Autoimmune hepatitis Diagnostic Study of Choice: Difference between revisions
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== Diagnostic Study of Choice == | == Diagnostic Study of Choice == | ||
=== Gold standard/Study of choice: === | === Gold standard/Study of choice: === | ||
*Liver biopsy is the gold standard test for the diagnosis of Autoimmune hepatitis | *Liver biopsy is the gold standard test for the diagnosis of Autoimmune hepatitis | ||
*Liver biopsy is performed by following methods: | *Liver biopsy is performed by following methods: | ||
** | **Percutaneous liver biopsy with or without ultrasound guidance | ||
**Transjugular liver biopsy | **Transjugular liver biopsy | ||
Histology findings usually found on biopsy: | |||
*Interface hepatitis (ie, piecemeal necrosis) is the histological hallmark | |||
**There is lymphoplasmacytic periportal infiltrate which invade the limiting plate | |||
**There is an abundance of plasma cells and eosinophils are usually present | |||
**Portal lesion spares the biliary tree | |||
*A plasma cell infiltrate lead to plasma cell hepatitis | |||
*Bridging necrosis | |||
*Fibrosis | |||
Fibrosis is present in most patients with autoimmune hepatitis. Without effective therapy, fibrosis starts to connect the portal and central areas, which ultimately leads to cirrhosis. | |||
==References== | ==References== | ||
Latest revision as of 02:02, 20 December 2017
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Autoimmune hepatitis Microchapters |
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Autoimmune hepatitis Diagnostic Study of Choice On the Web |
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American Roentgen Ray Society Images of Autoimmune hepatitis Diagnostic Study of Choice |
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Risk calculators and risk factors for Autoimmune hepatitis Diagnostic Study of Choice |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: :Manpreet Kaur, MD [2]
Overview
Diagnostic Study of Choice
Gold standard/Study of choice:
- Liver biopsy is the gold standard test for the diagnosis of Autoimmune hepatitis
- Liver biopsy is performed by following methods:
- Percutaneous liver biopsy with or without ultrasound guidance
- Transjugular liver biopsy
Histology findings usually found on biopsy:
- Interface hepatitis (ie, piecemeal necrosis) is the histological hallmark
- There is lymphoplasmacytic periportal infiltrate which invade the limiting plate
- There is an abundance of plasma cells and eosinophils are usually present
- Portal lesion spares the biliary tree
- A plasma cell infiltrate lead to plasma cell hepatitis
- Bridging necrosis
- Fibrosis
Fibrosis is present in most patients with autoimmune hepatitis. Without effective therapy, fibrosis starts to connect the portal and central areas, which ultimately leads to cirrhosis.