Leiomyosarcoma laboratory tests: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Leiomyosarcoma}} | {{Leiomyosarcoma}} | ||
{{CMG}};{{AE}}{{Nnasiri}} | |||
== Overview: == | |||
There are no specific laboratory findings associated with leiomyosarcoma, patients may have low [[hemoglobin]] and [[Red blood cell|red blood cells]] on their complete blood count, immunohistochemistry markers can be positive but non-diagnostics. | |||
== Lab test: == | |||
*There are no specific laboratory findings associated with leiomyosarcoma. | |||
*Elevated levels of [[CA-125]] and [[LDH]]( isozymes) in women with uterine [[sarcoma]], the usefulness of these markers are still being investigated. | |||
*There are [[immunohistochemistry]] markers associated with [[sarcoma]] but it can be positive in any other soft tissue tumors, some of these markers are include:<ref name="RG2016">{{cite journal|last1=R|first1=Stramare|last2=G|first2=Orsatti|title=Imaging Features, Differential Diagnosis and Management of Leiomyosarcomas: Case Series and Review of the Literature|journal=Journal of Cancer Science & Therapy|volume=08|issue=04|year=2016|issn=19485956|doi=10.4172/1948-5956.1000397}}</ref><ref name="pmid12144683">Goto A, Takeuchi S, Sugimura K, Maruo T (2002) [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=12144683 Usefulness of Gd-DTPA contrast-enhanced dynamic MRI and serum determination of LDH and its isozymes in the differential diagnosis of leiomyosarcoma from degenerated leiomyoma of the uterus.] ''Int J Gynecol Cancer'' 12 (4):354-61. PMID: [https://pubmed.gov/12144683 12144683]</ref><ref name="pmid18217961">Hoskins PJ, Le N (2008) [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=18217961 Preoperative tumor markers at diagnosis in women with malignant mixed müllerian tumors/carcinosarcoma of the uterus.] ''Int J Gynecol Cancer'' 18 (6):1200-1. [http://dx.doi.org/10.1111/j.1525-1438.2007.01187.x DOI:10.1111/j.1525-1438.2007.01187.x] PMID: [https://pubmed.gov/18217961 18217961]</ref> | |||
** [[Actin]] and [[desmin]] positive. | |||
** Diffusely positive with [[calponin]], h-[[caldesmon]]. | |||
** Negative with [[S100A1|S100]], [[c-kit]] and [[CD34]] | |||
==References== | ==References== | ||
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[[Category:Disease]] | [[Category:Disease]] | ||
[[Category:Gynecology]] | [[Category:Gynecology]] | ||
[[Category:Up-To-Date]] | [[Category:Up-To-Date]] | ||
[[Category:Oncology]] | [[Category:Oncology]] | ||
[[Category:Medicine]] | [[Category:Medicine]] | ||
[[Category:Gynecology]] | [[Category:Gynecology]] | ||
Latest revision as of 15:57, 4 April 2019
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Leiomyosarcoma Microchapters |
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Treatment |
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Case Studies |
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Leiomyosarcoma laboratory tests On the Web |
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American Roentgen Ray Society Images of Leiomyosarcoma laboratory tests |
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Risk calculators and risk factors for Leiomyosarcoma laboratory tests |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Nima Nasiri, M.D.[2]
Overview:
There are no specific laboratory findings associated with leiomyosarcoma, patients may have low hemoglobin and red blood cells on their complete blood count, immunohistochemistry markers can be positive but non-diagnostics.
Lab test:
- There are no specific laboratory findings associated with leiomyosarcoma.
- Elevated levels of CA-125 and LDH( isozymes) in women with uterine sarcoma, the usefulness of these markers are still being investigated.
- There are immunohistochemistry markers associated with sarcoma but it can be positive in any other soft tissue tumors, some of these markers are include:[1][2][3]
References
- ↑ R, Stramare; G, Orsatti (2016). "Imaging Features, Differential Diagnosis and Management of Leiomyosarcomas: Case Series and Review of the Literature". Journal of Cancer Science & Therapy. 08 (04). doi:10.4172/1948-5956.1000397. ISSN 1948-5956.
- ↑ Goto A, Takeuchi S, Sugimura K, Maruo T (2002) Usefulness of Gd-DTPA contrast-enhanced dynamic MRI and serum determination of LDH and its isozymes in the differential diagnosis of leiomyosarcoma from degenerated leiomyoma of the uterus. Int J Gynecol Cancer 12 (4):354-61. PMID: 12144683
- ↑ Hoskins PJ, Le N (2008) Preoperative tumor markers at diagnosis in women with malignant mixed müllerian tumors/carcinosarcoma of the uterus. Int J Gynecol Cancer 18 (6):1200-1. DOI:10.1111/j.1525-1438.2007.01187.x PMID: 18217961