Sinusoidal obstruction diagnostic study of choice: Difference between revisions
Jump to navigation
Jump to search
Created page with "__NOTOC__ {{Sinusoidal obstruction syndrome }} {{CMG}} {{AE}} == Overview == The two established criteria for the clinical diagnosis of sinusoidal obstruction syndrome are Bal..." |
|||
| (7 intermediate revisions by one other user not shown) | |||
| Line 1: | Line 1: | ||
__NOTOC__ | __NOTOC__ | ||
{{Sinusoidal obstruction syndrome }} | {{Sinusoidal obstruction syndrome }} | ||
{{CMG}} {{AE}} | {{CMG}} {{AE}} {{HS}} | ||
== Overview == | == Overview == | ||
The two established criteria for the clinical diagnosis of sinusoidal obstruction syndrome are Baltimore criteria and modified Seattle criteria. | The two established criteria for the clinical diagnosis of sinusoidal obstruction syndrome are [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4935979/ Baltimore criteria] and [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4935979/ modified Seattle criteria]. The most accurate method to confirm the diagnosis and evaluate the severity of sinusoidal obstruction syndrome is the measurement of the hepatic venous gradient pressure (HVGP). | ||
==Diagnostic Criteria == | ==Diagnostic Criteria == | ||
The diagnosis of sinusoidal obstruction syndrome should be considered in any patient who has undergone hematopoietic cell transplant and develops liver dysfunction. | The diagnosis of sinusoidal obstruction syndrome should be considered in any patient who has undergone [[Hematopoietic stem cell|hematopoietic cell transplant]] and develops [[Liver disease|liver dysfunction.]] | ||
* The two established criteria for the clinical diagnosis of sinusoidal obstruction syndrome are:<ref name="pmid27038846">{{cite journal| author=Valla DC, Cazals-Hatem D| title=Sinusoidal obstruction syndrome. | journal=Clin Res Hepatol Gastroenterol | year= 2016 | volume= 40 | issue= 4 | pages= 378-85 | pmid=27038846 | doi=10.1016/j.clinre.2016.01.006 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27038846 }} </ref><ref name="pmid18724548">{{cite journal |vauthors=Gozdzik J, Krasowska-Kwiecień A, Wedrychowicz A |title=[Sinusoidal obstruction disease (SOS), previous hepatic venoocclusive disease (VOD)--still serious complication after hematopoietic stem cell transplantation] |language=Polish |journal=Prz. Lek. |volume=65 |issue=4 |pages=203–8 |year=2008 |pmid=18724548 |doi= |url=}}</ref><ref name="pmid6363247">{{cite journal |vauthors=McDonald GB, Sharma P, Matthews DE, Shulman HM, Thomas ED |title=Venocclusive disease of the liver after bone marrow transplantation: diagnosis, incidence, and predisposing factors |journal=Hepatology |volume=4 |issue=1 |pages=116–22 |year=1984 |pmid=6363247 |doi= |url=}}</ref> | * The two established criteria for the clinical diagnosis of sinusoidal obstruction syndrome are:<ref name="pmid27038846">{{cite journal| author=Valla DC, Cazals-Hatem D| title=Sinusoidal obstruction syndrome. | journal=Clin Res Hepatol Gastroenterol | year= 2016 | volume= 40 | issue= 4 | pages= 378-85 | pmid=27038846 | doi=10.1016/j.clinre.2016.01.006 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27038846 }} </ref><ref name="pmid18724548">{{cite journal |vauthors=Gozdzik J, Krasowska-Kwiecień A, Wedrychowicz A |title=[Sinusoidal obstruction disease (SOS), previous hepatic venoocclusive disease (VOD)--still serious complication after hematopoietic stem cell transplantation] |language=Polish |journal=Prz. Lek. |volume=65 |issue=4 |pages=203–8 |year=2008 |pmid=18724548 |doi= |url=}}</ref><ref name="pmid6363247">{{cite journal |vauthors=McDonald GB, Sharma P, Matthews DE, Shulman HM, Thomas ED |title=Venocclusive disease of the liver after bone marrow transplantation: diagnosis, incidence, and predisposing factors |journal=Hepatology |volume=4 |issue=1 |pages=116–22 |year=1984 |pmid=6363247 |doi= |url=}}</ref> | ||
{| class="wikitable" | {| class="wikitable" | ||
| Line 12: | Line 13: | ||
|- | |- | ||
| | | | ||
* Within 30 days of transplantation, | * Within 30 days of transplantation, [[bilirubinemia]] > 34.2 mol/L (2 mg/dL), plus 2 other findings among the following: | ||
** Hepatomegaly, usually painful | ** [[Hepatomegaly]], usually painful | ||
** > 5% weight gain | ** > 5% weight gain | ||
** Ascites | ** [[Ascites]] | ||
| | | | ||
* Within 20 days of transplantation, two of three findings among the following: | * Within 20 days of transplantation, two of three findings among the following: | ||
** | ** [[Bilirubin]] > 34.2 mol/L (2 mg/dL) | ||
** Hepatomegaly or RUQ pain of liver origin | ** [[Hepatomegaly]] or RUQ pain of liver origin | ||
** > 2% weight gain due to fluid accumulation | ** > 2% weight gain due to fluid accumulation | ||
|} | |} | ||
==Diagnostic study of choice == | |||
===Portal hepatic venous gradient=== | |||
*The most accurate method to confirm the diagnosis and evaluate the severity of sinusoidal obstruction syndrome (SOS) is the measurement of the hepatic venous gradient pressure (HVGP) through the jugular vein.<ref name="pmid24843434">{{cite journal| author=Nakamura A, Osonoi T, Terauchi Y| title=Relationship between urinary sodium excretion and pioglitazone-induced edema. | journal=J Diabetes Investig | year= 2010 | volume= 1 | issue= 5 | pages= 208-11 | pmid=24843434 | doi=10.1111/j.2040-1124.2010.00046.x | pmc=4020723 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24843434 }} </ref> | |||
* The portal-hepatic venous pressure gradient is defined as the difference between the wedged and free hepatic venous pressure, it can be measured at the time of [[Liver biopsy|transjugular liver biopsy]]. | |||
* '''A hepatic venous gradient pressure (HVGP) ≥10 mmHg''' in a patient without previous liver disease is seen almost exclusively in sinusoidal obstruction syndrome (SOS).<ref name="pmid7709437">{{cite journal |vauthors=Shulman HM, Gooley T, Dudley MD, Kofler T, Feldman R, Dwyer D, McDonald GB |title=Utility of transvenous liver biopsies and wedged hepatic venous pressure measurements in sixty marrow transplant recipients |journal=Transplantation |volume=59 |issue=7 |pages=1015–22 |year=1995 |pmid=7709437 |doi= |url=}}</ref> | |||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
Latest revision as of 15:48, 28 February 2018
|
Sinusoidal obstruction syndrome Microchapters |
|
Differentiating Sinusoidal obstruction syndrome from Other Diseases |
|---|
|
Diagnosis |
|
Treatment |
|
Case Studies |
|
Sinusoidal obstruction diagnostic study of choice On the Web |
|
American Roentgen Ray Society Images of Sinusoidal obstruction diagnostic study of choice |
|
Sinusoidal obstruction diagnostic study of choice in the news |
|
Directions to Hospitals Treating Sinusoidal obstruction syndrome |
|
Risk calculators and risk factors for Sinusoidal obstruction diagnostic study of choice |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Husnain Shaukat, M.D [2]
Overview
The two established criteria for the clinical diagnosis of sinusoidal obstruction syndrome are Baltimore criteria and modified Seattle criteria. The most accurate method to confirm the diagnosis and evaluate the severity of sinusoidal obstruction syndrome is the measurement of the hepatic venous gradient pressure (HVGP).
Diagnostic Criteria
The diagnosis of sinusoidal obstruction syndrome should be considered in any patient who has undergone hematopoietic cell transplant and develops liver dysfunction.
- The two established criteria for the clinical diagnosis of sinusoidal obstruction syndrome are:[1][2][3]
| Baltimore Criteria | Seattle criteria |
|---|---|
|
|
Diagnostic study of choice
Portal hepatic venous gradient
- The most accurate method to confirm the diagnosis and evaluate the severity of sinusoidal obstruction syndrome (SOS) is the measurement of the hepatic venous gradient pressure (HVGP) through the jugular vein.[4]
- The portal-hepatic venous pressure gradient is defined as the difference between the wedged and free hepatic venous pressure, it can be measured at the time of transjugular liver biopsy.
- A hepatic venous gradient pressure (HVGP) ≥10 mmHg in a patient without previous liver disease is seen almost exclusively in sinusoidal obstruction syndrome (SOS).[5]
References
- ↑ Valla DC, Cazals-Hatem D (2016). "Sinusoidal obstruction syndrome". Clin Res Hepatol Gastroenterol. 40 (4): 378–85. doi:10.1016/j.clinre.2016.01.006. PMID 27038846.
- ↑ Gozdzik J, Krasowska-Kwiecień A, Wedrychowicz A (2008). "[Sinusoidal obstruction disease (SOS), previous hepatic venoocclusive disease (VOD)--still serious complication after hematopoietic stem cell transplantation]". Prz. Lek. (in Polish). 65 (4): 203–8. PMID 18724548.
- ↑ McDonald GB, Sharma P, Matthews DE, Shulman HM, Thomas ED (1984). "Venocclusive disease of the liver after bone marrow transplantation: diagnosis, incidence, and predisposing factors". Hepatology. 4 (1): 116–22. PMID 6363247.
- ↑ Nakamura A, Osonoi T, Terauchi Y (2010). "Relationship between urinary sodium excretion and pioglitazone-induced edema". J Diabetes Investig. 1 (5): 208–11. doi:10.1111/j.2040-1124.2010.00046.x. PMC 4020723. PMID 24843434.
- ↑ Shulman HM, Gooley T, Dudley MD, Kofler T, Feldman R, Dwyer D, McDonald GB (1995). "Utility of transvenous liver biopsies and wedged hepatic venous pressure measurements in sixty marrow transplant recipients". Transplantation. 59 (7): 1015–22. PMID 7709437.