Minimal change disease diagnostic study of choice: Difference between revisions
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{{Minimal change disease}} | |||
{{CMG}}; {{AE}} {{VKG}} | |||
== Overview == | |||
The [[diagnostic]] study of choice for [[minimal change disease]] is renal biopsy. | |||
Before considering renal biopsy steroid therapy can be initiated in patients who fulfill the following criteria because of the invasive process of the biopsy. | == Diagnostic Study of choice == | ||
* The diagnostic study of choice for [[minimal change disease]] is [[renal]] [[biopsy]].<ref name="pmid27940460">{{cite journal |vauthors=Vivarelli M, Massella L, Ruggiero B, Emma F |title=Minimal Change Disease |journal=Clin J Am Soc Nephrol |volume=12 |issue=2 |pages=332–345 |date=February 2017 |pmid=27940460 |pmc=5293332 |doi=10.2215/CJN.05000516 |url=}}</ref> | |||
Patients must be older than 1 year and less than 12 years. | * With four weeks of treatment with [[steroid]] therapy, most of the patients with minimal change disease ([[MCD]]) will respond positively. | ||
Normal complement levels | * Before considering renal biopsy steroid therapy can be initiated in patients who fulfill the following [[criteria]] because of the [[Invasive (medical)|invasive]] process of the [[biopsy]].<ref name="pmid7205481">{{cite journal |vauthors= |title=The primary nephrotic syndrome in children. Identification of patients with minimal change nephrotic syndrome from initial response to prednisone. A report of the International Study of Kidney Disease in Children |journal=J. Pediatr. |volume=98 |issue=4 |pages=561–4 |date=April 1981 |pmid=7205481 |doi= |url=}}</ref><ref name="pmid9035508">{{cite journal |vauthors=Norero C, Delucchi A, Lagos E, Rosati P |title=[Initial therapy of primary nephrotic syndrome in children: evaluation in a period of 18 months of two prednisone treatment schedules. Chilean Co-operative Group of Study of Nephrotic Syndrome in Children] |language=Spanish; Castilian |journal=Rev Med Chil |volume=124 |issue=5 |pages=567–72 |date=May 1996 |pmid=9035508 |doi= |url=}}</ref> | ||
No signs of hypertension, gross hematuria, or a marked increase in serum creatinine. | * Patients must be older than 1 year and less than 12 years. | ||
By following this protocol in patients with minimal change disease we can avoid unnecessary invasive approach in almost 80% of the patients. | * Normal [[complement]] levels. | ||
* No signs of [[hypertension]], gross [[hematuria]], or a marked increase in serum [[creatinine]]. | |||
* By following this protocol in patients with minimal change disease we can avoid unnecessary [[Invasive (medical)|invasive]] approach in almost 80% of the patients.<ref name="pmid72054812">{{cite journal |vauthors= |title=The primary nephrotic syndrome in children. Identification of patients with minimal change nephrotic syndrome from initial response to prednisone. A report of the International Study of Kidney Disease in Children |journal=J. Pediatr. |volume=98 |issue=4 |pages=561–4 |date=April 1981 |pmid=7205481 |doi= |url=}}</ref> | |||
== References == | |||
<references /> | |||
Latest revision as of 14:58, 13 June 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Vamsikrishna Gunnam M.B.B.S [2]
Overview
The diagnostic study of choice for minimal change disease is renal biopsy.
Diagnostic Study of choice
- The diagnostic study of choice for minimal change disease is renal biopsy.[1]
- With four weeks of treatment with steroid therapy, most of the patients with minimal change disease (MCD) will respond positively.
- Before considering renal biopsy steroid therapy can be initiated in patients who fulfill the following criteria because of the invasive process of the biopsy.[2][3]
- Patients must be older than 1 year and less than 12 years.
- Normal complement levels.
- No signs of hypertension, gross hematuria, or a marked increase in serum creatinine.
- By following this protocol in patients with minimal change disease we can avoid unnecessary invasive approach in almost 80% of the patients.[4]
References
- ↑ Vivarelli M, Massella L, Ruggiero B, Emma F (February 2017). "Minimal Change Disease". Clin J Am Soc Nephrol. 12 (2): 332–345. doi:10.2215/CJN.05000516. PMC 5293332. PMID 27940460.
- ↑ "The primary nephrotic syndrome in children. Identification of patients with minimal change nephrotic syndrome from initial response to prednisone. A report of the International Study of Kidney Disease in Children". J. Pediatr. 98 (4): 561–4. April 1981. PMID 7205481.
- ↑ Norero C, Delucchi A, Lagos E, Rosati P (May 1996). "[Initial therapy of primary nephrotic syndrome in children: evaluation in a period of 18 months of two prednisone treatment schedules. Chilean Co-operative Group of Study of Nephrotic Syndrome in Children]". Rev Med Chil (in Spanish; Castilian). 124 (5): 567–72. PMID 9035508.
- ↑ "The primary nephrotic syndrome in children. Identification of patients with minimal change nephrotic syndrome from initial response to prednisone. A report of the International Study of Kidney Disease in Children". J. Pediatr. 98 (4): 561–4. April 1981. PMID 7205481.