Pancoast tumor history and symptoms: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Pancoast tumor}} | {{Pancoast tumor}} | ||
{{CMG}} | {{CMG}}; {{AE}} {{Mazia}} | ||
==Overview== | ==Overview== | ||
The hallmark of Pancoast tumor is [[lung cancer]] located in the [[apex]] of the [[lung]]. A positive [[History and Physical examination|history]] of [[shoulder pain]] and [[atrophy]] of [[hand]] [[musculature]], [[Horner's syndrome]] and [[forearm]] [[edema]] is suggestive of Pancoast Syndrome. The most common [[symptoms]] of Pancoast tumor include [[cough]], [[hemoptysis]], [[dyspnea]], [[chest pain]], [[lack of appetite]], [[weight loss]], [[fatigue]]. Symptoms of [[Pancoast's syndrome]] resulting from Pancoast tumor include [[shoulder pain]] along the [[vertebral border of the scapula]], [[Horner's syndrome]], and [[Muscle weakness|weakness]] of [[hand]] [[muscles]]. Less common [[symptoms]] of [[Pancoast's syndrome]] include [[paraplegia]]. | |||
==History== | ==History== | ||
*The hallmark of Pancoast tumor is lung cancer located in the apex of the lung. A positive history of shoulder pain and atrophy of hand musculature, Horner's syndrome and forearm edema is suggestive of Pancoast | *The [[hallmark]] of Pancoast tumor is [[lung cancer]] located in the [[apex]] of the [[lung]]. A positive history of [[shoulder pain]] and [[atrophy]] of [[hand]] [[musculature]], [[Horner's syndrome]] and [[forearm]] [[edema]] is suggestive of [[Pancoast's syndrome]].<ref name="pmid10813231">{{cite journal |vauthors=Jones DR, Detterbeck FC |title=Pancoast tumors of the lung |journal=Curr Opin Pulm Med |volume=4 |issue=4 |pages=191–7 |date=July 1998 |pmid=10813231 |doi= |url= |author=}}</ref><ref name="pmid9205202">{{cite journal |vauthors=Detterbeck FC |title=Pancoast (superior sulcus) tumors |journal=Ann. Thorac. Surg. |volume=63 |issue=6 |pages=1810–8 |date=June 1997 |pmid=9205202 |doi= |url=}}</ref> | ||
==Symptoms== | ==Symptoms== | ||
*The most common symptoms of Pancoast tumor include: | *The most common [[symptoms]] of Pancoast tumor include:<ref name="pmid10813231">{{cite journal |vauthors=Jones DR, Detterbeck FC |title=Pancoast tumors of the lung |journal=Curr Opin Pulm Med |volume=4 |issue=4 |pages=191–7 |date=July 1998 |pmid=10813231 |doi= |url= |author=}}</ref><ref name="pmid9205202">{{cite journal |vauthors=Detterbeck FC |title=Pancoast (superior sulcus) tumors |journal=Ann. Thorac. Surg. |volume=63 |issue=6 |pages=1810–8 |date=June 1997 |pmid=9205202 |doi= |url=}}</ref><ref name="pmid9692463">{{cite journal |vauthors=Attar S, Krasna MJ, Sonett JR, Hankins JR, Slawson RG, Suter CM, McLaughlin JS |title=Superior sulcus (Pancoast) tumor: experience with 105 patients |journal=Ann. Thorac. Surg. |volume=66 |issue=1 |pages=193–8 |date=July 1998 |pmid=9692463 |doi= |url=}}</ref><ref name="pmid9358132">{{cite journal |vauthors=Arcasoy SM, Jett JR |title=Superior pulmonary sulcus tumors and Pancoast's syndrome |journal=N. Engl. J. Med. |volume=337 |issue=19 |pages=1370–6 |date=November 1997 |pmid=9358132 |doi=10.1056/NEJM199711063371907 |url=}}</ref><ref name="pmid9093348">{{cite journal |vauthors=Muscolino G, Valente M, Andreani S |title=Pancoast tumours: clinical assessment and long-term results of combined radiosurgical treatment |journal=Thorax |volume=52 |issue=3 |pages=284–6 |date=March 1997 |pmid=9093348 |pmc=1758512 |doi= |url=}}</ref> | ||
**Cough | **[[Cough]] | ||
**Hemoptysis | **[[Hemoptysis]] | ||
**Dyspnea | **[[Dyspnea]] | ||
**Chest pain | **[[Chest pain]] | ||
**Lack of appetite | **[[Lack of appetite]] | ||
**Weight loss | **[[Weight loss]] | ||
**Fatigue | **[[Fatigue]] | ||
*Symptoms of Pancoast | *[[Symptoms]] of [[Pancoast's syndrome]] resulting from Pancoast tumor include: | ||
**Shoulder pain along the vertebral border of scapula | **[[Shoulder pain]] along the [[Scapula|vertebral border of scapula]] | ||
**Horner's syndrome | **[[Horner's syndrome]] | ||
**Weakness of hand muscles | **[[Weakness]] of [[hand]] [[muscles]] | ||
*Less common symptoms of Pancoast syndrome include | *Less common [[symptoms]] of [[Pancoast's syndrome]] include: | ||
*Paraplegia | **[[Paraplegia]] | ||
'''Paraneoplastic Syndromes''' | |||
* Various [[Paraneoplastic phenomenon|paraneoplastic phenomena]] can arise in the setting of [[lung cancer]]:<ref name="Honnorat">{{cite journal | last =Honnorat | first = J | coauthors = Antoine JC | title = Paraneoplastic neurological syndromes | journal = Orphanet Journal of Rare Diseases | volume =2 | pages =22 | publisher = BioMed Central Ltd. | date = May 2007 | url=http://www.ojrd.com/content/2/1/22 | pmid =17480225 | doi=10.1186/1750-1172-2-22 | accessdate =2007-09-05 }}</ref><ref name="pmid10888708">{{cite journal| author=Kubo M, Ihn H, Yamane K, Kikuchi K, Yazawa N, Soma Y et al.| title=Serum KL-6 in adult patients with polymyositis and dermatomyositis. | journal=Rheumatology (Oxford) | year= 2000 | volume= 39 | issue= 6 | pages= 632-6 | pmid=10888708 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10888708 }} </ref> | |||
:* [[Endocrine]] | |||
::* [[SIADH]] causing [[hyponatraemia]]: [[Small cell lung cancer]] | |||
::* [[ACTH]] [[secretion]] ([[Cushing syndrome]]): [[Carcinoid tumor]] and [[small cell lung cancer]] | |||
::* Parathyroid Hormone-Related Peptide (PTHrP) causing [[hypercalcaemia]]: [[Squamous cell carcinoma of the lung]] | |||
::* [[Carcinoid syndrome]] | |||
::* [[Gynaecomastia]] | |||
:* [[Neurological]] | |||
::* [[Polyneuropathy]] | |||
::* [[Myelopathy]] | |||
::* [[Cerebellar]] [[degeneration]] | |||
::* [[Lambert-Eaton myasthenic syndrome]] | |||
:* Other | |||
::* [[Finger]] [[clubbing]] | |||
::* [[Hypertrophic pulmonary osteoarthropathy]] (HPOA): [[Squamous cell carcinoma of the lung]] | |||
::* [[Nephrotic syndrome]] | |||
::* [[Polymyositis]] | |||
::* [[Dermatomyositis]] | |||
::* [[Eosinophilia]] | |||
::* [[Acanthosis nigricans]] | |||
::* [[Thrombophlebitis]]: [[Adenocarcinoma of the lung]] | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
Latest revision as of 18:25, 15 March 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mazia Fatima, MBBS [2]
Overview
The hallmark of Pancoast tumor is lung cancer located in the apex of the lung. A positive history of shoulder pain and atrophy of hand musculature, Horner's syndrome and forearm edema is suggestive of Pancoast Syndrome. The most common symptoms of Pancoast tumor include cough, hemoptysis, dyspnea, chest pain, lack of appetite, weight loss, fatigue. Symptoms of Pancoast's syndrome resulting from Pancoast tumor include shoulder pain along the vertebral border of the scapula, Horner's syndrome, and weakness of hand muscles. Less common symptoms of Pancoast's syndrome include paraplegia.
History
- The hallmark of Pancoast tumor is lung cancer located in the apex of the lung. A positive history of shoulder pain and atrophy of hand musculature, Horner's syndrome and forearm edema is suggestive of Pancoast's syndrome.[1][2]
Symptoms
- The most common symptoms of Pancoast tumor include:[1][2][3][4][5]
- Symptoms of Pancoast's syndrome resulting from Pancoast tumor include:
- Less common symptoms of Pancoast's syndrome include:
Paraneoplastic Syndromes
- Various paraneoplastic phenomena can arise in the setting of lung cancer:[6][7]
-
- SIADH causing hyponatraemia: Small cell lung cancer
- ACTH secretion (Cushing syndrome): Carcinoid tumor and small cell lung cancer
- Parathyroid Hormone-Related Peptide (PTHrP) causing hypercalcaemia: Squamous cell carcinoma of the lung
- Carcinoid syndrome
- Gynaecomastia
- Other
References
- ↑ 1.0 1.1 Jones DR, Detterbeck FC (July 1998). "Pancoast tumors of the lung". Curr Opin Pulm Med. 4 (4): 191–7. PMID 10813231.
- ↑ 2.0 2.1 Detterbeck FC (June 1997). "Pancoast (superior sulcus) tumors". Ann. Thorac. Surg. 63 (6): 1810–8. PMID 9205202.
- ↑ Attar S, Krasna MJ, Sonett JR, Hankins JR, Slawson RG, Suter CM, McLaughlin JS (July 1998). "Superior sulcus (Pancoast) tumor: experience with 105 patients". Ann. Thorac. Surg. 66 (1): 193–8. PMID 9692463.
- ↑ Arcasoy SM, Jett JR (November 1997). "Superior pulmonary sulcus tumors and Pancoast's syndrome". N. Engl. J. Med. 337 (19): 1370–6. doi:10.1056/NEJM199711063371907. PMID 9358132.
- ↑ Muscolino G, Valente M, Andreani S (March 1997). "Pancoast tumours: clinical assessment and long-term results of combined radiosurgical treatment". Thorax. 52 (3): 284–6. PMC 1758512. PMID 9093348.
- ↑ Honnorat, J (May 2007). "Paraneoplastic neurological syndromes". Orphanet Journal of Rare Diseases. BioMed Central Ltd. 2: 22. doi:10.1186/1750-1172-2-22. PMID 17480225. Retrieved 2007-09-05. Unknown parameter
|coauthors=ignored (help) - ↑ Kubo M, Ihn H, Yamane K, Kikuchi K, Yazawa N, Soma Y; et al. (2000). "Serum KL-6 in adult patients with polymyositis and dermatomyositis". Rheumatology (Oxford). 39 (6): 632–6. PMID 10888708.