Sexcord/ stromal ovarian tumors risk factors: Difference between revisions
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{{Sexcord/ stromal ovarian tumors}} | {{Sexcord/ stromal ovarian tumors}} | ||
{{CMG}}; {{AE}} | {{CMG}}; {{AE}} ;{{M.N}} | ||
==Overview== | ==Overview== | ||
Common [[risk factors]] in the development of sexcord/ stromal ovarian tumors include [[preterm birth]], high [[gonadotrophin]] levels, increasing [[age]] at first [[pregnancy]], [[obese]] and non-white [[women]] | |||
==Risk Factors== | ==Risk Factors== | ||
There is very little data regarding the [[risk factors]] of sexcord-stromal ovarian tumors, however given below are some of the important [[risk factors]] for the development of sexcord-stromal ovarian tumors:<ref name="pmid24530563">{{cite journal |vauthors=Sieh W, Sundquist K, Sundquist J, Winkleby MA, Crump C |title=Intrauterine factors and risk of nonepithelial ovarian cancers |journal=Gynecol. Oncol. |volume=133 |issue=2 |pages=293–7 |date=May 2014 |pmid=24530563 |pmc=4006291 |doi=10.1016/j.ygyno.2014.02.007 |url=}}</ref><ref name="pmid21177423">{{cite journal |vauthors=Chen T, Surcel HM, Lundin E, Kaasila M, Lakso HA, Schock H, Kaaks R, Koskela P, Grankvist K, Hallmans G, Pukkala E, Zeleniuch-Jacquotte A, Toniolo P, Lehtinen M, Lukanova A |title=Circulating sex steroids during pregnancy and maternal risk of non-epithelial ovarian cancer |journal=Cancer Epidemiol. Biomarkers Prev. |volume=20 |issue=2 |pages=324–36 |date=February 2011 |pmid=21177423 |pmc=3082204 |doi=10.1158/1055-9965.EPI-10-0857 |url=}}</ref><ref name="pmid1329996">{{cite journal |vauthors=Horn-Ross PL, Whittemore AS, Harris R, Itnyre J |title=Characteristics relating to ovarian cancer risk: collaborative analysis of 12 U.S. case-control studies. VI. Nonepithelial cancers among adults. Collaborative Ovarian Cancer Group |journal=Epidemiology |volume=3 |issue=6 |pages=490–5 |date=November 1992 |pmid=1329996 |doi= |url=}}</ref><ref name="pmid11006030">{{cite journal |vauthors=Greggi S, Parazzini F, Paratore MP, Chatenoud L, Legge F, Mancuso S, La Vecchia C |title=Risk factors for ovarian cancer in central Italy |journal=Gynecol. Oncol. |volume=79 |issue=1 |pages=50–4 |date=October 2000 |pmid=11006030 |doi=10.1006/gyno.2000.5909 |url=}}</ref><ref name="pmid30281663">{{cite journal |vauthors=Zheng G, Yu H, Kanerva A, Försti A, Sundquist K, Hemminki K |title=Familial risks of ovarian cancer by age at diagnosis, proband type and histology |journal=PLoS ONE |volume=13 |issue=10 |pages=e0205000 |date=2018 |pmid=30281663 |pmc=6169923 |doi=10.1371/journal.pone.0205000 |url=}}</ref> | |||
*Preterm birth is a risk factor for developing sex cord-stromal tumors | *[[Preterm birth]] is a [[risk factor]] for developing sex cord-stromal tumors | ||
*High gonadotropin levels in preterm girls could mediate disease risk by the proliferative and steroidogenic effects of FSH and LH on granulosa and theca cells | *High [[gonadotropin]] levels in [[preterm]] girls could mediate [[disease]] risk by the [[Proliferate|proliferative]] and [[Steroid|steroidogenic]] effects of [[FSH]] and [[LH]] on [[granulosa]] and [[Theca cell|theca cells]] | ||
* | *[[Maternal]] sex-cord stromal tumors are associated with high levels of [[androgens]] during [[pregnancy]] ( indicating that elevated [[androgens]] may also play a role in the [[pathogenesis]] of sex-cord stromal tumors) | ||
*Pregnancy is a risk factor especially with increasing age at first term pregnancy | *[[Pregnancy]] is a [[risk factor]] especially with increasing [[age]] at first term [[pregnancy]] | ||
*There is [[evidence]] suggesting that [[granulosa cell tumors]] are more likely to occur in: <ref name="pmid19664811">{{cite journal |vauthors=Boyce EA, Costaggini I, Vitonis A, Feltmate C, Muto M, Berkowitz R, Cramer D, Horowitz NS |title=The epidemiology of ovarian granulosa cell tumors: a case-control study |journal=Gynecol. Oncol. |volume=115 |issue=2 |pages=221–5 |date=November 2009 |pmid=19664811 |doi=10.1016/j.ygyno.2009.06.040 |url=}}</ref> | |||
**Nonwhite | |||
**[[Obese]] | |||
**[[Women]] with [[family history]] of [[Breast cancer|breast]] or [[ovarian cancer]] | |||
==References== | ==References== | ||
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{{WS}} | {{WS}} | ||
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Latest revision as of 23:29, 2 May 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: ; Maneesha Nandimandalam, M.B.B.S.[2]
Overview
Common risk factors in the development of sexcord/ stromal ovarian tumors include preterm birth, high gonadotrophin levels, increasing age at first pregnancy, obese and non-white women
Risk Factors
There is very little data regarding the risk factors of sexcord-stromal ovarian tumors, however given below are some of the important risk factors for the development of sexcord-stromal ovarian tumors:[1][2][3][4][5]
- Preterm birth is a risk factor for developing sex cord-stromal tumors
- High gonadotropin levels in preterm girls could mediate disease risk by the proliferative and steroidogenic effects of FSH and LH on granulosa and theca cells
- Maternal sex-cord stromal tumors are associated with high levels of androgens during pregnancy ( indicating that elevated androgens may also play a role in the pathogenesis of sex-cord stromal tumors)
- Pregnancy is a risk factor especially with increasing age at first term pregnancy
- There is evidence suggesting that granulosa cell tumors are more likely to occur in: [6]
- Nonwhite
- Obese
- Women with family history of breast or ovarian cancer
References
- ↑ Sieh W, Sundquist K, Sundquist J, Winkleby MA, Crump C (May 2014). "Intrauterine factors and risk of nonepithelial ovarian cancers". Gynecol. Oncol. 133 (2): 293–7. doi:10.1016/j.ygyno.2014.02.007. PMC 4006291. PMID 24530563.
- ↑ Chen T, Surcel HM, Lundin E, Kaasila M, Lakso HA, Schock H, Kaaks R, Koskela P, Grankvist K, Hallmans G, Pukkala E, Zeleniuch-Jacquotte A, Toniolo P, Lehtinen M, Lukanova A (February 2011). "Circulating sex steroids during pregnancy and maternal risk of non-epithelial ovarian cancer". Cancer Epidemiol. Biomarkers Prev. 20 (2): 324–36. doi:10.1158/1055-9965.EPI-10-0857. PMC 3082204. PMID 21177423.
- ↑ Horn-Ross PL, Whittemore AS, Harris R, Itnyre J (November 1992). "Characteristics relating to ovarian cancer risk: collaborative analysis of 12 U.S. case-control studies. VI. Nonepithelial cancers among adults. Collaborative Ovarian Cancer Group". Epidemiology. 3 (6): 490–5. PMID 1329996.
- ↑ Greggi S, Parazzini F, Paratore MP, Chatenoud L, Legge F, Mancuso S, La Vecchia C (October 2000). "Risk factors for ovarian cancer in central Italy". Gynecol. Oncol. 79 (1): 50–4. doi:10.1006/gyno.2000.5909. PMID 11006030.
- ↑ Zheng G, Yu H, Kanerva A, Försti A, Sundquist K, Hemminki K (2018). "Familial risks of ovarian cancer by age at diagnosis, proband type and histology". PLoS ONE. 13 (10): e0205000. doi:10.1371/journal.pone.0205000. PMC 6169923. PMID 30281663.
- ↑ Boyce EA, Costaggini I, Vitonis A, Feltmate C, Muto M, Berkowitz R, Cramer D, Horowitz NS (November 2009). "The epidemiology of ovarian granulosa cell tumors: a case-control study". Gynecol. Oncol. 115 (2): 221–5. doi:10.1016/j.ygyno.2009.06.040. PMID 19664811.