Paroxysmal nocturnal hemoglobinuria natural history, complications and prognosis: Difference between revisions
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{{Paroxysmal nocturnal hemoglobinuria}} | {{Paroxysmal nocturnal hemoglobinuria}} | ||
{{CMG}}; {{AE}} | {{CMG}}; {{AE}} {{AEL}} | ||
==Overview== | ==Overview== | ||
If left untreated, patients with paroxysmal nocturnal hemoglobinuria may progress to develop thrombosis which is a main cause of death in PNH. Common complications include intracranial thrombosis, splenic vein thrombosis and portal vein thrombosis. Prognosis of paroxysmal nocturnal hemoglobinuria is good as long as anti-complemant therapy eculizumab is taken regularly. | If left untreated, patients with paroxysmal nocturnal hemoglobinuria may progress to develop [[thrombosis]] which is a main cause of death in PNH. Common complications include intracranial thrombosis, [[splenic vein thrombosis]], and [[portal vein thrombosis]]. Prognosis of paroxysmal nocturnal hemoglobinuria is good as long as anti-complemant therapy [[eculizumab]] is taken regularly. | ||
==Natural History, Complications, and Prognosis== | ==Natural History, Complications, and Prognosis== | ||
===Natural History=== | ===Natural History=== | ||
*If left untreated, patients with paroxysmal nocturnal hemoglobinuria may progress to develop thrombosis which is a main cause of death in PNH. | *If left untreated, patients with paroxysmal nocturnal hemoglobinuria may progress to develop [[thrombosis]] which is a main cause of death in PNH. | ||
*PNH is associated with high morbidity and mortality rate if appropriate treatment is not administrated regularly. | *PNH is associated with high morbidity and mortality rate if appropriate treatment is not administrated regularly. | ||
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*Common complications of paroxysmal nocturnal hemoglobinuria include: | *Common complications of paroxysmal nocturnal hemoglobinuria include: | ||
** Intracranial thrombosis | ** Intracranial thrombosis | ||
** Splenic vein thrombosis | ** [[Splenic vein thrombosis]] | ||
** Portal vein thrombosis | ** [[Portal vein thrombosis]] | ||
===Prognosis=== | ===Prognosis=== | ||
*Prognosis of paroxysmal nocturnal hemoglobinuria is good as long as anti-complemant therapy eculizumab is taken regularly. | *Prognosis of paroxysmal nocturnal hemoglobinuria is good as long as anti-complemant therapy eculizumab is taken regularly. | ||
*Eculizumab has shown decrease in the risk of thrombosis which is a main cause of death in patients with PNH. | *[[Eculizumab]] has shown decrease in the risk of thrombosis which is a main cause of death in patients with PNH. | ||
==References== | ==References== |
Latest revision as of 00:12, 1 November 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmed Elsaiey, MBBCH [2]
Overview
If left untreated, patients with paroxysmal nocturnal hemoglobinuria may progress to develop thrombosis which is a main cause of death in PNH. Common complications include intracranial thrombosis, splenic vein thrombosis, and portal vein thrombosis. Prognosis of paroxysmal nocturnal hemoglobinuria is good as long as anti-complemant therapy eculizumab is taken regularly.
Natural History, Complications, and Prognosis
Natural History
- If left untreated, patients with paroxysmal nocturnal hemoglobinuria may progress to develop thrombosis which is a main cause of death in PNH.
- PNH is associated with high morbidity and mortality rate if appropriate treatment is not administrated regularly.
Complications
- Common complications of paroxysmal nocturnal hemoglobinuria include:
- Intracranial thrombosis
- Splenic vein thrombosis
- Portal vein thrombosis
Prognosis
- Prognosis of paroxysmal nocturnal hemoglobinuria is good as long as anti-complemant therapy eculizumab is taken regularly.
- Eculizumab has shown decrease in the risk of thrombosis which is a main cause of death in patients with PNH.