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--><ref name="Oldref_17">{{cite journal | author=Cravo ML, Gloria LM, Selhub J, Nadeau MR, Camilo ME, Resende MP, Cardoso JN, Leitao CN, Mira FC | title=Hyperhomocysteinemia in chronic alcoholism: correlation with folate, vitamin B-12, and vitamin B-6 status | journal=The American journal of clinical nutrition | volume=63 | issue=2 | year=1996 | pages=220-4 | id=PMID 8561063}}</ref>== | --><ref name="Oldref_17">{{cite journal | author=Cravo ML, Gloria LM, Selhub J, Nadeau MR, Camilo ME, Resende MP, Cardoso JN, Leitao CN, Mira FC | title=Hyperhomocysteinemia in chronic alcoholism: correlation with folate, vitamin B-12, and vitamin B-6 status | journal=The American journal of clinical nutrition | volume=63 | issue=2 | year=1996 | pages=220-4 | id=PMID 8561063}}</ref>== | ||
A deficiency of folate can occur when your need for folate is increased, when dietary intake of folate is inadequate, and when your body excretes (or loses) more folate than usual. Medications that interfere with your body's ability to use folate may also increase the need for this vitamin. Some research indicates that exposure to [[ultraviolet light]], including the use of tanning beds, can lead to a folic acid deficiency. | A deficiency of folate can occur when your need for folate is increased, when dietary intake of folate is inadequate, and when your body excretes (or loses) more folate than usual. Medications that interfere with your body's ability to use folate may also increase the need for this vitamin. Some research indicates that exposure to [[ultraviolet light]], including the use of tanning beds, can lead to a folic acid deficiency.<ref name="BorradaleKimlin2012">{{cite journal|last1=Borradale|first1=David C|last2=Kimlin|first2=Michael G|title=Folate degradation due to ultraviolet radiation: possible implications for human health and nutrition|journal=Nutrition Reviews|volume=70|issue=7|year=2012|pages=414–422|issn=00296643|doi=10.1111/j.1753-4887.2012.00485.x}}</ref> | ||
===Life Threatening Causes=== | ===Life Threatening Causes=== | ||
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*[[Pregnancy]] | *[[Pregnancy]] | ||
*[[Short bowel syndrome]] | *[[Short bowel syndrome]] | ||
*[[Ulcerateive colitis]] | *[[Ulcerateive colitis|Ulcerative colitis]] | ||
*[[Vegetarianism]] | *[[Vegetarianism]] | ||
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===Causes in Alphabetical Order=== | ===Causes in Alphabetical Order=== | ||
{{columns-list | {{columns-list| | ||
*[[Advanced age]] | *[[Advanced age]] | ||
*[[Alcoholism]] | *[[Alcoholism]] | ||
Latest revision as of 20:59, 10 January 2020
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Kiran Singh, M.D. [2] Luke Rusowicz-Orazem, B.S.
Overview
Common causes of folate deficiency include gastrointestinal conditions, including malabsorption syndrome and other diseases obstructing folate absorption. Oncological causes, including leukemia, stomach cancer, and liver cancer are life threatening and should be promptly differentiated and diagnosed.[1]
Causes[2][3][4][5][6][7]
A deficiency of folate can occur when your need for folate is increased, when dietary intake of folate is inadequate, and when your body excretes (or loses) more folate than usual. Medications that interfere with your body's ability to use folate may also increase the need for this vitamin. Some research indicates that exposure to ultraviolet light, including the use of tanning beds, can lead to a folic acid deficiency.[8]
Life Threatening Causes
Common Causes
- Bacterial overgrowth of small intestine
- Blind loop syndrome
- Celiac disease
- Congenital impairment of folic acid metabolism
- Crohn's disease
- Infiltrative bowel disease
- Inflammatory bowel disease
- Liver disease
- Malabsorption syndrome
- Malnutrition
- Postoperative
- Pregnancy
- Short bowel syndrome
- Ulcerative colitis
- Vegetarianism
Causes by Organ System
Causes in Alphabetical Order
- Advanced age
- Alcoholism
- Anemia
- Bacterial overgrowth of small intestine
- Blind loop syndrome
- Celiac disease
- Chronic blood loss
- Chronic hemolytic anemia
- Congenital impairment of folic acid metabolism
- Crohn's disease
- Cycloserine
- Cystic fibrosis
- Daraprim
- Depression
- Enzyme defects
- Ethanol
- Ethotoin
- Exfoliative dermatitis
- Hyperthyroidism
- Infiltrative bowel disease
- Inflammatory bowel disease
- Kidney dialysis
- Lactation
- Leukemia
- Liver disease
- Macrocytic anemia
- Malabsorption
- Malabsorption syndrome
- Malnutrition
- Maloprim
- Metformin
- Methotrexate
- Overcooked foods
- Paraneoplastic syndrome
- Phenytoin
- Poor dietary intake
- Postoperative
- Pregnancy
- Primidone
- Psoriasis
- Pyrimethamine
- Seromycin pulvules
- Short bowel syndrome
- Solid tumors
- Substance abuse
- Sulfamethoxazole
- Sulfasalazine
- Tobacco smoking
- Triamterene
- Trimethoprim
- Ulcerateive colitis
- Vegetarianism
References
- ↑ Green R, Datta Mitra A (2017). "Megaloblastic Anemias: Nutritional and Other Causes". Med Clin North Am. 101 (2): 297–317. doi:10.1016/j.mcna.2016.09.013. PMID 28189172.
- ↑ Oakley GP Jr, Adams MJ, Dickinson CM (1996). "More folic acid for everyone, now". Journal of Nutrition. 126 (3): 751S–755S. PMID 8598560.
- ↑ McNulty H (1995). "Folate requirements for health in different population groups". British Journal of Biomedical Science. 52 (2): 110–9. PMID 8520248.
- ↑ Stolzenberg R (1994). "Possible folate deficiency with postsurgical infection". Nutrition in Clinical Practice. 9 (6): 247–50. PMID 7476802.
- ↑ Pietrzik KF and Thorand B (1997). "Folate economy in pregnancy". Nutrition. 13 (11–12): 975–7. PMID 9433714.
- ↑ Kelly GS (1998). "Folates: Supplemental forms and therapeutic applications". Altern Med Rev. 3 (3): 208–20. PMID 9630738.
- ↑ Cravo ML, Gloria LM, Selhub J, Nadeau MR, Camilo ME, Resende MP, Cardoso JN, Leitao CN, Mira FC (1996). "Hyperhomocysteinemia in chronic alcoholism: correlation with folate, vitamin B-12, and vitamin B-6 status". The American journal of clinical nutrition. 63 (2): 220–4. PMID 8561063.
- ↑ Borradale, David C; Kimlin, Michael G (2012). "Folate degradation due to ultraviolet radiation: possible implications for human health and nutrition". Nutrition Reviews. 70 (7): 414–422. doi:10.1111/j.1753-4887.2012.00485.x. ISSN 0029-6643.