SMTN: Difference between revisions
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'''Smoothelin''' is a [[protein]] that in humans is encoded by the ''SMTN'' [[gene]].<ref name="pmid9244445">{{cite journal | vauthors = Engelen JJ, Esterling LE, Albrechts JC, Detera-Wadleigh SD, van Eys GJ | title = Assignment of the human gene for smoothelin (SMTN) to chromosome 22q12 by fluorescence in situ hybridization and radiation hybrid mapping | journal = Genomics | volume = 43 | issue = 2 | pages = 245–7 |date=Sep 1997 | pmid = 9244445 | pmc = | doi = 10.1006/geno.1997.9999 }}</ref><ref name="pmid8707825">{{cite journal | vauthors = van der Loop FT, Schaart G, Timmer ED, Ramaekers FC, van Eys GJ | title = Smoothelin, a novel cytoskeletal protein specific for smooth muscle cells | journal = J Cell Biol | volume = 134 | issue = 2 | pages = 401–11 |date=Sep 1996 | pmid = 8707825 | pmc = 2120883 | doi =10.1083/jcb.134.2.401 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SMTN smoothelin| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6525| accessdate = }}</ref> | '''Smoothelin''' is a [[protein]] that in humans is encoded by the ''SMTN'' [[gene]].<ref name="pmid9244445">{{cite journal | vauthors = Engelen JJ, Esterling LE, Albrechts JC, Detera-Wadleigh SD, van Eys GJ | title = Assignment of the human gene for smoothelin (SMTN) to chromosome 22q12 by fluorescence in situ hybridization and radiation hybrid mapping | journal = Genomics | volume = 43 | issue = 2 | pages = 245–7 |date=Sep 1997 | pmid = 9244445 | pmc = | doi = 10.1006/geno.1997.9999 }}</ref><ref name="pmid8707825">{{cite journal | vauthors = van der Loop FT, Schaart G, Timmer ED, Ramaekers FC, van Eys GJ | title = Smoothelin, a novel cytoskeletal protein specific for smooth muscle cells | journal = J Cell Biol | volume = 134 | issue = 2 | pages = 401–11 |date=Sep 1996 | pmid = 8707825 | pmc = 2120883 | doi =10.1083/jcb.134.2.401 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SMTN smoothelin| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6525| accessdate = }}</ref> | ||
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{{PBB_Summary | {{PBB_Summary | ||
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| summary_text = This gene encodes a structural protein that is found exclusively in contractile smooth muscle cells. It associates with stress fibers and constitutes part of the cytoskeleton. This gene is localized to chromosome 22q12.3, distal to the TUPLE1 locus and outside the DiGeorge syndrome deletion. Alternative splicing of this gene results in three transcript variants.<ref name="entrez">{{cite web | title = Entrez Gene: SMTN smoothelin| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6525| accessdate = }}</ref> | | summary_text = This gene encodes a [[structural protein]] that is found exclusively in contractile [[smooth muscle]] cells. It associates with stress fibers and constitutes part of the [[cytoskeleton]]. This gene is localized to [[chromosome 22|chromosome 22q12.3]], distal to the TUPLE1 locus and outside the [[DiGeorge syndrome]] deletion. [[Alternative splicing]] of this gene results in three transcript variants.<ref name="entrez">{{cite web | title = Entrez Gene: SMTN smoothelin| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6525| accessdate = }}</ref> | ||
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Latest revision as of 12:27, 9 January 2019
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Smoothelin is a protein that in humans is encoded by the SMTN gene.[1][2][3]
This gene encodes a structural protein that is found exclusively in contractile smooth muscle cells. It associates with stress fibers and constitutes part of the cytoskeleton. This gene is localized to chromosome 22q12.3, distal to the TUPLE1 locus and outside the DiGeorge syndrome deletion. Alternative splicing of this gene results in three transcript variants.[3]
References
- ↑ Engelen JJ, Esterling LE, Albrechts JC, Detera-Wadleigh SD, van Eys GJ (Sep 1997). "Assignment of the human gene for smoothelin (SMTN) to chromosome 22q12 by fluorescence in situ hybridization and radiation hybrid mapping". Genomics. 43 (2): 245–7. doi:10.1006/geno.1997.9999. PMID 9244445.
- ↑ van der Loop FT, Schaart G, Timmer ED, Ramaekers FC, van Eys GJ (Sep 1996). "Smoothelin, a novel cytoskeletal protein specific for smooth muscle cells". J Cell Biol. 134 (2): 401–11. doi:10.1083/jcb.134.2.401. PMC 2120883. PMID 8707825.
- ↑ 3.0 3.1 "Entrez Gene: SMTN smoothelin".
Further reading
- Luft FC (1999). "Differentiating one smooth operator from another". J. Mol. Med. 77 (2): 255–7. doi:10.1007/s001090050347. PMID 10023778.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- van Eys GJ, Völler MC, Timmer ED, et al. (1997). "Smoothelin expression characteristics: development of a smooth muscle cell in vitro system and identification of a vascular variant". Cell Struct. Funct. 22 (1): 65–72. doi:10.1247/csf.22.65. PMID 9113392.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. 1999. doi:10.1101/gr.8.11.1097. PMID 9847074.
- Krämer J, Aguirre-Arteta AM, Thiel C, et al. (1999). "A novel isoform of the smooth muscle cell differentiation marker smoothelin". J. Mol. Med. 77 (2): 294–8. doi:10.1007/s001090050352. PMID 10023782.
- Johansson B, Eriksson A, Ramaekers F, Thornell L (2000). "Smoothelin in adult and developing human arteries and myocardium". Histochem. Cell Biol. 112 (4): 291–9. doi:10.1007/s004180050450. PMID 10550614.
- Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
- Gsell S, Eschenhagen T, Kaspareit G, et al. (2000). "Apparent up-regulation of stimulatory G-protein alpha subunits in the pregnant human myometrium is mimicked by elevated smoothelin expression". FASEB J. 14 (1): 17–26. PMID 10627276.
- Krämer J, Quensel C, Meding J, et al. (2001). "Identification and characterization of novel smoothelin isoforms in vascular smooth muscle". J. Vasc. Res. 38 (2): 120–32. doi:10.1159/000051039. PMID 11316948.
- Rensen SS, Thijssen VL, De Vries CJ, et al. (2002). "Expression of the smoothelin gene is mediated by alternative promoters". Cardiovasc. Res. 55 (4): 850–63. doi:10.1016/S0008-6363(02)00491-1. PMID 12176134.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
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