Focal segmental glomerulosclerosis natural history, complications and prognosis: Difference between revisions
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==Overview== | ==Overview== | ||
==Natural History, Complications, and Prognosis== | ==Natural History, Complications, and Prognosis== | ||
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===Prognosis=== | ===Prognosis=== | ||
*There are several clinical and pathological features which predict the outcome. | *There are several clinical and pathological features which predict the outcome. | ||
*Factors which are associated with worse prognosis of focal segmental glomerulosclerosis include:<ref name="urlFocal Segmental Glomerulosclerosis in Nephrotic Adults: Presentation, Prognosis, and Response to Therapy of the Histologic Variants">{{cite web |url=http://jasn.asnjournals.org/content/15/8/2169 |title=Focal Segmental Glomerulosclerosis in Nephrotic Adults: Presentation, Prognosis, and Response to Therapy of the Histologic Variants |format= |work= |accessdate=}}</ref> | *Factors which are associated with worse prognosis of focal segmental glomerulosclerosis include:<ref name="urlFocal Segmental Glomerulosclerosis in Nephrotic Adults: Presentation, Prognosis, and Response to Therapy of the Histologic Variants">{{cite web |url=http://jasn.asnjournals.org/content/15/8/2169 |title=Focal Segmental Glomerulosclerosis in Nephrotic Adults: Presentation, Prognosis, and Response to Therapy of the Histologic Variants |format= |work= |accessdate=}}</ref><ref name="FSGS">{{cite web |url=http://cdn.intechopen.com/pdfs/22820/InTech-Focal_segmental_glomerulosclerosis.pdf|title= Focal segmental glomerulosclerosis.|last1= Sohal |first1= DS |last2= Prabhakar |first2= SS|date=November 02, 2011|website= Interchopen |publisher= InTech |accessdate=3 December 2013}}</ref>: | ||
**Black race | **Black race | ||
**Increased degrees of proteinuria | **Increased degrees of proteinuria | ||
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**Increased severity of interstitial fibrosis | **Increased severity of interstitial fibrosis | ||
**Tubular atrophy in biopsy specimens | **Tubular atrophy in biopsy specimens | ||
==References== | ==References== |
Latest revision as of 20:09, 4 June 2018
Focal segmental glomerulosclerosis Microchapters |
Differentiating Focal segmental glomerulosclerosis from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Ali Poyan Mehr, M.D. [2] Associate Editor(s)-in-Chief: Olufunmilola Olubukola M.D.[3]
Overview
Natural History, Complications, and Prognosis
Natural History
- The symptoms of focal segmental glomerulosclerosis usually develop in the first/ second/ third decade of life, and start with symptoms such as ___.
- The symptoms of (disease name) typically develop ___ years after exposure to ___.
- If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].
Complications
Common complications of focal segmental glomerulosclerosis include:[1]
- End stage renal disease
- Malnutrition
- Infections
- Nephrotic syndrome
Prognosis
- There are several clinical and pathological features which predict the outcome.
- Factors which are associated with worse prognosis of focal segmental glomerulosclerosis include:[2][3]:
- Black race
- Increased degrees of proteinuria
- renal insufficiency
- Increased severity of interstitial fibrosis
- Tubular atrophy in biopsy specimens
References
- ↑ Korbet SM (1999). "Clinical picture and outcome of primary focal segmental glomerulosclerosis". Nephrol Dial Transplant. 14 Suppl 3: 68–73. PMID 10382985.
- ↑ "Focal Segmental Glomerulosclerosis in Nephrotic Adults: Presentation, Prognosis, and Response to Therapy of the Histologic Variants".
- ↑ Sohal, DS; Prabhakar, SS (November 02, 2011). "Focal segmental glomerulosclerosis" (PDF). Interchopen. InTech. Retrieved 3 December 2013. Check date values in:
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