Folate deficiency diagnostic study of choice: Difference between revisions
Line 8: | Line 8: | ||
=== Study of choice === | === Study of choice === | ||
There is no single diagnostic study of choice or gold standard test for the diagnosis of folate deficiency, <ref name="Snow1999">{{cite journal|last1=Snow|first1=Christopher F.|title=Laboratory Diagnosis of Vitamin B12 and Folate Deficiency|journal=Archives of Internal Medicine|volume=159|issue=12|year=1999|pages=1289|issn=0003-9926|doi=10.1001/archinte.159.12.1289}}</ref> but [[Homocysteine]] and [[methylmalonic acid]] levels can be helpful in confirmation.[[Homocysteine]] but not [[methylmalonic acid]] is increased in [[folate]] deficiency.<ref name="pmid10926922">{{cite journal| author=Klee GG| title=Cobalamin and folate evaluation: measurement of methylmalonic acid and homocysteine vs vitamin B(12) and folate. | journal=Clin Chem | year= 2000 | volume= 46 | issue= 8 Pt 2 | pages= 1277-83 | pmid=10926922 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10926922 }}</ref> | There is no single diagnostic study of choice or gold standard test for the diagnosis of folate deficiency, <ref name="Snow1999">{{cite journal|last1=Snow|first1=Christopher F.|title=Laboratory Diagnosis of Vitamin B12 and Folate Deficiency|journal=Archives of Internal Medicine|volume=159|issue=12|year=1999|pages=1289|issn=0003-9926|doi=10.1001/archinte.159.12.1289}}</ref> but [[Homocysteine]] and [[methylmalonic acid]] levels can be helpful in confirmation.[[Homocysteine]] but not [[methylmalonic acid]] is increased in [[folate]] deficiency.<ref name="pmid10926922">{{cite journal| author=Klee GG| title=Cobalamin and folate evaluation: measurement of methylmalonic acid and homocysteine vs vitamin B(12) and folate. | journal=Clin Chem | year= 2000 | volume= 46 | issue= 8 Pt 2 | pages= 1277-83 | pmid=10926922 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10926922 }}</ref><ref name="pmid24942828">{{cite journal| author=Devalia V, Hamilton MS, Molloy AM, British Committee for Standards in Haematology| title=Guidelines for the diagnosis and treatment of cobalamin and folate disorders. | journal=Br J Haematol | year= 2014 | volume= 166 | issue= 4 | pages= 496-513 | pmid=24942828 | doi=10.1111/bjh.12959 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24942828 }}</ref> | ||
===== Sequence of Diagnostic Studies ===== | ===== Sequence of Diagnostic Studies ===== |
Latest revision as of 08:21, 3 February 2019
Folate deficiency Microchapters |
Diagnosis |
---|
Treatment |
Case Studies |
Folate deficiency diagnostic study of choice On the Web |
American Roentgen Ray Society Images of Folate deficiency diagnostic study of choice |
Risk calculators and risk factors for Folate deficiency diagnostic study of choice |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
There is no single diagnostic study of choice or gold standard test for the diagnosis of folate deficiency.
Diagnostic Study of Choice
Study of choice
There is no single diagnostic study of choice or gold standard test for the diagnosis of folate deficiency, [1] but Homocysteine and methylmalonic acid levels can be helpful in confirmation.Homocysteine but not methylmalonic acid is increased in folate deficiency.[2][3]
Sequence of Diagnostic Studies
The various investigations must be performed in the following order:
- CBC
- Peripheral smear
- Liver function test esp. indirect biluribin
- LDH
- Serum folate level
- RBC folate level
- plasma or serum homocysteine or methylmalonic acid
- serum Vitamin b12 level and finally
- serum iron panel
References
- ↑ Snow, Christopher F. (1999). "Laboratory Diagnosis of Vitamin B12 and Folate Deficiency". Archives of Internal Medicine. 159 (12): 1289. doi:10.1001/archinte.159.12.1289. ISSN 0003-9926.
- ↑ Klee GG (2000). "Cobalamin and folate evaluation: measurement of methylmalonic acid and homocysteine vs vitamin B(12) and folate". Clin Chem. 46 (8 Pt 2): 1277–83. PMID 10926922.
- ↑ Devalia V, Hamilton MS, Molloy AM, British Committee for Standards in Haematology (2014). "Guidelines for the diagnosis and treatment of cobalamin and folate disorders". Br J Haematol. 166 (4): 496–513. doi:10.1111/bjh.12959. PMID 24942828.