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{{Ankylosing spondylitis}}
{{Ankylosing spondylitis}}
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==Overview==
==Overview==
Ankylosing spondylitis is a form of arthritis which is progressive and painful .In ankylosing spondylitis some or all of the joints and bones of the spine fuse together and causes pain and restriction of the movement of the spine.The spinal involvement is more extensive in ankylosing spondylitis (AS) Ankylosing spondylitis symptoms can range from back pain and stiffness and in long term it can lead to disability.Although cause of ankylosing spondylitis is unknown but mostly it is associated with genetic marker called HLA-B27.
[[Ankylosing spondylitis]] is a form of [[arthritis]] which is progressive and [[Pain|painful]] .In [[ankylosing spondylitis]] some or all of the [[Joint|joints]] and [[bones]] of the [[spine]] fuse together and causes pain and restriction of the movement of the [[spine]].The spinal involvement is more extensive in [[ankylosing spondylitis]] (AS).[[Ankylosing spondylitis]] symptoms can range from [[back pain]] and [[stiffness]] and in long term it can lead to [[disability]].Although cause of [[ankylosing spondylitis]] is unknown but mostly it is associated with [[Genetics|genetic]] marker called [[HLA-B27]].


==History and Symptoms==
==History and Symptoms==
* Symptoms of ankylosing spondylitis include chronic dull pain in the lower back, stiffness of the lower back, decreased mobility of the spine and chest expansion.
Symptoms of [[ankylosing spondylitis]] include [[chronic]] dull pain in the lower back, [[Arthritis|stiffness]] of the lower back, decreased [[mobility]] of the [[spine]] and [[chest]] expansion.


=== History ===
=== History ===
Patients with ankylosing spondylitis may have a positive history of
Patients with [[ankylosing spondylitis]] may have a positive history of:<ref name="pmid150512162">{{cite journal |vauthors=Monnet D, Breban M, Hudry C, Dougados M, Brézin AP |title=Ophthalmic findings and frequency of extraocular manifestations in patients with HLA-B27 uveitis: a study of 175 cases |journal=Ophthalmology |volume=111 |issue=4 |pages=802–9 |date=April 2004 |pmid=15051216 |doi=10.1016/j.ophtha.2003.07.011 |url=}}</ref><ref name="pmid9255111">{{cite journal |vauthors=Gran JT, Skomsvoll JF |title=The outcome of ankylosing spondylitis: a study of 100 patients |journal=Br. J. Rheumatol. |volume=36 |issue=7 |pages=766–71 |date=July 1997 |pmid=9255111 |doi= |url=}}</ref><ref name="pmid12412210">{{cite journal |vauthors=Burgos-Vargas R, Pacheco-Tena C, Vázquez-Mellado J |title=A short-term follow-up of enthesitis and arthritis in the active phase of juvenile onset spondyloarthropathies |journal=Clin. Exp. Rheumatol. |volume=20 |issue=5 |pages=727–31 |date=2002 |pmid=12412210 |doi= |url=}}</ref><ref name="pmid7837155">{{cite journal |vauthors=Amor B, Santos RS, Nahal R, Listrat V, Dougados M |title=Predictive factors for the longterm outcome of spondyloarthropathies |journal=J. Rheumatol. |volume=21 |issue=10 |pages=1883–7 |date=October 1994 |pmid=7837155 |doi= |url=}}</ref><ref name="pmid3708234">{{cite journal |vauthors=Wordsworth BP, Mowat AG |title=A review of 100 patients with ankylosing spondylitis with particular reference to socio-economic effects |journal=Br. J. Rheumatol. |volume=25 |issue=2 |pages=175–80 |date=May 1986 |pmid=3708234 |doi= |url=}}</ref>
* Inflammatory back pain due to
* [[Inflammation|Inflammatory]] back [[pain]] due to:
** Sacroiliitis  
** [[Sacroiliitis]]
** Axial arthritis of the spine
** [[Axial]] [[arthritis]] of the [[spine]]
* Peripheral arthritis.
* Peripheral [[arthritis]]
* Enthesitis.
* [[Enthesitis]]
* Anterior uveitis.
* [[Anterior uveitis]]
* Referred pain to one or the other buttock or to the back of the thigh from the sacroiliac joint.
 
* Hip pain upon waking especially in the morning.
==== Common Symptoms ====
* Back pain relieved by movement.
Common symptoms of [[ankylosing spondylitis]] include:
* Difficulty flexing the spine due to fusion of the spine.
* [[Referred pain]] to one or the other [[buttock]] or to the back of the [[thigh]] from the [[sacroiliac joint]]
* Difficulty taking a deep breath due to decreased chest expansion.
 
* Swelling of knees.
* [[Hip (anatomy)|Hip]] pain upon waking especially in the morning
* [[Back pain]] relieved by movement
* Difficulty [[Flexion|flexing]] the [[spine]] due to fusion of the spine
* Difficulty taking a deep [[breath]] due to decreased [[chest expansion]]
* [[Swelling]] of [[Knee|knees]]
 
=== Less Common Symptoms ===
Less common symptoms of ankylosing spondylitis include:
* [[Redness]]
* [[Floaters]]
* [[Sensitivity]] to light
* [[Inflammation]] of the [[prostate]]


==References==
==References==

Latest revision as of 03:10, 30 July 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Manpreet Kaur, MD [2]

Overview

Ankylosing spondylitis is a form of arthritis which is progressive and painful .In ankylosing spondylitis some or all of the joints and bones of the spine fuse together and causes pain and restriction of the movement of the spine.The spinal involvement is more extensive in ankylosing spondylitis (AS).Ankylosing spondylitis symptoms can range from back pain and stiffness and in long term it can lead to disability.Although cause of ankylosing spondylitis is unknown but mostly it is associated with genetic marker called HLA-B27.

History and Symptoms

Symptoms of ankylosing spondylitis include chronic dull pain in the lower back, stiffness of the lower back, decreased mobility of the spine and chest expansion.

History

Patients with ankylosing spondylitis may have a positive history of:[1][2][3][4][5]

Common Symptoms

Common symptoms of ankylosing spondylitis include:

Less Common Symptoms

Less common symptoms of ankylosing spondylitis include:

References

  1. Monnet D, Breban M, Hudry C, Dougados M, Brézin AP (April 2004). "Ophthalmic findings and frequency of extraocular manifestations in patients with HLA-B27 uveitis: a study of 175 cases". Ophthalmology. 111 (4): 802–9. doi:10.1016/j.ophtha.2003.07.011. PMID 15051216.
  2. Gran JT, Skomsvoll JF (July 1997). "The outcome of ankylosing spondylitis: a study of 100 patients". Br. J. Rheumatol. 36 (7): 766–71. PMID 9255111.
  3. Burgos-Vargas R, Pacheco-Tena C, Vázquez-Mellado J (2002). "A short-term follow-up of enthesitis and arthritis in the active phase of juvenile onset spondyloarthropathies". Clin. Exp. Rheumatol. 20 (5): 727–31. PMID 12412210.
  4. Amor B, Santos RS, Nahal R, Listrat V, Dougados M (October 1994). "Predictive factors for the longterm outcome of spondyloarthropathies". J. Rheumatol. 21 (10): 1883–7. PMID 7837155.
  5. Wordsworth BP, Mowat AG (May 1986). "A review of 100 patients with ankylosing spondylitis with particular reference to socio-economic effects". Br. J. Rheumatol. 25 (2): 175–80. PMID 3708234.

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