016 version of [[World Health Organization|WHO]] [[classification]] for [[AML]] ([[erythroid]]/[[myeloid]] type) :'''
* 20% or more [[blast|blasts]] in [[Bone marrow|bo]]<nowiki/>[[Bone marrow|ne marrow]] irrespective of the number of [[erythroid]] precursors


==[[Erythroleukemia natural history, complications and prognosis|Natural History, Complications and Prognosis]]==
* [[Diagnosis]] of pure [[erythroid]] [[leukemia]]:
 
** [[Erythroblasts]] (at the stage of [[Proerythroblast|pronormoblast]] > 80% of the [[Bone marrow|marrow]] [[Cell (biology)|cells]] in [[Patient|patients]] without exposure to [[cytotoxic]] agent and without [[AML]] [[genetic]] abnormalities). [[Erythroblasts]] may have [[vacuolization]] in the [[cytoplasm]] surrounding the [[nucleus]] (pearl necklace). 
 
==Pathophysiology==
* Erythroleukemia is the [[neoplastic]] proliferation of [[myeloid]] and [[erythroid]] precursors of [[bone marrow]] [[Hematopoietic stem cell|hematopoietic stem cells]].
* Erythroleukemia accounts for 3 - 5% of all [[AML]] cases.<ref name="pmid210911472">{{cite journal |vauthors=Santos FP, Bueso-Ramos CE, Ravandi F |title=Acute erythroleukemia: diagnosis and management |journal=Expert Rev Hematol |volume=3 |issue=6 |pages=705–18 |date=December 2010 |pmid=21091147 |doi=10.1586/ehm.10.62 |url=}}</ref>
* A pure [[erythroid]] proliferation may also occur. 
* The [[erythroblasts]] do not [[Staining|stain]] with [[myeloperoxidase|myeloperoxidase (MPO)]].
* [[Marker|Markers]] of [[myeloid]] lineage can not be expressed on the [[erythroblasts]].
'''Microscopic Examanination:'''
* [[Erythroblasts]] may have [[vacuolization]] in the [[cytoplasm]] surrounding the [[nucleus]] (pearl necklace). 
'''Immunohistochemistry'''
 
[[Leukemia|Leukemic]] [[Cell (biology)|cells]] are positive for [[myeloid]] [[Marker|markers]] such as:<ref name="pmid2386768">{{cite journal |vauthors=Cuneo A, Van Orshoven A, Michaux JL, Boogaerts M, Louwagie A, Doyen C, Dal Cin P, Fagioli F, Castoldi G, Van den Berghe H |title=Morphologic, immunologic and cytogenetic studies in erythroleukaemia: evidence for multilineage involvement and identification of two distinct cytogenetic-clinicopathological types |journal=Br. J. Haematol. |volume=75 |issue=3 |pages=346–54 |date=July 1990 |pmid=2386768 |doi= |url=}}</ref>
* [[CD117]]
* [[CD13]]
* [[CD33]]
* [[myeloperoxidase|Myeloperoxidase (MPO)]]
[[Megakaryocyte|Megakaryocytes]] [[Antigen|antigens]] can be positive in some cases of erythroleukemia, such as:
* CD41
* [[CD61]]
 
==Causes==
Erythroleukemia may be caused by [[translocation]] t(1;16) generating the [[fusion gene]] [[NFIA]]/[[CBFA2T3]].<ref name="pmid23032695">{{cite journal |vauthors=Micci F, Thorsen J, Panagopoulos I, Nyquist KB, Zeller B, Tierens A, Heim S |title=High-throughput sequencing identifies an NFIA/CBFA2T3 fusion gene in acute erythroid leukemia with t(1;16)(p31;q24) |journal=Leukemia |volume=27 |issue=4 |pages=980–2 |date=April 2013 |pmid=23032695 |pmc=3626019 |doi=10.1038/leu.2012.266 |url=}}</ref>
 
==Differentiating Erythroleukemia from Other Diseases==
* Erythroleukemia must be differentiated from [[MDS]] with [[erythroid]] predominance, other types of [[AML]] with increased [[erythroid]] precursors, [[AML]] with [[myelodysplasia]]-related changes.
* Non-[[Cancer|neoplastic]] disorders that can cause [[erythroid]] predominance in the [[bone marrow]] such as [[megaloblastic anemia]] due to [[vitamin B12]] or [[folate]] deficiency, heavy metal [[intoxication]] such as [[arsenic]], drug effects (such as [[antineoplastic agents]] or [[chloramphenicol]]) are other [[Differential diagnosis|differential diagnoses]].<ref name="pmid208070442">{{cite journal |vauthors=Zuo Z, Polski JM, Kasyan A, Medeiros LJ |title=Acute erythroid leukemia |journal=Arch. Pathol. Lab. Med. |volume=134 |issue=9 |pages=1261–70 |date=September 2010 |pmid=20807044 |doi=10.1043/2009-0350-RA.1 |url=}}</ref>
 
==Epidemiology and Demographics==
* The [[incidence]] of erythroleukemia is approximately 0.077 per 100,000 individuals worldwide.<ref name="pmid11477115">{{cite journal |vauthors=Wells AW, Bown N, Reid MM, Hamilton PJ, Jackson GH, Taylor PR |title=Erythroleukaemia in the north of England: a population based study |journal=J. Clin. Pathol. |volume=54 |issue=8 |pages=608–12 |date=August 2001 |pmid=11477115 |pmc=1731487 |doi= |url=}}</ref>
 
* Erythroleukemia commonly affects individuals older than 50 years of age with a [[median]] age of 65.<ref name="pmid210911473">{{cite journal |vauthors=Santos FP, Bueso-Ramos CE, Ravandi F |title=Acute erythroleukemia: diagnosis and management |journal=Expert Rev Hematol |volume=3 |issue=6 |pages=705–18 |date=December 2010 |pmid=21091147 |doi=10.1586/ehm.10.62 |url=}}</ref>
 
* There is no racial predilection to erythroleukemia. 
 
* Men are more commonly affected by erythroleukemia than women. The [[male]] to [[female]] ratio is approximately 2 to 1.
 
 
==Risk Factors==
* There are no established [[Risk factor|risk factors]] for [[de novo]] cases of erythroleukemia.
 
* The most potent [[risk factor]] in the development of [[secondary]] erythroleukemia is previous [[myelodysplastic syndrome|myelodysplastic syndrome (MDS)]].<ref name="pmid1486289">{{cite journal |vauthors=Atkinson J, Hrisinko MA, Weil SC |title=Erythroleukemia: a review of 15 cases meeting 1985 FAB criteria and survey of the literature |journal=Blood Rev. |volume=6 |issue=4 |pages=204–14 |date=December 1992 |pmid=1486289 |doi= |url=}}</ref>
 
* Other [[Risk factor|risk factors]] include: 
 
** [[Ionizing radiation]] such as [[Thorium dioxide]] [[Suspension (chemistry)|suspension]] ([[Thorotrast]])
** Previous use of [[chemotherapy]] [[drugs]] such as [[Alkylating agent|alkylating agents]]
** [[Familial]] erythroleukemia, [[Dominance relationship|autosomal dominant]] [[Disorder (medicine)|disorder]] 
 
==Screening==
There is insufficient evidence to recommend routine [[screening]] for erythroleukemia.
 
==Natural History, Complications, and Prognosis==
* If left untreated, [[Patient|patients]] with erythroleukemia may progress to develop [[bleeding]] due to [[disseminated intravascular coagulation|disseminated intravascular coagulation (DIC)]].
 
* Common [[Complication (medicine)|complications]] of erythroleukemia include [[infection]] and [[bleeding]]. [[Therapy]] related [[Complication (medicine)|complications]] are [[rash]], [[Cardiomyopathy|cardiomyopathy]] and [[cerebellar]] [[toxicity]]''.''
 
* [[Prognosis]] is generally poor.
* [[Median]] survival ranges from 3 - 9 months after the initial [[diagnosis]].<ref name="pmid28420120">{{cite journal |vauthors=Almeida AM, Prebet T, Itzykson R, Ramos F, Al-Ali H, Shammo J, Pinto R, Maurillo L, Wetzel J, Musto P, Van De Loosdrecht AA, Costa MJ, Esteves S, Burgstaller S, Stauder R, Autzinger EM, Lang A, Krippl P, Geissler D, Falantes JF, Pedro C, Bargay J, Deben G, Garrido A, Bonanad S, Diez-Campelo M, Thepot S, Ades L, Sperr WR, Valent P, Fenaux P, Sekeres MA, Greil R, Pleyer L |title=Clinical Outcomes of 217 Patients with Acute Erythroleukemia According to Treatment Type and Line: A Retrospective Multinational Study |journal=Int J Mol Sci |volume=18 |issue=4 |pages= |date=April 2017 |pmid=28420120 |pmc=5412421 |doi=10.3390/ijms18040837 |url=}}</ref>
* A high [[proerythroblast]]/[[myeloblast]] ratio correlates with worse outcome.<ref name="pmid17852448">{{cite journal |vauthors=Srinivas U, Kumar R, Pati H, Saxena R, Tyagi S |title=Sub classification and clinico-hematological correlation of 40 cases of acute erythroleukemia - can proerythroblast/myeloblast and proerythroblast/total erythroid cell ratios help subclassify? |journal=Hematology |volume=12 |issue=5 |pages=381–5 |date=October 2007 |pmid=17852448 |doi=10.1080/10245330701393816 |url=}}</ref>


==Diagnosis==
==Diagnosis==
[[Erythroleukemia history and symptoms|History and Symptoms]] | [[Erythroleukemia physical examination|Physical Examination]] | [[Erythroleukemia laboratory findings|Laboratory Findings]] | [[Erythroleukemia chest x ray|Chest X Ray]] | [[Erythroleukemia CT|CT]] | [[Erythroleukemia MRI|MRI]] | [[Erythroleukemia echocardiography or ultrasound|Echocardiography or Ultrasound]] | [[Erythroleukemia other diagnostic studies|Other Diagnostic Studies]]
===Diagnostic Study of Choice===


==Treatment==
===== Bone Marrow Biopsy =====
The [[diagnosis]] of erythroleukemia is based on the 2016 version of [[World Health Organization|WHO]] [[classification]] for [[AML]]:
* [[AML]] ([[erythroid]]/[[myeloid]] type): 20% or more [[blast|blasts]] in th<nowiki/>e [[bone marrow]] irrespective of the number of [[erythroid]] precursors
* Pure [[erythroid]] [[leukemia]]: [[Erythroblasts]], at the stage of [[pronormoblast]], more than 80% of the [[marrow]] [[Cells (biology)|cells]] in [[Patient|patients]] without exposure to [[cytotoxic]] agent and without [[AML]] [[Genetics|genetic]] abnormalities. [[Erythroblasts]] may have [[vacuolization]] in the [[cytoplasm]] surrounding the [[nucleus]] (pearl necklace).
 
===History and Symptoms===
* [[Fatigue]]
* [[Malaise]]
* [[Bone pain]]
* [[Abdominal pain]]
* [[Weight loss]]
* [[Easy bruising]]
* [[Fever]]
* [[Dyspnea]]
Less common [[Symptom|symptoms]] of erythroleukemia include diffuse [[joint pain]].
 
===Physical Examination===
[[Patient|Patients]] with erythroleukemia usually appear [[anemic]]. [[Physical examination]] of [[Patient|patients]] with erythroleukemia may include:<ref name="pmid20807044">{{cite journal |vauthors=Zuo Z, Polski JM, Kasyan A, Medeiros LJ |title=Acute erythroid leukemia |journal=Arch. Pathol. Lab. Med. |volume=134 |issue=9 |pages=1261–70 |date=September 2010 |pmid=20807044 |doi=10.1043/2009-0350-RA.1 |url=}}</ref>
* [[Ecchymoses]] or [[petechiae]]
* [[Hepatomegaly]]
* [[Splenomegaly]]
* [[Lymphadenopathy]]
* [[Headache]]
 
===Laboratory Findings===
* [[Pancytopenia]]<ref name="pmid26293512">{{cite journal |vauthors=Peng J, Hasserjian RP, Tang G, Patel KP, Goswami M, Jabbour EJ, Garcia-Manero G, Medeiros LJ, Wang SA |title=Myelodysplastic syndromes following therapy with hypomethylating agents (HMAs): development of acute erythroleukemia may not influence assessment of treatment response |journal=Leuk. Lymphoma |volume=57 |issue=4 |pages=812–9 |date=2016 |pmid=26293512 |doi=10.3109/10428194.2015.1079318 |url=}}</ref>
* Few [[peripheral blood]] [[blast]]<nowiki/>[[blast|s]]<ref name="pmid16337853">{{cite journal |vauthors=Lessard M, Struski S, Leymarie V, Flandrin G, Lafage-Pochitaloff M, Mozziconacci MJ, Talmant P, Bastard C, Charrin C, Baranger L, Hélias C, Cornillet-Lefebvre P, Mugneret F, Cabrol C, Pagès MP, Fert-Ferret D, Nguyen-Khac F, Quilichini B, Barin C, Berger R |title=Cytogenetic study of 75 erythroleukemias |journal=Cancer Genet. Cytogenet. |volume=163 |issue=2 |pages=113–22 |date=December 2005 |pmid=16337853 |doi=10.1016/j.cancergencyto.2005.05.006 |url=}}</ref>
* [[Dysplasia]] in [[bone marrow]] and [[peripheral blood]]
* [[Dysplasia|Dysplastic]] [[PAS stain|PAS]] positive [[erythroblasts]] with overexpression of the [[multidrug resistance|multidrug resistance (MDR)]] [[gene]] product [[P-glycoprotein]]
* High frequency of [[mutations]], especially of [[TP53]]<ref name="pmid23648669">{{cite journal |vauthors=Grossmann V, Bacher U, Haferlach C, Schnittger S, Pötzinger F, Weissmann S, Roller A, Eder C, Fasan A, Zenger M, Staller M, Kern W, Kohlmann A, Haferlach T |title=Acute erythroid leukemia (AEL) can be separated into distinct prognostic subsets based on cytogenetic and molecular genetic characteristics |journal=Leukemia |volume=27 |issue=9 |pages=1940–3 |date=September 2013 |pmid=23648669 |doi=10.1038/leu.2013.144 |url=}}</ref>
 
===Electrocardiogram===
* [[Electrocardiogram]] is useful for the assessment of [[QT interval]] prior to starting [[chemotherapy]]. 
* It is also useful for assessing [[arrhythmias]] induced by [[anthracycline]] [[chemotherapy]].<ref name="pmid25616318">{{cite journal| author=Hefti E, Blanco JG| title=Anthracycline-Related Cardiotoxicity in Patients with Acute Myeloid Leukemia and Down Syndrome: A Literature Review. | journal=Cardiovasc Toxicol | year= 2016 | volume= 16 | issue= 1 | pages= 5-13 | pmid=25616318 | doi=10.1007/s12012-015-9307-1 | pmc=4514565 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25616318  }}</ref>
* For more information, click [[Acute myeloid leukemia electrocardiogram|here]].
 
===X-ray===
* An [[x-ray]] may be helpful in the [[diagnosis]] of [[Complication (medicine)|complications]] of erythroleukemia management which include [[infection]], volume overload. 
* [[Chest X-ray|Chest x-ray]] is also useful for [[venous]] [[catheter]] placement for [[chemotherapy]].
 
===Echocardiography or Ultrasound===
* An [[echocardiogram]] is helpful for assessing [[cardiac]] function ([[ejection fraction]]) in [[Patient|patients]] with [[acute myeloid leukemia]] before and after receiving [[anthracycline]] [[chemotherapy]]. <ref name="pmid24947931">{{cite journal |vauthors=Armenian SH, Gelehrter SK, Vase T, Venkatramani R, Landier W, Wilson KD, Herrera C, Reichman L, Menteer JD, Mascarenhas L, Freyer DR, Venkataraman K, Bhatia S |title=Screening for cardiac dysfunction in anthracycline-exposed childhood cancer survivors |journal=Clin. Cancer Res. |volume=20 |issue=24 |pages=6314–23 |date=December 2014 |pmid=24947931 |pmc=4268342 |doi=10.1158/1078-0432.CCR-13-3490 |url=}}</ref>
 
* An [[ultrasound]] is useful for the [[diagnosis]] of [[lower extremity]] [[thrombosis]], which commonly occurs in [[Patient|patients]] with [[acute myeloid leukemia]].<ref name="pmid20124617">{{cite journal |vauthors=Oehadian A, Iqbal M, Sumantri R |title=Deep vein thrombosis in acute myelogenous leukemia |journal=Acta Med Indones |volume=41 |issue=4 |pages=200–4 |date=October 2009 |pmid=20124617 |doi= |url=}}</ref>
 
===CT scan===
* [[Abdominal]] and [[chest]] [[Computed tomography|CT scan]] may be helpful in the [[diagnosis]] of [[acute myeloid leukemia]].
* Findings on [[CT scan]] suggestive of [[acute myeloid leukemia]] include [[lymphadenopathy]], [[hepatomegaly]], [[splenomegaly]] and [[pulmonary embolism]] because of [[Deep vein thrombosis|deep venous thrombosis]].<ref name="pmid27642861">{{cite journal |vauthors=Vallipuram J, Dhalla S, Bell CM, Dresser L, Han H, Husain S, Minden MD, Paul NS, So M, Steinberg M, Vallipuram M, Wong G, Morris AM |title=Chest CT scans are frequently abnormal in asymptomatic patients with newly diagnosed acute myeloid leukemia |journal=Leuk. Lymphoma |volume=58 |issue=4 |pages=834–841 |date=April 2017 |pmid=27642861 |doi=10.1080/10428194.2016.1213825 |url=}}</ref>
 
* Non [[contrast]] [[brain]] [[CT scan]] is useful to rule out [[CNS]] [[Bleeding|bleed]].<ref name="pmid22931433">{{cite journal |vauthors=Chen CY, Tai CH, Cheng A, Wu HC, Tsay W, Liu JH, Chen PY, Huang SY, Yao M, Tang JL, Tien HF |title=Intracranial hemorrhage in adult patients with hematological malignancies |journal=BMC Med |volume=10 |issue= |pages=97 |date=August 2012 |pmid=22931433 |pmc=3482556 |doi=10.1186/1741-7015-10-97 |url=}}</ref>
 
===MRI===
[[Brain]] [[MRI]] is helpful in the [[diagnosis]] of [[CNS]] [[bleeding]] in [[acute myeloid leukemia|acute myeloid leukemia (AML)]].<ref name="pmid26239467">{{cite journal |vauthors=Cervantes GM, Cayci Z |title=Intracranial CNS Manifestations of Myeloid Sarcoma in Patients with Acute Myeloid Leukemia: Review of the Literature and Three Case Reports from the Author's Institution |journal=J Clin Med |volume=4 |issue=5 |pages=1102–12 |date=May 2015 |pmid=26239467 |pmc=4470219 |doi=10.3390/jcm4051102 |url=}}</ref>
 
===Other Imaging Findings===
There are no other [[imaging]] findings associated with erythroleukemia.
 
===Other Diagnostic Studies===
 
===== Flow Cytometry: =====
* The [[myeloid]] [[blast|blasts]] are often postive for [[myeloid]] [[marker]] such as [[CD117]], [[CD13]], [[CD33]] and [[Myeloperoxidase|MPO]].<ref name="pmid21393910">{{cite journal |vauthors=Sharma A, Buxi G, Walia R, Yadav RB, Sharma S |title=Childhood acute erythroleukemia diagnosis by flow cytometry |journal=Indian J Pathol Microbiol |volume=54 |issue=1 |pages=173–5 |date=2011 |pmid=21393910 |doi=10.4103/0377-4929.77395 |url=}}</ref>
 
* The [[erythroblasts]] lack [[myeloid]] [[Antigen|antigens]]. They are postive for [[glycophorin A]].


[[Erythroleukemia medical therapy|Medical Therapy]] | [[Erythroleukemia cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Erythroleukemia future or investigational therapies|Future or Investigational Therapies]]
===== Cytogenetics: =====
* Loss of all or part of the long arm (q) of [[Chromosome|chromosomes]] 5 and/or 7. <ref name="pmid14862892">{{cite journal |vauthors=Atkinson J, Hrisinko MA, Weil SC |title=Erythroleukemia: a review of 15 cases meeting 1985 FAB criteria and survey of the literature |journal=Blood Rev. |volume=6 |issue=4 |pages=204–14 |date=December 1992 |pmid=1486289 |doi= |url=}}</ref>


==Case Studies==
==Treatment==
===Medical Therapy===
* [[Pharmacology|Pharmacologic]] [[Medicine|medical]] [[therapy]] is recommended for [[Patient|patients]] with erythroleukemia who are not candidates for intensive [[chemotherapy]] or [[Allogeneic|allogenic]] [[hematopoietic stem cell]] [[Organ transplant|transplantation]].<ref name="pmid284201202">{{cite journal |vauthors=Almeida AM, Prebet T, Itzykson R, Ramos F, Al-Ali H, Shammo J, Pinto R, Maurillo L, Wetzel J, Musto P, Van De Loosdrecht AA, Costa MJ, Esteves S, Burgstaller S, Stauder R, Autzinger EM, Lang A, Krippl P, Geissler D, Falantes JF, Pedro C, Bargay J, Deben G, Garrido A, Bonanad S, Diez-Campelo M, Thepot S, Ades L, Sperr WR, Valent P, Fenaux P, Sekeres MA, Greil R, Pleyer L |title=Clinical Outcomes of 217 Patients with Acute Erythroleukemia According to Treatment Type and Line: A Retrospective Multinational Study |journal=Int J Mol Sci |volume=18 |issue=4 |pages= |date=April 2017 |pmid=28420120 |pmc=5412421 |doi=10.3390/ijms18040837 |url=}}</ref>


:[[Erythroleukemia case study one|Case #1]]
* [[Pharmacology|Pharmacologic]] [[Medicine|medical]] [[Therapy|therapies]] for erythroleukemia include hypomethylating agents (HMA) such as:<ref name="pmid20026804">{{cite journal |vauthors=Fenaux P, Mufti GJ, Hellström-Lindberg E, Santini V, Gattermann N, Germing U, Sanz G, List AF, Gore S, Seymour JF, Dombret H, Backstrom J, Zimmerman L, McKenzie D, Beach CL, Silverman LR |title=Azacitidine prolongs overall survival compared with conventional care regimens in elderly patients with low bone marrow blast count acute myeloid leukemia |journal=J. Clin. Oncol. |volume=28 |issue=4 |pages=562–9 |date=February 2010 |pmid=20026804 |doi=10.1200/JCO.2009.23.8329 |url=}}</ref>


==Related chapters==
** [[Azacytidine|Azacitidine]]
*[[Acute myeloid leukemia]]
** [[Decitabine]]
For more information about [[Acute myeloid leukemia|acute myeloid leukemia (AML)]] [[Medicine|medical]] [[therapy]], click [[Acute myeloid leukemia medical therapy|here]].


===Surgery===
* Allo-SCT ([[Allogeneic|Allogenic]] [[hematopoietic stem cell]] [[Organ transplant|transplantation]])<ref name="pmid284201202" />


[[Category:Disease]]
===Primary Prevention===
[[Category:Hematology]]
There are no established measures for the [[Prevention (medical)|primary prevention]] of erythroleukemia.
[[Category:Types of cancer]]
[[Category:Oncology]]


{{Hematological malignancy histology}}
===Secondary Prevention===
Effective measures for the [[Prevention (medical)|secondary prevention]] of erythroleukemia include maintenance of [[Remission (medicine)|remission]] treatment post-[[Organ transplant|transplant]].<ref name="pmid21897227">{{cite journal |vauthors=Oran B, de Lima M |title=Prevention and treatment of acute myeloid leukemia relapse after allogeneic stem cell transplantation |journal=Curr. Opin. Hematol. |volume=18 |issue=6 |pages=388–94 |date=November 2011 |pmid=21897227 |doi=10.1097/MOH.0b013e32834b6158 |url=}}</ref>


[[es:Eritroleucemia]]
==References==
{{reflist|2}}


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Latest revision as of 14:31, 8 May 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mahda Alihashemi M.D. [2] [3] [4] Synonyms and keywords:Pure erythroid leukemia, FAB ( French-American-British) M6, acute erythroid leukemia, Di Guglielmo’s disease

Overview

Erythroleukemia was first discovered by M. Copelli, in 1912. In 1917, Di Guglielmo, Italian hematologist, described leukemic nature of the erythroleukemia. Erythroleukemia accounts for < 5 % of acute myeloid leukemia (AML). Erythroleukemia may be classified into 2 groups: De novo cases of erythroleukemia and secondary erythroleukemia. Erythroleukemia may be classified according to previous version WHO into 2 sub-types : The erythroid/myeloid type and the pure type. Erythroleukemia is the neoplastic proliferation of myeloid and erythroid precursors of bone marrow hematopoietic stem cells. A pure erythroid proliferation may also occur. The erythroblasts do not stain with myeloperoxidase (MPO). Markers of myeloid lineage can not be expressed on the erythroblasts. Leukemic cells are positive for myeloid markers such as CD117, CD13, CD33, andmyeloperoxidase (MPO). Megakaryocytes antigens can be positive in some cases of erythroleukemia, such as CD41 and CD61. Erythroleukemia may be caused by translocation t(1;16) generating the fusion gene NFIA/CBFA2T3. Erythroleukemia must be differentiated from MDS with erythroid predominance, other types of AML with increased erythroid precursors, AML with myelodysplasia-related changes. Non-neoplastic disorders that can cause erythroid predominance in the bone marrow such as megaloblastic anemia due to vitamin B12 or folate deficiency, heavy metal intoxication such as arsenic, drug effects (such as antineoplastic agents or chloramphenicol) are other differential diagnoses. The incidence of erythroleukemia is approximately 0.077 per 100,000 individuals worldwide. Erythroleukemia commonly affects individuals older than 50 years of age with a median age of 65. There is no racial predilection to erythroleukemia. Men are more commonly affected by erythroleukemia than women. The male to female ratio is approximately 2 to 1. There are no established risk factors for de novo cases of erythroleukemia. The most potent risk factor in the development of secondary erythroleukemia is previous myelodysplastic syndrome (MDS). There is insufficient evidence to recommend routine screening for erythroleukemia. If left untreated, patients with erythroleukemia may progress to develop bleeding due to disseminated intravascular coagulation (DIC). Common complications of erythroleukemia include infection and bleeding. Therapy related complications are rash, cardiomyopathy and cerebellar toxicity. Prognosis is generally poor. Median survival ranges from 3 - 9 months after the initial diagnosis. A high proerythroblast/myeloblast ratio correlates with worse outcome. The diagnosis of erythroleukemia is based on the 2016 version of WHO classification for AML. History and symptoms include fatigue, Malaise, bone pain, abdominal pain, weight loss, Easy bruising, Fever, and Dyspnea. Patients with erythroleukemia usually appear anemic. Physical examination of patients with erythroleukemia may include Ecchymoses or petechiae, Hepatomegaly, Splenomegaly, Lymphadenopathy, and headache. Laboratory findings include Pancytopenia, few peripheral blood blasts, Dysplasia in bone marrow and peripheral blood, dysplastic PAS positive erythroblasts with overexpression of the multidrug resistance (MDR) gene product P-glycoprotein, and high frequency of mutations, especially of TP53. Electrocardiogram is useful for the assessment of QT interval prior to starting chemotherapy. An x-ray may be helpful in the diagnosis of complications of erythroleukemia management which include infection, volume overload. Chest x-ray is also useful for venous catheter placement for chemotherapy. An echocardiogram is helpful for assessing cardiac function (ejection fraction) in patients with acute myeloid leukemia before and after receiving anthracycline chemotherapy. An ultrasound is useful for the diagnosis of lower extremity thrombosis, which commonly occurs in patients with acute myeloid leukemia. Abdominal and chest CT scan may be helpful in the diagnosis of acute myeloid leukemia. Findings on CT scan suggestive of acute myeloid leukemia include lymphadenopathy, hepatomegaly, splenomegaly and pulmonary embolism because of deep venous thrombosis. Brain MRI is helpful in the diagnosis of CNS bleeding in acute myeloid leukemia (AML). There are no other imaging findings associated with erythroleukemia. Other diagnostic studies include cytogenetics and flow cytometry. Pharmacologic medical therapy is recommended for patients with erythroleukemia who are not candidates for intensive chemotherapy or allogenic hematopoietic stem cell transplantation. Pharmacologic medical therapies for erythroleukemia include hypomethylating agents (HMA) such as azacitidine and Decitabine. Surgical interventions include allogenic hematopoietic stem cell transplantation (Allo-SCT). There are no established measures for the primary prevention of erythroleukemia. Effective measures for the secondary prevention of erythroleukemia include maintenance of remission treatment post-transplant.

Historical Perspective

  • Erythroleukemia was first discovered by M. Copelli, in 1912.[1]

Classification

  • Erythroleukemia accounts for < 5 % of acute myeloid leukemia (AML).
  • Erythroleukemia may be classified into 2 groups: De novo cases of erythroleukemia and secondary erythroleukemia.
  • Erythroleukemia may be classified according to previous version WHO into 2 sub-types : The erythroid/myeloid type and the pure type.[2]

2016 version of WHO classification for AML (erythroid/myeloid type) :

Pathophysiology

Microscopic Examanination:

Immunohistochemistry

Leukemic cells are positive for myeloid markers such as:[4]

Megakaryocytes antigens can be positive in some cases of erythroleukemia, such as:

Causes

Erythroleukemia may be caused by translocation t(1;16) generating the fusion gene NFIA/CBFA2T3.[5]

Differentiating Erythroleukemia from Other Diseases

Epidemiology and Demographics

  • The incidence of erythroleukemia is approximately 0.077 per 100,000 individuals worldwide.[7]
  • Erythroleukemia commonly affects individuals older than 50 years of age with a median age of 65.[8]
  • There is no racial predilection to erythroleukemia.
  • Men are more commonly affected by erythroleukemia than women. The male to female ratio is approximately 2 to 1.


Risk Factors

Screening

There is insufficient evidence to recommend routine screening for erythroleukemia.

Natural History, Complications, and Prognosis

Diagnosis

Diagnostic Study of Choice

Bone Marrow Biopsy

The diagnosis of erythroleukemia is based on the 2016 version of WHO classification for AML:

History and Symptoms

Less common symptoms of erythroleukemia include diffuse joint pain.

Physical Examination

Patients with erythroleukemia usually appear anemic. Physical examination of patients with erythroleukemia may include:[12]

Laboratory Findings

Electrocardiogram

X-ray

Echocardiography or Ultrasound

CT scan

MRI

Brain MRI is helpful in the diagnosis of CNS bleeding in acute myeloid leukemia (AML).[21]

Other Imaging Findings

There are no other imaging findings associated with erythroleukemia.

Other Diagnostic Studies

Flow Cytometry:
Cytogenetics:

Treatment

Medical Therapy

For more information about acute myeloid leukemia (AML) medical therapy, click here.

Surgery

Primary Prevention

There are no established measures for the primary prevention of erythroleukemia.

Secondary Prevention

Effective measures for the secondary prevention of erythroleukemia include maintenance of remission treatment post-transplant.[26]

References

  1. ↑ Santos FP, Bueso-Ramos CE, Ravandi F (December 2010). "Acute erythroleukemia: diagnosis and management". Expert Rev Hematol. 3 (6): 705–18. doi:10.1586/ehm.10.62. PMID 21091147.
  2. ↑ Forestier E, Heim S, Blennow E, Borgström G, Holmgren G, Heinonen K, Johannsson J, Kerndrup G, Andersen MK, Lundin C, Nordgren A, Rosenquist R, Swolin B, Johansson B (May 2003). "Cytogenetic abnormalities in childhood acute myeloid leukaemia: a Nordic series comprising all children enrolled in the NOPHO-93-AML trial between 1993 and 2001". Br. J. Haematol. 121 (4): 566–77. PMID 12752097.
  3. ↑ Santos FP, Bueso-Ramos CE, Ravandi F (December 2010). "Acute erythroleukemia: diagnosis and management". Expert Rev Hematol. 3 (6): 705–18. doi:10.1586/ehm.10.62. PMID 21091147.
  4. ↑ Cuneo A, Van Orshoven A, Michaux JL, Boogaerts M, Louwagie A, Doyen C, Dal Cin P, Fagioli F, Castoldi G, Van den Berghe H (July 1990). "Morphologic, immunologic and cytogenetic studies in erythroleukaemia: evidence for multilineage involvement and identification of two distinct cytogenetic-clinicopathological types". Br. J. Haematol. 75 (3): 346–54. PMID 2386768.
  5. ↑ Micci F, Thorsen J, Panagopoulos I, Nyquist KB, Zeller B, Tierens A, Heim S (April 2013). "High-throughput sequencing identifies an NFIA/CBFA2T3 fusion gene in acute erythroid leukemia with t(1;16)(p31;q24)". Leukemia. 27 (4): 980–2. doi:10.1038/leu.2012.266. PMC 3626019. PMID 23032695.
  6. ↑ Zuo Z, Polski JM, Kasyan A, Medeiros LJ (September 2010). "Acute erythroid leukemia". Arch. Pathol. Lab. Med. 134 (9): 1261–70. doi:10.1043/2009-0350-RA.1. PMID 20807044.
  7. ↑ Wells AW, Bown N, Reid MM, Hamilton PJ, Jackson GH, Taylor PR (August 2001). "Erythroleukaemia in the north of England: a population based study". J. Clin. Pathol. 54 (8): 608–12. PMC 1731487. PMID 11477115.
  8. ↑ Santos FP, Bueso-Ramos CE, Ravandi F (December 2010). "Acute erythroleukemia: diagnosis and management". Expert Rev Hematol. 3 (6): 705–18. doi:10.1586/ehm.10.62. PMID 21091147.
  9. ↑ Atkinson J, Hrisinko MA, Weil SC (December 1992). "Erythroleukemia: a review of 15 cases meeting 1985 FAB criteria and survey of the literature". Blood Rev. 6 (4): 204–14. PMID 1486289.
  10. ↑ Almeida AM, Prebet T, Itzykson R, Ramos F, Al-Ali H, Shammo J, Pinto R, Maurillo L, Wetzel J, Musto P, Van De Loosdrecht AA, Costa MJ, Esteves S, Burgstaller S, Stauder R, Autzinger EM, Lang A, Krippl P, Geissler D, Falantes JF, Pedro C, Bargay J, Deben G, Garrido A, Bonanad S, Diez-Campelo M, Thepot S, Ades L, Sperr WR, Valent P, Fenaux P, Sekeres MA, Greil R, Pleyer L (April 2017). "Clinical Outcomes of 217 Patients with Acute Erythroleukemia According to Treatment Type and Line: A Retrospective Multinational Study". Int J Mol Sci. 18 (4). doi:10.3390/ijms18040837. PMC 5412421. PMID 28420120.
  11. ↑ Srinivas U, Kumar R, Pati H, Saxena R, Tyagi S (October 2007). "Sub classification and clinico-hematological correlation of 40 cases of acute erythroleukemia - can proerythroblast/myeloblast and proerythroblast/total erythroid cell ratios help subclassify?". Hematology. 12 (5): 381–5. doi:10.1080/10245330701393816. PMID 17852448.
  12. ↑ Zuo Z, Polski JM, Kasyan A, Medeiros LJ (September 2010). "Acute erythroid leukemia". Arch. Pathol. Lab. Med. 134 (9): 1261–70. doi:10.1043/2009-0350-RA.1. PMID 20807044.
  13. ↑ Peng J, Hasserjian RP, Tang G, Patel KP, Goswami M, Jabbour EJ, Garcia-Manero G, Medeiros LJ, Wang SA (2016). "Myelodysplastic syndromes following therapy with hypomethylating agents (HMAs): development of acute erythroleukemia may not influence assessment of treatment response". Leuk. Lymphoma. 57 (4): 812–9. doi:10.3109/10428194.2015.1079318. PMID 26293512.
  14. ↑ Lessard M, Struski S, Leymarie V, Flandrin G, Lafage-Pochitaloff M, Mozziconacci MJ, Talmant P, Bastard C, Charrin C, Baranger L, Hélias C, Cornillet-Lefebvre P, Mugneret F, Cabrol C, Pagès MP, Fert-Ferret D, Nguyen-Khac F, Quilichini B, Barin C, Berger R (December 2005). "Cytogenetic study of 75 erythroleukemias". Cancer Genet. Cytogenet. 163 (2): 113–22. doi:10.1016/j.cancergencyto.2005.05.006. PMID 16337853.
  15. ↑ Grossmann V, Bacher U, Haferlach C, Schnittger S, Pötzinger F, Weissmann S, Roller A, Eder C, Fasan A, Zenger M, Staller M, Kern W, Kohlmann A, Haferlach T (September 2013). "Acute erythroid leukemia (AEL) can be separated into distinct prognostic subsets based on cytogenetic and molecular genetic characteristics". Leukemia. 27 (9): 1940–3. doi:10.1038/leu.2013.144. PMID 23648669.
  16. ↑ Hefti E, Blanco JG (2016). "Anthracycline-Related Cardiotoxicity in Patients with Acute Myeloid Leukemia and Down Syndrome: A Literature Review". Cardiovasc Toxicol. 16 (1): 5–13. doi:10.1007/s12012-015-9307-1. PMC 4514565. PMID 25616318.
  17. ↑ Armenian SH, Gelehrter SK, Vase T, Venkatramani R, Landier W, Wilson KD, Herrera C, Reichman L, Menteer JD, Mascarenhas L, Freyer DR, Venkataraman K, Bhatia S (December 2014). "Screening for cardiac dysfunction in anthracycline-exposed childhood cancer survivors". Clin. Cancer Res. 20 (24): 6314–23. doi:10.1158/1078-0432.CCR-13-3490. PMC 4268342. PMID 24947931.
  18. ↑ Oehadian A, Iqbal M, Sumantri R (October 2009). "Deep vein thrombosis in acute myelogenous leukemia". Acta Med Indones. 41 (4): 200–4. PMID 20124617.
  19. ↑ Vallipuram J, Dhalla S, Bell CM, Dresser L, Han H, Husain S, Minden MD, Paul NS, So M, Steinberg M, Vallipuram M, Wong G, Morris AM (April 2017). "Chest CT scans are frequently abnormal in asymptomatic patients with newly diagnosed acute myeloid leukemia". Leuk. Lymphoma. 58 (4): 834–841. doi:10.1080/10428194.2016.1213825. PMID 27642861.
  20. ↑ Chen CY, Tai CH, Cheng A, Wu HC, Tsay W, Liu JH, Chen PY, Huang SY, Yao M, Tang JL, Tien HF (August 2012). "Intracranial hemorrhage in adult patients with hematological malignancies". BMC Med. 10: 97. doi:10.1186/1741-7015-10-97. PMC 3482556. PMID 22931433.
  21. ↑ Cervantes GM, Cayci Z (May 2015). "Intracranial CNS Manifestations of Myeloid Sarcoma in Patients with Acute Myeloid Leukemia: Review of the Literature and Three Case Reports from the Author's Institution". J Clin Med. 4 (5): 1102–12. doi:10.3390/jcm4051102. PMC 4470219. PMID 26239467.
  22. ↑ Sharma A, Buxi G, Walia R, Yadav RB, Sharma S (2011). "Childhood acute erythroleukemia diagnosis by flow cytometry". Indian J Pathol Microbiol. 54 (1): 173–5. doi:10.4103/0377-4929.77395. PMID 21393910.
  23. ↑ Atkinson J, Hrisinko MA, Weil SC (December 1992). "Erythroleukemia: a review of 15 cases meeting 1985 FAB criteria and survey of the literature". Blood Rev. 6 (4): 204–14. PMID 1486289.
  24. ↑ 24.0 24.1 Almeida AM, Prebet T, Itzykson R, Ramos F, Al-Ali H, Shammo J, Pinto R, Maurillo L, Wetzel J, Musto P, Van De Loosdrecht AA, Costa MJ, Esteves S, Burgstaller S, Stauder R, Autzinger EM, Lang A, Krippl P, Geissler D, Falantes JF, Pedro C, Bargay J, Deben G, Garrido A, Bonanad S, Diez-Campelo M, Thepot S, Ades L, Sperr WR, Valent P, Fenaux P, Sekeres MA, Greil R, Pleyer L (April 2017). "Clinical Outcomes of 217 Patients with Acute Erythroleukemia According to Treatment Type and Line: A Retrospective Multinational Study". Int J Mol Sci. 18 (4). doi:10.3390/ijms18040837. PMC 5412421. PMID 28420120.
  25. ↑ Fenaux P, Mufti GJ, Hellström-Lindberg E, Santini V, Gattermann N, Germing U, Sanz G, List AF, Gore S, Seymour JF, Dombret H, Backstrom J, Zimmerman L, McKenzie D, Beach CL, Silverman LR (February 2010). "Azacitidine prolongs overall survival compared with conventional care regimens in elderly patients with low bone marrow blast count acute myeloid leukemia". J. Clin. Oncol. 28 (4): 562–9. doi:10.1200/JCO.2009.23.8329. PMID 20026804.
  26. ↑ Oran B, de Lima M (November 2011). "Prevention and treatment of acute myeloid leukemia relapse after allogeneic stem cell transplantation". Curr. Opin. Hematol. 18 (6): 388–94. doi:10.1097/MOH.0b013e32834b6158. PMID 21897227.


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