Fanconi syndrome causes: Difference between revisions

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{{Fanconi syndrome}}
{{Fanconi syndrome}}


{{CMG}}; {{AE}}  
{{CMG}}; {{AE}} {{VE}}  
==Overview==
==Overview==
Fanconi syndrome could be the result or complication of various causes affecting the normal function of Proximal convoluted tubule (PCT) ; in a simple and useful classification method, the causes could be classified as:
Fanconi syndrome could be the result or complication of various causes affecting the normal function of Proximal convoluted tubule (PCT); in a simple and useful classification method, the causes could be classified as<ref name="pmid23235953">{{cite journal| author=Haque SK, Ariceta G, Batlle D| title=Proximal renal tubular acidosis: a not so rare disorder of multiple etiologies. | journal=Nephrol Dial Transplant | year= 2012 | volume= 27 | issue= 12 | pages= 4273-87 | pmid=23235953 | doi=10.1093/ndt/gfs493 | pmc=3616759 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23235953  }}</ref><ref name=":0">Enriko Klootwijk, Stephanie Dufek, Naomi Issler, Detlef Bockenhauer & Robert Kleta (2016)Pathophysiology, current treatments and future targets in hereditary forms of renal Fanconi syndrome,Expert Opinion on Orphan Drugs, 5:1, 45-54, DOI: 10.1080/21678707.2017.1259560</ref>:
* '''Genetic causes'''  
* '''Genetic causes'''  
** ''Accumulation of a toxic substance''  (e.g. Cystinosis, Tyrozinemia, Lysinuric Protein Intolerance, Glycogen Storage Diseases, Galactosemia, wilson, fructose intolerance)
** ''Accumulation of a toxic substance''  (e.g. [[Cystinosis]], [[Tyrosinemia]], Lysinuric Protein Intolerance, [[Glycogen storage disease|Glycogen Storage Diseases]], [[Galactosemia]], [[Wilson's disease|Wilson]], [[Hereditary Fructose Intolerance|Fructose Intolerance]])
** ''Energy provision failure'' (e.g. Mitochondriopathies)   
** ''Energy provision failure'' (e.g. Mitochondriopathies)   
** ''Disruption of endocytosis and intra-cellular transport mechanisms'' (e.g. ARC syndrome, Lowe syndrome and Dent disease).
** ''Disruption of [[endocytosis]] and intracellular transport mechanisms'' (e.g. ARC syndrome, [[Oculocerebrorenal syndrome|Lowe syndrome]] and [[Dent's disease|Dent disease]]).
* '''Exogenous causes''' (e.g. Heavy metals exposure, Drugs, Chemotherapy)
* '''Exogenous causes''' (e.g. Heavy metals exposure, Drugs, Chemotherapy)
* '''Acquired causes''' (e.g. Multiple myeloma, Amyloidosis, Paroxysmal nocturnal hemoglobinuria)
* '''Acquired causes''' (e.g. [[Multiple myeloma]], [[Amyloidosis]], [[Paroxysmal nocturnal hemoglobinuria]])


==Causes==
==Causes==
===Genetic Causes===
===Genetic Causes<ref name="pmid23235953" /><ref name=":0" />===
* '''Accumulation of a toxic substance'''
* '''Accumulation of a toxic substance'''
** Cystinosis  
** [[Cystinosis]]
*** The most common inherited cause of Fanconi syndrome in children
*** The most common inherited cause of Fanconi syndrome in children
** Tyrozinemia
** [[Tyrosinemia]]
** Lysinuric Protein Intolerance  
** Lysinuric Protein Intolerance  
** Glycogen Storage Disease type I  
** [[Glycogen storage disease type I|Glycogen Storage Disease type I]]
** Galactosemia
** [[Galactosemia]]
** Wilson
** [[Wilson's disease|Wilson]]
** Fructose intolerance
** [[Hereditary fructose intolerance|Fructose intolerance]]
** Fanconi-Bickel syndrome
** [[Glycogen storage disease type XI|Fanconi-Bickel syndrome]]
* '''Energy provision failure'''
* '''Energy provision failure'''
** Mitochondriopathies
** Mitochondriopathies
* '''Disruption of endocytosis and intra-cellular transport'''
* '''Disruption of endocytosis and intracellular transport'''
** Lowe syndrome   
** [[Oculocerebrorenal syndrome|Lowe syndrome]]  
** NaPi-IIa gene mutation
** NaPi-IIa gene mutation
** EHHADH gene mutations
** [[EHHADH]] gene mutations
** Dent disease
** [[Dent's disease|Dent disease]]


=== '''Exogenous causes''' ===
=== '''Exogenous causes'''<ref name="pmid23235953" /><ref name="pmid125524902">{{cite journal| author=Izzedine H, Launay-Vacher V, Isnard-Bagnis C, Deray G| title=Drug-induced Fanconi's syndrome. | journal=Am J Kidney Dis | year= 2003 | volume= 41 | issue= 2 | pages= 292-309 | pmid=12552490 | doi=10.1053/ajkd.2003.50037 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12552490  }}</ref> ===
* '''Drugs'''
* '''Drugs'''
** Anti viral & Anti-retroviral drugs
** Antiviral & Anti-retroviral drugs
*** ''Adefovir''
*** ''[[Adefovir]]''
*** ''Tenofovir''
*** ''[[Tenofovir]]''
*** ''Didanosine''
*** ''[[Didanosine]]''
*** ''Cidofovir''
*** ''[[Cidofovir]]''
*** ''Lamivudine''
*** ''[[Lamivudine]]''
*** ''Stavudine''
*** ''[[Stavudine]]''


** Antibacterial Drugs
** Antibacterial Drugs
*** ''Tetracyclines''
*** ''[[Tetracycline antibiotics|Tetracyclines]]''
*** ''Aminoglycosides''
*** ''[[Aminoglycoside|Aminoglycosides]]''


** Anticonvulsants
** Anticonvulsants
*** ''Valproic acid''
*** ''[[Valproic acid]]''


* '''Heavy metals'''
* '''Heavy metals'''
** ''Lead''
** ''[[Lead]]''
** ''cadmium''
** ''[[Cadmium]]''
** ''Mercury''
** ''[[Mercury (element)|Mercury]]''
** ''Copper''
** ''[[Copper]]''
* '''Chemotherapy'''
* '''Chemotherapy'''


** ''Alkylating & Platinating Agents''
** ''Alkylating & Platinating Agents''
*** ''Cisplatin''
*** ''[[Cisplatin]]''
*** ''Streptozocin''  
*** ''[[Streptozocin]]''  
*** ''Carboplatin''
*** ''[[Carboplatin]]''
*** ''Ifosfamide''
*** ''[[Ifosfamide]]''
*** ''Oxaplatin''
*** ''Oxaplatin''


** ''Mercaptopurine''
** ''[[Mercaptopurine]]''


=== '''Acquired causes''' ===
=== '''Acquired causes'''<ref name=":0" /><ref name="pmid23235953" /><ref name="pmid29326807">{{cite journal| author=Ria R, Dammacco F, Vacca A| title=Heavy-Chain Diseases and Myeloma-Associated Fanconi Syndrome: an Update. | journal=Mediterr J Hematol Infect Dis | year= 2018 | volume= 10 | issue= 1 | pages= e2018011 | pmid=29326807 | doi=10.4084/MJHID.2018.011 | pmc=5760076 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29326807  }}</ref> ===
* ''Nephrotic syndrome''
* ''[[Nephrotic syndrome]]''
* ''Multiple myeloma''
* ''[[Multiple myeloma]]''
* Amyloidosis  
* [[Amyloidosis]]
* Paroxysmal nocturnal hemoglobinuria(PNH)
* [[Paroxysmal nocturnal hemoglobinuria|Paroxysmal nocturnal hemoglobinuria(PNH)]]
* ''Sjögren syndrome''
* ''[[Sjögren's syndrome|Sjögren syndrome]]''
* ''Renal transplantation''
* ''Renal transplantation''
* ''Acute tubulointerstitial nephritis with uveitis (TINU) syndrome''
* ''Acute tubulointerstitial nephritis with uveitis (TINU) syndrome''
* ''Autoimmune interstitial nephritis and membranous nephropathy''
* ''Autoimmune interstitial nephritis and membranous nephropathy''
* ''Anorexia nervosa''
* ''[[Anorexia nervosa]]''
* ''Untreated condition of distal renal tubular acidosis''
* ''Untreated condition of distal renal tubular acidosis''


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Less common causes of Fanconi syndrome mostly found on case reports include:
Less common causes of Fanconi syndrome mostly found on case reports include:


*Other drugs such as: Fumaric Acid, Ranitidine, Salicylate, Methyl-3-Chromone in high doses and for long periods
*Other drugs such as: Fumaric Acid, [[Ranitidine]], [[Salicylic acid|Salicylate]], Methyl-3-Chromone in high doses and for long periods
*Chronic Alcohol abuse  
*[[Alcohol abuse|Chronic Alcohol abuse]]
*Crude Chinese herbal drugs (sometimes called Boui-ougi-tou)
*Crude Chinese herbal drugs (sometimes called Boui-ougi-tou)
*L-Lysine
*[[L-Lysine]]
*Glue Sniffing
*Glue Sniffing
*Autosomal dominant Fanconi syndrome with macrosomia and young onset diabetes mellitus
*Autosomal dominant Fanconi syndrome with macrosomia and [[Maturity onset diabetes of the young|young-onset diabetes mellitus]]
*Arthrogryposis–renal dysfunction–cholestasis (ARC) syndrome
*Arthrogryposis–renal dysfunction–cholestasis (ARC) syndrome
*Idiopathic Fanconi syndrome
*Idiopathic Fanconi syndrome
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===Causes in Alphabetical Order===
===Causes in Alphabetical Order===
List the causes of the disease in alphabetical order.
List the causes of the disease in alphabetical order.
{{columns-list|3|
{{columns-list|
*Adefovir
*Adefovir
*Aminoglycosides
*Aminoglycosides

Latest revision as of 20:56, 10 January 2020


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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Vahid Eidkhani, M.D.

Overview

Fanconi syndrome could be the result or complication of various causes affecting the normal function of Proximal convoluted tubule (PCT); in a simple and useful classification method, the causes could be classified as[1][2]:

Causes

Genetic Causes[1][2]

Exogenous causes[1][3]

Acquired causes[2][1][4]

Less Common Causes

Less common causes of Fanconi syndrome mostly found on case reports include:

  • Other drugs such as: Fumaric Acid, Ranitidine, Salicylate, Methyl-3-Chromone in high doses and for long periods
  • Chronic Alcohol abuse
  • Crude Chinese herbal drugs (sometimes called Boui-ougi-tou)
  • L-Lysine
  • Glue Sniffing
  • Autosomal dominant Fanconi syndrome with macrosomia and young-onset diabetes mellitus
  • Arthrogryposis–renal dysfunction–cholestasis (ARC) syndrome
  • Idiopathic Fanconi syndrome

Causes in Alphabetical Order

List the causes of the disease in alphabetical order.

  • Adefovir
  • Aminoglycosides
  • Cidofovir
  • Cisplatin
  • Cystinosis
  • Dent disease
  • Didanosine
  • Fanconi-Bickel syndrome
  • Galactosemia
  • Glycogen Storage disease (type I)
  • Hereditary fructose intolerance
  • Ifosfamide
  • Lamivudine
  • Lowe’s syndrome
  • Mitochondriopathies
  • Oxaplatin
  • Stavudine
  • Streptozocin
  • Tenofovir
  • Tyrosinemia
  • Valproic acid
  • Wilson’s disease
  • Tetracyclines

References

  1. ↑ 1.0 1.1 1.2 1.3 Haque SK, Ariceta G, Batlle D (2012). "Proximal renal tubular acidosis: a not so rare disorder of multiple etiologies". Nephrol Dial Transplant. 27 (12): 4273–87. doi:10.1093/ndt/gfs493. PMC 3616759. PMID 23235953.
  2. ↑ 2.0 2.1 2.2 Enriko Klootwijk, Stephanie Dufek, Naomi Issler, Detlef Bockenhauer & Robert Kleta (2016)Pathophysiology, current treatments and future targets in hereditary forms of renal Fanconi syndrome,Expert Opinion on Orphan Drugs, 5:1, 45-54, DOI: 10.1080/21678707.2017.1259560
  3. ↑ Izzedine H, Launay-Vacher V, Isnard-Bagnis C, Deray G (2003). "Drug-induced Fanconi's syndrome". Am J Kidney Dis. 41 (2): 292–309. doi:10.1053/ajkd.2003.50037. PMID 12552490.
  4. ↑ Ria R, Dammacco F, Vacca A (2018). "Heavy-Chain Diseases and Myeloma-Associated Fanconi Syndrome: an Update". Mediterr J Hematol Infect Dis. 10 (1): e2018011. doi:10.4084/MJHID.2018.011. PMC 5760076. PMID 29326807.

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