Lung cancer causes: Difference between revisions
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==Overview== | ==Overview== | ||
The direct cause of lung | The direct cause of lung cancer is [[DNA mutations]] that often result in either activation of [[Proto-oncogene|proto-oncogenes]] (e.g. '''[[KRAS|K-RAS]]''') or the inactivation of [[Tumor suppressor gene|tumors suppressor genes]] (e.g. '''[[TP53]]''') or both. The risk of these [[genetic mutations]] may be increased following exposure to environmental insults. | ||
==Causes== | ==Causes== | ||
*The direct cause of lung | *The direct cause of lung cancer is [[DNA mutations]] that often result in either activation of [[Proto-oncogene|proto-oncogenes]] (e.g. '''[[KRAS|K-RAS]]''') or the inactivation of [[Tumor suppressor gene|tumors suppressor genes]] (e.g. '''[[TP53]]''') or both.<ref>American Cancer Society. Cancer Facts & Figures 2017. | ||
Atlanta: American Cancer Society; 2017.<ref/> | Atlanta: American Cancer Society; 2017.</ref><ref name="pmid23122493">{{cite journal |vauthors=Karachaliou N, Mayo C, Costa C, Magrí I, Gimenez-Capitan A, Molina-Vila MA, Rosell R |title=KRAS mutations in lung cancer |journal=Clin Lung Cancer |volume=14 |issue=3 |pages=205–14 |year=2013 |pmid=23122493 |doi=10.1016/j.cllc.2012.09.007 |url=}}</ref> | ||
*The risk of these | *The risk of these [[genetic mutations]] may be increased following exposure to environmental insults, which are regarded as [[Risk factor|risk factors]] that [[Predisposition|predispose]] to the development of lung cancer. | ||
*To view a comprehensive list of risk factors that increase the risk of lung cancer, click [[Lung cancer risk factors|'''here''']] | *To view a comprehensive list of [[Risk factor|risk factors]] that increase the risk of lung cancer, click [[Lung cancer risk factors|'''here''']]. | ||
==References== | ==References== | ||
Latest revision as of 13:47, 3 July 2019
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Lung cancer causes On the Web |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Kim-Son H. Nguyen M.D. Cafer Zorkun, M.D., Ph.D. [2] Dildar Hussain, MBBS [3]
Overview
The direct cause of lung cancer is DNA mutations that often result in either activation of proto-oncogenes (e.g. K-RAS) or the inactivation of tumors suppressor genes (e.g. TP53) or both. The risk of these genetic mutations may be increased following exposure to environmental insults.
Causes
- The direct cause of lung cancer is DNA mutations that often result in either activation of proto-oncogenes (e.g. K-RAS) or the inactivation of tumors suppressor genes (e.g. TP53) or both.[1][2]
- The risk of these genetic mutations may be increased following exposure to environmental insults, which are regarded as risk factors that predispose to the development of lung cancer.
- To view a comprehensive list of risk factors that increase the risk of lung cancer, click here.
References
- ↑ American Cancer Society. Cancer Facts & Figures 2017. Atlanta: American Cancer Society; 2017.
- ↑ Karachaliou N, Mayo C, Costa C, Magrí I, Gimenez-Capitan A, Molina-Vila MA, Rosell R (2013). "KRAS mutations in lung cancer". Clin Lung Cancer. 14 (3): 205–14. doi:10.1016/j.cllc.2012.09.007. PMID 23122493.