Hairy cell leukemia diagnotic study of choice

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Vamsikrishna Gunnam M.B.B.S [2]; Grammar Reviewer: Natalie Harpenau, B.S.[3]

Overview

Peripheral blood smears are the gold standard test for the diagnosis of hairy cell leukemia.

Diagnostic Study of Choice

Study of choice

Peripheral blood smear:

Peripheral blood smear is one of the gold standard tests for the diagnosis of hairy cell leukemia.

The following result of peripheral blood smears is confirmatory of hairy cell leukemia:

• Oval nuclei and abundant cytoplasm with "hairy" projections
• "Fried egg" appearance
• Loose chromatin
• Mast cells numbers elevate
• Extravasated red cells are positive in peripheral blood smear of hairy cell leukemia patients