Cryoglobulinemia history and symptoms: Difference between revisions
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==Overview== | ==Overview== | ||
Patients having cryoglobulinemia may have positive history of hepatitis C infection, hepatitis B infection, leg ulcers or recurrent thrombosis. Symptoms vary depending on the type of cryoglobulinemia and the organs involved. | |||
==History== | ==History== | ||
Patients having cryoglobulinemia may have positive history of: | |||
* Hepatitis C infection | |||
* Hepatitis B infection | |||
* Leg ulcers | |||
* Recurrent thrombosis | |||
==Symptoms == | ==Symptoms == | ||
Symptoms vary depending on the type of cryoglobulinemia and the organs involved. Symptoms of cryoglobulinemia may include: | Symptoms vary depending on the type of cryoglobulinemia and the organs involved. Symptoms of cryoglobulinemia may include:<ref name="pmid4216269">{{cite journal| author=Brouet JC, Clauvel JP, Danon F, Klein M, Seligmann M| title=Biologic and clinical significance of cryoglobulins. A report of 86 cases. | journal=Am J Med | year= 1974 | volume= 57 | issue= 5 | pages= 775-88 | pmid=4216269 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=4216269 }} </ref><ref name="pmid7704562">{{cite journal| author=Monti G, Galli M, Invernizzi F, Pioltelli P, Saccardo F, Monteverde A et al.| title=Cryoglobulinaemias: a multi-centre study of the early clinical and laboratory manifestations of primary and secondary disease. GISC. Italian Group for the Study of Cryoglobulinaemias. | journal=QJM | year= 1995 | volume= 88 | issue= 2 | pages= 115-26 | pmid=7704562 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7704562 }} </ref><ref name="pmid10787003">{{cite journal| author=Ramos-Casals M, Trejo O, García-Carrasco M, Cervera R, Font J| title=Mixed cryoglobulinemia: new concepts. | journal=Lupus | year= 2000 | volume= 9 | issue= 2 | pages= 83-91 | pmid=10787003 | doi=10.1191/096120300678828127 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10787003 }} </ref> | ||
=== Pulmonary symptoms: === | === Pulmonary symptoms: === | ||
Latest revision as of 14:31, 1 May 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Cafer Zorkun, M.D., Ph.D. [2]Feham Tariq, MD [3]
Overview
Patients having cryoglobulinemia may have positive history of hepatitis C infection, hepatitis B infection, leg ulcers or recurrent thrombosis. Symptoms vary depending on the type of cryoglobulinemia and the organs involved.
History
Patients having cryoglobulinemia may have positive history of:
- Hepatitis C infection
- Hepatitis B infection
- Leg ulcers
- Recurrent thrombosis
Symptoms
Symptoms vary depending on the type of cryoglobulinemia and the organs involved. Symptoms of cryoglobulinemia may include:[1][2][3]
Pulmonary symptoms:
- Difficulty breathing and cough
Renal symptoms:
- Renal involvement is more common in type II than in type III.
- Nephrotic range proteinuria with edema
Cutaneous symptoms:
Gastrointestinal symptoms
- Abdominal pain
General symptoms:
- Nonspecific constitutional symptoms
- Fever
- Arthralgia, specifically affecting metacarophangeal, proximal phalangeal, knees and ankles. It worsens with exposure to the cold.
- Myalgia
- Fatigue
References
- ↑ Brouet JC, Clauvel JP, Danon F, Klein M, Seligmann M (1974). "Biologic and clinical significance of cryoglobulins. A report of 86 cases". Am J Med. 57 (5): 775–88. PMID 4216269.
- ↑ Monti G, Galli M, Invernizzi F, Pioltelli P, Saccardo F, Monteverde A; et al. (1995). "Cryoglobulinaemias: a multi-centre study of the early clinical and laboratory manifestations of primary and secondary disease. GISC. Italian Group for the Study of Cryoglobulinaemias". QJM. 88 (2): 115–26. PMID 7704562.
- ↑ Ramos-Casals M, Trejo O, García-Carrasco M, Cervera R, Font J (2000). "Mixed cryoglobulinemia: new concepts". Lupus. 9 (2): 83–91. doi:10.1191/096120300678828127. PMID 10787003.