Primary biliary cirrhosis diagnostic study of choice: Difference between revisions
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{{Primary biliary cirrhosis}} | {{Primary biliary cirrhosis}} | ||
{{CMG}}; {{AE}} {{AA}} | {{CMG}}; {{AE}} {{Anmol}}, {{AA}} | ||
==Overview== | ==Overview== | ||
The diagnosis of | [[Anti-mitochondrial antibody]] (AMA) titer is the diagnostic study of choice for the diagnosis of primary biliary cirrhosis. The diagnosis of primary biliary cirrhosis is made in the absence of extrahepatic [[biliary obstruction]], no other comorbid condition affecting the [[liver]] with the presence of at least two of the criteria including an [[alkaline phosphatase]] 1.5 times the upper limit of normal, [[Anti-mitochondrial antibody|anti-mitochondrial antibodies]] with titer 1:40 or higher, and histology of liver demonstrating primary biliary cirrhosis. | ||
==Diagnostic Study of Choice== | |||
*[[Anti-mitochondrial antibody]] (AMA) titer is the diagnostic study of choice for the diagnosis of primary biliary cirrhosis.<ref name="pmid18456179">{{cite journal| author=Muratori L, Granito A, Muratori P, Pappas G, Bianchi FB| title=Antimitochondrial antibodies and other antibodies in primary biliary cirrhosis: diagnostic and prognostic value. | journal=Clin Liver Dis | year= 2008 | volume= 12 | issue= 2 | pages= 261-76; vii | pmid=18456179 | doi=10.1016/j.cld.2008.02.009 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18456179 }} </ref><ref name="pmid14263538">{{cite journal| author=WALKER JG, DONIACH D, ROITT IM, SHERLOCK S| title=SEROLOGICAL TESTS IN DIAGNOSIS OF PRIMARY BILIARY CIRRHOSIS. | journal=Lancet | year= 1965 | volume= 1 | issue= 7390 | pages= 827-31 | pmid=14263538 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=14263538 }} </ref> | |||
*A titer of > 1:40 is suggestive of primary biliary cirrhosis. | |||
{| | |||
|- style="background: #4479BA; color: #FFFFFF; text-align: center;" | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Test | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Sensitivity | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Specificity | |||
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! style="background: #696969; color: #FFFFFF; text-align: center;" |AMA titer | |||
| style="background: #DCDCDC; padding: 5px; text-align: center;" |95% | |||
| style="background: #DCDCDC; padding: 5px; text-align: center;" |98% | |||
|} | |||
==Diagnostic Criteria== | ==Diagnostic Criteria== | ||
The diagnosis of primary biliary cirrhosis is made in the absence of extrahepatic biliary obstruction, no other comorbid condition affecting the liver with the presence of at least two of the following:<ref name="pmid19554543">{{cite journal| author=Lindor KD, Gershwin ME, Poupon R, Kaplan M, Bergasa NV, Heathcote EJ et al.| title=Primary biliary cirrhosis. | journal=Hepatology | year= 2009 | volume= 50 | issue= 1 | pages= 291-308 | pmid=19554543 | doi=10.1002/hep.22906 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19554543 }} </ref> | The diagnosis of primary biliary cirrhosis is made in the absence of extrahepatic [[biliary obstruction]], no other comorbid condition affecting the [[liver]] with the presence of at least two of the following:<ref name="pmid19554543">{{cite journal| author=Lindor KD, Gershwin ME, Poupon R, Kaplan M, Bergasa NV, Heathcote EJ et al.| title=Primary biliary cirrhosis. | journal=Hepatology | year= 2009 | volume= 50 | issue= 1 | pages= 291-308 | pmid=19554543 | doi=10.1002/hep.22906 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19554543 }} </ref> | ||
*An alkaline phosphatase 1.5 times the upper limit of normal | *An [[alkaline phosphatase]] 1.5 times the upper limit of normal | ||
*Anti-mitochondrial antibodies with titer 1:40 or higher | *[[Anti-mitochondrial antibody|Anti-mitochondrial antibodies]] with titer 1:40 or higher | ||
*Histology of liver demonstrating primary biliary cirrhosis | *Histology of liver demonstrating primary biliary cirrhosis | ||
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<small>'''ABBREVIATIONS: AIH - | <small>'''ABBREVIATIONS: AIH - Autoimmune hepatitis; ALP; Alkaline phosphatase; AMA - Antimitochondrial antibody; CT - Computed tomography; GGT - Gamma-glutamyl transpeptidase; IHBD - Intrahepatic bile duct; MRCP - Magnetic resonance cholangiopancreatography; MRI - Magnetic resonance imaging; PBC - Primary biliary cirrhosis; PSC - Primary sclerosing cholangitis; SSC - Secondary sclerosing cholangitis; VBDS - Vanishing bile duct syndrome'''</small> | ||
==References== | ==References== | ||
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{{WS}} | {{WS}} | ||
[[Category:Gastroenterology]] | |||
[[Category:Hepatology]] | |||
[[Category:Disease]] | |||
[[Category:Rheumatology]] | |||
[[Category:Medicine]] | |||
[[Category:Up-To-Date]] | |||
Latest revision as of 23:49, 29 July 2020
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Primary Biliary Cirrhosis Microchapters |
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Differentiating Primary Biliary Cirrhosis from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Anmol Pitliya, M.B.B.S. M.D.[2], Aysha Anwar, M.B.B.S[3]
Overview
Anti-mitochondrial antibody (AMA) titer is the diagnostic study of choice for the diagnosis of primary biliary cirrhosis. The diagnosis of primary biliary cirrhosis is made in the absence of extrahepatic biliary obstruction, no other comorbid condition affecting the liver with the presence of at least two of the criteria including an alkaline phosphatase 1.5 times the upper limit of normal, anti-mitochondrial antibodies with titer 1:40 or higher, and histology of liver demonstrating primary biliary cirrhosis.
Diagnostic Study of Choice
- Anti-mitochondrial antibody (AMA) titer is the diagnostic study of choice for the diagnosis of primary biliary cirrhosis.[1][2]
- A titer of > 1:40 is suggestive of primary biliary cirrhosis.
| Test | Sensitivity | Specificity |
|---|---|---|
| AMA titer | 95% | 98% |
Diagnostic Criteria
The diagnosis of primary biliary cirrhosis is made in the absence of extrahepatic biliary obstruction, no other comorbid condition affecting the liver with the presence of at least two of the following:[3]
- An alkaline phosphatase 1.5 times the upper limit of normal
- Anti-mitochondrial antibodies with titer 1:40 or higher
- Histology of liver demonstrating primary biliary cirrhosis
Diagnostic Algorithm
Algorithm showing Diagnostic approach for primary biliary cirrhosis[4]
| Abnormal ALP | |||||||||||||||||||||||||||||||||||||||||
| Confirm if the ALP is of liver origin | |||||||||||||||||||||||||||||||||||||||||
| Abnormal GGT and/or total bilirubin and/or total cholesterol | |||||||||||||||||||||||||||||||||||||||||
| Drug history | |||||||||||||||||||||||||||||||||||||||||
| Yes | No | ||||||||||||||||||||||||||||||||||||||||
| Discontiue drug and observe | Ultrasound | ||||||||||||||||||||||||||||||||||||||||
| Normal bile ducts | Dilated bile duct(s) | Pattern suggestive of infiltration | |||||||||||||||||||||||||||||||||||||||
| AMA postitve | AMA negative | Focal lesions | Biopsy* | ||||||||||||||||||||||||||||||||||||||
| Probable PBC | No | Yes | |||||||||||||||||||||||||||||||||||||||
| Confirmation of disease and histological stage | CT and/or MRI | ||||||||||||||||||||||||||||||||||||||||
| Biopsy | IHBD stone | Liver neoplasm | |||||||||||||||||||||||||||||||||||||||
| Ocassional AIH | Definite PBC | MRCP | Biopsy | ||||||||||||||||||||||||||||||||||||||
| Normal | Strictures | ||||||||||||||||||||||||||||||||||||||||
| Biopsy | PSC SSC | ||||||||||||||||||||||||||||||||||||||||
| PBC | Cholestasis Small duct PSC VBDS | *Infiltration into liver e.g.: Malignant lymphoma | |||||||||||||||||||||||||||||||||||||||
ABBREVIATIONS: AIH - Autoimmune hepatitis; ALP; Alkaline phosphatase; AMA - Antimitochondrial antibody; CT - Computed tomography; GGT - Gamma-glutamyl transpeptidase; IHBD - Intrahepatic bile duct; MRCP - Magnetic resonance cholangiopancreatography; MRI - Magnetic resonance imaging; PBC - Primary biliary cirrhosis; PSC - Primary sclerosing cholangitis; SSC - Secondary sclerosing cholangitis; VBDS - Vanishing bile duct syndrome
References
- ↑ Muratori L, Granito A, Muratori P, Pappas G, Bianchi FB (2008). "Antimitochondrial antibodies and other antibodies in primary biliary cirrhosis: diagnostic and prognostic value". Clin Liver Dis. 12 (2): 261–76, vii. doi:10.1016/j.cld.2008.02.009. PMID 18456179.
- ↑ WALKER JG, DONIACH D, ROITT IM, SHERLOCK S (1965). "SEROLOGICAL TESTS IN DIAGNOSIS OF PRIMARY BILIARY CIRRHOSIS". Lancet. 1 (7390): 827–31. PMID 14263538.
- ↑ Lindor KD, Gershwin ME, Poupon R, Kaplan M, Bergasa NV, Heathcote EJ; et al. (2009). "Primary biliary cirrhosis". Hepatology. 50 (1): 291–308. doi:10.1002/hep.22906. PMID 19554543.
- ↑ Kumagi T, Heathcote EJ (2008). "Primary biliary cirrhosis". Orphanet J Rare Dis. 3: 1. doi:10.1186/1750-1172-3-1. PMC 2266722. PMID 18215315.