Endometrial cancer classification: Difference between revisions

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Latest revision as of 18:41, 26 November 2018

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Roukoz A. Karam, M.D.[2]

Overview

Endometrial cancer may be classified according to histology into either type I comprising 80% of endometrial cancers or type II accounting for around 20%.

Classification

Endometrial cancer may be classified according to histology into 2 types:^[1]

Type	Histology	Prognosis	Pathogenesis	Prevalence
Type I	Endometroid (adenocarcinoma)	Favorable (estrogen-responsive)	• May arise from atypical hyperplasia • Linked to unopposed estrogen stimulation	80%
Type II	• Endometroid • Serous • Clear cell • Mucinous • Squamous • Mesonephric • Undifferentiated	Typically bad prognosis	• Develops from atrophic endometrium • Not linked to hormonally driven pathogenesis	15-20%

References

↑ Bokhman JV (1983). "Two pathogenetic types of endometrial carcinoma". Gynecol Oncol. 15 (1): 10–7. PMID 6822361.

Template:WikiDoc Sources

[pmid6822361-1] Bokhman JV (1983). "Two pathogenetic types of endometrial carcinoma". Gynecol Oncol. 15 (1): 10–7. PMID 6822361.

[1]

@@ Line 1: / Line 1: @@
 __NOTOC__
 {{Endometrial cancer}}
-{{CMG}}{{AE}}{{MD}}
+{{CMG}}{{AE}}{{RAK}}
 ==Overview==
@@ Line 7: / Line 7: @@
 ==Classification==
-Endometrial cancer may be classified according to histology into 2 types:
+Endometrial cancer may be classified according to histology into 2 types:<ref name="pmid6822361">{{cite journal| author=Bokhman JV| title=Two pathogenetic types of endometrial carcinoma. | journal=Gynecol Oncol | year= 1983 | volume= 15 | issue= 1 | pages= 10-7 | pmid=6822361 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6822361  }} </ref>
-* Type I
-**
-* Type II
 {| class="wikitable"
 ! style="background:#4479BA; color: #FFFFFF;" align="center" + |Type
@@ Line 22: / Line 18: @@
 | style="background:#F5F5F5;" align="center" + |Endometroid (adenocarcinoma)
 | style="background:#F5F5F5;" align="center" + |Favorable (estrogen-responsive)
-| style="background:#F5F5F5;" align="left" + |• May arise from atypical hyperplasia </br> • Linked to unopposed estrogen stimulation
+| style="background:#F5F5F5;" align="left" + |• May arise from atypical hyperplasia <br> • Linked to unopposed estrogen stimulation
 | style="background:#F5F5F5;" align="center" + |80%
 |-
 | style="background:#DCDCDC;" align="center" + |Type II
-| style="background:#F5F5F5;" align="left" + |• Endometroid </br>• Serous </br>• Clear cell </br>• Mucinous </br>• Squamous </br>• Mesonephric </br>• Undifferentiated
+| style="background:#F5F5F5;" align="left" + |• Endometroid <br>• Serous <br>• Clear cell <br>• Mucinous <br>• Squamous <br>• Mesonephric <br>• Undifferentiated
 | style="background:#F5F5F5;" align="center" + |Typically bad prognosis
-| style="background:#F5F5F5;" align="left" + |• Develops from atrophic endometrium </br>• Not linked to hormonally driven pathogenesis
+| style="background:#F5F5F5;" align="left" + |• Develops from atrophic endometrium <br>• Not linked to hormonally driven pathogenesis
 | style="background:#F5F5F5;" align="center" + |15-20%
 |}
-===Classification Based on Pathogenesis===
-* Endometrial cancers are classified into either type 1 or type 2:<ref>{{Cite web | title = endometrial cancer classification | url =http://www.cancer.gov/types/uterine/hp/endometrial-treatment-pdq#section/_9 }}</ref>
-:* Type 1 may arise from complex atypical [[hyperplasia]] and is pathogenetically linked to unopposed estrogenic stimulation.
-:* Type 2 develops from atrophic [[endometrium]] and is not linked to hormonally driven pathogenesis.
-===Classification Based on Histopathological Subtype===
-There are 7 subtypes of endometrial cancer based on histopathology:
-: 1. Endometrioid (75%–80%)(The most common endometrial cancer cell type is endometrioid adenocarcinoma, which is composed of malignant [[glandular]] epithelial elements)
-::* Ciliated adenocarcinoma
-::* Secretory adenocarcinoma
-::* [[Papillary]] or villoglandular
-::* Adenocarcinoma with squamous differentiation
-:::* Adenoacanthoma
-:::* Adenosquamous (Adenosquamous tumors contain malignant elements of both glandular and squamous epithelium)
-: 2. Uterine papillary serous (<10%)
-: 3. Mucinous (1%)
-: 4. Clear cell (4%)
-: 5. [[Squamous cell]] (<1%)
-: 6. Mixed (10%)
-: 7. Undifferentiated
 ==References==

Endometrial cancer classification: Difference between revisions

Latest revision as of 18:41, 26 November 2018

Overview

Classification

References

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