Ankylosing spondylitis epidemiology and demographics: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Ankylosing spondylitis}} | {{Ankylosing spondylitis}} | ||
{{CMG}} {{AE}} {{ | {{CMG}} {{AE}} {{MKK}} | ||
==Overview== | ==Overview== | ||
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=== '''Prevalence''' === | === '''Prevalence''' === | ||
* The prevalence of ankylosing spondylitis is approximately 7-490 per 100,000 individuals worldwide.<ref name="pmid23841117">{{cite journal |vauthors=Reveille JD, Weisman MH |title=The epidemiology of back pain, axial spondyloarthritis and HLA-B27 in the United States |journal=Am. J. Med. Sci. |volume=345 |issue=6 |pages=431–6 |date=June 2013 |pmid=23841117 |pmc=4122314 |doi= |url=}}</ref><ref name="BaklandNossent20052">{{cite journal|last1=Bakland|first1=Gunnstein|last2=Nossent|first2=Hans C.|last3=Gran|first3=Jan T.|title=Incidence and prevalence of ankylosing spondylitis in Northern Norway|journal=Arthritis & Rheumatism|volume=53|issue=6|year=2005|pages=850–855|issn=0004-3591|doi=10.1002/art.21577}}</ref> | * The [[prevalence]] of [[ankylosing spondylitis]] is approximately 7-490 per 100,000 individuals worldwide.<ref name="pmid23841117">{{cite journal |vauthors=Reveille JD, Weisman MH |title=The epidemiology of back pain, axial spondyloarthritis and HLA-B27 in the United States |journal=Am. J. Med. Sci. |volume=345 |issue=6 |pages=431–6 |date=June 2013 |pmid=23841117 |pmc=4122314 |doi= |url=}}</ref><ref name="BaklandNossent20052">{{cite journal|last1=Bakland|first1=Gunnstein|last2=Nossent|first2=Hans C.|last3=Gran|first3=Jan T.|title=Incidence and prevalence of ankylosing spondylitis in Northern Norway|journal=Arthritis & Rheumatism|volume=53|issue=6|year=2005|pages=850–855|issn=0004-3591|doi=10.1002/art.21577}}</ref> | ||
* In the year 2009, according to National Health and Nutrition Examination Survey (NHANES) the incidence of ankylosing spondylitis was estimated to be 6.1% cases per 100,000 individuals worldwide. | * In the year 2009, according to National Health and Nutrition Examination Survey ([[Third National Health And Nutrition Examination Survey|NHANES]]) the incidence of ankylosing spondylitis was estimated to be 6.1% cases per 100,000 individuals worldwide. | ||
=== Incidence<ref name="pmid18290744">{{cite journal |vauthors=Mundwiler ML, Siddique K, Dym JM, Perri B, Johnson JP, Weisman MH |title=Complications of the spine in ankylosing spondylitis with a focus on deformity correction |journal=Neurosurg Focus |volume=24 |issue=1 |pages=E6 |date=2008 |pmid=18290744 |doi=10.3171/FOC/2008/24/1/E6 |url=}}</ref><ref name="BaklandNossent2005">{{cite journal|last1=Bakland|first1=Gunnstein|last2=Nossent|first2=Hans C.|last3=Gran|first3=Jan T.|title=Incidence and prevalence of ankylosing spondylitis in Northern Norway|journal=Arthritis & Rheumatism|volume=53|issue=6|year=2005|pages=850–855|issn=0004-3591|doi=10.1002/art.21577}}</ref><ref name="pmid15468363">{{cite journal |vauthors=Vosse D, Feldtkeller E, Erlendsson J, Geusens P, van der Linden S |title=Clinical vertebral fractures in patients with ankylosing spondylitis |journal=J. Rheumatol. |volume=31 |issue=10 |pages=1981–5 |date=October 2004 |pmid=15468363 |doi= |url=}}</ref> === | === Incidence<ref name="pmid18290744">{{cite journal |vauthors=Mundwiler ML, Siddique K, Dym JM, Perri B, Johnson JP, Weisman MH |title=Complications of the spine in ankylosing spondylitis with a focus on deformity correction |journal=Neurosurg Focus |volume=24 |issue=1 |pages=E6 |date=2008 |pmid=18290744 |doi=10.3171/FOC/2008/24/1/E6 |url=}}</ref><ref name="BaklandNossent2005">{{cite journal|last1=Bakland|first1=Gunnstein|last2=Nossent|first2=Hans C.|last3=Gran|first3=Jan T.|title=Incidence and prevalence of ankylosing spondylitis in Northern Norway|journal=Arthritis & Rheumatism|volume=53|issue=6|year=2005|pages=850–855|issn=0004-3591|doi=10.1002/art.21577}}</ref><ref name="pmid15468363">{{cite journal |vauthors=Vosse D, Feldtkeller E, Erlendsson J, Geusens P, van der Linden S |title=Clinical vertebral fractures in patients with ankylosing spondylitis |journal=J. Rheumatol. |volume=31 |issue=10 |pages=1981–5 |date=October 2004 |pmid=15468363 |doi= |url=}}</ref> === | ||
* The incidence of ankylosing spondylitis is approximately 7.26 per 100,000 persons in the adult population | * The [[incidence]] of [[ankylosing spondylitis]] is approximately 7.26 per 100,000 persons in the adult population. | ||
* The incidence of fractures in ankylosing spondylitis is approximately 4 to 18 percent . | * The [[incidence]] of fractures in [[ankylosing spondylitis]] is approximately 4 to 18 percent . | ||
* The incidence of ankylosing spondylitis is approximately 6–7 per 100,000 persons in caucasian populations. | * The incidence of ankylosing spondylitis is approximately 6–7 per 100,000 persons in caucasian populations. | ||
=== Mortality rate <ref name="pmid27437020">{{cite journal |vauthors=Oh JS, Doh JW, Shim JJ, Lee KS |title=Leading a Patient of Ankylosing Spondylitis to Death by Iatrogenic Spinal Fracture |journal=Korean J Spine |volume=13 |issue=2 |pages=80–2 |date=June 2016 |pmid=27437020 |pmc=4949174 |doi=10.14245/kjs.2016.13.2.80 |url=}}</ref><ref name="pmid21784726">{{cite journal |vauthors=Bakland G, Gran JT, Nossent JC |title=Increased mortality in ankylosing spondylitis is related to disease activity |journal=Ann. Rheum. Dis. |volume=70 |issue=11 |pages=1921–5 |date=November 2011 |pmid=21784726 |doi=10.1136/ard.2011.151191 |url=}}</ref> === | === Mortality rate <ref name="pmid27437020">{{cite journal |vauthors=Oh JS, Doh JW, Shim JJ, Lee KS |title=Leading a Patient of Ankylosing Spondylitis to Death by Iatrogenic Spinal Fracture |journal=Korean J Spine |volume=13 |issue=2 |pages=80–2 |date=June 2016 |pmid=27437020 |pmc=4949174 |doi=10.14245/kjs.2016.13.2.80 |url=}}</ref><ref name="pmid21784726">{{cite journal |vauthors=Bakland G, Gran JT, Nossent JC |title=Increased mortality in ankylosing spondylitis is related to disease activity |journal=Ann. Rheum. Dis. |volume=70 |issue=11 |pages=1921–5 |date=November 2011 |pmid=21784726 |doi=10.1136/ard.2011.151191 |url=}}</ref> === | ||
* The mortality rate of ankylosing spondylitis is approximately was 1.60 (95% CI 1.44-1.77). | * The [[mortality]] rate of [[ankylosing spondylitis]] is approximately was 1.60 (95% CI 1.44-1.77). | ||
* The mortality rate of ankylosing spondylitis increased mostly because of circulatory disease that associated with ankylosing spondylitis. | * The mortality rate of ankylosing spondylitis increased mostly because of [[circulatory]] disease that associated with [[ankylosing spondylitis]]. | ||
=== Age<ref name="PradeepKeat2008">{{cite journal|last1=Pradeep|first1=D. J.|last2=Keat|first2=A.|last3=Gaffney|first3=K.|title=Predicting outcome in ankylosing spondylitis|journal=Rheumatology|volume=47|issue=7|year=2008|pages=942–945|issn=1462-0324|doi=10.1093/rheumatology/ken195}}</ref><ref name="pmid22422491">{{cite journal |vauthors=Montilla C, Del Pino-Montes J, Collantes-Estevez E, Font P, Zarco P, Mulero J, Gratacós J, Rodríguez C, Juanola X, Fernández-Sueiro JL, Almodovar R |title=Clinical features of late-onset ankylosing spondylitis: comparison with early-onset disease |journal=J. Rheumatol. |volume=39 |issue=5 |pages=1008–12 |date=May 2012 |pmid=22422491 |doi=10.3899/jrheum.111082 |url=}}</ref> === | === Age<ref name="PradeepKeat2008">{{cite journal|last1=Pradeep|first1=D. J.|last2=Keat|first2=A.|last3=Gaffney|first3=K.|title=Predicting outcome in ankylosing spondylitis|journal=Rheumatology|volume=47|issue=7|year=2008|pages=942–945|issn=1462-0324|doi=10.1093/rheumatology/ken195}}</ref><ref name="pmid22422491">{{cite journal |vauthors=Montilla C, Del Pino-Montes J, Collantes-Estevez E, Font P, Zarco P, Mulero J, Gratacós J, Rodríguez C, Juanola X, Fernández-Sueiro JL, Almodovar R |title=Clinical features of late-onset ankylosing spondylitis: comparison with early-onset disease |journal=J. Rheumatol. |volume=39 |issue=5 |pages=1008–12 |date=May 2012 |pmid=22422491 |doi=10.3899/jrheum.111082 |url=}}</ref> === | ||
* The incidence of ankylosing spondylitis increases with age; the median age at diagnosis is second and third decades of life years. | * The incidence of [[ankylosing spondylitis]] increases with [[age]]; the median age at [[diagnosis]] is second and third decades of life years. | ||
* Mostly 80% of the patients with ankylosing spondylitis(AS) experience symptoms at ≤ 30 years of age, But only 5% will present with symptoms at ≥ 45 years of age. | * Mostly 80% of the patients with [[ankylosing spondylitis]](AS) experience symptoms at ≤ 30 years of age, But only 5% will present with [[Symptom|symptoms]] at ≥ 45 years of age. | ||
=== Race<ref name="pmid21430444">{{cite journal |vauthors=Reveille JD |title=Epidemiology of spondyloarthritis in North America |journal=Am. J. Med. Sci. |volume=341 |issue=4 |pages=284–6 |date=April 2011 |pmid=21430444 |pmc=3063892 |doi=10.1097/MAJ.0b013e31820f8c99 |url=}}</ref> === | === Race<ref name="pmid21430444">{{cite journal |vauthors=Reveille JD |title=Epidemiology of spondyloarthritis in North America |journal=Am. J. Med. Sci. |volume=341 |issue=4 |pages=284–6 |date=April 2011 |pmid=21430444 |pmc=3063892 |doi=10.1097/MAJ.0b013e31820f8c99 |url=}}</ref> === | ||
* Ankylosing spondylitis(AS) usually affects individuals of the North America race. Japan individuals are less likely to develop ankylosing spondylitis(AS). | * [[Ankylosing spondylitis]](AS) usually affects individuals of the North America [[race]]. Japan individuals are less likely to develop ankylosing spondylitis(AS). | ||
=== Gender<ref name="PradeepKeat20082">{{cite journal|last1=Pradeep|first1=D. J.|last2=Keat|first2=A.|last3=Gaffney|first3=K.|title=Predicting outcome in ankylosing spondylitis|journal=Rheumatology|volume=47|issue=7|year=2008|pages=942–945|issn=1462-0324|doi=10.1093/rheumatology/ken195}}</ref> === | === Gender<ref name="PradeepKeat20082">{{cite journal|last1=Pradeep|first1=D. J.|last2=Keat|first2=A.|last3=Gaffney|first3=K.|title=Predicting outcome in ankylosing spondylitis|journal=Rheumatology|volume=47|issue=7|year=2008|pages=942–945|issn=1462-0324|doi=10.1093/rheumatology/ken195}}</ref> === | ||
* Men are more commonly affected by Ankylosing spondylitis(AS) than women. The men to women ratio is approximately 2:1. | * Men are more commonly affected by [[Ankylosing spondylitis]](AS) than women. The men to women ratio is approximately 2:1. | ||
==References== | ==References== | ||
Latest revision as of 03:07, 30 July 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Manpreet Kaur, MD [2]
Overview
The prevalence of axial spondyloarthritis (axSpA) or ankylosing spondylitis in a population depends upon the following 1)Ethnic groups 2) Selection of subjects for evaluation and 3) The criteria for diagnosis.It shows a clear evidence that correlation between the prevalence of ankylosing spondylitis (AS)/axial spondyloarthritis (axSpA) in a given population and the prevalence of human leukocyte antigen HLA-B27 exits.
Epidemiology and Demographics
Prevalence
- The prevalence of ankylosing spondylitis is approximately 7-490 per 100,000 individuals worldwide.[1][2]
- In the year 2009, according to National Health and Nutrition Examination Survey (NHANES) the incidence of ankylosing spondylitis was estimated to be 6.1% cases per 100,000 individuals worldwide.
Incidence[3][4][5]
- The incidence of ankylosing spondylitis is approximately 7.26 per 100,000 persons in the adult population.
- The incidence of fractures in ankylosing spondylitis is approximately 4 to 18 percent .
- The incidence of ankylosing spondylitis is approximately 6–7 per 100,000 persons in caucasian populations.
Mortality rate [6][7]
- The mortality rate of ankylosing spondylitis is approximately was 1.60 (95% CI 1.44-1.77).
- The mortality rate of ankylosing spondylitis increased mostly because of circulatory disease that associated with ankylosing spondylitis.
Age[8][9]
- The incidence of ankylosing spondylitis increases with age; the median age at diagnosis is second and third decades of life years.
- Mostly 80% of the patients with ankylosing spondylitis(AS) experience symptoms at ≤ 30 years of age, But only 5% will present with symptoms at ≥ 45 years of age.
Race[10]
- Ankylosing spondylitis(AS) usually affects individuals of the North America race. Japan individuals are less likely to develop ankylosing spondylitis(AS).
Gender[11]
- Men are more commonly affected by Ankylosing spondylitis(AS) than women. The men to women ratio is approximately 2:1.
References
- ↑ Reveille JD, Weisman MH (June 2013). "The epidemiology of back pain, axial spondyloarthritis and HLA-B27 in the United States". Am. J. Med. Sci. 345 (6): 431–6. PMC 4122314. PMID 23841117.
- ↑ Bakland, Gunnstein; Nossent, Hans C.; Gran, Jan T. (2005). "Incidence and prevalence of ankylosing spondylitis in Northern Norway". Arthritis & Rheumatism. 53 (6): 850–855. doi:10.1002/art.21577. ISSN 0004-3591.
- ↑ Mundwiler ML, Siddique K, Dym JM, Perri B, Johnson JP, Weisman MH (2008). "Complications of the spine in ankylosing spondylitis with a focus on deformity correction". Neurosurg Focus. 24 (1): E6. doi:10.3171/FOC/2008/24/1/E6. PMID 18290744.
- ↑ Bakland, Gunnstein; Nossent, Hans C.; Gran, Jan T. (2005). "Incidence and prevalence of ankylosing spondylitis in Northern Norway". Arthritis & Rheumatism. 53 (6): 850–855. doi:10.1002/art.21577. ISSN 0004-3591.
- ↑ Vosse D, Feldtkeller E, Erlendsson J, Geusens P, van der Linden S (October 2004). "Clinical vertebral fractures in patients with ankylosing spondylitis". J. Rheumatol. 31 (10): 1981–5. PMID 15468363.
- ↑ Oh JS, Doh JW, Shim JJ, Lee KS (June 2016). "Leading a Patient of Ankylosing Spondylitis to Death by Iatrogenic Spinal Fracture". Korean J Spine. 13 (2): 80–2. doi:10.14245/kjs.2016.13.2.80. PMC 4949174. PMID 27437020.
- ↑ Bakland G, Gran JT, Nossent JC (November 2011). "Increased mortality in ankylosing spondylitis is related to disease activity". Ann. Rheum. Dis. 70 (11): 1921–5. doi:10.1136/ard.2011.151191. PMID 21784726.
- ↑ Pradeep, D. J.; Keat, A.; Gaffney, K. (2008). "Predicting outcome in ankylosing spondylitis". Rheumatology. 47 (7): 942–945. doi:10.1093/rheumatology/ken195. ISSN 1462-0324.
- ↑ Montilla C, Del Pino-Montes J, Collantes-Estevez E, Font P, Zarco P, Mulero J, Gratacós J, Rodríguez C, Juanola X, Fernández-Sueiro JL, Almodovar R (May 2012). "Clinical features of late-onset ankylosing spondylitis: comparison with early-onset disease". J. Rheumatol. 39 (5): 1008–12. doi:10.3899/jrheum.111082. PMID 22422491.
- ↑ Reveille JD (April 2011). "Epidemiology of spondyloarthritis in North America". Am. J. Med. Sci. 341 (4): 284–6. doi:10.1097/MAJ.0b013e31820f8c99. PMC 3063892. PMID 21430444.
- ↑ Pradeep, D. J.; Keat, A.; Gaffney, K. (2008). "Predicting outcome in ankylosing spondylitis". Rheumatology. 47 (7): 942–945. doi:10.1093/rheumatology/ken195. ISSN 1462-0324.