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==Overview==
==Overview==
Secondary prevention may be effective in reducing the incidence of esophageal cancer, if treated early at the dysplasia stage with monoclonal antibody therapy. At present, there is no particular program in place to reduce the incidence of esophageal cancer.
Secondary prevention may be effective in reducing the [[incidence]] of esophageal cancer, if treated early at the [[dysplasia]] stage with [[Monoclonal antibodies|monoclonal antibody]] therapy. At present, there is no particular program in place to reduce the incidence of esophageal cancer.


==Secondary Prevention==
==Secondary Prevention==
*In 1983, a study was carried out in Hishun village, China.
Secondary prevention can be effective in high risk groups with advanced [[dysplasia]] if they are treated (with monoclonal antibodies) early enough in the dysplastic phase before cancer occurs.<ref name="pmid3219974">{{cite journal |vauthors=Lin PZ, Zhang JS, Cao SG, Rong ZP, Gao RQ, Han R, Shu SP |title=[Secondary prevention of esophageal cancer--intervention on precancerous lesions of the esophagus] |language=Chinese |journal=Zhonghua Zhong Liu Za Zhi |volume=10 |issue=3 |pages=161–6 |year=1988 |pmid=3219974 |doi= |url=}}</ref>
*Due to different dietary factors, the incidence of esophageal cancer amongst these people was particularly high.
*A high risk group who frequently smoke and drink alcohol were identified in Hishun village, China.
*6758 subjects were examined by esophageal exfoliative cytology, 1729 had marked dysplasia and 2411 had mild dysplasia of esophageal epithelium.
*They were examined by esophageal exfoliative cytology.
*Those with marked dysplasia were randomly divided into 3 groups and given: antitumor B (Chinese herbs); retinamide (4-Ethoxycarbophenylretinamide) and placebo.
*One third of the participants were found to have advanced esophageal [[dysplasia]].
*The subjects with mild dysplasia were randomly divided  into 2 groups for treatment with riboflavin and placebo.
*They were placed on an antitumor B regimen for 3 years.
*They took their respective treatments for 3 years and were then reexamined using cytology.
*Patients who were treated with monoclonal antibodies subsequently showed a reduction in the incidence of esophageal cancer by 53%.
*The incidence of esophageal cancer in the antitumor B group was reduced by 53% as compared with that of the placebo group (8.3%).
*These results demonstrate the effectiveness of secondary prevention in the prevention of esophageal cancer.
*The incidence of esophageal cancer in retinamide and riboflavin groups were reduced by 33.7% and 19% as compared with those of the control groups.
*These results demonstrated that the secondary prevention of esophageal cancer is effective in the prevention of esophageal cancer.<ref name="pmid3219974">{{cite journal |vauthors=Lin PZ, Zhang JS, Cao SG, Rong ZP, Gao RQ, Han R, Shu SP |title=[Secondary prevention of esophageal cancer--intervention on precancerous lesions of the esophagus] |language=Chinese |journal=Zhonghua Zhong Liu Za Zhi |volume=10 |issue=3 |pages=161–6 |year=1988 |pmid=3219974 |doi= |url=}}</ref>


==References==
==References==

Latest revision as of 16:48, 5 January 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Hadeel Maksoud M.D.[2]

Overview

Secondary prevention may be effective in reducing the incidence of esophageal cancer, if treated early at the dysplasia stage with monoclonal antibody therapy. At present, there is no particular program in place to reduce the incidence of esophageal cancer.

Secondary Prevention

Secondary prevention can be effective in high risk groups with advanced dysplasia if they are treated (with monoclonal antibodies) early enough in the dysplastic phase before cancer occurs.[1]

  • A high risk group who frequently smoke and drink alcohol were identified in Hishun village, China.
  • They were examined by esophageal exfoliative cytology.
  • One third of the participants were found to have advanced esophageal dysplasia.
  • They were placed on an antitumor B regimen for 3 years.
  • Patients who were treated with monoclonal antibodies subsequently showed a reduction in the incidence of esophageal cancer by 53%.
  • These results demonstrate the effectiveness of secondary prevention in the prevention of esophageal cancer.

References

  1. Lin PZ, Zhang JS, Cao SG, Rong ZP, Gao RQ, Han R, Shu SP (1988). "[Secondary prevention of esophageal cancer--intervention on precancerous lesions of the esophagus]". Zhonghua Zhong Liu Za Zhi (in Chinese). 10 (3): 161–6. PMID 3219974.


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